Inflammatory bowel disease(IBD)represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients’quality of life.Effective diagnostic strategies involve clinical ...Inflammatory bowel disease(IBD)represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients’quality of life.Effective diagnostic strategies involve clinical assessments,endoscopic evaluations,imaging studies,and biomarker testing,where early diagnosis is essential for effective management and prevention of long-term complications,highlighting the need for continual advancements in diagnostic methods.The intricate interplay between genetic factors and the outcomes of biological therapy is of critical importance.Unraveling the genetic determinants that influence responses and failures to biological therapy holds significant promise for optimizing treatment strategies for patients with IBD on biologics.Through an indepth examination of current literature,this review article synthesizes critical genetic markers associated with therapeutic efficacy and resistance in IBD.Understanding these genetic actors paves the way for personalized approaches,informing clinicians on predicting,tailoring,and enhancing the effectiveness of biological therapies for improved outcomes in patients with IBD.展开更多
Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy...Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy on serum inflammatory factors. Methods: In this study, 90 patients with acute cerebral infarction hospitalized in Zhuji People’s Hospital from December 2023 to December 2024 were selected and divided into two groups of 45 patients in each group. The control group used standard medical treatment, and the treatment group compared the changes of serum inflammatory factors IL-CRP, TNF-α, and Hcy with Huoxue Tongmai capsule for 7 days, 14 days and 30 days, and discussed the changes of the modified Rankin scale score (mRS) and National Institutes of Health Stroke Scale (NIHSS) score. Results: At 7 days, 14 days, and 30 days of treatment, the NIHSS score, mRS score, hs-CRP, IL-6, TNF-α, and Hcy levels were statistically significant (P α, and Hcy levels in the treatment group were significantly lower than those in the control group (P Conclusion: Patients with acute cerebral infarction received Huoxue Tongmai capsule combined with edaravone right camphor, which can reduce the inflammatory reaction, improve the nerve function and improve the prognosis.展开更多
Objective:To analyze the clinical value of Pulmicort Respules inhalation combined with cetirizine in the treatment of pediatric asthma.Methods:From December 2023 to December 2024,82 children with asthma admitted to ou...Objective:To analyze the clinical value of Pulmicort Respules inhalation combined with cetirizine in the treatment of pediatric asthma.Methods:From December 2023 to December 2024,82 children with asthma admitted to our hospital were randomly divided into a control group and an observation group,with 41 cases in each group.The clinical symptom relief time(shortness of breath,cough,dyspnea,lung wheezing),lung function indicators(FEV1,FVC,FEV1/FVC),inflammatory indicators(TNF-α,IL-6,IL-8),and clinical treatment effects were analyzed in the two groups.Results:The relief time for shortness of breath,cough,dyspnea,and lung wheezing in the observation group was shorter than that in the control group(P<0.05).After treatment,compared with the control group,the levels of FEV1,FVC,FEV1/FVC,and treatment efficiency in the observation group were higher,while the levels of TNF-α,IL-6,and IL-8 were lower(P<0.05).Conclusion:The combination of Pulmicort Respules inhalation and cetirizine oral therapy for children with asthma can shorten the improvement time of clinical symptoms,inhibit inflammation,and improve lung function.展开更多
Objective To examine the mechanistic of organochlorine-associated changes in lung function.Methods This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth period.Personal exposure t...Objective To examine the mechanistic of organochlorine-associated changes in lung function.Methods This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth period.Personal exposure to organochlorines was quantified using wearable passive samplers,while inflammatory factors and thyroid hormones were analyzed from blood samples.Participants’lung function was evaluated.After stratifying participants according to their thyroid hormone levels,we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone groups.Mediation analysis was further conducted to elucidate the relationships among organochlorine exposures,inflammatory factors,and lung function.Results Bis(2-chloro-1-methylethyl)ether(BCIE),was negatively associated with forced vital capacity(FVC,–2.05%,95%CI:–3.11%to–0.97%),and associated with changes in inflammatory factors such as interleukin(IL)-2,IL-7,IL-8,and IL-13 in the low thyroid hormone group.The mediation analysis indicated a mediating effect of IL-2(15.63%,95%CI:0.91%to 44.64%)and IL-13(13.94%,95%CI:0.52%to 41.07%)in the association between BCIE exposure and FVC.Conclusion Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels,with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function.展开更多
Objective:To investigate the impact of early initiation of intensive lipid-lowering therapy on the postoperative efficacy and inflammatory factors in patients with acute coronary syndrome(ACS)undergoing percutaneous c...Objective:To investigate the impact of early initiation of intensive lipid-lowering therapy on the postoperative efficacy and inflammatory factors in patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI).Methods:A total of 100 ACS patients undergoing PCI admitted to our hospital were selected as the study subjects.They were randomly divided into a control group(treated with statin combined with ezetimibe,n=41),a study group 1(initiated with statin combined with PCSK9 inhibitor immediately after surgery,n=32),and a study group 2(routinely administered oral statin and initiated with combined PCSK9 inhibitor before discharge,n=27).The therapeutic efficacy,inflammatory factor levels,and incidence of adverse events were compared and analyzed among the three groups.Results:The therapeutic regimen in study group 1 demonstrated the optimal efficacy and impact on inflammatory factors,followed by study group 2,while the control group showed relatively weaker efficacy,with statistically significant differences(p<0.05).The overall incidence of adverse reactions was 30.00%in the control group,5.00%in study group 1,and 10.00%in study group 2,with statistically significant differences among the groups(p<0.05),with the lowest incidence observed in study group 1.Conclusion:Early intensive lipid-lowering therapy can effectively improve lipid metabolism,suppress inflammatory responses,and reduce cardiovascular events in ACS patients after PCI,suggesting its pleiotropic cardiovascular protective effects.展开更多
BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver cancer subtype with limited effective treatment options.Emerging evidence suggests that inflammatory factors play a critical role in ICC progr...BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver cancer subtype with limited effective treatment options.Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment(TME).However,causal relationships between specific inflammatory factors and ICC risk remain unclear.AIM To investigate the causal relationship between inflammatory factors and ICC.METHODS This study used Mendelian randomization(MR)and Bayesian weighted MR(BWMR)analyses to investigate the causal impact of inflammatory factors on ICC risk.Genetic data from genome-wide association studies were utilized to identify and validate instrumental variables for 91 inflammatory factors,followed by sensitivity analyses to ensure robustness.RESULTS MR analysis identified significant associations between elevated levels of artemin and matrix metalloproteinase(MMP)-10 and increased ICC risk.BWMR and meta-MR analysis results validated these associations.Sensitivity analyses confirmed the stability of these findings,indicating that specific inflammatory factors may contribute causally to ICC development.CONCLUSION This study provides evidence that certain inflammatory factors,particularly artemin and MMP-10,are causally linked to ICC risk,identifying them as potential risk factors and therapeutic targeting.These findings enhance the understanding of the inflammatory components of the TME in ICC,supporting the development of targeted intervention strategies.展开更多
BACKGROUND Data on adsorptive extracorporeal membrane oxygenation(ECMO)(combined with HA380 hemoperfusion column)on the inflammatory factors in patients with cardiogenic shock(CS)remains limited.AIM To investigate the...BACKGROUND Data on adsorptive extracorporeal membrane oxygenation(ECMO)(combined with HA380 hemoperfusion column)on the inflammatory factors in patients with cardiogenic shock(CS)remains limited.AIM To investigate the effects of adsorptive ECMO on the inflammatory factors in patients with CS.METHODS A retrospective analysis was performed on 81 patients with CS caused by acute myocardial infarction,fulminant myocarditis,or cardiac surgery who required venoarterial ECMO support at TEDA International Cardiovascular Hospital from December 2020 to December 2024.Patients were divided into the conventional ECMO group(42 cases)and the adsorptive ECMO group(ECMO combined with hemoperfusion,39 cases).The adsorptive ECMO group received 2 columns of HA380 initiation on the first day(the first column connected within 2 hours of ECMO and the second after 12 hours of ECMO),followed by 1 column each day,with each column used for 4–6 hours,totaling 24–30 hours of treatment.Baseline data were compared between the two groups:Inflammatory factor levels(at 0,6,12,24,48,and 72 hours after ECMO or hemoperfusion initiation);ECMO support duration;successful weaning rate;continuous renal replacement therapy(CRRT)utilization;Sequential Organ Failure Assessment(SOFA)score;Vasoactive-Inotropic Score(VIS);systemic inflammatory response syndrome(SIRS)incidence;and in-hospital survival and 30-/90-day survival after discharge.RESULTS The adsorptive ECMO group showed significantly lower levels of C-reactive protein,interleukin(IL)-6,tumor necrosis factor(TNF)-α,and lactate from 6 to 72 hours compared with the conventional ECMO group(all P<0.05),with IL-6 decreasing by 94.4%and tumour necrosis factor alpha by 70.1%from baseline at 72 hours.The adsorptive ECMO group had a significantly shorter ECMO duration[114.0(75.0–139.0)hours vs 135.0(73.0–199.3)hours,P=0.032];higher successful weaning rate(66.7%vs 42.9%,P=0.032);a trend toward lower CRRT utilization(54.8%vs 38.5%,P=0.070);lower post-weaning SOFA score[7(6–8)vs 9(8–10),P<0.001];significantly reduced VIS(8.4±1.3 vs 9.8±1.6,P<0.001);and a trend toward lower SIRS incidence(10.3%vs 26.2%,P=0.065).There were no significant differences in complications,in-hospital survival(64.1%vs 52.4%,P=0.285);or 30-/90-day survival between the two groups(all P>0.05).CONCLUSION Adsorptive ECMO efficiently clears IL-6 and TNF-α,significantly improving ECMO weaning success rate and hemodynamics.However,it has no significant impact on survival,and its efficacy requires validation through prospective studies.展开更多
BACKGROUND Although thoracotomy has been the conventional treatment for patients with early esophageal cancer(EEC),its drawbacks underscore the demand for more effective therapeutic strategies to improve surgical outc...BACKGROUND Although thoracotomy has been the conventional treatment for patients with early esophageal cancer(EEC),its drawbacks underscore the demand for more effective therapeutic strategies to improve surgical outcomes.AIM To comprehensively analyze the effect of totally thoracoscopic esophagectomy(TTE)on postoperative complications and serum inflammatory factors in patients diagnosed with EEC.METHODS A total of 113 patients with EEC,who were admitted to our hospital between September 2022 and December 2024,were recruited for this study.Specifically,55 patients were assigned to the control group and underwent conventional surgical procedures,whereas 58 patients formed the research group and underwent TTE.Subsequently,a series of comparisons and analyses were conducted between the two groups.These comparisons included surgery-related parameters,such as incision length,operation duration,and the number and extent of lymph node dissection;postoperative complications,namely,empyema,pulmonary infection,incision infection,anastomotic fistula,and delayed gastric emptying;postoperative pain,which was quantitatively evaluated by the Numerical Rating Scale;postoperative hospitalization duration;serum inflammatory factors,including interleukin(IL)-6,IL-8,and tumor necrosis factor-α;and stress response-associated indicators,such as C-reactive protein,cortisol,and adrenaline.RESULTS Statistical data demonstrated that compared with the control group,the research group exhibited substantially shorter incision length and postoperative hospitalization duration.The two groups had comparable number and extent of lymph node dissection.Notably,both the overall incidence of postoperative complications and the Numerical Rating Scale score on postoperative day 3 were remarkably lower in the research group.Although the levels of IL-6,IL-8,tumor necrosis factor-α,C-reactive protein,cortisol,and adrenaline in the research group increased statistically postoperatively,they were still considerably lower than those in the control group.CONCLUSION In patients with EEC,TTE not only reduces the risk of postoperative complications but also effectively alleviates the body’s inflammatory and stress responses associated with surgery.展开更多
BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft...BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.展开更多
BACKGROUND Dental implants are widely used to replace missing teeth.Currently,clinicians assess osseointegration success by measuring the implant’s stability within the bone and monitoring the marginal tissue height....BACKGROUND Dental implants are widely used to replace missing teeth.Currently,clinicians assess osseointegration success by measuring the implant’s stability within the bone and monitoring the marginal tissue height.Diabetes,especially type 2 diabetes mellitus(T2DM),has been reported to impair implant healing,drastically reducing implant success rates.AIM To analyze the high-risk factors for inflammatory response and prognosis after dental implantation in patients with T2DM,and provide strong evidence for reducing the incidence of postimplant peri-implantitis(PI).METHODS We performed a retrospective review of 146 patients with T2DM who had dental implants placed at Tianjin Fifth Central Hospital,between September 2021 and September 2023,which was regarded as the observation group.Moreover,60 ageand gender-matched individuals with normal blood glucose levels served as the control group.The general information,postoperative periodontal indices,and levels of inflammatory factors were comprehensively analyzed and compared.Furthermore,the incidence of postimplant PI was counted,and multivariate logistic regression was used to identify the determinants of postimplant PI.RESULTS In terms of the periodontal indices,the probing depth,modified sulcus bleeding index,and marginal bone loss in the observation cohorts began to increase significantly at 6 months and 3 months,respectively,after the completion of dental implant restoration.The T2DM cases demonstrated significantly elevated counts of leukocytes,lymphocytes,and neutrophils compared to the controls at 24 hours postoperatively.Moreover,the TNF-α,IL-1β,and IL-6 concentrations started to increase significantly in the gingival crevicular fluid 3 months after the completion of dental implant restoration in both cohorts,with the observation group exhibiting higher levels than the controls at each time point.63 out of the 146 cases developed PI.Multivariate logistic regression analysis indicated that high glycosylated hemoglobin levels,smoking,daily tooth-brushing frequency of less than once,and the anterior tooth as the implant site independently contributed to postimplant PI in T2DM cases,while a tooth-brushing duration of≥3 minutes was a protective factor.CONCLUSION Patients with T2DM are at risk of developing PI following dental implantation.Clinically,it is necessary to enhance the identification of risk factors for postimplant PI,improve risk prediction,prevention,and control,and formulate targeted intervention countermeasures to reduce the occurrence of postimplant PI.展开更多
Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteri...Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteristics of gut microbiota of children and their mothers,and examine the correlation of the microbial composition in mother–child pairs.Methods:We conducted a case-control study including children with PIBD and their mothers as the case group,as well as healthy children and their mothers as the control group.Questionnaires were used to collect information such as family illness history and maternal and early-life events.Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA(rRNA)sequencing to analyze the composition and its potential association with PIBD.Results:A total of 54 pairs of cases and 122 pairs of controls were recruited.A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD,and a higher education level of the father was associated with a decreased risk of PIBD.Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers.Similarities were observed in the gut microbiota of mothers and children in the same groups.Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.Conclusions:PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics.The mother–child gut microbiota is closely related,suggesting the transmission and influence of the gut microbiota between mothers and children.This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.展开更多
BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AI...BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.展开更多
AIM To analyze the efficacy of laparoscopic radical resection of CRC(LRRCC)in treating older patients with CRC and the effect of this procedure on inflammatory factors.METHODS The study included 104 older patients wit...AIM To analyze the efficacy of laparoscopic radical resection of CRC(LRRCC)in treating older patients with CRC and the effect of this procedure on inflammatory factors.METHODS The study included 104 older patients with CRC admitted from August 2022 to August 2024.Participants undergoing open radical resection of CRC were categorized as the control group(50 patients),whereas those receiving LRRCC were classified as the research group(54 patients).Subsequently,comparative analyses involved data on efficacy,postoperative complications(ileus,incision infection,anastomotic fistula,and pulmonary infection),surgery-related parameters(operation duration and intraoperative bleeding volume),postoperative recoveryrelated indicators(time to first postoperative passage of flatus and defecation and length of hospital stay),and inflammatory factors(tumor necrosis factor-α,highsensitivity C-reactive protein,and interleukin-6).RESULTS Data revealed markedly superior therapeutic efficacy and a lower overall postoperative complication rate in the research group compared to the control group.The research group demonstrated substantially less intraoperative bleeding,less time to first postoperative passage of flatus and defecation,and a shorter length of hospital stay despite a notably longer operation duration compared to the control group.Further,tumor necrosis factor-α,high-sensitivity C-reactive protein,and interleukin-6 levels in the research group were significantly reduced 3 days postoperatively compared to both the preoperative and control group values.CONCLUSION LRRCC for older patients with CRC exhibited superior therapeutic efficacy compared to open radical resection and significantly suppressed postoperative stress-related inflammatory responses,which merits clinical application and promotion.展开更多
