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Methotrexate in the management of Crohn’s disease:A practice survey of gastroenterologists in France
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作者 Guillaume Bonnaud Jennifer Becker +2 位作者 Myriam Chebbah Agnès Courbeyrette Patrick Faure 《World Journal of Gastroenterology》 2025年第33期82-92,共11页
BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current ... BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current use of MTX among French gastroenterologists.METHODS An online questionnaire was distributed between March and August 2023 to 116 French gastroenterologists managing CD.A total of 87 respondents completed the survey and were included in the analysis.RESULTS Respondents reported a mean annual caseload of 140 CD patients(median:50).Overall,71%prescribed MTX,predominantly in injectable form(92%),either as monotherapy or in combination with biologics or cyclosporin.MTX was prescribed for mild-to-moderate CD by 64%of respondents,and for severe CD by 58%,often in combination with an anti-tumor necrosis factor agent(89%and 94%,respectively).Injectable MTX was favored(84%)in specific clinical scenarios:Patients with articular manifestations(77%),Epstein-Barr virus-negative status(65%),or aged over 65 years(58%).Among the 29%of non-prescribers,the primary reason cited was lack of familiarity with MTX use(60%).Both prescribers and non-prescribers expressed the need for clearer guidelines and real-world data to support MTX use.CONCLUSION Regardless of prescribing habits,most respondents had a favorable opinion of MTX and recognized its good longterm safety profile.French learned societies and medical associations should provide consensus guidelines on MTX use,supported by validated real-world safety and effectiveness data. 展开更多
关键词 METHOTREXATE Crohn’s disease Combination therapy IMMUNOSUPPRESSANT AZATHIOPRINE Guidelines france Practice survey Real-world evidence
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Differences between the healthcare systems of Quebec and France for the treatment of pain due to spinal disorders
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作者 Lea Evangeline Boyer Mathieu Boudier-Revéret Min Cheol Chang 《World Journal of Clinical Cases》 SCIE 2024年第15期2682-2685,共4页
In Quebec,Canada,the public healthcare system offers free medical services.However,patients with spinal pain often encounter long waiting times for specialist appointments and limited physiotherapy coverage.In contras... In Quebec,Canada,the public healthcare system offers free medical services.However,patients with spinal pain often encounter long waiting times for specialist appointments and limited physiotherapy coverage.In contrast,private clinics provide expedited care but are relatively scarce and entail out-of-pocket expenses.Once a patient with pain caused by a spinal disorder meets a pain medicine specialist,spinal intervention is quickly performed when indicated,and patients are provided lifestyle advice.Transforaminal epidural steroid injections are frequently administered to patients with radicular pain,and steroid injections are administered on a facet joint to control low back or neck pain.Additionally,medial branch blocks are performed prior to thermocoagulation.France’s universal healthcare system ensures accessibility at controlled costs.It emphasizes physical activity and provides free physical therapy services.However,certain interventions,such as transforaminal and interlaminar epidural injections,are not routinely used in France owing to limited therapeutic efficacy and safety concerns.This underutilization may be a potential cause of chronic pain for many patients.By examining the differences,strengths,and weaknesses of these two systems,valuable insights can be gained for the enhancement of global spinal pain management strategies,ultimately leading to improved patient outcomes and satisfaction. 展开更多
关键词 Spinal pain Healthcare system france Quebec Pain treatment
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Early Quality Life Impairment in Alzheimer Disease’s Patients in Geriatric Department: About 214 Cases in Pitié Salpêtrière Hospital of Paris (France)
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作者 Andia Abdoulkader Audrey Rouet +4 位作者 Benedicte Dieudonné Jacque Boaddert Charlotte Tomeo Sandrine Greffard Marc Verny 《Open Journal of Internal Medicine》 2024年第1期30-42,共13页
Alzheimer’s disease (AD) is the most common neurodegenerative disease causing an alteration of life quality in the terminal stage. The purpose was to report 14 years of experience about the early impact on the qualit... Alzheimer’s disease (AD) is the most common neurodegenerative disease causing an alteration of life quality in the terminal stage. The purpose was to report 14 years of experience about the early impact on the quality of life of patients with AD. Methodology: Descriptive retrospective study over 14 years in the geriatric department of Pitié Salpêtrière Hospital, using the activity of daily living, Instrumental activity of daily living, neuropsychological inventory and Hoen Yahr scale evaluated at the time of diagnosis of AD according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer Disease’s and Related Disorders Association diagnostic criteria. Results: A total of 214 exploitable files had been listed. At the moment of diagnosis, the mean age was 