Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to...Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.展开更多
The well-facilitated farmland projects(WFFPs)involve the typical sustainable intensification of farmland use and play a key role in raising food production in China.However,whether such WFFPs can enhance the nitrogen(...The well-facilitated farmland projects(WFFPs)involve the typical sustainable intensification of farmland use and play a key role in raising food production in China.However,whether such WFFPs can enhance the nitrogen(N)use efficiency and reduce environmental impacts is still unclear.Here,we examined the data from 502 valid questionnaires collected from WFFPs in the major grain-producing area,the Huang-Huai-Hai Region(HHHR)in China,with 429 samples for wheat,328 for maize,and 122 for rice.We identified gaps in N use efficiency(NUE)and N losses from the production of the three crops between the sampled WFFPs and counties based on the statistical data.The results showed that compared to the county-level(wheat,39.1%;maize,33.8%;rice,35.1%),the NUEs for wheat(55.2%),maize(52.1%),and rice(50.2%)in the WFFPs were significantly improved(P<0.05).In addition,the intensities of ammonia(NH3)volatilization(9.9-12.2 kg N ha–1),N leaching(6.5-16.9 kg N ha–1),and nitrous oxide(N2O)emissions(1.2-1.6 kg N ha–1)from crop production in the sampled WFFPs were significantly lower than the county averages(P<0.05).Simulations showed that if the N rates are reduced by 10.0,15.0,and 20.0%for the counties,the NUEs of wheat,maize,and rice in the HHHR will increase by 2.9-6.3,2.4-5.2,and 2.6-5.7%,respectively.If the N rate is reduced to the WFFP level in each county,the NUEs of the three crops will increase by 12.9-19.5%,and the N leaching,NH3,and N2O emissions will be reduced by 48.9-56.2,37.4-42.9,and 46.0-66.5%,respectively.Our findings highlight that efficient N management practices in sustainable intensive farmland have considerable potential for reducing environmental impacts.展开更多
Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has s...Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.展开更多
Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eig...Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eighty seven patients with first AMI were divided into two groups: group A ( n =42), pPCI group, the patients underwent PCI within 6h after onset of AMI; group B ( n =45), rtPA+PCI group, the patients underwent PCI after thrombolysis within 6h after onset of AMI; Myocardial viability was measured by 99m Tc MIBI SPECT. While, the parameters of cardiac function LVEF and ventricular systolic synchrony LVPS were measured by 99m Tc gated cardiac blood pool image on the first and the fourth weekend. Results (1) The peak CK MB was significantly lower in group A than that in group B( P <0.01 ). (2) Myocardial infarction area (MIA) was decreased and radioactivity counts in MIA was significantly increased in group A and B on the 4th weekend compared with that on the first weekend ( P <0.01 ), but there were no significant difference between group A and group B. (3) LVEF, LVPS were no significant difference between group A and group B.Conclusions (1)pPCI in acute myocardial infartion can limit infarct area, maintain ventricular systolic synchrony and improve ventricular function; (2) but, in those hospitals that there were no any condition for PCI, they should transfer the patients to central hospital for PCI after thrombolysis at the first time. It is beneficial to improve myocardial viability and ventricular systolic synchrony of AMI patients in short time.展开更多
CO2 separation performance in facilitated transport membranes has been reported depended not only on the CO2 carrier properties but also to a great extent on the polymeric matrix regarding the capacity of retaining wa...CO2 separation performance in facilitated transport membranes has been reported depended not only on the CO2 carrier properties but also to a great extent on the polymeric matrix regarding the capacity of retaining water and carriers as well as the processability for coating defect-free ultra-thin films. In this study, the blends of hydrophilic polymers polyvinyl pyrrolidone(PVP) and polyvinyl alcohol(PVA) were studied to find an optimal polymer matrix to host carriers in facilitated transport membranes for enhanced CO2 separation. It is found out that the optimized blend is 50/50 PVA/PVP by weight, which shows a significant increase in the water uptake(from 63 to 84%) at equilibrium state compared to the neat PVA. Polyethyleneimine(PEI) was employed to provide sample carriers to evaluate the synergistic effect of PVA and PVP on the CO2 separation performance. A thin film composite(TFC) membrane of the optimized blend(50/50 PVA/PVP with 50 wt% PEI) was fabricated on polysulfone(PSf) porous support. The fabrication of the TFC membranes is simple and low cost, and CO2 permeance of the optimized blend membrane is nearly doubled with the CO2/N2 selectivity remained unchanged, showing great potential for industrial applications of the resulted membranes.展开更多
