This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de...This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.展开更多
Recent studies have shown that shorter periods of ejaculatory abstinence may enhance certain sperm parameters,but the molecular mechanisms underlying these improvements are still unclear.This study explored whether re...Recent studies have shown that shorter periods of ejaculatory abstinence may enhance certain sperm parameters,but the molecular mechanisms underlying these improvements are still unclear.This study explored whether reduced abstinence periods could improve semen quality,particularly for use in assisted reproductive technologies(ART).We analyzed semen samples from men with normal sperm counts(n=101)and those with low sperm motility or concentration(n=53)after 3-7 days of abstinence and then after 1-3h of abstinence,obtained from the Reproductive&Genetic Hospital of CITIC-Xiangya(Changsha,China).Physiological and biochemical sperm parameters were evaluated,and the dynamics of transfer RNA(tRNA)-derived fragments(tRFs)were analyzed using deep RNA sequencing in five consecutive samples from men with normal sperm counts.Our results revealed significant improvement in sperm motility and a decrease in the DNA fragmentation index after the 1-to 3-h abstinence period.Additionally,we identified 245 differentially expressed tRFs,and the mitogen-activated protein kinase(MAPK)signaling pathway was the most enriched.Further investigations showed significant changes in tRF-Lys-TTT and its target gene mitogen-activated protein kinase kinase 2(MAP2K2),which indicates a role of tRFs in improving sperm function.These findings provide new insights into how shorter abstinence periods influence sperm quality and suggest that tRFs may serve as biomarkers for male fertility.This research highlights the potential for optimizingART protocols and improving reproductive outcomes through molecular approaches that target sperm function.展开更多
Total or severe teratospermia affects the prognosis of fertility and causes serious problems for patients undergoing assisted reproduction[1].The pathophysiological mechanism of teratospermia is unclear.It has been sh...Total or severe teratospermia affects the prognosis of fertility and causes serious problems for patients undergoing assisted reproduction[1].The pathophysiological mechanism of teratospermia is unclear.It has been shown that patients with sperm parameters abnormalities and abnormal morphology have a high rate of fragmentation and sperm DNA decondensation[2,3],and that sperm DNA fragmentation analysis could be used as a predictor factor of fertility potential[4].展开更多
Rock fragmentation is an important indicator for assessing the quality of blasting operations.However,accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters ...Rock fragmentation is an important indicator for assessing the quality of blasting operations.However,accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters and rock properties.For this reason,optimized by the Bayesian optimization algorithm(BOA),four hybrid machine learning models,including random forest,adaptive boosting,gradient boosting,and extremely randomized trees,were developed in this study.A total of 102 data sets with seven input parameters(spacing-to-burden ratio,hole depth-to-burden ratio,burden-to-hole diameter ratio,stemming length-to-burden ratio,powder factor,in situ block size,and elastic modulus)and one output parameter(rock fragment mean size,X_(50))were adopted to train and validate the predictive models.The root mean square error(RMSE),the mean absolute error(MAE),and the coefficient of determination(R^(2))were used as the evaluation metrics.The evaluation results demonstrated that the hybrid models showed superior performance than the standalone models.The hybrid model consisting of gradient boosting and BOA(GBoost-BOA)achieved the best prediction results compared with the other hybrid models,with the highest R^(2)value of 0.96 and the smallest values of RMSE and MAE of 0.03 and 0.02,respectively.Furthermore,sensitivity analysis was carried out to study the effects of input variables on rock fragmentation.In situ block size(XB),elastic modulus(E),and stemming length-to-burden ratio(T/B)were set as the main influencing factors.The proposed hybrid model provided a reliable prediction result and thus could be considered an alternative approach for rock fragment prediction in mining engineering.展开更多
In the application of high-pressure water jet assisted breaking of deep underground rock engineering,the influence mechanism of rock temperature on the rock fragmentation process under jet action is still unclear.Ther...In the application of high-pressure water jet assisted breaking of deep underground rock engineering,the influence mechanism of rock temperature on the rock fragmentation process under jet action is still unclear.Therefore,the fluid evolution characteristics and rock fracture behavior during jet impingement were studied.The results indicate that the breaking process of high-temperature rock by jet impact can be divided into four stages:initial fluid-solid contact stage,intense thermal exchange stage,perforation and fracturing stage,and crack propagation and penetration stage.With the increase of rock temperature,the jet reflection angles and the time required for complete cooling of the impact surface significantly decrease,while the number of cracks and crack propagation rate significantly increase,and the rock breaking critical time is shortened by up to 34.5%.Based on numerical simulation results,it was found that the center temperature of granite at 400℃ rapidly decreased from 390 to 260℃ within 0.7 s under jet impact.In addition,a critical temperature and critical heat flux prediction model considering the staged breaking of hot rocks was established.These findings provide valuable insights to guide the water jet technology assisted deep ground hot rock excavation project.展开更多
