BACKGROUND The prevalence of coronary heart disease(CHD)is higher in patients with depression than in the general population.Recently,multiple novel biomarkers have been proposed to predict CHD risk,and these factors ...BACKGROUND The prevalence of coronary heart disease(CHD)is higher in patients with depression than in the general population.Recently,multiple novel biomarkers have been proposed to predict CHD risk,and these factors have been reported to be altered in patients with depression.AIM To explore whether these new biomarkers are associated with an increased risk of CHD in patients with depression.METHODS We recruited 279 healthy controls and 164 sex-and age-matched patients with depression and collected their clinical characteristics and laboratory values of novel cardiovascular biomarkers.The Framingham CHD risk score was used to assess the CHD risk of all individuals,and the cardiovascular markers related to the CHD risk in patients with depression were analyzed.RESULTS Patients with depression had an increased CHD risk of 5.3%(95%confidence interval:4.470-6.103)and altered novel cardiovascular biomarkers compared to healthy controls,which included lower levels of thyroid stimulating hormone,albumin,total bilirubin,total cholesterol,high-density lipoprotein cholesterol,and higher levels of triglyceride(TG)and uric acid.Further regression analysis showed that illness duration,family history of depression,serum TG,and urea acid levels were significantly correlated with the Framingham risk score in patients with depression.CONCLUSION Patients with depression had a higher CHD risk and that their illness duration,family history of depression,serum TG,and uric acid levels could play important roles in predicting CHD risk.Moreover,elevated CHD risk in patients with depression was not only related to physiological changes caused by depression but also to their genetic susceptibility.展开更多
目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因...目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因素。结果:研究人群未来10 a CVD高发生风险的比例为40.6%,且男性高于女性(47.1%vs 37.6%,P<0.001)。Logistic回归分析显示,男性(B=0.524,OR=1.690,95%CI为1.377~2.073)、腹型肥胖(B=0.709,OR=2.031,95%CI为1.632~2.529)、TG(B=0.097,OR=1.102,95%CI为1.023~1.187)、尿白蛋白异常(B=0.670,OR=1.955,95%CI为1.486~2.572)均是CVD高发生风险的危险因素。结论:郑州市中老年人群未来10 a CVD的发生风险很高;加强对中老年人群尤其是男性,合并腹型肥胖、高血脂、高血压、糖尿病以及糖尿病高危人群的CVD一级预防和管理,可能有效降低CVD的发生风险。展开更多
目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中...目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中医院的MS患者90例,根据随机数字表法将其分为禁食组和对照组,每组各45例,同期选取90例健康体检者纳入正常组。对照组患者予正常饮食及运动处方干预,禁食组患者予中医禁食疗法干预,两组患者均干预10d。比较正常组体检时与禁食组、对照组干预前后体质量指数(body mass index,BMI)、血压、血脂、血糖指标、AIP和FRS,分析禁食组、对照组干预疗效,应用Pearson相关性分析探讨MS患者AIP、FRS与临床指标的关系。结果干预前后,禁食组、对照组患者的BMI、收缩压、舒张压、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、AIP、FRS均显著高于正常组,高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平显著低于正常组(P<0.05);干预后,禁食组患者的BMI、收缩压、舒张压、LDL-C、TG、TC、FPG、AIP、FRS均显著低于本组干预前和对照组(P<0.05),HDL-C水平显著高于本组干预前和对照组(P<0.05)。禁食组患者干预后的总有效率显著高于对照组(P<0.05)。MS患者的AIP与BMI、TG水平呈正相关,与HDL-C水平呈负相关(P<0.05),FRS与BMI、收缩压、舒张压、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关(P<0.05)。结论MS患者的AIP、FRS显著增高,且与BMI、血脂等指标有关,应用中医禁食疗法可显著降低AIP、FRS,改善临床指标及疗效,有利于降低心血管疾病风险。展开更多
基金Supported by the National Natural Science Foundation of China,No.82301737.
文摘BACKGROUND The prevalence of coronary heart disease(CHD)is higher in patients with depression than in the general population.Recently,multiple novel biomarkers have been proposed to predict CHD risk,and these factors have been reported to be altered in patients with depression.AIM To explore whether these new biomarkers are associated with an increased risk of CHD in patients with depression.METHODS We recruited 279 healthy controls and 164 sex-and age-matched patients with depression and collected their clinical characteristics and laboratory values of novel cardiovascular biomarkers.The Framingham CHD risk score was used to assess the CHD risk of all individuals,and the cardiovascular markers related to the CHD risk in patients with depression were analyzed.RESULTS Patients with depression had an increased CHD risk of 5.3%(95%confidence interval:4.470-6.103)and altered novel cardiovascular biomarkers compared to healthy controls,which included lower levels of thyroid stimulating hormone,albumin,total bilirubin,total cholesterol,high-density lipoprotein cholesterol,and higher levels of triglyceride(TG)and uric acid.Further regression analysis showed that illness duration,family history of depression,serum TG,and urea acid levels were significantly correlated with the Framingham risk score in patients with depression.CONCLUSION Patients with depression had a higher CHD risk and that their illness duration,family history of depression,serum TG,and uric acid levels could play important roles in predicting CHD risk.Moreover,elevated CHD risk in patients with depression was not only related to physiological changes caused by depression but also to their genetic susceptibility.
文摘目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因素。结果:研究人群未来10 a CVD高发生风险的比例为40.6%,且男性高于女性(47.1%vs 37.6%,P<0.001)。Logistic回归分析显示,男性(B=0.524,OR=1.690,95%CI为1.377~2.073)、腹型肥胖(B=0.709,OR=2.031,95%CI为1.632~2.529)、TG(B=0.097,OR=1.102,95%CI为1.023~1.187)、尿白蛋白异常(B=0.670,OR=1.955,95%CI为1.486~2.572)均是CVD高发生风险的危险因素。结论:郑州市中老年人群未来10 a CVD的发生风险很高;加强对中老年人群尤其是男性,合并腹型肥胖、高血脂、高血压、糖尿病以及糖尿病高危人群的CVD一级预防和管理,可能有效降低CVD的发生风险。
文摘目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中医院的MS患者90例,根据随机数字表法将其分为禁食组和对照组,每组各45例,同期选取90例健康体检者纳入正常组。对照组患者予正常饮食及运动处方干预,禁食组患者予中医禁食疗法干预,两组患者均干预10d。比较正常组体检时与禁食组、对照组干预前后体质量指数(body mass index,BMI)、血压、血脂、血糖指标、AIP和FRS,分析禁食组、对照组干预疗效,应用Pearson相关性分析探讨MS患者AIP、FRS与临床指标的关系。结果干预前后,禁食组、对照组患者的BMI、收缩压、舒张压、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、AIP、FRS均显著高于正常组,高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平显著低于正常组(P<0.05);干预后,禁食组患者的BMI、收缩压、舒张压、LDL-C、TG、TC、FPG、AIP、FRS均显著低于本组干预前和对照组(P<0.05),HDL-C水平显著高于本组干预前和对照组(P<0.05)。禁食组患者干预后的总有效率显著高于对照组(P<0.05)。MS患者的AIP与BMI、TG水平呈正相关,与HDL-C水平呈负相关(P<0.05),FRS与BMI、收缩压、舒张压、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关(P<0.05)。结论MS患者的AIP、FRS显著增高,且与BMI、血脂等指标有关,应用中医禁食疗法可显著降低AIP、FRS,改善临床指标及疗效,有利于降低心血管疾病风险。