Carbon dioxide(CO_(2))capture by gas-separation membranes has become increasingly attractive due to its high energy efficiency,relatively low cost,and environmental impact.Polyvinylamine(PVAm)-based facilitated transp...Carbon dioxide(CO_(2))capture by gas-separation membranes has become increasingly attractive due to its high energy efficiency,relatively low cost,and environmental impact.Polyvinylamine(PVAm)-based facilitated transport(FT)membranes were developed in the last decade for CO_(2) capture.This work discusses the challenges of applying PVAm-based FT membranes from materials to processes for postcombustion CO_(2) capture in power plants and cement factories.Experiences learned from a pilot demonstration system can be used to guide the design of other membranes for CO_(2) capture.The importance of module and process design is emphasized in the achievement of a high-performance membrane system.Moreover,the results from process simulation and cost estimation indicate that a three-stage membrane system is feasible for achieving a high CO_(2) purity of 95 vol%.The specific CO_(2) capture cost was found to significantly depend on the required CO_(2) capture ratio,and a moderate CO_(2) capture ratio of 50%presented a cost of 63.7USD per tonne CO_(2) captured.Thus,FT membrane systems were found to be more competitive for partial CO_(2) capture.展开更多
As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic p...As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.展开更多
Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of f...Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of facilitated potassium ion transfer by an ionophore dibenzo 18 crown 6(DB18C6) across a micro water/1,2 dichloroethane(W/DCE) interface supported at the tip of a silanized micropipette. Our experimental results verify that this facilitated ion transfer across the liquid/liquid interface did occur by an interfacial complexation dissociation process(TIC TID mechanism). The ratio of the diffusion coefficient of DB18C6 to that of its complexed ion in the DCE phase was calculated to be 1.74±0.07.展开更多
To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahep...To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahepatic cholangiocarcinoma.Invasive carcinoma,tubular or mucinous adenocarcinoma is present in approximately 40%-80%of IPNBs[1–3].IPNB is frequently found in the resection margins of patients undergoing hepatectomy for cholangiocarcinoma[4].展开更多
The application of Information and Communication Technologies has transformed traditional Teaching and Learning in the past decade to computerized-based era. This evolution has resulted from the emergence of the digit...The application of Information and Communication Technologies has transformed traditional Teaching and Learning in the past decade to computerized-based era. This evolution has resulted from the emergence of the digital system and has greatly impacted on the global education and socio-cultural development. Multimedia has been absorbed into the education sector for producing a new learning concept and a combination of educational and entertainment approach. This research is concerned with the application of Window Speech Recognition and Microsoft Visual Basic 2008 Integrated/Interactive Development Environment in Multimedia-Assisted Courseware prototype development for Primary School Mathematics contents, namely, single digits and the addition. The Teaching and Learning techniques—Explain, Instruct and Facilitate are proposed and these could be viewed as instructors’ centered strategy, instructors’—learners’ dual communication and learners' active participation. The prototype is called M-EIF and deployed only users' voices;hence the activation of Window Speech Recognition is required prior to a test run.展开更多
Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no e...Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no effective treatment available for ALS and consequently,most patients die several years post diagnosis.The neurodegeneration that occurs in ALS is considered to be a non-cell autonomous process involving interactions between the motor neuron and its diverse extracellular microenvironments via an unknown mechanism.Distal Axonopathy is one of the early disease signs;however,the involvement and contribution of neighboring tissues and specifically,the muscle environment to the disease pathology remain controversial.Few works have concluded that muscles play a minor role or none at all in ALS pathology.展开更多
Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites...Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites x-1, x-2 (or x+1, x+2) are empty. It is nongradient and lacks invariant measures of product form. The purpose of this paper is to identify the invariant measures and to show that they satisfy both exponential decay of correlations and equivalence of ensembles. These properties will play a pivotal role in deriving the hydrodynamic limit.展开更多
