Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insuffici...Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.展开更多
Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study...Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.展开更多
A 20-year-old man presented with for 6-month history of facial acne. He had erythema and red papules on the face secondary to BPO-induced contact dermatitis. He was administered topical corticosteroid. Contact dermati...A 20-year-old man presented with for 6-month history of facial acne. He had erythema and red papules on the face secondary to BPO-induced contact dermatitis. He was administered topical corticosteroid. Contact dermatitis improved with this treatment, and he had red papules, comedones, prominent postinflammatory hyperpigmentation (PIH), postinflammatory erythema (PIE), erosions and erythema associated with acne vulgaris. He was subsequently treated with oral minocycline 100 mg/d and topical adapalene and ozenoxacin lotion once daily for 3 months. The inflammatory lesions and comedo subsided;however, PIH, PIE, atrophic scar and erosion persisted. During 3 months, the patient underwent chemical peeling using 20% glycolic acid (GA) and subsequent vitamin C iontophoresis twice at 1-month intervals. He showed almost disappearance of red papules and comedones but persistent PIH, PIE and erosion after 3 months of treatment. He was thereafter prescribed topical glyceryl-octyl-ascorbic acid/ascorbyl 2-phosphate 6-palmitate/DL-a-tocopherol phosphate complex for local application twice daily for 3 months. After 7 months of treatment, PIH, PIE, erosion and atrophic scar faded significantly with only trace residual erosions, atrophic scar and PIH. Subsequently, he was prescribed local application of 2% isostearyl-L-ascorbic acid gel vitamin C gel twice daily for 3 months. After 15 months, PIH, PIE, erosion and atrophic scar disappeared completely with significant improvement. Comprehensive sequential therapy resulted in significant improvement. It is suggested that medical treatment using systemic and topical antimicrobials and topical adapalene reduces inflammatory lesions and comedones initially. Subsequent chemical peeling using GA and vitamin C iontophoresis could improve PIH. These synergistic effects might have contributed to the significant improvement observed in this case. Comprehensive sequential treatment using chemical peeling, vitamin C iontophoresis and topical vitamin C can be a useful treatment strategy for PIH in acne vulgaris.展开更多
文摘Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.
文摘Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.
文摘A 20-year-old man presented with for 6-month history of facial acne. He had erythema and red papules on the face secondary to BPO-induced contact dermatitis. He was administered topical corticosteroid. Contact dermatitis improved with this treatment, and he had red papules, comedones, prominent postinflammatory hyperpigmentation (PIH), postinflammatory erythema (PIE), erosions and erythema associated with acne vulgaris. He was subsequently treated with oral minocycline 100 mg/d and topical adapalene and ozenoxacin lotion once daily for 3 months. The inflammatory lesions and comedo subsided;however, PIH, PIE, atrophic scar and erosion persisted. During 3 months, the patient underwent chemical peeling using 20% glycolic acid (GA) and subsequent vitamin C iontophoresis twice at 1-month intervals. He showed almost disappearance of red papules and comedones but persistent PIH, PIE and erosion after 3 months of treatment. He was thereafter prescribed topical glyceryl-octyl-ascorbic acid/ascorbyl 2-phosphate 6-palmitate/DL-a-tocopherol phosphate complex for local application twice daily for 3 months. After 7 months of treatment, PIH, PIE, erosion and atrophic scar faded significantly with only trace residual erosions, atrophic scar and PIH. Subsequently, he was prescribed local application of 2% isostearyl-L-ascorbic acid gel vitamin C gel twice daily for 3 months. After 15 months, PIH, PIE, erosion and atrophic scar disappeared completely with significant improvement. Comprehensive sequential therapy resulted in significant improvement. It is suggested that medical treatment using systemic and topical antimicrobials and topical adapalene reduces inflammatory lesions and comedones initially. Subsequent chemical peeling using GA and vitamin C iontophoresis could improve PIH. These synergistic effects might have contributed to the significant improvement observed in this case. Comprehensive sequential treatment using chemical peeling, vitamin C iontophoresis and topical vitamin C can be a useful treatment strategy for PIH in acne vulgaris.
