As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic p...As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.展开更多
To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahep...To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahepatic cholangiocarcinoma.Invasive carcinoma,tubular or mucinous adenocarcinoma is present in approximately 40%-80%of IPNBs[1–3].IPNB is frequently found in the resection margins of patients undergoing hepatectomy for cholangiocarcinoma[4].展开更多
Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no e...Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no effective treatment available for ALS and consequently,most patients die several years post diagnosis.The neurodegeneration that occurs in ALS is considered to be a non-cell autonomous process involving interactions between the motor neuron and its diverse extracellular microenvironments via an unknown mechanism.Distal Axonopathy is one of the early disease signs;however,the involvement and contribution of neighboring tissues and specifically,the muscle environment to the disease pathology remain controversial.Few works have concluded that muscles play a minor role or none at all in ALS pathology.展开更多
The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates th...The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.展开更多
New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.Th...New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.The 41st such service center,it is located in the upmarket Sandton City Office Tower building in the affluent northern suburbs,enjoying convenient transportation.Travelers to China,who previously needed to apply for a visa at the Chinese Embassy in Pretona or the Consulate General of China in Johannesburg, can now apply at the center, making the visa application process faster and more convenient. A senior visa officer at the Johannesburg consulate talked to ChinAfrica about the need for the center and how to apply there for a visa.展开更多
Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and ...Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and sustains the correct cell fate of neural stem cells/neuroblasts in the Drosophila 3rd instar larval central brain.We show that the FACT complex binds to the promoter region of the estrogen-related receptor(ERR)gene and positively regulates ERR expression.ERR is known to act as an aerobic glycolytic switch by upregulating the enzymes required for glycolysis.Dysfunction of the FACT complex leads to the downregulation of ERR transcription,resulting in a decreased ratio of glycolysis to oxidative phosphorylation(G/O)in neuroblasts.Consequently,neuroblasts exhibit smaller cell sizes,lower proliferation potential,and altered cell fates.Overexpression of ERR or suppression of mitochondrial oxidative phosphorylation in neuroblasts increases the relative G/O ratio and rescues defective phenotypes caused by dysfunction of the FACT complex.Thus,the G/O ratio,mediated by the FACT complex,plays a crucial role in neuroblast cell fate maintenance.Our study may shed light on the mechanism by which mutations in the FACT complex lead to intellectual disability in humans.展开更多
Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been us...Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS’, where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR, RhA G, and RhNUDXin rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods.展开更多
With the support by the National Natural Science Foundation of China,the research team directed by Prof.Wang XiaoGang(王晓刚)at the Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang Univ...With the support by the National Natural Science Foundation of China,the research team directed by Prof.Wang XiaoGang(王晓刚)at the Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,recently reported that lncRNA regulates osteoblast activity and bone formation in mice by up-regulating the osteogenic transcription factor Osterix,which was published in Nature Metabolism(2019,1:485—496).展开更多
The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the gl...The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.展开更多
Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potenti...Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potential risk to groundwater due to colloid-facilitated transport.However,the extent to which soil colloidsmay enhance the spreading of PBDEs in groundwater is largely unknown.Herein,we report the co-transport of decabromodiphenyl ester(BDE-209)and soil colloids in saturated porous media.The colloids released froma soil sample collected at an e-waste recycling site in Tianjin,China,contain high concentration of PBDEs,with BDE-209 being the most abundant conger(320±30 mg/kg).The colloids exhibit relatively high mobility in saturated sand columns,under conditions commonly observed in groundwater environments.Notably,under all the tested conditions(i.e.,varying flow velocity,pH,ionic species and ionic strength),the mass of eluted BDE-209 correlates linearly with that of eluted soil colloids,even though the mobility of the colloids varies markedly depending on the specific hydrodynamic and solution chemistry conditions involved.Additionally,the mass of BDE-209 retained in the columns also correlates strongly with themass of retained colloids.Apparently,the PBDEs remain bound to soil colloids during transport in porous media.Findings in this study indicate that soil colloidsmay significantly promote the transport of PBDEs in groundwater by serving as an effective carrier.This might be the reason why the highly insoluble and adsorptive PBDEs are found in groundwater at some PBDE-contaminated sites.展开更多
Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to...Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.展开更多