This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocatio...This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocation (RSA). The proposed method, Dynamic Threshold-Based Routing and Spectrum Allocation with Fragmentation Awareness (DT-RSAF), integrates rerouting and spectrum defragmentation as needed. By leveraging Yen’s shortest path algorithm, DT-RSAF enhances resource utilization while ensuring improved service continuity. A dynamic threshold mechanism enables the algorithm to adapt to varying network conditions, while its fragmentation awareness effectively mitigates spectrum fragmentation. Simulation results on NSFNET and COST 239 topologies demonstrate that DT-RSAF significantly outperforms methods such as K-Shortest Path Routing and Spectrum Allocation (KSP-RSA), Load Balanced and Fragmentation-Aware (LBFA), and the Invasive Weed Optimization-based RSA (IWO-RSA). Under heavy traffic, DT-RSAF reduces the blocking probability by up to 15% and achieves lower Bandwidth Fragmentation Ratios (BFR), ranging from 74% to 75%, compared to 77% - 80% for KSP-RSA, 75% - 77% for LBFA, and approximately 76% for IWO-RSA. DT-RSAF also demonstrated reasonable computation times compared to KSP-RSA, LBFA, and IWO-RSA. On a small-sized network, its computation time was 8710 times faster than that of Integer Linear Programming (ILP) on the same network topology. Additionally, it achieved a similar execution time to LBFA and outperformed IWO-RSA in terms of efficiency. These results highlight DT-RSAF’s capability to maintain large contiguous frequency blocks, making it highly effective for accommodating high-bandwidth requests in EONs while maintaining reasonable execution times.展开更多
This review examines the processes of laser heating,melting,evaporation,fragmentation,and breakdown of metal nanoparticles,as well as the dependences and values of the threshold laser parameters that initiate these pr...This review examines the processes of laser heating,melting,evaporation,fragmentation,and breakdown of metal nanoparticles,as well as the dependences and values of the threshold laser parameters that initiate these processes.Literature results are analyzed from experimental studies of these processes with gold,silver,and other nanoparticles,including laser surface melting and evaporation of nanoparticles and Coulomb fragmentation of nanoparticles by ultrashort laser pulses.A theoretical model and description of the thermal mechanisms of mentioned processes with metal(solid)nanoparticles in a liquid(solid)medium,initiated by the action of laser pulses with the threshold fluences,are presented.Comparison of the obtained results with experimental data confirms the accuracy of the model and makes it possible to use them to evaluate the parameters of laser thermal processing of nanoparticles.Applications of the processes include the laser melting,reshaping,and fragmentation of nanoparticles,the formation of nanostructures and nanonetworks,the laser processing of nanoparticles located on substrates,and their cladding on surfaces in various laser nanotechnologies.The use of laser ignition,combustion,and incandescence of nanoparticles is discussed,as is the use of nanoparticle-triggered laser breakdown for spectroscopy.These laser processes are used in photothermal nanotechnologies,nanoenergy,laser processing of nanoparticles,nonlinear optical devices,high-temperature material science,etc.In general,this review presents a modern picture of the state of laser technology and high-temperature processes with nanoparticles and their applications,being focused on the latest publications with an emphasis on recent results from 2021-2024.展开更多
Habitat fragmentation poses a significant threat to bird communities, especially those in open and semi-open ecosystems such as steppes. This study investigates how steppe birds adapt to and utilize fragmented habitat...Habitat fragmentation poses a significant threat to bird communities, especially those in open and semi-open ecosystems such as steppes. This study investigates how steppe birds adapt to and utilize fragmented habitats by combining niche modeling with ecological trait analysis. We conducted standardized point surveys to examine the habitat preferences of 32 bird species in Inner Mongolia, China, and quantified their habitat niche parameters using the Outlying Mean Index (OMI). Our results reveal distinct habitat preferences among species, with some thriving in intact environments while others are better adapted to fragmented areas. Grassland species showed high specialization along the fragmentation gradient, while others exhibited adaptability to varying levels of fragmentation. Using a Generalized Additive Model (GAM), we identified three key traits influencing habitat occupancy: hand-wing index, body mass, and range size. Specifically, species with medium hand-wing indices, moderate body mass, and larger range sizes were more likely to occupy heavily fragmented habitats. These findings provide empirical evidence on how habitat fragmentation affects bird species in steppe ecosystems. The study highlights the importance of functional traits in understanding avian responses to habitat fragmentation and offers a foundation for developing effective conservation strategies to preserve biodiversity in fragmented landscapes.展开更多
Liquid-filled containers(LFC)are widely used to store and transport petroleum,chemical reagents,and other resources.As an important target of military strikes and terrorist bombings,LFC are vulnerable to blast waves a...Liquid-filled containers(LFC)are widely used to store and transport petroleum,chemical reagents,and other resources.As an important target of military strikes and terrorist bombings,LFC are vulnerable to blast waves and fragments.To explore the protective effect of polyurea elastomer on LFC,the damage characteristics of polyurea coated liquid-filled container(PLFC)under the combined loading of blast shock wave and fragments were studied experimentally.The microstructure of the polyurea layer was observed by scanning electron microscopy,and the fracture and self-healing phenomena were analyzed.The simulation approach was used to explain the combined blast-and fragments-induced on the PLFC in detail.Finally,the effects of shock wave and fragment alone and in combination on the damage of PLFC were comprehensively compared.Results showed that the polyurea reduces the perforation rate of the fragment to the LFC,and the self-healing phenomenon could also reduce the liquid loss rate inside the container.The polyurea reduces the degree of depression in the center of the LFC,resulting in a decrease in the distance between adjacent fragments penetrating the LFC,and an increase in the probability of transfixion and fracture between holes.Under the close-in blast,the detonation shock wave reached the LFC before the fragment.Polyurea does not all have an enhanced effect on the protection of LFC.The presence of internal water enhances the anti-blast performance of the container,and the hydrodynamic ram(HRAM)formed by the fragment impacting the water aggravated the plastic deformation of the container.The combined action has an enhancement effect on the deformation of the LFC.The depth of the container depression was 27%higher than that of the blast shock wave alone;thus,it cannot be simply summarized as linear superposition.展开更多