In this article,we comment on the article by Blüthner et al.The article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a Germ...In this article,we comment on the article by Blüthner et al.The article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German cohort.It highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing complications.The study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial approach.Additionally,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other regions.This detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early diagnosis.The importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.展开更多
BACKGROUND Non-small cell lung cancer(NSCLC)is frequently characterized by poor response to cisplatin(DDP)-based chemotherapy,with increasing evidence suggesting that inflammatory cytokines in the tumor microenvironme...BACKGROUND Non-small cell lung cancer(NSCLC)is frequently characterized by poor response to cisplatin(DDP)-based chemotherapy,with increasing evidence suggesting that inflammatory cytokines in the tumor microenvironment contribute to chemoresistance.AIM To investigate the role of inflammatory cytokines in DDP resistance and to effect of IL-6 inhibition on chemosensitivity in NSCLC.METHODS Twenty NSCLC patients were grouped into DDP-sensitive or DDP-resistant cohorts based on their clinical response.Cytokine levels in tumor tissues and NSCLC cell lines,including DDP-resistant A549/DDP and SK-MES-1/DDP,were quantified using enzyme-linked immunosorbent assay.To verify the effects of interleukin(IL)-6 on DDP resistance,NSCLC and resistant cells were treated with IL-6 inhibitors tocilizumab(TCZ),followed by DDP treatment.Cell viability,apoptosis,migration and invasion were detected via cell counting kit-8,flow cytometry,scratch assay,and transwell,respectively.RESULTS IL-6,IL-8,and tumor necrosis factor-αlevels were significantly elevated in DDP-resistance tissues and cell models compared to sensitive controls(P<0.05).TCZ treatment significantly reduced the half-maximal inhibitory concentration of DDP in resistant cells,induced apoptosis,and hindered migration and invasion(P<0.05).IL-6 and IL-8 were identified as key cytokines associated with DDP resistance.CONCLUSION These findings demonstrated that IL-6 and related cytokines contribute to DDP resistance in NSCLC.IL-6 inhibition restores chemosensitivity and may serve as a promising therapeutic strategy in resistant NSCLC.展开更多
Fatigue is a prevalent and often debilitating symptom in individuals with inflammatory bowel disease(IBD),affecting a substantial proportion of patients,even during periods of disease remission.The prevalence of fatig...Fatigue is a prevalent and often debilitating symptom in individuals with inflammatory bowel disease(IBD),affecting a substantial proportion of patients,even during periods of disease remission.The prevalence of fatigue in IBD remains high,affecting around half of the IBD patients and being more common in patients with active disease than those in remission.Several risk factors contribute to fatigue in IBD,including active disease and pro-inflammatory state,nutritional deficiencies and anemia,sleep disturbances,psychological comorbidities,microbiota changes and the gut-brain axis,muscle dysfunction,sarcopenia,and physical inactivity.Assessing fatigue in IBD is challenging due to its subjective nature and the lack of a uniformly quantifiable method.Fatigue significantly impacts the quality of life,affecting physical functioning,psychological and emotional wellbeing,and social and relational consequences.The management of fatigue in IBD requires a comprehensive,multidisciplinary approach.This includes addressing disease activity through conventional drug treatment,biologicals and small molecules,and surgical treatment.Psychological interventions such as cognitive behavioral therapy,problem-solving therapy,solution-focused therapy,mindfulness-based cognitive therapy,and brief behavioral therapy have shown promise in improving fatigue.Nutritional interventions,including treating deficiencies and supplementation,and lifestyle interventions,such as physical exercise,aromatherapy,and sleep interventions,are also important components of fatigue management.Pharmacological interventions like modafinil and bupropion may be considered in refractory cases.This review aims to summarize the current evidence on fatigue in IBD,including its prevalence,risk factors,assessment methods,outcomes,and management strategies.展开更多
Inflammatory bowel disease is a chronic,debilitating disorder of the gastrointestinal tract.The etiology of inflammatory bowel disease has not been elucidated,but is thought to be multifactorial with both environmenta...Inflammatory bowel disease is a chronic,debilitating disorder of the gastrointestinal tract.The etiology of inflammatory bowel disease has not been elucidated,but is thought to be multifactorial with both environmental and genetic influences.A large body of research has been conducted to elucidate the etiology of inflammatory bowel disease.This article reviews this literature,emphasizing the studies of breastfeeding and the studies of genetic factors,particularly NOD2 polymorphisms.展开更多
[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randoml...[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.展开更多
Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn’s disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a fami...Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn’s disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.展开更多
AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that ...AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research.展开更多
基金Supported by The European Union-Next Generation EU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008。
文摘Inflammatory bowel disease(IBD)represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients’quality of life.Effective diagnostic strategies involve clinical assessments,endoscopic evaluations,imaging studies,and biomarker testing,where early diagnosis is essential for effective management and prevention of long-term complications,highlighting the need for continual advancements in diagnostic methods.The intricate interplay between genetic factors and the outcomes of biological therapy is of critical importance.Unraveling the genetic determinants that influence responses and failures to biological therapy holds significant promise for optimizing treatment strategies for patients with IBD on biologics.Through an indepth examination of current literature,this review article synthesizes critical genetic markers associated with therapeutic efficacy and resistance in IBD.Understanding these genetic actors paves the way for personalized approaches,informing clinicians on predicting,tailoring,and enhancing the effectiveness of biological therapies for improved outcomes in patients with IBD.