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.展开更多
Supported catalysts based on metal nanoparticles are a class of widely used heterogeneous catalysts in industry.The catalytic performances of supported metal catalysts are highly determined by many parameters of metal...Supported catalysts based on metal nanoparticles are a class of widely used heterogeneous catalysts in industry.The catalytic performances of supported metal catalysts are highly determined by many parameters of metal nanoparticles such as their particle size,composition,surface structure and also interfacial interaction with supports[1].展开更多
Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has s...Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.展开更多
Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for...Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for Implementation Research(CFIR).Methods The sample consisted of 17 nurses from three urology wards at a tertiary hospital in Beijing,China,who had participated in the EBP.Guided by the CFIR,we identified constructs influencing the sustainability of implementation by conducting a directed content analysis of the 17 individual in-depth interviews.By rating,the valence and magnitude of each construct were determined.Results This study identified 19 factors across the five domains of the CFIR.Among these determinants,16 were identified as barriers,while three were recognized as facilitators.Common barriers across different contexts were identified,such as delayed evidence updating,the complexity of intervention components and steps,and incompatibility between the implementation process and clinical practices.In contrast,facilitators of intervention implementation were regular communication and feedback,support and drive from principals and a positive cultural atmosphere.In addition,we identified“regular evidence updating”as an independent construct outside of the CFIR,a finding that will provide key information for updating the CFIR framework.Conclusions Regular evidence updating is crucial for the sustainability of EBP implementation.Researchers should receive consistent feedback from practitioners and adjust or modify the EBP as necessary.Additionally,researchers must consider the compatibility or adaptability of the EBP’s content with clinical practice in formulating it rather than adding additional complexity to the original workflow.展开更多
Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Sem...Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Semi-structured interviews were conducted with 10 frail KTRs who participated in a 3-month Baduanjin practice.The Colaizzi seven-step analysis method was used to analyze,summarize,and extract themes from the interview data.Results:Two themes were extracted:facilitators and barriers.Facilitators included intrinsic motivation and perceived benefits,while barriers included conflicts with practice time,worsening physical condition,lack of immediate benefits,and difficulty integrating into daily life.Conclusion:The practice of Baduanjin by frail KTRs is influenced by various factors.Healthcare professionals should develop personalized intervention plans that take into account these factors and the needs of the patients.展开更多
Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their fu...Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their functions have not yet been confirmed,especially for SULTR3 in rice.In this study,we analyzed the expression patterns,subcellular localization,and inorganic phosphate(Pi)transporter activity of SULTR3 proteins in yeast.Except for OsSULTR3.4,which localized to the plasma membrane,other OsSULTR3 members were localized to the endoplasmic reticulum(ER)membrane in rice protoplast cells.展开更多
Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive dise...Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive disease on lichi,litchi downy blight.PlM90 was reported as a key oosporogenesis regulator.Here,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 mutant.To investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing technology.Compared with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and pathogenicity.Furthermore,PlMFS1 deletion significantly affected P.litchii utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial growth.PlMFS1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired P.litchii pathogenicity.To our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.展开更多
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).展开更多
BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts betwee...BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.展开更多
文摘As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.
文摘To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahepatic cholangiocarcinoma.Invasive carcinoma,tubular or mucinous adenocarcinoma is present in approximately 40%-80%of IPNBs[1–3].IPNB is frequently found in the resection margins of patients undergoing hepatectomy for cholangiocarcinoma[4].
基金supported by the Israel Science Foundation(grant number 561-11)the European Research Council(grant number 309377)to EP
文摘Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no effective treatment available for ALS and consequently,most patients die several years post diagnosis.The neurodegeneration that occurs in ALS is considered to be a non-cell autonomous process involving interactions between the motor neuron and its diverse extracellular microenvironments via an unknown mechanism.Distal Axonopathy is one of the early disease signs;however,the involvement and contribution of neighboring tissues and specifically,the muscle environment to the disease pathology remain controversial.Few works have concluded that muscles play a minor role or none at all in ALS pathology.
