The approach recently proposed by Liu and Qu was extended to correlate excess enthalpies of highly asymmetric binary systems.In this approach,FRKS equation of state was used, and Lij（T,x）function was applied in plac...The approach recently proposed by Liu and Qu was extended to correlate excess enthalpies of highly asymmetric binary systems.In this approach,FRKS equation of state was used, and Lij（T,x）function was applied in place of single value of the binary interaction parameter Lij.Twenty four binary systems,including benzene -(C11～C17)lakane,benzene -methyl naphthalene,xylene-（C3～C8）al-cohol,l-Hepetanol-（C6～C9）alkane,methanol,ethanol-chlorobenzene,were selected to do the test.For most of these binary systems, no equation of state method has been found accurate.The results obtained show that this method can improve significantly the correlation of excess enthalpies for highly asymmetric binary systems.The calculated excess enthalpies for most of the selected systems are in good agreement with experimental data.展开更多
The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver an...The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver antioxidant activity. Samples were analyzed by FRAP （ferric-reducing antioxidant power）, FRK （free radicals） and DPPH （2,2-diphenyl-l-picrylhydrazyl） methods. Oxidative stress values （metallo thionein, reduced glutathione, oxidized glutathione and reduced/oxidized glutation ration） were measured in the blood and liver. Biochemical parameters （serum albumin, uric acid and bilirubin） were monitored in the blood. The antioxidant activity measured by the FRK method was higher in the oregano supplement （P 〈 0.05） than in plantain and rosemary supplements.展开更多
HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as i...HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection.展开更多
文摘The approach recently proposed by Liu and Qu was extended to correlate excess enthalpies of highly asymmetric binary systems.In this approach,FRKS equation of state was used, and Lij（T,x）function was applied in place of single value of the binary interaction parameter Lij.Twenty four binary systems,including benzene -(C11～C17)lakane,benzene -methyl naphthalene,xylene-（C3～C8）al-cohol,l-Hepetanol-（C6～C9）alkane,methanol,ethanol-chlorobenzene,were selected to do the test.For most of these binary systems, no equation of state method has been found accurate.The results obtained show that this method can improve significantly the correlation of excess enthalpies for highly asymmetric binary systems.The calculated excess enthalpies for most of the selected systems are in good agreement with experimental data.
文摘The aim of the study was to evaluate the effect of 1.5% herb supplement of RL （rosemary leaves）, YB （yarrow blooms）, PL （plantain leaves）, OS （oreganos talks） or red GP （grape pomace） on the broiler liver antioxidant activity. Samples were analyzed by FRAP （ferric-reducing antioxidant power）, FRK （free radicals） and DPPH （2,2-diphenyl-l-picrylhydrazyl） methods. Oxidative stress values （metallo thionein, reduced glutathione, oxidized glutathione and reduced/oxidized glutation ration） were measured in the blood and liver. Biochemical parameters （serum albumin, uric acid and bilirubin） were monitored in the blood. The antioxidant activity measured by the FRK method was higher in the oregano supplement （P 〈 0.05） than in plantain and rosemary supplements.
基金supported by grants from the Program of Shanghai Academic Research Leader(21XD1402900)the Natural Science Foundation of Shanghai(21ZR1481400)+3 种基金the National Natural Science Foundation of China(31972900)the National Youth Talent Support Program(Ten Thousand Talent Program)the National Key Research and Development Program of China(2018YFC1705505)the National Megaproject on Key Infectious Diseases(2017ZX10202102).
文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection.
