BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current ...BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current use of MTX among French gastroenterologists.METHODS An online questionnaire was distributed between March and August 2023 to 116 French gastroenterologists managing CD.A total of 87 respondents completed the survey and were included in the analysis.RESULTS Respondents reported a mean annual caseload of 140 CD patients(median:50).Overall,71%prescribed MTX,predominantly in injectable form(92%),either as monotherapy or in combination with biologics or cyclosporin.MTX was prescribed for mild-to-moderate CD by 64%of respondents,and for severe CD by 58%,often in combination with an anti-tumor necrosis factor agent(89%and 94%,respectively).Injectable MTX was favored(84%)in specific clinical scenarios:Patients with articular manifestations(77%),Epstein-Barr virus-negative status(65%),or aged over 65 years(58%).Among the 29%of non-prescribers,the primary reason cited was lack of familiarity with MTX use(60%).Both prescribers and non-prescribers expressed the need for clearer guidelines and real-world data to support MTX use.CONCLUSION Regardless of prescribing habits,most respondents had a favorable opinion of MTX and recognized its good longterm safety profile.French learned societies and medical associations should provide consensus guidelines on MTX use,supported by validated real-world safety and effectiveness data.展开更多
为了对裂纹疲劳寿命进行快速准确预测,针对常用的疲劳实验和数值仿真实验中各自存在的实验条件受限、计算步骤繁琐、计算过程耗时较长等问题,以大型桥梁钢桁架中的裂纹为研究对象,提出一种结合裂纹分析软件FRANC3D和长短期记忆(long sho...为了对裂纹疲劳寿命进行快速准确预测,针对常用的疲劳实验和数值仿真实验中各自存在的实验条件受限、计算步骤繁琐、计算过程耗时较长等问题,以大型桥梁钢桁架中的裂纹为研究对象,提出一种结合裂纹分析软件FRANC3D和长短期记忆(long short term memory,简称LSTM)网络模型的裂纹疲劳寿命预测方法。首先,建立钢桁架的有限元模型,通过裂纹分析软件FRANC3D进行疲劳裂纹扩展分析并建立相关数据集;其次,通过疲劳裂纹的扩展仿真数据关注裂纹的扩展状况,收集裂纹特征信息对裂纹疲劳寿命进行预测。实验结果表明,所提出的方法具有较高的预测准确性,同时极大地提升了训练速度,可为裂纹疲劳寿命预测提供参考。展开更多
文摘BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current use of MTX among French gastroenterologists.METHODS An online questionnaire was distributed between March and August 2023 to 116 French gastroenterologists managing CD.A total of 87 respondents completed the survey and were included in the analysis.RESULTS Respondents reported a mean annual caseload of 140 CD patients(median:50).Overall,71%prescribed MTX,predominantly in injectable form(92%),either as monotherapy or in combination with biologics or cyclosporin.MTX was prescribed for mild-to-moderate CD by 64%of respondents,and for severe CD by 58%,often in combination with an anti-tumor necrosis factor agent(89%and 94%,respectively).Injectable MTX was favored(84%)in specific clinical scenarios:Patients with articular manifestations(77%),Epstein-Barr virus-negative status(65%),or aged over 65 years(58%).Among the 29%of non-prescribers,the primary reason cited was lack of familiarity with MTX use(60%).Both prescribers and non-prescribers expressed the need for clearer guidelines and real-world data to support MTX use.CONCLUSION Regardless of prescribing habits,most respondents had a favorable opinion of MTX and recognized its good longterm safety profile.French learned societies and medical associations should provide consensus guidelines on MTX use,supported by validated real-world safety and effectiveness data.
文摘为了对裂纹疲劳寿命进行快速准确预测,针对常用的疲劳实验和数值仿真实验中各自存在的实验条件受限、计算步骤繁琐、计算过程耗时较长等问题,以大型桥梁钢桁架中的裂纹为研究对象,提出一种结合裂纹分析软件FRANC3D和长短期记忆(long short term memory,简称LSTM)网络模型的裂纹疲劳寿命预测方法。首先,建立钢桁架的有限元模型,通过裂纹分析软件FRANC3D进行疲劳裂纹扩展分析并建立相关数据集;其次,通过疲劳裂纹的扩展仿真数据关注裂纹的扩展状况,收集裂纹特征信息对裂纹疲劳寿命进行预测。实验结果表明,所提出的方法具有较高的预测准确性,同时极大地提升了训练速度,可为裂纹疲劳寿命预测提供参考。
