AIM:To assess tomographic changes and subclinical edema detection in Fuchs’endothelial corneal dystrophy(FECD)through Scheimpflug tomography in a group of phakic patients contemplating cataract surgery.METHODS:A retr...AIM:To assess tomographic changes and subclinical edema detection in Fuchs’endothelial corneal dystrophy(FECD)through Scheimpflug tomography in a group of phakic patients contemplating cataract surgery.METHODS:A retrospective study was conducted on 30 phakic eyes from patients diagnosed with FECD but without clinical edema,and 59 phakic eyes from a control group without corneal alterations.Comprehensive ophthalmic examinations were conducted,including slitlamp biomicroscopy,corneal specular microscopy(CSM),and Scheimpflug tomography.RESULTS:The study encompassed 30 phakic eyes with FECD(mean age 59.8±13.1y)and 59 control eyes(mean age 61.3±7.7y).The best-corrected visual acuity was higher in the control group compared to the FECD group[0(0,0.08)vs 0.05(0,0.15)logMAR;P=0.042].CSM revealed significant differences between the FECD and control groups in several parameters:number of analyzed cells(26±13 vs 135±42,P<0.001),cell density(2049±376 vs 2479±225 cells/mm2,P<0.001),mean cell area[463(434,544)vs 397(383,431)μm2;P<0.001],coefficient of variation(54.8%±18.7%vs 41.0%±7.2%,P<0.001),and hexagonal cells[0(0,47%)vs 47%(40%,53%),P<0.001].Although often used as a clinical parameter for detecting edema,central corneal thickness measured by CSM showed no significant difference between the FECD and control groups(530±57 vs 546±30μm,P=0.179).Significant differences were noted in various Pentacam measurements between the groups.Specifically,parameters like loss of parallel isopachs(13 vs 0 eyes,P<0.001),displacement of the thinnest point(11 vs 0 eyes,P<0.001),posterior focal depression(25 vs 7 eyes,P<0.001),and increased light scatter[21.4(17.6;23.9)vs 18.0(16.8,21.8),P=0.01]were significantly more prevalent in FECD eyes,reflecting the presence of subclinical edema and loss of corneal transparency.CONCLUSION:Scheimpflug tomography allows for an objective assessment of FECD,offering the capability to detect subclinical edema at an early stage,monitor disease progression,and serve as a predictor of corneal decompensation following cataract surgery.展开更多
Introduction Fuchs endothelial corneal dystrophy(FECD)is an inherited,degenerative disease of the corneal endothelial cells(CECs).It is characterized by a progressive deterioration of endothelial cells,altered extrace...Introduction Fuchs endothelial corneal dystrophy(FECD)is an inherited,degenerative disease of the corneal endothelial cells(CECs).It is characterized by a progressive deterioration of endothelial cells,altered extracellular matrix(ECM)production,and development of guttae(1,2).The presence of guttae has been shown to significantly impair corneal endothelial function,leading to corneal oedema and visual impairment.展开更多