文摘Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy on serum inflammatory factors. Methods: In this study, 90 patients with acute cerebral infarction hospitalized in Zhuji People’s Hospital from December 2023 to December 2024 were selected and divided into two groups of 45 patients in each group. The control group used standard medical treatment, and the treatment group compared the changes of serum inflammatory factors IL-CRP, TNF-α, and Hcy with Huoxue Tongmai capsule for 7 days, 14 days and 30 days, and discussed the changes of the modified Rankin scale score (mRS) and National Institutes of Health Stroke Scale (NIHSS) score. Results: At 7 days, 14 days, and 30 days of treatment, the NIHSS score, mRS score, hs-CRP, IL-6, TNF-α, and Hcy levels were statistically significant (P α, and Hcy levels in the treatment group were significantly lower than those in the control group (P Conclusion: Patients with acute cerebral infarction received Huoxue Tongmai capsule combined with edaravone right camphor, which can reduce the inflammatory reaction, improve the nerve function and improve the prognosis.
文摘Objective:To analyze the clinical value of Pulmicort Respules inhalation combined with cetirizine in the treatment of pediatric asthma.Methods:From December 2023 to December 2024,82 children with asthma admitted to our hospital were randomly divided into a control group and an observation group,with 41 cases in each group.The clinical symptom relief time(shortness of breath,cough,dyspnea,lung wheezing),lung function indicators(FEV1,FVC,FEV1/FVC),inflammatory indicators(TNF-α,IL-6,IL-8),and clinical treatment effects were analyzed in the two groups.Results:The relief time for shortness of breath,cough,dyspnea,and lung wheezing in the observation group was shorter than that in the control group(P<0.05).After treatment,compared with the control group,the levels of FEV1,FVC,FEV1/FVC,and treatment efficiency in the observation group were higher,while the levels of TNF-α,IL-6,and IL-8 were lower(P<0.05).Conclusion:The combination of Pulmicort Respules inhalation and cetirizine oral therapy for children with asthma can shorten the improvement time of clinical symptoms,inhibit inflammation,and improve lung function.
基金supported by the National Key Research and Development Program of China(No.2022YFC3702700)the National Natural Science Foundation of China(No.82025030)the National Research Program for Key Issues in Air Pollution Control of China(No.DQGG0401)。
文摘Objective To examine the mechanistic of organochlorine-associated changes in lung function.Methods This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth period.Personal exposure to organochlorines was quantified using wearable passive samplers,while inflammatory factors and thyroid hormones were analyzed from blood samples.Participants’lung function was evaluated.After stratifying participants according to their thyroid hormone levels,we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone groups.Mediation analysis was further conducted to elucidate the relationships among organochlorine exposures,inflammatory factors,and lung function.Results Bis(2-chloro-1-methylethyl)ether(BCIE),was negatively associated with forced vital capacity(FVC,–2.05%,95%CI:–3.11%to–0.97%),and associated with changes in inflammatory factors such as interleukin(IL)-2,IL-7,IL-8,and IL-13 in the low thyroid hormone group.The mediation analysis indicated a mediating effect of IL-2(15.63%,95%CI:0.91%to 44.64%)and IL-13(13.94%,95%CI:0.52%to 41.07%)in the association between BCIE exposure and FVC.Conclusion Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels,with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function.