82.1 years with extremes 68 to 95 with sex ratio 1.6 in women’s favor. The mean socio-cultural level was 4.9 with extremes about 0 to 7. There was poly pathology with a mean Cumulative Illness Rate Scale = 4.6 with extremes 0 to 16. the mean cognitive status was moderate = 22.5 with extremes 0 to 30. Quality life showed moderate impairment of IADL = 9.2 with extreme 3 to 11 compared to activity of daily living. The activity of daily living was more affected in 68 - 80-year-olds, while poly pathology impacted more on IADL in men. The cognitive impairment was more deficient in IADL when the MMSE test was low. The common disorders at the NPI were psychological, behavioral and psychotic. Conclusion: At the early diagnosis of Alzheimer’s Disease cognitive deficiencies were predominant and influenced on global Instrumental activity and psychological, behavioral disorders. 展开更多
关键词 Alzheimer’s Disease IADL ADL NPI PARIS france
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Air France: Committed to Become the Most Popular European Airlines in China──Interview with Aubreton , chief representative of Air France in China
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《China's Foreign Trade》 2001年第5期22-23,共2页
关键词 Committed to Become the Most Popular European Airlines in China chief representative of Air france in China Air france
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A New Accumulation Model of Coal Seams in France Extensional Basins 被引量:1
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作者 Wang Hua Wang Genfa Faculty of Earth Resources, China University of Geosciences, Wuhan 430074, China 《Journal of Earth Science》 SCIE CAS CSCD 2000年第3期103-107,共5页
This paper, based on the sedimentary features of the coal seams in the typical extensional (faulted) coal basins between two inland mountainous areas of the Central Massif (France) deals with the accumulation mechanis... This paper, based on the sedimentary features of the coal seams in the typical extensional (faulted) coal basins between two inland mountainous areas of the Central Massif (France) deals with the accumulation mechanism and the corresponding sedimentary tectonic conditions of these thick coalbeds, and proposes a new coal accumulation model for the inland lacustrine basin thick coalbeds. The presence of a great number of gravity flow sediments such as detrital flow, diluted slurry flow or turbidity current sediments in the coal seams, and that of the contemporaneous gravity slump and deformation structure in the coal seam itself both indicate that the lacustrine environment in the accumulation of the thick coalbeds was characterized by the relatively deep flood and violent sedimentation. This model can not only interpret reasonably the accumulation mechanism of the thick coalbeds developed in the fault basins in the Central Massif, France, but also show its features distinctively from those of the accumulation model of the traditional thick coalbeds. 展开更多
关键词 thick coalbeds accumulation model sedimentary architecture Central Massif france.
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Brief History of Chinese Medicine in France 被引量:2
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作者 Marc Mezard 《Chinese Medicine and Culture》 2018年第3期103-107,共5页
In the 17th century,Chinese medicine appeared in France;since then,it never stopped evolving and is applied by French practitioners.Today,acupuncture is widely used in clinic treatment in France.
关键词 Chinese acupuncture Chinese medicine france
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Cultural Tourism Enlightenment from France for Hebei Province, China 被引量:1
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作者 WANG Lei WANG Jinyan +1 位作者 XING Huibin Azizan Marzuki 《Journal of Landscape Research》 2012年第12期59-61,共3页
French is one of the best cultural tourism destinations in the world. Its development experiences in terms of cultural tourism are valuable for Hebei, whose competitiveness of cultural tourism is weak comparatively in... French is one of the best cultural tourism destinations in the world. Its development experiences in terms of cultural tourism are valuable for Hebei, whose competitiveness of cultural tourism is weak comparatively in spite of rich cultural resources. Specifically, France achieves great successes of cultural tourism through scientific planning, producing tourism products injected by cultures, and developing tourism festivals. On this basis, four suggestions are recommended to improve cultural tourism in Hebei Province based on its actual situation, namely building cultural brand of tourism, strengthening government management, and developing tourism derivatives, and reinforcing talent training. 展开更多
关键词 CULTURAL TOURISM DEVELOPMENT TOURISM in france TOURISM DEVELOPMENT pattern Hebei Province
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The Global Boundary Stratotype Section and Point(GSSP)for the base of the Albian Stage,of the Cretaceous,the Col de Pré-Guittard section,Arnayon,Drôme,France 被引量:1
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作者 Jim W.Kennedy Andy S.Gale +3 位作者 Brian T.Huber Maria R.Petrizzo Paul Bown Hugh C.Jenkyns 《Episodes》 2017年第3期177-188,共12页