文摘The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.
文摘New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.The 41st such service center,it is located in the upmarket Sandton City Office Tower building in the affluent northern suburbs,enjoying convenient transportation.Travelers to China,who previously needed to apply for a visa at the Chinese Embassy in Pretona or the Consulate General of China in Johannesburg, can now apply at the center, making the visa application process faster and more convenient. A senior visa officer at the Johannesburg consulate talked to ChinAfrica about the need for the center and how to apply there for a visa.
基金supported by grants from the National Key R&D Program of China(2018YFC1004904 and 2013CB945601).
文摘Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and sustains the correct cell fate of neural stem cells/neuroblasts in the Drosophila 3rd instar larval central brain.We show that the FACT complex binds to the promoter region of the estrogen-related receptor(ERR)gene and positively regulates ERR expression.ERR is known to act as an aerobic glycolytic switch by upregulating the enzymes required for glycolysis.Dysfunction of the FACT complex leads to the downregulation of ERR transcription,resulting in a decreased ratio of glycolysis to oxidative phosphorylation(G/O)in neuroblasts.Consequently,neuroblasts exhibit smaller cell sizes,lower proliferation potential,and altered cell fates.Overexpression of ERR or suppression of mitochondrial oxidative phosphorylation in neuroblasts increases the relative G/O ratio and rescues defective phenotypes caused by dysfunction of the FACT complex.Thus,the G/O ratio,mediated by the FACT complex,plays a crucial role in neuroblast cell fate maintenance.Our study may shed light on the mechanism by which mutations in the FACT complex lead to intellectual disability in humans.
基金supported by the National Natural Science Foundation of China (31501791, 31660579, and 31360492)Leading talents in science and technology (2016HA005)funded in part by Beijing Natural Science Foundation (6162017)
文摘Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS’, where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR, RhA G, and RhNUDXin rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods.
文摘With the support by the National Natural Science Foundation of China,the research team directed by Prof.Wang XiaoGang(王晓刚)at the Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,recently reported that lncRNA regulates osteoblast activity and bone formation in mice by up-regulating the osteogenic transcription factor Osterix,which was published in Nature Metabolism(2019,1:485—496).
基金supported by the Major Subject of the National Social Science Foundation of China(21&ZD093)the Basic Research Funds of Chinese Academy of Agricultural Sciences(16100520240017)+1 种基金the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAASCSAERD-202402,10-IAED-04-2024)the earmarked fund for China Agriculture Research System(CARS-08).
文摘The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.
基金supported by the National Key Research and Development Program of China(No.2019YFC1804202)the National Natural Science Foundation of China(No.22020102004)+1 种基金the Tianjin Municipal Science and Technology Bureau(No.21JCZDJC00280)the Fundamental Research Funds for the Central Universities by the Ministry of Education of China(No.T2017002).
文摘Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potential risk to groundwater due to colloid-facilitated transport.However,the extent to which soil colloidsmay enhance the spreading of PBDEs in groundwater is largely unknown.Herein,we report the co-transport of decabromodiphenyl ester(BDE-209)and soil colloids in saturated porous media.The colloids released froma soil sample collected at an e-waste recycling site in Tianjin,China,contain high concentration of PBDEs,with BDE-209 being the most abundant conger(320±30 mg/kg).The colloids exhibit relatively high mobility in saturated sand columns,under conditions commonly observed in groundwater environments.Notably,under all the tested conditions(i.e.,varying flow velocity,pH,ionic species and ionic strength),the mass of eluted BDE-209 correlates linearly with that of eluted soil colloids,even though the mobility of the colloids varies markedly depending on the specific hydrodynamic and solution chemistry conditions involved.Additionally,the mass of BDE-209 retained in the columns also correlates strongly with themass of retained colloids.Apparently,the PBDEs remain bound to soil colloids during transport in porous media.Findings in this study indicate that soil colloidsmay significantly promote the transport of PBDEs in groundwater by serving as an effective carrier.This might be the reason why the highly insoluble and adsorptive PBDEs are found in groundwater at some PBDE-contaminated sites.