The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates th...The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.展开更多
Support SMEs Increase the scale of financial supports at various levels to support SMEs, sustain light & textile projects with promising market prospect, notable driving of employment and remarkable social benefit...Support SMEs Increase the scale of financial supports at various levels to support SMEs, sustain light & textile projects with promising market prospect, notable driving of employment and remarkable social benefits, and step up investments in construction of credit guarantee system and service展开更多
New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.Th...New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.The 41st such service center,it is located in the upmarket Sandton City Office Tower building in the affluent northern suburbs,enjoying convenient transportation.Travelers to China,who previously needed to apply for a visa at the Chinese Embassy in Pretona or the Consulate General of China in Johannesburg, can now apply at the center, making the visa application process faster and more convenient. A senior visa officer at the Johannesburg consulate talked to ChinAfrica about the need for the center and how to apply there for a visa.展开更多
1 INTRODUCTIONMany attempts to develop semipermeable membranes for gas separation have beendone over the past twenty years [1,2].However,it is still difficult to prepare apolymer film which makes certain gas separatio...1 INTRODUCTIONMany attempts to develop semipermeable membranes for gas separation have beendone over the past twenty years [1,2].However,it is still difficult to prepare apolymer film which makes certain gas separation processed within range of being econ-omically and technically feasible,since most polymeric materials are relativelyimpermeable to gases.Facilitated transport concept which was first proposed展开更多
Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and ...Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and sustains the correct cell fate of neural stem cells/neuroblasts in the Drosophila 3rd instar larval central brain.We show that the FACT complex binds to the promoter region of the estrogen-related receptor(ERR)gene and positively regulates ERR expression.ERR is known to act as an aerobic glycolytic switch by upregulating the enzymes required for glycolysis.Dysfunction of the FACT complex leads to the downregulation of ERR transcription,resulting in a decreased ratio of glycolysis to oxidative phosphorylation(G/O)in neuroblasts.Consequently,neuroblasts exhibit smaller cell sizes,lower proliferation potential,and altered cell fates.Overexpression of ERR or suppression of mitochondrial oxidative phosphorylation in neuroblasts increases the relative G/O ratio and rescues defective phenotypes caused by dysfunction of the FACT complex.Thus,the G/O ratio,mediated by the FACT complex,plays a crucial role in neuroblast cell fate maintenance.Our study may shed light on the mechanism by which mutations in the FACT complex lead to intellectual disability in humans.展开更多
文摘Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.
基金supported by the National Key Research and Development Program of China(2022YFB3903505)the National Natural Science Foundation of China(72221002)。
文摘The well-facilitated farmland projects(WFFPs)involve the typical sustainable intensification of farmland use and play a key role in raising food production in China.However,whether such WFFPs can enhance the nitrogen(N)use efficiency and reduce environmental impacts is still unclear.Here,we examined the data from 502 valid questionnaires collected from WFFPs in the major grain-producing area,the Huang-Huai-Hai Region(HHHR)in China,with 429 samples for wheat,328 for maize,and 122 for rice.We identified gaps in N use efficiency(NUE)and N losses from the production of the three crops between the sampled WFFPs and counties based on the statistical data.The results showed that compared to the county-level(wheat,39.1%;maize,33.8%;rice,35.1%),the NUEs for wheat(55.2%),maize(52.1%),and rice(50.2%)in the WFFPs were significantly improved(P<0.05).In addition,the intensities of ammonia(NH3)volatilization(9.9-12.2 kg N ha–1),N leaching(6.5-16.9 kg N ha–1),and nitrous oxide(N2O)emissions(1.2-1.6 kg N ha–1)from crop production in the sampled WFFPs were significantly lower than the county averages(P<0.05).Simulations showed that if the N rates are reduced by 10.0,15.0,and 20.0%for the counties,the NUEs of wheat,maize,and rice in the HHHR will increase by 2.9-6.3,2.4-5.2,and 2.6-5.7%,respectively.If the N rate is reduced to the WFFP level in each county,the NUEs of the three crops will increase by 12.9-19.5%,and the N leaching,NH3,and N2O emissions will be reduced by 48.9-56.2,37.4-42.9,and 46.0-66.5%,respectively.Our findings highlight that efficient N management practices in sustainable intensive farmland have considerable potential for reducing environmental impacts.
文摘Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.