Following the unanimous approval of the Executive Committee on the International Union of Geological Sciences as notified on April 8,2016,the Global boundary Stratotype Section and Point for the base of the Albian Sta... Following the unanimous approval of the Executive Committee on the International Union of Geological Sciences as notified on April 8,2016,the Global boundary Stratotype Section and Point for the base of the Albian Stage of the Cretaceous is defined at the first occurrence datum of the planktonic foraminiferan Microhedbergella renilaevis Huber and Leckie,2011 at a level 37.4 meters above the base of the Marnes Bleues Formation and 40 cm above the base of the Niveau Kilian marker bed in the section SSE of the Col de Pré-Guittard,Arnayon,Drôme,France.The first occurrence of Microhedbergella renilaevis is placed within a 100-m section of argillaceous sediments with 28 secondary markers including calcareous nannofossils,planktonic foraminifera,an inoceramid bivalve,ammonites,stable carbon isotopes,and local marker beds. 展开更多
关键词 CRETACEOUS france Albian stage marnes bleues formation Col de Pr Guittard section planktonic foraminiferan microhedbergella renilaevis Arnayon global boundary stratotype section point
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The Séchilienne (France) Landslide:a Non-typical Progressive Failure Implying Major Risks
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作者 Jean-Louis DURVILLE Christophe BONNARD Pierre POTHERAT 《Journal of Mountain Science》 SCIE CSCD 2011年第2期117-123,共7页
The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris wil... The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris will dam the valley. Then the failure of the dam by overtopping and rapid erosion might result in a catastrophic flood and dramatic consequences for human life, environment and economy throughout the valley. The paper presents the hazard assessment based on geological and hydrological surveys, including small scale hydraulic tests, as well as the risk evaluation that has been performed. The risk management relies first upon a high level monitoring and an emergency plan; various mitigation strategies have been considered. 展开更多
关键词 LANDSLIDE Progressive failure Séchilienne france
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A Lion of France
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作者 张心怡 王锦秀(指导) 《疯狂英语(新悦读)》 2017年第3期58-61,共4页
Born in Corsica,a place reigned[统治]by the French,Napoleon was predestined[注定的]to be extraordinary.It was the historical background that shaped Napoleon’s strong belief in nationalism and his determination,which ... Born in Corsica,a place reigned[统治]by the French,Napoleon was predestined[注定的]to be extraordinary.It was the historical background that shaped Napoleon’s strong belief in nationalism and his determination,which became the momentum[动力]in his personal success.Few people are born with the required knowledge and power to support their dreams,neither was Napoleon.In his early youth,he read all the books available related to the history of his hometown and France,knowing that his ambition to reverse[完全改变]the destiny of his country would be impossible unless he had learned enough lessons from the past. 展开更多
关键词 reigned france
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Major Results and Research Challenges in Cotton Molecular Genetics at CIRAD(France)
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作者 LACAPE Jean-marc CLAVERIE M DESSAUW D GIBAND M VIOT C 《棉花学报》 CSCD 北大核心 2008年第S1期16-,共1页
CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural systems.Among others crops,cotton is the focus of a series of research programs in different disciplines from e... CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural systems.Among others crops,cotton is the focus of a series of research programs in different disciplines from economics to breeding.Major areas in genetics and breeding relate to(1) genetic diversity,(2) cultivar development through classical and molecular breeding,and(3) 展开更多
关键词 gene QTL france Major Results and Research Challenges in Cotton Molecular Genetics at CIRAD
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To Know the World to Know Oneself——My 40 Years of Experience with France
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作者 ZHENG RUOLIN 《China Today》 2018年第5期48-51,共4页
FORTY years ago,in 1978,1 was working in a factory in Shanghai.At that time,the gateway to foreign countries seemed to me even more remote than that of paradise.I had already heard of the French Republic,but only beca... FORTY years ago,in 1978,1 was working in a factory in Shanghai.At that time,the gateway to foreign countries seemed to me even more remote than that of paradise.I had already heard of the French Republic,but only because my father was Zheng Yonghui,an illustrious literary translator who spoke fluent French. 展开更多
关键词 EXPERIENCE with france the World to KNOW ONESELF
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The Central Academy of Fine Arts Art Museum Reproducing the Journey of Pioneering Chinese Artists Abroad in France
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作者 Li Jianya 《China & The World Cultural Exchange》 2019年第2期40-42,共3页
At the opening ceremony of this exhibition on January 12, Fan Di'an, Chairman of Chinese Artists Association and CAFA President, said:"The exhibition is a demonstration of the academic research and achievemen... At the opening ceremony of this exhibition on January 12, Fan Di'an, Chairman of Chinese Artists Association and CAFA President, said:"The exhibition is a demonstration of the academic research and achievements of a generation of Chinese artists abroad in France. 展开更多