文摘Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.
基金supported by the National Natural Science Foundation of China,No.82104412(to TD)Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD)+1 种基金the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM)Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
文摘The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.
文摘Supported catalysts based on metal nanoparticles are a class of widely used heterogeneous catalysts in industry.The catalytic performances of supported metal catalysts are highly determined by many parameters of metal nanoparticles such as their particle size,composition,surface structure and also interfacial interaction with supports[1].
文摘Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.
基金supported by the Peking University Nursing Discipline Research Development Fund(No.TYZH2023001)。
文摘Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for Implementation Research(CFIR).Methods The sample consisted of 17 nurses from three urology wards at a tertiary hospital in Beijing,China,who had participated in the EBP.Guided by the CFIR,we identified constructs influencing the sustainability of implementation by conducting a directed content analysis of the 17 individual in-depth interviews.By rating,the valence and magnitude of each construct were determined.Results This study identified 19 factors across the five domains of the CFIR.Among these determinants,16 were identified as barriers,while three were recognized as facilitators.Common barriers across different contexts were identified,such as delayed evidence updating,the complexity of intervention components and steps,and incompatibility between the implementation process and clinical practices.In contrast,facilitators of intervention implementation were regular communication and feedback,support and drive from principals and a positive cultural atmosphere.In addition,we identified“regular evidence updating”as an independent construct outside of the CFIR,a finding that will provide key information for updating the CFIR framework.Conclusions Regular evidence updating is crucial for the sustainability of EBP implementation.Researchers should receive consistent feedback from practitioners and adjust or modify the EBP as necessary.Additionally,researchers must consider the compatibility or adaptability of the EBP’s content with clinical practice in formulating it rather than adding additional complexity to the original workflow.
基金funded by the General Program of the National Natural Science Foundation of China(82072553)the Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-026).
文摘Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Semi-structured interviews were conducted with 10 frail KTRs who participated in a 3-month Baduanjin practice.The Colaizzi seven-step analysis method was used to analyze,summarize,and extract themes from the interview data.Results:Two themes were extracted:facilitators and barriers.Facilitators included intrinsic motivation and perceived benefits,while barriers included conflicts with practice time,worsening physical condition,lack of immediate benefits,and difficulty integrating into daily life.Conclusion:The practice of Baduanjin by frail KTRs is influenced by various factors.Healthcare professionals should develop personalized intervention plans that take into account these factors and the needs of the patients.
基金supported by the National Natural Science Foundation of China(Grant Nos.32130096 and 32172667)the Central Public-Interest Scientific Institution Basal Research Fund,China(Grant No.Y2022QC14).
文摘Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their functions have not yet been confirmed,especially for SULTR3 in rice.In this study,we analyzed the expression patterns,subcellular localization,and inorganic phosphate(Pi)transporter activity of SULTR3 proteins in yeast.Except for OsSULTR3.4,which localized to the plasma membrane,other OsSULTR3 members were localized to the endoplasmic reticulum(ER)membrane in rice protoplast cells.
基金funded by the Natural Science Foundation of Guangdong Province,China(Grant Nos.2023A1515012617,2022A1515010458 and 2023A1515030267)Guangzhou Science&Technology Program(Grant No.202201010410)the earmarked fund for CARS-32。
文摘Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive disease on lichi,litchi downy blight.PlM90 was reported as a key oosporogenesis regulator.Here,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 mutant.To investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing technology.Compared with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and pathogenicity.Furthermore,PlMFS1 deletion significantly affected P.litchii utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial growth.PlMFS1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired P.litchii pathogenicity.To our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.
基金funded by NIH grants HL154720-03S1, AG057587, AG074283, DK122708-03S1, BrightFocus ADR A20183775Brown Foundation 2020 Healthy Aging Initiative (to WC)
文摘Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).
文摘BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.