Fragmentation is a common phenomenon in the runout process of large rockslides.Rocks have different strengths under the influence of the rock type and weathering degree,resulting in varying fragmentation characteristi...Fragmentation is a common phenomenon in the runout process of large rockslides.Rocks have different strengths under the influence of the rock type and weathering degree,resulting in varying fragmentation characteristics.However,the limited understanding of how rock strength influences the postfragmentation kinematic characteristics of rockslides is limited.Taking a natural rockslide as an example,this paper quantitatively analyzes the runout and deposition of the rockslide using the discrete element method(DEM)and examines the impacts of the rock strength on the runout and deposition characteristics of the rockslide.The results reveal that(1)Rock strength significantly influences fragmentation and runout characteristics:medium-to-high strength rocks exhibit two-stage fragmentation(10-20 s and 55-65 s),while weak-strength rocks achieve 98%fragmentation within 20 s.Optimal kinetic energy conversion occurs in medium-strength rocks,with a maximum velocity difference of 39.3 m/s between the anterior and posterior edges.(2)The sudden change in the cross-sectional dimensions of high-strength rocks under a high spreading velocity(>60 m/s)may amplify air blast hazards.(3)Deposition patterns reveal that the spatial distribution of fragments preserves original positional order;high-strength rocks produce larger fragments(nominal fragment size increases from 0.028 of weak-strength rocks to 0.607);and centroid displacement increases from 1907 m to 2117 m with rock strength in open terrains.(4)Energy dissipation analysis shows that frictional dissipation(>60%)>collisional dissipation(~37%)>>fragmentation dissipation(<2%)in the process of rockslide runout.The rock strength induces<5%variation in partitioning of energy dissipation.展开更多
Rockfall represents a significant geological hazard in mountainous regions,characterized by a sudden and unpredictable feature.The process of dynamic fragmentation and energy conversion in a rockfall event remains com...Rockfall represents a significant geological hazard in mountainous regions,characterized by a sudden and unpredictable feature.The process of dynamic fragmentation and energy conversion in a rockfall event remains complex and not fully understood.This study aims to gain a further understanding of the energy transfer mechanism during rockfall impact and fragmentation by impact tests using a variety of rock-like sphere specimens.The experiments mainly focus on the quantitative correlation between fragmentation degree and influence factors,i.e.impact angle and velocity on steel and granite slabs.The analysis focuses on the energy distribution characteristics,energy dissipation mechanisms,and the energy conversion rate of the fragments during impact and fragmentation.The results show that there is a significant correlation between the energy conversion rate and the fragmentation degree.In normal impact tests,elasto-plastic deformation energy and fracture energy are found to be two primary categories of energy dissipation.The proportion of total kinetic energy after impact is inversely proportional to the initial energy.A comparative analysis between normal and inclined slab impact tests reveals that the impact angle significantly influences the energy conversion rate,which controls the fragmentation degree as well.In addition,the fragmentation degree is inversely proportional to the restitution coefficient.These findings contribute to a better understanding of the energy conversion mechanism during rockfall impact and fragmentation,providing valuable insight for the development of effective strategies to mitigate such rockfall hazards.展开更多
We investigate distinct non-Hermitian skin effects(NHSEs)in real and Fock spaces induced by the interplay between the Hilbert space fragmentation and multiple non-Hermitian pumping channels.Using an extended Hatano–N...We investigate distinct non-Hermitian skin effects(NHSEs)in real and Fock spaces induced by the interplay between the Hilbert space fragmentation and multiple non-Hermitian pumping channels.Using an extended Hatano–Nelson model with next-nearest neighbor hopping and strong interaction as an example,we found that two fermions loaded in the lattice exhibit different real-space NHSE depending on the Hilbert space fragments to which they belong.Moreover,in the high-energy sector resulting from fragmentation,the two-particle-bound states form a one-dimensional lattice in Fock space,producing a Fock-space NHSE.At half-filling,richer patterns of Fock-space skin-like localization emerge for the different fragmented energy sectors and subsectors while realspace NHSE is suppressed by many-body effects.This study extends our understanding of the interplay between NHSE and Hilbert space fragmentation and provides detailed insights into their manifestation in interacting non-Hermitian systems.展开更多
Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding dril...Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.展开更多
The publisher regrets that the article type for this publication was incorrectly labeled as a Research Article.The correct designation should be Review Article.This correction does not affect the content or conclusion...The publisher regrets that the article type for this publication was incorrectly labeled as a Research Article.The correct designation should be Review Article.This correction does not affect the content or conclusions of the article.The publisher apologizes for any inconvenience caused.展开更多
Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the a...Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the alterations related to reproductive hormones,semen parameters and their association with body mass index(BMI).Methods:Participants in this observational study were divided into three groups based on their BMI:proven fertile,normal weight men(n=200);overweight men(n=200);and obese men(n=200).After 3 days of abstinence,seminal fluid was collected from all participants and analyzed.Blood samples were also collected on the same day for hormonal analysis.Sperm DNA fragmentation and protamine deficiency were also assessed.Results:A total of 600 men with a mean age of(34.3±7.9)2 years were included in the study.Obese males(BMI 30 kg/m or higher)exhibited significant reductions in semen volume,sperm concentration,total sperm motility percentage,progressive motility,non-progressive motility,and levels of total testosterone,follicle-stimulating hormone(FSH)and luteinizing hormone(LH)compared to overweight(BMI 25 to 29.9 kg/m2)and normal weight males(BMI 18.5 to 24.9 kg/m2)(P<0.001).Conversely,obese males showed a significant increase in prolactin level,sperm DNA fragmentation,and protamine deficiency compared to overweight and normal weight males(P<0.001).Significant negative correlations were demonstrated between BMI and sperm concentration,motility,total testosterone,FSH and LH(P<0.001),whereas prolactin,sperm DNA fragmentation and protamine deficiency were positively correlated with BMI(P<0.001).Conclusions:This study provides clear evidence that obesity contributes potentially to male infertility by inducing sperm DNA fragmentation and protamine deficiency,as well as negatively impacting reproductive hormones and semen quality.展开更多