关键词 CENTRAL ACADEMY MUSEUM Reproducing ARTISTS ABROAD in france
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Acute Renal Failure during Progressive Systemic Sclerosis in the Regional University Teaching Hospital of Brest-La Cavale Blanche (France)
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作者 Comlan Albert Dovonou Cossi Adébayo Alassani +5 位作者 Séraphin Ahoui Lauren Gueguen Arthur Capdeville Elie Cornec-Le Gall Laurent Doucet Yannick Le Meur 《Open Journal of Rheumatology and Autoimmune Diseases》 2017年第3期158-166,共9页
Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. It is pathology with a predilection for women. The present clinica... Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. It is pathology with a predilection for women. The present clinical case is that of a man with the renal complications of scleroderma and the difficulties of the treatment even in the developed countries like France. In the present case, the management of this disease required a high dose of corticosteroid therapy and extra-renal purification. Early detection of complications through a minimal clinical examination supplemented with paraclinic tests has proved necessary. 展开更多
关键词 SYSTEMIC SCLEROSIS ACUTE RENAL Failure Brest france
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France’s Strategy on Migration Issues in the Mediterranean
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作者 Kazunari Sakai Gilles Ferragu 《International Relations and Diplomacy》 2020年第2期45-54,共10页
The Mediterranean Sea is recognized by France as the most important adjacent area and also the gate to Africa,France’s vast sphere of influence beyond the Mediterranean.The political turmoil here since the Arab Sprin... The Mediterranean Sea is recognized by France as the most important adjacent area and also the gate to Africa,France’s vast sphere of influence beyond the Mediterranean.The political turmoil here since the Arab Spring has begun,especially emergence of a flood of refugees coming to the EU,was a serious problem for France.The current situation of EU,which is shaken over the acceptance of immigrants and refugees,is grave for France,having a strategic pillar which is to raise the own presence in global politics by obtaining the leadership in the EU.France sets out to put the migration and refugee issues to rest,to maintain EU’s political power and to seize the initiative in the EU.This article will analyze such a national strategy of France focusing on the process from Chirac’s administration to Macron’s. 展开更多
关键词 france DIPLOMACY EU MIGRATION Mediterranean
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How value relevant are earnings when they are transitory? Empirical evidence for France
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作者 Melita Charitou 《Journal of Modern Accounting and Auditing》 2010年第12期42-49,共8页
Capital market participants take seriously into consideration the value relevance of earnings for security valuation.This study examines the value relevance of earnings when earnings are transitory,i.e.,there is great... Capital market participants take seriously into consideration the value relevance of earnings for security valuation.This study examines the value relevance of earnings when earnings are transitory,i.e.,there is great variability in earnings.It hypothesizes that the relationship between earnings and security returns worsens when earnings are transitory and this robustness is country specific.The dataset consists of more than 1,100 French firm-year observations over a nine year period.Empirical results show that when earnings are transitory,investors pay more attention to operating cash flows and less attention to earnings,a result indicating that investors penalize firms with unstable earnings.These results should be of great importance to financial analysts,investors and bankers for investing and credit decisions,especially after the recent global financial crisis. 展开更多
关键词 Transitory earnings capital markets EARNINGS france empirical
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The Custodians of State Policies Dealing With the Financial Crisis: A Comparison Between France and the US
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作者 William Genieys Jean Joana 《International Relations and Diplomacy》 2017年第6期322-341,共20页
Following the 2008 global economic crisis and rolling out of austerity measures, elites of the state seem to have become a "political species" of their own, now under threat of extinction. The study of the health an... Following the 2008 global economic crisis and rolling out of austerity measures, elites of the state seem to have become a "political species" of their own, now under threat of extinction. The study of the health and defense policy reforms in France and the US during the 1990s and 2000s shows that far from disappearing, the influence of state elites is being strategically reconfigured to defend some sector-specific policies. Similarly to those "custodians of policy" dear to P. Selznick, small groups of elites are gaining expertise within strategic sectors of public policy; they are also making the need to control the cost of public spending their royal battle, in order to safeguard what they see as the crucial role of the public good. In