文摘Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eighty seven patients with first AMI were divided into two groups: group A ( n =42), pPCI group, the patients underwent PCI within 6h after onset of AMI; group B ( n =45), rtPA+PCI group, the patients underwent PCI after thrombolysis within 6h after onset of AMI; Myocardial viability was measured by 99m Tc MIBI SPECT. While, the parameters of cardiac function LVEF and ventricular systolic synchrony LVPS were measured by 99m Tc gated cardiac blood pool image on the first and the fourth weekend. Results (1) The peak CK MB was significantly lower in group A than that in group B( P <0.01 ). (2) Myocardial infarction area (MIA) was decreased and radioactivity counts in MIA was significantly increased in group A and B on the 4th weekend compared with that on the first weekend ( P <0.01 ), but there were no significant difference between group A and group B. (3) LVEF, LVPS were no significant difference between group A and group B.Conclusions (1)pPCI in acute myocardial infartion can limit infarct area, maintain ventricular systolic synchrony and improve ventricular function; (2) but, in those hospitals that there were no any condition for PCI, they should transfer the patients to central hospital for PCI after thrombolysis at the first time. It is beneficial to improve myocardial viability and ventricular systolic synchrony of AMI patients in short time.
基金the Norwegian Research Council for the financial support to this work through the Nano2021 program (project number 239172)
文摘CO2 separation performance in facilitated transport membranes has been reported depended not only on the CO2 carrier properties but also to a great extent on the polymeric matrix regarding the capacity of retaining water and carriers as well as the processability for coating defect-free ultra-thin films. In this study, the blends of hydrophilic polymers polyvinyl pyrrolidone(PVP) and polyvinyl alcohol(PVA) were studied to find an optimal polymer matrix to host carriers in facilitated transport membranes for enhanced CO2 separation. It is found out that the optimized blend is 50/50 PVA/PVP by weight, which shows a significant increase in the water uptake(from 63 to 84%) at equilibrium state compared to the neat PVA. Polyethyleneimine(PEI) was employed to provide sample carriers to evaluate the synergistic effect of PVA and PVP on the CO2 separation performance. A thin film composite(TFC) membrane of the optimized blend(50/50 PVA/PVP with 50 wt% PEI) was fabricated on polysulfone(PSf) porous support. The fabrication of the TFC membranes is simple and low cost, and CO2 permeance of the optimized blend membrane is nearly doubled with the CO2/N2 selectivity remained unchanged, showing great potential for industrial applications of the resulted membranes.
文摘Carbon dioxide(CO_(2))capture by gas-separation membranes has become increasingly attractive due to its high energy efficiency,relatively low cost,and environmental impact.Polyvinylamine(PVAm)-based facilitated transport(FT)membranes were developed in the last decade for CO_(2) capture.This work discusses the challenges of applying PVAm-based FT membranes from materials to processes for postcombustion CO_(2) capture in power plants and cement factories.Experiences learned from a pilot demonstration system can be used to guide the design of other membranes for CO_(2) capture.The importance of module and process design is emphasized in the achievement of a high-performance membrane system.Moreover,the results from process simulation and cost estimation indicate that a three-stage membrane system is feasible for achieving a high CO_(2) purity of 95 vol%.The specific CO_(2) capture cost was found to significantly depend on the required CO_(2) capture ratio,and a moderate CO_(2) capture ratio of 50%presented a cost of 63.7USD per tonne CO_(2) captured.Thus,FT membrane systems were found to be more competitive for partial CO_(2) capture.
文摘As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.
基金Supported by Chinese Academ y of Sciences(CAS) National Natural Science Foundation of China(No. 2 982 5 111) andthe Third World Academ y of Science(TWAS) and the State Key L aboratory of Electroanalytical Chem istry of the CAS.
文摘Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of facilitated potassium ion transfer by an ionophore dibenzo 18 crown 6(DB18C6) across a micro water/1,2 dichloroethane(W/DCE) interface supported at the tip of a silanized micropipette. Our experimental results verify that this facilitated ion transfer across the liquid/liquid interface did occur by an interfacial complexation dissociation process(TIC TID mechanism). The ratio of the diffusion coefficient of DB18C6 to that of its complexed ion in the DCE phase was calculated to be 1.74±0.07.
文摘To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahepatic cholangiocarcinoma.Invasive carcinoma,tubular or mucinous adenocarcinoma is present in approximately 40%-80%of IPNBs[1–3].IPNB is frequently found in the resection margins of patients undergoing hepatectomy for cholangiocarcinoma[4].