文摘Objective:To investigate the impact of early initiation of intensive lipid-lowering therapy on the postoperative efficacy and inflammatory factors in patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI).Methods:A total of 100 ACS patients undergoing PCI admitted to our hospital were selected as the study subjects.They were randomly divided into a control group(treated with statin combined with ezetimibe,n=41),a study group 1(initiated with statin combined with PCSK9 inhibitor immediately after surgery,n=32),and a study group 2(routinely administered oral statin and initiated with combined PCSK9 inhibitor before discharge,n=27).The therapeutic efficacy,inflammatory factor levels,and incidence of adverse events were compared and analyzed among the three groups.Results:The therapeutic regimen in study group 1 demonstrated the optimal efficacy and impact on inflammatory factors,followed by study group 2,while the control group showed relatively weaker efficacy,with statistically significant differences(p<0.05).The overall incidence of adverse reactions was 30.00%in the control group,5.00%in study group 1,and 10.00%in study group 2,with statistically significant differences among the groups(p<0.05),with the lowest incidence observed in study group 1.Conclusion:Early intensive lipid-lowering therapy can effectively improve lipid metabolism,suppress inflammatory responses,and reduce cardiovascular events in ACS patients after PCI,suggesting its pleiotropic cardiovascular protective effects.
基金Supported by National Key Research and Development Program of China,No.2021YFA1301104.
文摘BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver cancer subtype with limited effective treatment options.Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment(TME).However,causal relationships between specific inflammatory factors and ICC risk remain unclear.AIM To investigate the causal relationship between inflammatory factors and ICC.METHODS This study used Mendelian randomization(MR)and Bayesian weighted MR(BWMR)analyses to investigate the causal impact of inflammatory factors on ICC risk.Genetic data from genome-wide association studies were utilized to identify and validate instrumental variables for 91 inflammatory factors,followed by sensitivity analyses to ensure robustness.RESULTS MR analysis identified significant associations between elevated levels of artemin and matrix metalloproteinase(MMP)-10 and increased ICC risk.BWMR and meta-MR analysis results validated these associations.Sensitivity analyses confirmed the stability of these findings,indicating that specific inflammatory factors may contribute causally to ICC development.CONCLUSION This study provides evidence that certain inflammatory factors,particularly artemin and MMP-10,are causally linked to ICC risk,identifying them as potential risk factors and therapeutic targeting.These findings enhance the understanding of the inflammatory components of the TME in ICC,supporting the development of targeted intervention strategies.
基金Supported by the Priority Project of the Multi-Source Investment Fund Program,China,No.S21DYZD3172the Tianjin Key Medical Discipline(Specialty)Construction Project,China,No.TJYXZDXK-020A.
文摘BACKGROUND Data on adsorptive extracorporeal membrane oxygenation(ECMO)(combined with HA380 hemoperfusion column)on the inflammatory factors in patients with cardiogenic shock(CS)remains limited.AIM To investigate the effects of adsorptive ECMO on the inflammatory factors in patients with CS.METHODS A retrospective analysis was performed on 81 patients with CS caused by acute myocardial infarction,fulminant myocarditis,or cardiac surgery who required venoarterial ECMO support at TEDA International Cardiovascular Hospital from December 2020 to December 2024.Patients were divided into the conventional ECMO group(42 cases)and the adsorptive ECMO group(ECMO combined with hemoperfusion,39 cases).The adsorptive ECMO group received 2 columns of HA380 initiation on the first day(the first column connected within 2 hours of ECMO and the second after 12 hours of ECMO),followed by 1 column each day,with each column used for 4–6 hours,totaling 24–30 hours of treatment.Baseline data were compared between the two groups:Inflammatory factor levels(at 0,6,12,24,48,and 72 hours after ECMO or hemoperfusion initiation);ECMO support duration;successful weaning rate;continuous renal replacement therapy(CRRT)utilization;Sequential Organ Failure Assessment(SOFA)score;Vasoactive-Inotropic Score(VIS);systemic inflammatory response syndrome(SIRS)incidence;and in-hospital survival and 30-/90-day survival after discharge.RESULTS The adsorptive ECMO group showed significantly lower levels of C-reactive protein,interleukin(IL)-6,tumor necrosis factor(TNF)-α,and lactate from 6 to 72 hours compared with the conventional ECMO group(all P<0.05),with IL-6 decreasing by 94.4%and tumour necrosis factor alpha by 70.1%from baseline at 72 hours.The adsorptive ECMO group had a significantly shorter ECMO duration[114.0(75.0–139.0)hours vs 135.0(73.0–199.3)hours,P=0.032];higher successful weaning rate(66.7%vs 42.9%,P=0.032);a trend toward lower CRRT utilization(54.8%vs 38.5%,P=0.070);lower post-weaning SOFA score[7(6–8)vs 9(8–10),P<0.001];significantly reduced VIS(8.4±1.3 vs 9.8±1.6,P<0.001);and a trend toward lower SIRS incidence(10.3%vs 26.2%,P=0.065).There were no significant differences in complications,in-hospital survival(64.1%vs 52.4%,P=0.285);or 30-/90-day survival between the two groups(all P>0.05).CONCLUSION Adsorptive ECMO efficiently clears IL-6 and TNF-α,significantly improving ECMO weaning success rate and hemodynamics.However,it has no significant impact on survival,and its efficacy requires validation through prospective studies.
基金Supported by Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan Project,No.2023ZL424.