The formation process of blasting craters and blasting fragments is simulated using the continuumdiscontinuum element method(CDEM),providing a reference for blasting engineering design.The calculation model of the bla...The formation process of blasting craters and blasting fragments is simulated using the continuumdiscontinuum element method(CDEM),providing a reference for blasting engineering design.The calculation model of the blasting funnel is established,and the formation and fragmentation effect of the blasting crater under different explosive burial depths and different explosive package masses are numerically simulated.The propagation law of the explosion stress wave and the formation mechanism of the blasting crater are studied,and the relationship between the rock-crushing effect and blasting design parameters is quantitatively evaluated.Comparing the results of numerical simulation with the results of field tests and theoretical calculations indicated that the three are consistent,which proves the accuracy of numerical simulation.The results showed that the area of the blasting crater rises with the increase of explosive package mass and explosive burial depth.Taking the proportion of broken blocks with particle size ranging from 0.01 to 0.1 m as the research object,it can be found that the proportion of broken blocks with an explosive burial depth of 0.62 to 1.12 m is 0.45 to 0.18 times that with an explosive burial depth of 0.5 m.The proportion of broken blocks with an explosive radius of 4 to 12 cm is 1.14 to 3.29 times that with an explosive radius of 2 cm.The quantitative analysis of the blasting effect and blasting design parameters provides guidance for the design of blasting engineering.展开更多
The fragile and intricate geological environment of the Qinghai-Tibet Plateau gives rise to numerous precarious rocks along the riverbanks,posing significant risks for the upcoming construction of hydropower stations....The fragile and intricate geological environment of the Qinghai-Tibet Plateau gives rise to numerous precarious rocks along the riverbanks,posing significant risks for the upcoming construction of hydropower stations.In order to identify potential rockfalls that could endanger the Zixia hydropower project,a comprehensive analysis employing various methods was conducted to investigate the kinematic characteristics and dynamic fragmentation of such precarious rocks.Initially,UAV oblique photography and field survey were used to create a digital elevation model with a resolution of 0.25 m and map the spatial distribution of precarious rocks.Subsequently,the development characteristics of joints within rock masses were analyzed through an adit investigation.Following these preliminary steps,a transportation simulation utilizing RocPro3D,considering stochastic initiation orientation,was employed to predict the trajectories of 18 precarious rocks.As a result,two hazardous rocks that pose a direct threat to the cofferdam were identified.Finally,considering the influence of internal structure planes,a discrete element method was applied for accurately simulating the kinematic characteristics and dynamic fragmentation of these hazardous rocks.The findings underscore several key observations:(1)Slopeparallel structure planes within these hazardous rocks play a pivotal role in both the progressive failure during initiation and dynamic fragmentation during transportation;(2)Hazardous rocksⅢ-1 andⅣ-1 would pose a direct threat to the cofferdam.Notably,block b4 from hazardous rockⅢ-1,could potentially impact the cofferdam with an energy of 4598.65 kJ and an impact force of 3007.5 kN;and(3)Continuous collisions encountered during transportation facilitate the disintegration of rock masses along structure planes and generate substantial high-velocity fragments.Finally,to cope with the impact risk of collapsing blocks,a reinforced retaining wall as the mitigation measure is recommended.展开更多
Objective:To evaluate how DNA fragmentation index(DFI)and chromatin denaturation index(CDI)relate to semen parameters across different types of male infertility,thereby improving the understanding and assessment of sp...Objective:To evaluate how DNA fragmentation index(DFI)and chromatin denaturation index(CDI)relate to semen parameters across different types of male infertility,thereby improving the understanding and assessment of sperm quality.Methods:A prospective and descriptive cohort study was conducted over two years at the Integrated Physiology Laboratory of the University of Carthage in collaboration with the Alyssa Fertility Group,Tunisia.A total of 163 participants were classified into five groups based on their semen parameters:normozoospermia,oligozoospermia,asthenozoospermia,teratozoospermia,and oligoastheno-teratozoospermia.The normozoospermia group was selected from volunteers who had children.Semen samples were analyzed according to WHO guidelines.DFI was measured using Halosperm®and CDI was tested using aniline blue staining.Results:Both DFI and CDI were significantly higher in all infertility groups,with the oligozoospermia group showing the highest DFI and CDI.Negative correlations were found between DFI/CDI and sperm motility,concentration,and morphology in the affected groups.The normozoospermia group served as a control with the lowest DFI and CDI values.Conclusions:DFI and CDI are increasingly recognized as important biomarkers for evaluating sperm quality in cases of male infertility.Their elevated levels in patients with oligozoospermia,asthenozoospermia,teratozoospermia,and oligo-asthenoteratozoospermia underscore their potential role in not only diagnosing male infertility but also in assessing the overall reproductive outcomes for affected individuals,thus guiding more effective treatment strategies.展开更多