文摘The application of Information and Communication Technologies has transformed traditional Teaching and Learning in the past decade to computerized-based era. This evolution has resulted from the emergence of the digital system and has greatly impacted on the global education and socio-cultural development. Multimedia has been absorbed into the education sector for producing a new learning concept and a combination of educational and entertainment approach. This research is concerned with the application of Window Speech Recognition and Microsoft Visual Basic 2008 Integrated/Interactive Development Environment in Multimedia-Assisted Courseware prototype development for Primary School Mathematics contents, namely, single digits and the addition. The Teaching and Learning techniques—Explain, Instruct and Facilitate are proposed and these could be viewed as instructors’ centered strategy, instructors’—learners’ dual communication and learners' active participation. The prototype is called M-EIF and deployed only users' voices;hence the activation of Window Speech Recognition is required prior to a test run.
基金supported by the Israel Science Foundation(grant number 561-11)the European Research Council(grant number 309377)to EP
文摘Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no effective treatment available for ALS and consequently,most patients die several years post diagnosis.The neurodegeneration that occurs in ALS is considered to be a non-cell autonomous process involving interactions between the motor neuron and its diverse extracellular microenvironments via an unknown mechanism.Distal Axonopathy is one of the early disease signs;however,the involvement and contribution of neighboring tissues and specifically,the muscle environment to the disease pathology remain controversial.Few works have concluded that muscles play a minor role or none at all in ALS pathology.
基金Supported in part by the National Natural Science Foundation of China(11731012, 11871425, 12271475)Fundamental Research Funds for Central Universities grant(2020XZZX002-03)。
文摘Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites x-1, x-2 (or x+1, x+2) are empty. It is nongradient and lacks invariant measures of product form. The purpose of this paper is to identify the invariant measures and to show that they satisfy both exponential decay of correlations and equivalence of ensembles. These properties will play a pivotal role in deriving the hydrodynamic limit.
文摘The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.
文摘Support SMEs Increase the scale of financial supports at various levels to support SMEs, sustain light & textile projects with promising market prospect, notable driving of employment and remarkable social benefits, and step up investments in construction of credit guarantee system and service
文摘New application center in South Africa facilitates travels to ChinaAfrica’s first Chinese Visa Application Service Center opened its doors in Johannesburg,South Africa,on March 17 after a whole year’s preparation.The 41st such service center,it is located in the upmarket Sandton City Office Tower building in the affluent northern suburbs,enjoying convenient transportation.Travelers to China,who previously needed to apply for a visa at the Chinese Embassy in Pretona or the Consulate General of China in Johannesburg, can now apply at the center, making the visa application process faster and more convenient. A senior visa officer at the Johannesburg consulate talked to ChinAfrica about the need for the center and how to apply there for a visa.
文摘1 INTRODUCTIONMany attempts to develop semipermeable membranes for gas separation have beendone over the past twenty years [1,2].However,it is still difficult to prepare apolymer film which makes certain gas separation processed within range of being econ-omically and technically feasible,since most polymeric materials are relativelyimpermeable to gases.Facilitated transport concept which was first proposed
基金supported by grants from the National Key R&D Program of China(2018YFC1004904 and 2013CB945601).
文摘Defects in the FAcilitates Chromatin Transcription(FACT)complex,a histone chaperone composed of SSRP1 and SUPT16H,are implicated in intellectual disability.Here,we reveal that the FACT complex promotes glycolysis and sustains the correct cell fate of neural stem cells/neuroblasts in the Drosophila 3rd instar larval central brain.We show that the FACT complex binds to the promoter region of the estrogen-related receptor(ERR)gene and positively regulates ERR expression.ERR is known to act as an aerobic glycolytic switch by upregulating the enzymes required for glycolysis.Dysfunction of the FACT complex leads to the downregulation of ERR transcription,resulting in a decreased ratio of glycolysis to oxidative phosphorylation(G/O)in neuroblasts.Consequently,neuroblasts exhibit smaller cell sizes,lower proliferation potential,and altered cell fates.Overexpression of ERR or suppression of mitochondrial oxidative phosphorylation in neuroblasts increases the relative G/O ratio and rescues defective phenotypes caused by dysfunction of the FACT complex.Thus,the G/O ratio,mediated by the FACT complex,plays a crucial role in neuroblast cell fate maintenance.Our study may shed light on the mechanism by which mutations in the FACT complex lead to intellectual disability in humans.