文摘BACKGROUND Although thoracotomy has been the conventional treatment for patients with early esophageal cancer(EEC),its drawbacks underscore the demand for more effective therapeutic strategies to improve surgical outcomes.AIM To comprehensively analyze the effect of totally thoracoscopic esophagectomy(TTE)on postoperative complications and serum inflammatory factors in patients diagnosed with EEC.METHODS A total of 113 patients with EEC,who were admitted to our hospital between September 2022 and December 2024,were recruited for this study.Specifically,55 patients were assigned to the control group and underwent conventional surgical procedures,whereas 58 patients formed the research group and underwent TTE.Subsequently,a series of comparisons and analyses were conducted between the two groups.These comparisons included surgery-related parameters,such as incision length,operation duration,and the number and extent of lymph node dissection;postoperative complications,namely,empyema,pulmonary infection,incision infection,anastomotic fistula,and delayed gastric emptying;postoperative pain,which was quantitatively evaluated by the Numerical Rating Scale;postoperative hospitalization duration;serum inflammatory factors,including interleukin(IL)-6,IL-8,and tumor necrosis factor-α;and stress response-associated indicators,such as C-reactive protein,cortisol,and adrenaline.RESULTS Statistical data demonstrated that compared with the control group,the research group exhibited substantially shorter incision length and postoperative hospitalization duration.The two groups had comparable number and extent of lymph node dissection.Notably,both the overall incidence of postoperative complications and the Numerical Rating Scale score on postoperative day 3 were remarkably lower in the research group.Although the levels of IL-6,IL-8,tumor necrosis factor-α,C-reactive protein,cortisol,and adrenaline in the research group increased statistically postoperatively,they were still considerably lower than those in the control group.CONCLUSION In patients with EEC,TTE not only reduces the risk of postoperative complications but also effectively alleviates the body’s inflammatory and stress responses associated with surgery.
文摘BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.
基金Supported by Tianjin Municipality Health Science and Technology Project,No.TJWJ2023MS052.
文摘BACKGROUND Dental implants are widely used to replace missing teeth.Currently,clinicians assess osseointegration success by measuring the implant’s stability within the bone and monitoring the marginal tissue height.Diabetes,especially type 2 diabetes mellitus(T2DM),has been reported to impair implant healing,drastically reducing implant success rates.AIM To analyze the high-risk factors for inflammatory response and prognosis after dental implantation in patients with T2DM,and provide strong evidence for reducing the incidence of postimplant peri-implantitis(PI).METHODS We performed a retrospective review of 146 patients with T2DM who had dental implants placed at Tianjin Fifth Central Hospital,between September 2021 and September 2023,which was regarded as the observation group.Moreover,60 ageand gender-matched individuals with normal blood glucose levels served as the control group.The general information,postoperative periodontal indices,and levels of inflammatory factors were comprehensively analyzed and compared.Furthermore,the incidence of postimplant PI was counted,and multivariate logistic regression was used to identify the determinants of postimplant PI.RESULTS In terms of the periodontal indices,the probing depth,modified sulcus bleeding index,and marginal bone loss in the observation cohorts began to increase significantly at 6 months and 3 months,respectively,after the completion of dental implant restoration.The T2DM cases demonstrated significantly elevated counts of leukocytes,lymphocytes,and neutrophils compared to the controls at 24 hours postoperatively.Moreover,the TNF-α,IL-1β,and IL-6 concentrations started to increase significantly in the gingival crevicular fluid 3 months after the completion of dental implant restoration in both cohorts,with the observation group exhibiting higher levels than the controls at each time point.63 out of the 146 cases developed PI.Multivariate logistic regression analysis indicated that high glycosylated hemoglobin levels,smoking,daily tooth-brushing frequency of less than once,and the anterior tooth as the implant site independently contributed to postimplant PI in T2DM cases,while a tooth-brushing duration of≥3 minutes was a protective factor.CONCLUSION Patients with T2DM are at risk of developing PI following dental implantation.Clinically,it is necessary to enhance the identification of risk factors for postimplant PI,improve risk prediction,prevention,and control,and formulate targeted intervention countermeasures to reduce the occurrence of postimplant PI.
基金supported by the National Key R&D Program of China(Nos.2021YFA1301300,2019YFA0905600,and 2023YFC2706503)the National Natural Science Foundation of China(Nos.82170557 and 82000510).
文摘Objective:The risk factors and role of mother–child gut microbiota in pediatric inflammatory bowel disease(PIBD)remain unclear.We aimed to explore the clinical risk factors associated with PIBD,analyze the characteristics of gut microbiota of children and their mothers,and examine the correlation of the microbial composition in mother–child pairs.Methods:We conducted a case-control study including children with PIBD and their mothers as the case group,as well as healthy children and their mothers as the control group.Questionnaires were used to collect information such as family illness history and maternal and early-life events.Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA(rRNA)sequencing to analyze the composition and its potential association with PIBD.Results:A total of 54 pairs of cases and 122 pairs of controls were recruited.A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD,and a higher education level of the father was associated with a decreased risk of PIBD.Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers.Similarities were observed in the gut microbiota of mothers and children in the same groups.Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.Conclusions:PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics.The mother–child gut microbiota is closely related,suggesting the transmission and influence of the gut microbiota between mothers and children.This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.
文摘BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.
基金Supported by the Medical Research Project of Jiangsu Health Commission,No.Z2021010.