the American cases study, the image of the "revolving door", which encapsulates the idea of professional mobility back and forth from the private to the public sector, implies a fragmented state, open to external pressures of social groups. We document career and professional trajectories marked by a strong commitment to a given policy area. Circulation, we note, is frequent between these positions in the public sector. While these findings do not in and of themselves allow us to fully assess the influence wielded by these elites, this study identifies the social and political resources and forms of specialization which predispose them to play important roles in shaping public policy. For the past 30 years, the question of varieties of liheralisation has been put forward as an explanatory factor for a wide range of public policies (Schrnidt & Thatcher, 2013; Thelen, 2014). In this perspective, numerous authors have theorised the dismantling of democratic states and the weakening of public authority that would follow (Suleiman, 2003; Fukuyama, 2004; Bez^s, 2009; Bonneli & Pelletier, 2010; Lodge, 2013). Research on public policy has focused on the success of neoliberal ideas among European and North American political elites (Pierson, 1994; Prasad, 2006; Fourcade, 2009) on the calling into question of the neo-Keynesian paradigm (Hall, 1986; Crouch, 2011) and on the development of budgetary constraints (Bezbs & Sinr, 2011; Streeck & Schafer, 2013; Blyth, 2013). Other work emphasises the idea that the effects of economic globalization-reinforced by those of the financial crisis of 2008-have accelerated the weakening of state capacity in western democracies by accelerating the expansion of market relations within national political systems (Streeck & Thelen, 2005; Jabko, 2012). At the same time, this period has seen renewed interest in national regulation (Lodge, 2011). Even so, if analysis is limited to the evolution of public policies as a simple functional response to the evolution of the international, financial, or ideological contexts in which they are found, research tends to underestimate the role played by competition among the elite groups involved with their elaboration and their capacity for resilient attachment to the power of public authority. For this reason, the hypothesis of the dismantling of the state, allegedly accelerated by the crisis of 2008, should be revisited. 展开更多
关键词 élites defense policy health policy france USA
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A Review of Influential Chinese Artists Studying Abroad in France in the Early 1900s (II)
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作者 Qi Yue 《China & The World Cultural Exchange》 2019年第5期15-18,共4页
Editor's note : About a hundred years ago, a large number of progress young Chinese with great ambitions went to France for Work-Study programs to introduce French science and arts to China, so as to save the nati... Editor's note : About a hundred years ago, a large number of progress young Chinese with great ambitions went to France for Work-Study programs to introduce French science and arts to China, so as to save the nation and the people. Among them, a generation of Chinese artists studying in France created splendid works which had played an essential role in the history of Chinese arts in the 20th century. 展开更多
关键词 REVIEW CHINESE ARTISTS france
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Making Cultural Integration Work——Lessons form the Successful Air France KLM Combination
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作者 Marc Raynaud 《China's Foreign Trade》 2008年第Z3期59-61,共3页
The reccnt Alcatel Lucent failure is an example of how many mergers run into considerable implementing difficulties in the months following their launch. Despite promising perspectives,no coherent whole seems to come ... The reccnt Alcatel Lucent failure is an example of how many mergers run into considerable implementing difficulties in the months following their launch. Despite promising perspectives,no coherent whole seems to come out of the merger,just as anticipated synergies have a hard time materializing. 展开更多
关键词 Lessons form the Successful Air france KLM Combination WORK KLM Making Cultural Integration Work very
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FRANCE:TURNING TO“NEW GAULLISM”
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作者 Zhang Liangneng Associate Research Professor, China Institute of Contemporary International Relations. 《Contemporary International Relations》 1995年第6期1-10,共10页
On May 7th, Jacques Chirac, candidate of the Rally for the Republic (RPR)and Mayor of Paris, defeated the Socialist candidate Lionel Jospin in the secondround of the French presidential election and was elected the fi... On May 7th, Jacques Chirac, candidate of the Rally for the Republic (RPR)and Mayor of Paris, defeated the Socialist candidate Lionel Jospin in the secondround of the French presidential election and was elected the fifth president of theFifth Republic. Alain Juppe, Chirac’s close assistant and former foreign minister,was appointed as the prime minister of the new cabinet. Thus ended the formerPresident Francois Mitterrand’s Socialist rule of 14 years and ushered in an epochof Gaullist Chirac, a man who will lead France into the 21st century. 展开更多
关键词 NEW GAULLISM france
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