目的:探讨超声乳化吸除术治疗Fuchs综合征并发白内障的临床效果。方法:分析在我院行超声乳化吸除术的Fuchs综合征并发白内障患者18例18眼,术中观察并发症的情况,术前及术后测量视力、眼压、角膜内皮细胞密度,术后观察眼内炎症反应程度...目的:探讨超声乳化吸除术治疗Fuchs综合征并发白内障的临床效果。方法:分析在我院行超声乳化吸除术的Fuchs综合征并发白内障患者18例18眼,术中观察并发症的情况,术前及术后测量视力、眼压、角膜内皮细胞密度,术后观察眼内炎症反应程度、并发症等情况。结果:平均随访时间为9.8±3.3mo。术中唯一的并发症为周边虹膜出血(17%)。最佳矫正视力(Log MAR)术前为0.98±0.85,术后6mo为0.08±0.14,差异具有统计学意义(P<0.001)。眼压术前为15.11±2.63mm Hg,术后有2眼一过性高眼压,术后6mo为14.94±2.49 mm Hg,与术前相比,差异无统计学意义(P>0.05)。术后角膜内皮细胞丢失率为10%±6%。术后2眼出现轻度的瞳孔区纤维素样渗出,1眼囊袋收缩综合征以及4眼后发性白内障。结论:超声乳化吸除术治疗Fuchs综合征并发白内障安全有效、并发症少。展开更多
文摘AIM:To assess tomographic changes and subclinical edema detection in Fuchs’endothelial corneal dystrophy(FECD)through Scheimpflug tomography in a group of phakic patients contemplating cataract surgery.METHODS:A retrospective study was conducted on 30 phakic eyes from patients diagnosed with FECD but without clinical edema,and 59 phakic eyes from a control group without corneal alterations.Comprehensive ophthalmic examinations were conducted,including slitlamp biomicroscopy,corneal specular microscopy(CSM),and Scheimpflug tomography.RESULTS:The study encompassed 30 phakic eyes with FECD(mean age 59.8±13.1y)and 59 control eyes(mean age 61.3±7.7y).The best-corrected visual acuity was higher in the control group compared to the FECD group[0(0,0.08)vs 0.05(0,0.15)logMAR;P=0.042].CSM revealed significant differences between the FECD and control groups in several parameters:number of analyzed cells(26±13 vs 135±42,P<0.001),cell density(2049±376 vs 2479±225 cells/mm2,P<0.001),mean cell area[463(434,544)vs 397(383,431)μm2;P<0.001],coefficient of variation(54.8%±18.7%vs 41.0%±7.2%,P<0.001),and hexagonal cells[0(0,47%)vs 47%(40%,53%),P<0.001].Although often used as a clinical parameter for detecting edema,central corneal thickness measured by CSM showed no significant difference between the FECD and control groups(530±57 vs 546±30μm,P=0.179).Significant differences were noted in various Pentacam measurements between the groups.Specifically,parameters like loss of parallel isopachs(13 vs 0 eyes,P<0.001),displacement of the thinnest point(11 vs 0 eyes,P<0.001),posterior focal depression(25 vs 7 eyes,P<0.001),and increased light scatter[21.4(17.6;23.9)vs 18.0(16.8,21.8),P=0.01]were significantly more prevalent in FECD eyes,reflecting the presence of subclinical edema and loss of corneal transparency.CONCLUSION:Scheimpflug tomography allows for an objective assessment of FECD,offering the capability to detect subclinical edema at an early stage,monitor disease progression,and serve as a predictor of corneal decompensation following cataract surgery.
文摘Introduction Fuchs endothelial corneal dystrophy(FECD)is an inherited,degenerative disease of the corneal endothelial cells(CECs).It is characterized by a progressive deterioration of endothelial cells,altered extracellular matrix(ECM)production,and development of guttae(1,2).The presence of guttae has been shown to significantly impair corneal endothelial function,leading to corneal oedema and visual impairment.
文摘目的:探讨超声乳化吸除术治疗Fuchs综合征并发白内障的临床效果。方法:分析在我院行超声乳化吸除术的Fuchs综合征并发白内障患者18例18眼,术中观察并发症的情况,术前及术后测量视力、眼压、角膜内皮细胞密度,术后观察眼内炎症反应程度、并发症等情况。结果:平均随访时间为9.8±3.3mo。术中唯一的并发症为周边虹膜出血(17%)。最佳矫正视力(Log MAR)术前为0.98±0.85,术后6mo为0.08±0.14,差异具有统计学意义(P<0.001)。眼压术前为15.11±2.63mm Hg,术后有2眼一过性高眼压,术后6mo为14.94±2.49 mm Hg,与术前相比,差异无统计学意义(P>0.05)。术后角膜内皮细胞丢失率为10%±6%。术后2眼出现轻度的瞳孔区纤维素样渗出,1眼囊袋收缩综合征以及4眼后发性白内障。结论:超声乳化吸除术治疗Fuchs综合征并发白内障安全有效、并发症少。