Electronic circular dichroism(ECD)spectrum is an important tool for as-sessing molecular chirality.Tradition-al methods,like linear response time-dependent density functional theory(LR-TDDFT),predict ECD spectra well ...Electronic circular dichroism(ECD)spectrum is an important tool for as-sessing molecular chirality.Tradition-al methods,like linear response time-dependent density functional theory(LR-TDDFT),predict ECD spectra well for small or medium-sized molecules,but struggle with large sys-tems due to high computational costs,making it a significant challenge to ac-curately and efficiently predict the ECD properties of complex systems.Within the framework of the generalized energy-based fragmentation(GEBF)method for localized excited states(ESs)calculation,we propose a combination algorithm for calculating rotatory strengths of ESs in condensed phase systems.This algorithm estimates the rotatory strength of the total system by calculating and combin-ing the transition electric and magnetic dipole moments of subsystems.We have used the GEBF method to calculate the ECD properties of chiral drug molecule derivatives,green fluo-rescent protein,and cyclodextrin derivatives,and compared their results with traditional methods or experimental data.The results show that this method can efficiently and accu-rately predict the ECD spectra of these systems.Thus,the GEBF method for ECD spectra demonstrates great potential in the chiral analysis of complex systems and chiral material design,promising to become a powerful theoretical tool in chiral chemistry.展开更多
This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabri...This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabricated fragments are employed to examine the damage under blast shock waves and combined blast and fragments loading on various liquid-filled cylindrical shell structures.The test results are compared to numerical calculations and theoretical analysis for the structure's deformation,the liquid medium's movement,and the pressure waves'propagation characteristics under different liquid-filling methods.The results showed that the filling method influences the blast protection and the struc-ture's energy absorption performance.The external filling method reduces the structural deformation,and the internal filling method increases the damage effect.The gapped internal filling method improves the structure's energy absorption efficiency.The pressure wave loading on the liquid-filled cylindrical shell structure differs depending on filling methods.Explosive shock waves and high-speed fragments show a damage enhancement effect on the liquid-filled cylindrical shell structure,depending on the thickness of the internal liquid container layer.The specific impulse on the inner surface of the cylindrical shell positively correlates to the radial deformation of the cylindrical shell structure,and the external liquid layer limits the radial structural deformation.展开更多
基金supported by Poongsan-KAIST Future Research Center Projectthe fund support provided by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Grant No.2023R1A2C2005661)。
文摘This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.
基金supported by grants from the National Key R&D Program of China(2022YFC2702700)Natural Science Foundation of Hunan Province(2024JJ6725 and 2022JJ40657)+1 种基金Hunan Provincial Grant for Innovative Province Construction(2019SK4012)the Reproductive and Genetic Hospital of CITIC-Xiangya Foundation(YNXM-202003).
文摘Recent studies have shown that shorter periods of ejaculatory abstinence may enhance certain sperm parameters,but the molecular mechanisms underlying these improvements are still unclear.This study explored whether reduced abstinence periods could improve semen quality,particularly for use in assisted reproductive technologies(ART).We analyzed semen samples from men with normal sperm counts(n=101)and those with low sperm motility or concentration(n=53)after 3-7 days of abstinence and then after 1-3h of abstinence,obtained from the Reproductive&Genetic Hospital of CITIC-Xiangya(Changsha,China).Physiological and biochemical sperm parameters were evaluated,and the dynamics of transfer RNA(tRNA)-derived fragments(tRFs)were analyzed using deep RNA sequencing in five consecutive samples from men with normal sperm counts.Our results revealed significant improvement in sperm motility and a decrease in the DNA fragmentation index after the 1-to 3-h abstinence period.Additionally,we identified 245 differentially expressed tRFs,and the mitogen-activated protein kinase(MAPK)signaling pathway was the most enriched.Further investigations showed significant changes in tRF-Lys-TTT and its target gene mitogen-activated protein kinase kinase 2(MAP2K2),which indicates a role of tRFs in improving sperm function.These findings provide new insights into how shorter abstinence periods influence sperm quality and suggest that tRFs may serve as biomarkers for male fertility.This research highlights the potential for optimizingART protocols and improving reproductive outcomes through molecular approaches that target sperm function.
文摘Total or severe teratospermia affects the prognosis of fertility and causes serious problems for patients undergoing assisted reproduction[1].The pathophysiological mechanism of teratospermia is unclear.It has been shown that patients with sperm parameters abnormalities and abnormal morphology have a high rate of fragmentation and sperm DNA decondensation[2,3],and that sperm DNA fragmentation analysis could be used as a predictor factor of fertility potential[4].
基金National Natural Science Foundation of China,Grant/Award Number:52374153。
文摘Rock fragmentation is an important indicator for assessing the quality of blasting operations.However,accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters and rock properties.For this reason,optimized by the Bayesian optimization algorithm(BOA),four hybrid machine learning models,including random forest,adaptive boosting,gradient boosting,and extremely randomized trees,were developed in this study.A total of 102 data sets with seven input parameters(spacing-to-burden ratio,hole depth-to-burden ratio,burden-to-hole diameter ratio,stemming length-to-burden ratio,powder factor,in situ block size,and elastic modulus)and one output parameter(rock fragment mean size,X_(50))were adopted to train and validate the predictive models.The root mean square error(RMSE),the mean absolute error(MAE),and the coefficient of determination(R^(2))were used as the evaluation metrics.The evaluation results demonstrated that the hybrid models showed superior performance than the standalone models.The hybrid model consisting of gradient boosting and BOA(GBoost-BOA)achieved the best prediction results compared with the other hybrid models,with the highest R^(2)value of 0.96 and the smallest values of RMSE and MAE of 0.03 and 0.02,respectively.Furthermore,sensitivity analysis was carried out to study the effects of input variables on rock fragmentation.In situ block size(XB),elastic modulus(E),and stemming length-to-burden ratio(T/B)were set as the main influencing factors.The proposed hybrid model provided a reliable prediction result and thus could be considered an alternative approach for rock fragment prediction in mining engineering.