文摘AIM To analyze the efficacy of laparoscopic radical resection of CRC(LRRCC)in treating older patients with CRC and the effect of this procedure on inflammatory factors.METHODS The study included 104 older patients with CRC admitted from August 2022 to August 2024.Participants undergoing open radical resection of CRC were categorized as the control group(50 patients),whereas those receiving LRRCC were classified as the research group(54 patients).Subsequently,comparative analyses involved data on efficacy,postoperative complications(ileus,incision infection,anastomotic fistula,and pulmonary infection),surgery-related parameters(operation duration and intraoperative bleeding volume),postoperative recoveryrelated indicators(time to first postoperative passage of flatus and defecation and length of hospital stay),and inflammatory factors(tumor necrosis factor-α,highsensitivity C-reactive protein,and interleukin-6).RESULTS Data revealed markedly superior therapeutic efficacy and a lower overall postoperative complication rate in the research group compared to the control group.The research group demonstrated substantially less intraoperative bleeding,less time to first postoperative passage of flatus and defecation,and a shorter length of hospital stay despite a notably longer operation duration compared to the control group.Further,tumor necrosis factor-α,high-sensitivity C-reactive protein,and interleukin-6 levels in the research group were significantly reduced 3 days postoperatively compared to both the preoperative and control group values.CONCLUSION LRRCC for older patients with CRC exhibited superior therapeutic efficacy compared to open radical resection and significantly suppressed postoperative stress-related inflammatory responses,which merits clinical application and promotion.
文摘In this article,we comment on the article by Blüthner et al.The article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German cohort.It highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing complications.The study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial approach.Additionally,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other regions.This detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early diagnosis.The importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.
文摘BACKGROUND Non-small cell lung cancer(NSCLC)is frequently characterized by poor response to cisplatin(DDP)-based chemotherapy,with increasing evidence suggesting that inflammatory cytokines in the tumor microenvironment contribute to chemoresistance.AIM To investigate the role of inflammatory cytokines in DDP resistance and to effect of IL-6 inhibition on chemosensitivity in NSCLC.METHODS Twenty NSCLC patients were grouped into DDP-sensitive or DDP-resistant cohorts based on their clinical response.Cytokine levels in tumor tissues and NSCLC cell lines,including DDP-resistant A549/DDP and SK-MES-1/DDP,were quantified using enzyme-linked immunosorbent assay.To verify the effects of interleukin(IL)-6 on DDP resistance,NSCLC and resistant cells were treated with IL-6 inhibitors tocilizumab(TCZ),followed by DDP treatment.Cell viability,apoptosis,migration and invasion were detected via cell counting kit-8,flow cytometry,scratch assay,and transwell,respectively.RESULTS IL-6,IL-8,and tumor necrosis factor-αlevels were significantly elevated in DDP-resistance tissues and cell models compared to sensitive controls(P<0.05).TCZ treatment significantly reduced the half-maximal inhibitory concentration of DDP in resistant cells,induced apoptosis,and hindered migration and invasion(P<0.05).IL-6 and IL-8 were identified as key cytokines associated with DDP resistance.CONCLUSION These findings demonstrated that IL-6 and related cytokines contribute to DDP resistance in NSCLC.IL-6 inhibition restores chemosensitivity and may serve as a promising therapeutic strategy in resistant NSCLC.
文摘Fatigue is a prevalent and often debilitating symptom in individuals with inflammatory bowel disease(IBD),affecting a substantial proportion of patients,even during periods of disease remission.The prevalence of fatigue in IBD remains high,affecting around half of the IBD patients and being more common in patients with active disease than those in remission.Several risk factors contribute to fatigue in IBD,including active disease and pro-inflammatory state,nutritional deficiencies and anemia,sleep disturbances,psychological comorbidities,microbiota changes and the gut-brain axis,muscle dysfunction,sarcopenia,and physical inactivity.Assessing fatigue in IBD is challenging due to its subjective nature and the lack of a uniformly quantifiable method.Fatigue significantly impacts the quality of life,affecting physical functioning,psychological and emotional wellbeing,and social and relational consequences.The management of fatigue in IBD requires a comprehensive,multidisciplinary approach.This includes addressing disease activity through conventional drug treatment,biologicals and small molecules,and surgical treatment.Psychological interventions such as cognitive behavioral therapy,problem-solving therapy,solution-focused therapy,mindfulness-based cognitive therapy,and brief behavioral therapy have shown promise in improving fatigue.Nutritional interventions,including treating deficiencies and supplementation,and lifestyle interventions,such as physical exercise,aromatherapy,and sleep interventions,are also important components of fatigue management.Pharmacological interventions like modafinil and bupropion may be considered in refractory cases.This review aims to summarize the current evidence on fatigue in IBD,including its prevalence,risk factors,assessment methods,outcomes,and management strategies.
文摘Inflammatory bowel disease is a chronic,debilitating disorder of the gastrointestinal tract.The etiology of inflammatory bowel disease has not been elucidated,but is thought to be multifactorial with both environmental and genetic influences.A large body of research has been conducted to elucidate the etiology of inflammatory bowel disease.This article reviews this literature,emphasizing the studies of breastfeeding and the studies of genetic factors,particularly NOD2 polymorphisms.
文摘[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.
文摘Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn’s disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.
文摘AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research.
