The aim of this article is to emphasize the importance of nuclear medicine in fungal infection characterization through a case report. Case： patient female, with AML-M2, hospitalized with fever, dyspnea, nausea, myas...The aim of this article is to emphasize the importance of nuclear medicine in fungal infection characterization through a case report. Case： patient female, with AML-M2, hospitalized with fever, dyspnea, nausea, myasthenia, abdominal pain and diarrhea. In the physical examination exacerbated lesion in abdominal wall and subcutaneous nodules in upper and lower limbs. The computed tomography of the chest evinced area of attenuation in ground-glass opacities in the middle lobe, tending to consolidation and bilateral nodular opacities with ground-glass halo which suggested an infiammatory/infectious process of fungal etiology. Immunoscintigraphy with ^99mTc-besilesomab （Scintimun） identified focal infectious processes in activity, scattered over cutaneous and subcutaneous tissues, predominantly in extremities. In blood culture test, there was a growth ofFusarium sp. There is a difficulty in the diagnosis of fungal infections, both in clinical and imaging methods. There is no specific method to reaching the target. In addition, fungal diseases can be divided into focally localized or disseminated infections. There is a greater difficulty in the diagnosis of immunocompromised individuals due to the deficiency of basic defense mechanisms. Scintimun （scintigraphy with besilesomab） is a useful tool of nuclear medicine in the diagnosis of infectious and inflammatory diseases to allow the image of the whole-body and in vivo detection of early pathological and physiological phenomena, even before anatomical alterations occur.展开更多
Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been des...Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. This case illustrates the ever increasing spectrum of rare but offending pathogenic fungi. Early diagnosis of infection with a specific pathogen may lead to changes in antifungal therapy and may be critical for an improved outcome.展开更多
Fusarium species(including Fusarium anthophilum)have many insidious effects on mankind,animals,and plants.Their attack may lead to diseases or spoilage,and the production of mycotoxins.This study was conducted t...Fusarium species(including Fusarium anthophilum)have many insidious effects on mankind,animals,and plants.Their attack may lead to diseases or spoilage,and the production of mycotoxins.This study was conducted to find solutions to the infections by F.anthophilum.Three sub-trials(botanical,chemical and biocontrol sub-trials)were set up using completely randomized design,and each treatment was replicated thrice.The percentage inhibition of F.anthophilum in the botanicals-alone subtrial(i.e.,Eucalyptus,Euphorbia,Andrographis,and Melaleuca spp.)at 50%and 100%concentrations ranged from 20%to 100%.At 72,120,and 168 HAI(hours after inoculation),Eucalyptus(all concentrations)controlled the pathogen significantly more,followed by Melaleuca(all concentrations).All the botanicals(at both concentrations)controlled Fusarium sp.significantly more compared to the control.Based on the second sub-trial:the best synthetic fungicide+Trichoderma harzianum treatment was Mancozeb100%,and the percentage inhibition by these combined chemical+biocontrol treatments ranged from 28%to 50%.Mancozeb100%,followed by Metalaxyl+Cu(I)O 100%produced the highest inhibition.All chemical treatments were significantly different compared to the control(120 hours after inoculation).Based on the third subtrial:the best Botanical+T.harzianum treatment was Alligator pepper100%followed by Tumeric100%.The percentage inhibition of Fusarium sp.by these treatments ranged from 28%to 70%.Alligator pepper100%followed by Tumeric100%,then Tumeric50%,and Eucalyptus100%…were significantly different compared to the control.Combining different agents was effective in controlling the pathogen.However,lower percentage inhibitions were obtained.More research on integrating the control agents is being admonished.展开更多
文摘The aim of this article is to emphasize the importance of nuclear medicine in fungal infection characterization through a case report. Case： patient female, with AML-M2, hospitalized with fever, dyspnea, nausea, myasthenia, abdominal pain and diarrhea. In the physical examination exacerbated lesion in abdominal wall and subcutaneous nodules in upper and lower limbs. The computed tomography of the chest evinced area of attenuation in ground-glass opacities in the middle lobe, tending to consolidation and bilateral nodular opacities with ground-glass halo which suggested an infiammatory/infectious process of fungal etiology. Immunoscintigraphy with ^99mTc-besilesomab （Scintimun） identified focal infectious processes in activity, scattered over cutaneous and subcutaneous tissues, predominantly in extremities. In blood culture test, there was a growth ofFusarium sp. There is a difficulty in the diagnosis of fungal infections, both in clinical and imaging methods. There is no specific method to reaching the target. In addition, fungal diseases can be divided into focally localized or disseminated infections. There is a greater difficulty in the diagnosis of immunocompromised individuals due to the deficiency of basic defense mechanisms. Scintimun （scintigraphy with besilesomab） is a useful tool of nuclear medicine in the diagnosis of infectious and inflammatory diseases to allow the image of the whole-body and in vivo detection of early pathological and physiological phenomena, even before anatomical alterations occur.
文摘Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. This case illustrates the ever increasing spectrum of rare but offending pathogenic fungi. Early diagnosis of infection with a specific pathogen may lead to changes in antifungal therapy and may be critical for an improved outcome.
文摘Fusarium species(including Fusarium anthophilum)have many insidious effects on mankind,animals,and plants.Their attack may lead to diseases or spoilage,and the production of mycotoxins.This study was conducted to find solutions to the infections by F.anthophilum.Three sub-trials(botanical,chemical and biocontrol sub-trials)were set up using completely randomized design,and each treatment was replicated thrice.The percentage inhibition of F.anthophilum in the botanicals-alone subtrial(i.e.,Eucalyptus,Euphorbia,Andrographis,and Melaleuca spp.)at 50%and 100%concentrations ranged from 20%to 100%.At 72,120,and 168 HAI(hours after inoculation),Eucalyptus(all concentrations)controlled the pathogen significantly more,followed by Melaleuca(all concentrations).All the botanicals(at both concentrations)controlled Fusarium sp.significantly more compared to the control.Based on the second sub-trial:the best synthetic fungicide+Trichoderma harzianum treatment was Mancozeb100%,and the percentage inhibition by these combined chemical+biocontrol treatments ranged from 28%to 50%.Mancozeb100%,followed by Metalaxyl+Cu(I)O 100%produced the highest inhibition.All chemical treatments were significantly different compared to the control(120 hours after inoculation).Based on the third subtrial:the best Botanical+T.harzianum treatment was Alligator pepper100%followed by Tumeric100%.The percentage inhibition of Fusarium sp.by these treatments ranged from 28%to 70%.Alligator pepper100%followed by Tumeric100%,then Tumeric50%,and Eucalyptus100%…were significantly different compared to the control.Combining different agents was effective in controlling the pathogen.However,lower percentage inhibitions were obtained.More research on integrating the control agents is being admonished.