基金supported by National Natural Science Foundation of China (No.U23A20597)National Major Science and Technology Project of China (No.2024ZD1003803)+1 种基金Chongqing Science Fund for Distinguished Young Scholars of Chongqing Municipality (No.CSTB2022NSCQ-JQX0028)Natural Science Foundation of Chongqing (No.CSTB2024NSCQ-MSX0503)。
文摘In the application of high-pressure water jet assisted breaking of deep underground rock engineering,the influence mechanism of rock temperature on the rock fragmentation process under jet action is still unclear.Therefore,the fluid evolution characteristics and rock fracture behavior during jet impingement were studied.The results indicate that the breaking process of high-temperature rock by jet impact can be divided into four stages:initial fluid-solid contact stage,intense thermal exchange stage,perforation and fracturing stage,and crack propagation and penetration stage.With the increase of rock temperature,the jet reflection angles and the time required for complete cooling of the impact surface significantly decrease,while the number of cracks and crack propagation rate significantly increase,and the rock breaking critical time is shortened by up to 34.5%.Based on numerical simulation results,it was found that the center temperature of granite at 400℃ rapidly decreased from 390 to 260℃ within 0.7 s under jet impact.In addition,a critical temperature and critical heat flux prediction model considering the staged breaking of hot rocks was established.These findings provide valuable insights to guide the water jet technology assisted deep ground hot rock excavation project.
文摘This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocation (RSA). The proposed method, Dynamic Threshold-Based Routing and Spectrum Allocation with Fragmentation Awareness (DT-RSAF), integrates rerouting and spectrum defragmentation as needed. By leveraging Yen’s shortest path algorithm, DT-RSAF enhances resource utilization while ensuring improved service continuity. A dynamic threshold mechanism enables the algorithm to adapt to varying network conditions, while its fragmentation awareness effectively mitigates spectrum fragmentation. Simulation results on NSFNET and COST 239 topologies demonstrate that DT-RSAF significantly outperforms methods such as K-Shortest Path Routing and Spectrum Allocation (KSP-RSA), Load Balanced and Fragmentation-Aware (LBFA), and the Invasive Weed Optimization-based RSA (IWO-RSA). Under heavy traffic, DT-RSAF reduces the blocking probability by up to 15% and achieves lower Bandwidth Fragmentation Ratios (BFR), ranging from 74% to 75%, compared to 77% - 80% for KSP-RSA, 75% - 77% for LBFA, and approximately 76% for IWO-RSA. DT-RSAF also demonstrated reasonable computation times compared to KSP-RSA, LBFA, and IWO-RSA. On a small-sized network, its computation time was 8710 times faster than that of Integer Linear Programming (ILP) on the same network topology. Additionally, it achieved a similar execution time to LBFA and outperformed IWO-RSA in terms of efficiency. These results highlight DT-RSAF’s capability to maintain large contiguous frequency blocks, making it highly effective for accommodating high-bandwidth requests in EONs while maintaining reasonable execution times.
文摘This review examines the processes of laser heating,melting,evaporation,fragmentation,and breakdown of metal nanoparticles,as well as the dependences and values of the threshold laser parameters that initiate these processes.Literature results are analyzed from experimental studies of these processes with gold,silver,and other nanoparticles,including laser surface melting and evaporation of nanoparticles and Coulomb fragmentation of nanoparticles by ultrashort laser pulses.A theoretical model and description of the thermal mechanisms of mentioned processes with metal(solid)nanoparticles in a liquid(solid)medium,initiated by the action of laser pulses with the threshold fluences,are presented.Comparison of the obtained results with experimental data confirms the accuracy of the model and makes it possible to use them to evaluate the parameters of laser thermal processing of nanoparticles.Applications of the processes include the laser melting,reshaping,and fragmentation of nanoparticles,the formation of nanostructures and nanonetworks,the laser processing of nanoparticles located on substrates,and their cladding on surfaces in various laser nanotechnologies.The use of laser ignition,combustion,and incandescence of nanoparticles is discussed,as is the use of nanoparticle-triggered laser breakdown for spectroscopy.These laser processes are used in photothermal nanotechnologies,nanoenergy,laser processing of nanoparticles,nonlinear optical devices,high-temperature material science,etc.In general,this review presents a modern picture of the state of laser technology and high-temperature processes with nanoparticles and their applications,being focused on the latest publications with an emphasis on recent results from 2021-2024.
基金supported by the National Natural Science Foundation of China(No.32201304)the Fundamental Research Funds for the Central Universities(No.2412022QD026).
文摘Habitat fragmentation poses a significant threat to bird communities, especially those in open and semi-open ecosystems such as steppes. This study investigates how steppe birds adapt to and utilize fragmented habitats by combining niche modeling with ecological trait analysis. We conducted standardized point surveys to examine the habitat preferences of 32 bird species in Inner Mongolia, China, and quantified their habitat niche parameters using the Outlying Mean Index (OMI). Our results reveal distinct habitat preferences among species, with some thriving in intact environments while others are better adapted to fragmented areas. Grassland species showed high specialization along the fragmentation gradient, while others exhibited adaptability to varying levels of fragmentation. Using a Generalized Additive Model (GAM), we identified three key traits influencing habitat occupancy: hand-wing index, body mass, and range size. Specifically, species with medium hand-wing indices, moderate body mass, and larger range sizes were more likely to occupy heavily fragmented habitats. These findings provide empirical evidence on how habitat fragmentation affects bird species in steppe ecosystems. The study highlights the importance of functional traits in understanding avian responses to habitat fragmentation and offers a foundation for developing effective conservation strategies to preserve biodiversity in fragmented landscapes.
基金supported by the National Natural Science Foundation of China(Grant Nos.12102480,52278543 and 51978660)Natural Science Foundation of Jiangsu Province(Grant No.BK20231489)。
文摘Liquid-filled containers(LFC)are widely used to store and transport petroleum,chemical reagents,and other resources.As an important target of military strikes and terrorist bombings,LFC are vulnerable to blast waves and fragments.To explore the protective effect of polyurea elastomer on LFC,the damage characteristics of polyurea coated liquid-filled container(PLFC)under the combined loading of blast shock wave and fragments were studied experimentally.The microstructure of the polyurea layer was observed by scanning electron microscopy,and the fracture and self-healing phenomena were analyzed.The simulation approach was used to explain the combined blast-and fragments-induced on the PLFC in detail.Finally,the effects of shock wave and fragment alone and in combination on the damage of PLFC were comprehensively compared.Results showed that the polyurea reduces the perforation rate of the fragment to the LFC,and the self-healing phenomenon could also reduce the liquid loss rate inside the container.The polyurea reduces the degree of depression in the center of the LFC,resulting in a decrease in the distance between adjacent fragments penetrating the LFC,and an increase in the probability of transfixion and fracture between holes.Under the close-in blast,the detonation shock wave reached the LFC before the fragment.Polyurea does not all have an enhanced effect on the protection of LFC.The presence of internal water enhances the anti-blast performance of the container,and the hydrodynamic ram(HRAM)formed by the fragment impacting the water aggravated the plastic deformation of the container.The combined action has an enhancement effect on the deformation of the LFC.The depth of the container depression was 27%higher than that of the blast shock wave alone;thus,it cannot be simply summarized as linear superposition.
基金support from the National Natural Science Foundation of China(41977233,U22A20601)Student Research Training Program of Fuzhou University(S202210386061).
文摘Fragmentation is a common phenomenon in the runout process of large rockslides.Rocks have different strengths under the influence of the rock type and weathering degree,resulting in varying fragmentation characteristics.However,the limited understanding of how rock strength influences the postfragmentation kinematic characteristics of rockslides is limited.Taking a natural rockslide as an example,this paper quantitatively analyzes the runout and deposition of the rockslide using the discrete element method(DEM)and examines the impacts of the rock strength on the runout and deposition characteristics of the rockslide.The results reveal that(1)Rock strength significantly influences fragmentation and runout characteristics:medium-to-high strength rocks exhibit two-stage fragmentation(10-20 s and 55-65 s),while weak-strength rocks achieve 98%fragmentation within 20 s.Optimal kinetic energy conversion occurs in medium-strength rocks,with a maximum velocity difference of 39.3 m/s between the anterior and posterior edges.(2)The sudden change in the cross-sectional dimensions of high-strength rocks under a high spreading velocity(>60 m/s)may amplify air blast hazards.(3)Deposition patterns reveal that the spatial distribution of fragments preserves original positional order;high-strength rocks produce larger fragments(nominal fragment size increases from 0.028 of weak-strength rocks to 0.607);and centroid displacement increases from 1907 m to 2117 m with rock strength in open terrains.(4)Energy dissipation analysis shows that frictional dissipation(>60%)>collisional dissipation(~37%)>>fragmentation dissipation(<2%)in the process of rockslide runout.The rock strength induces<5%variation in partitioning of energy dissipation.
基金financially supported by the Joint Funds of the National Natural Science Foundation of China(Grant No.U23A2047)the General Project of the Natural Science Foundation of Sichuan Province,China(Grant No.2023NSFSC0264).
文摘Rockfall represents a significant geological hazard in mountainous regions,characterized by a sudden and unpredictable feature.The process of dynamic fragmentation and energy conversion in a rockfall event remains complex and not fully understood.This study aims to gain a further understanding of the energy transfer mechanism during rockfall impact and fragmentation by impact tests using a variety of rock-like sphere specimens.The experiments mainly focus on the quantitative correlation between fragmentation degree and influence factors,i.e.impact angle and velocity on steel and granite slabs.The analysis focuses on the energy distribution characteristics,energy dissipation mechanisms,and the energy conversion rate of the fragments during impact and fragmentation.The results show that there is a significant correlation between the energy conversion rate and the fragmentation degree.In normal impact tests,elasto-plastic deformation energy and fracture energy are found to be two primary categories of energy dissipation.The proportion of total kinetic energy after impact is inversely proportional to the initial energy.A comparative analysis between normal and inclined slab impact tests reveals that the impact angle significantly influences the energy conversion rate,which controls the fragmentation degree as well.In addition,the fragmentation degree is inversely proportional to the restitution coefficient.These findings contribute to a better understanding of the energy conversion mechanism during rockfall impact and fragmentation,providing valuable insight for the development of effective strategies to mitigate such rockfall hazards.
基金supported by the National Natural Science Foundation of China(Grant No.12474159)the Fundamental Research Funds for the Central University,Sun Yat-sen University(Grant No.24qnpy119)the China Postdoctoral Science Foundation(Grant No.2024T171067)。
文摘We investigate distinct non-Hermitian skin effects(NHSEs)in real and Fock spaces induced by the interplay between the Hilbert space fragmentation and multiple non-Hermitian pumping channels.Using an extended Hatano–Nelson model with next-nearest neighbor hopping and strong interaction as an example,we found that two fermions loaded in the lattice exhibit different real-space NHSE depending on the Hilbert space fragments to which they belong.Moreover,in the high-energy sector resulting from fragmentation,the two-particle-bound states form a one-dimensional lattice in Fock space,producing a Fock-space NHSE.At half-filling,richer patterns of Fock-space skin-like localization emerge for the different fragmented energy sectors and subsectors while realspace NHSE is suppressed by many-body effects.This study extends our understanding of the interplay between NHSE and Hilbert space fragmentation and provides detailed insights into their manifestation in interacting non-Hermitian systems.
基金supported by the Major Program of National Natural Science Foundation of China(No.52192624)the Innovative Research Group Project of National Natural Science Foundation of China(No.52421002)+3 种基金Major Science and Technology Project of Yunnan Province(No.202302AF080001)NSFC Key International(Regional)Cooperative Research Projects(No.52020105001)General Program of National Natural Science Foundation of China(Nos.52204019 and 52274016)the Foundation of State Key Laboratory of Petroleum Resources and Prospecting(No.PRE/DX-2402)。
文摘Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.
文摘The publisher regrets that the article type for this publication was incorrectly labeled as a Research Article.The correct designation should be Review Article.This correction does not affect the content or conclusions of the article.The publisher apologizes for any inconvenience caused.
文摘Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the alterations related to reproductive hormones,semen parameters and their association with body mass index(BMI).Methods:Participants in this observational study were divided into three groups based on their BMI:proven fertile,normal weight men(n=200);overweight men(n=200);and obese men(n=200).After 3 days of abstinence,seminal fluid was collected from all participants and analyzed.Blood samples were also collected on the same day for hormonal analysis.Sperm DNA fragmentation and protamine deficiency were also assessed.Results:A total of 600 men with a mean age of(34.3±7.9)2 years were included in the study.Obese males(BMI 30 kg/m or higher)exhibited significant reductions in semen volume,sperm concentration,total sperm motility percentage,progressive motility,non-progressive motility,and levels of total testosterone,follicle-stimulating hormone(FSH)and luteinizing hormone(LH)compared to overweight(BMI 25 to 29.9 kg/m2)and normal weight males(BMI 18.5 to 24.9 kg/m2)(P<0.001).Conversely,obese males showed a significant increase in prolactin level,sperm DNA fragmentation,and protamine deficiency compared to overweight and normal weight males(P<0.001).Significant negative correlations were demonstrated between BMI and sperm concentration,motility,total testosterone,FSH and LH(P<0.001),whereas prolactin,sperm DNA fragmentation and protamine deficiency were positively correlated with BMI(P<0.001).Conclusions:This study provides clear evidence that obesity contributes potentially to male infertility by inducing sperm DNA fragmentation and protamine deficiency,as well as negatively impacting reproductive hormones and semen quality.
基金funded by the National Natural Science Foundation of China(Program Nos.52379128,52209162)Natural Science Foundation of Hubei Province of China(Program Nos.2023AFA048,2023AFB657)+3 种基金Hubei Provincial Key Laboratory of Construction and Management in Hydropower Engineering(Program Nos.2023KSD03,2023KSD04)Natural Science Research of Jiangsu Higher Education Institutions of China(Program No.21KJB580001)Educational Commission of Hubei Province of China(Program No.T2020005)the Young Top-Notch Talent Cultivation Program of Hubei Province.
文摘The formation process of blasting craters and blasting fragments is simulated using the continuumdiscontinuum element method(CDEM),providing a reference for blasting engineering design.The calculation model of the blasting funnel is established,and the formation and fragmentation effect of the blasting crater under different explosive burial depths and different explosive package masses are numerically simulated.The propagation law of the explosion stress wave and the formation mechanism of the blasting crater are studied,and the relationship between the rock-crushing effect and blasting design parameters is quantitatively evaluated.Comparing the results of numerical simulation with the results of field tests and theoretical calculations indicated that the three are consistent,which proves the accuracy of numerical simulation.The results showed that the area of the blasting crater rises with the increase of explosive package mass and explosive burial depth.Taking the proportion of broken blocks with particle size ranging from 0.01 to 0.1 m as the research object,it can be found that the proportion of broken blocks with an explosive burial depth of 0.62 to 1.12 m is 0.45 to 0.18 times that with an explosive burial depth of 0.5 m.The proportion of broken blocks with an explosive radius of 4 to 12 cm is 1.14 to 3.29 times that with an explosive radius of 2 cm.The quantitative analysis of the blasting effect and blasting design parameters provides guidance for the design of blasting engineering.
基金gratefully acknowledge support from the National Key Research and Development Program of China(Grant No.2022YFC3005704)the National Natural Science Foundation of China(Grant No.42277143)the Sichuan Province natural Science Foundation project(Grant No.2024NSFSC0100).
文摘The fragile and intricate geological environment of the Qinghai-Tibet Plateau gives rise to numerous precarious rocks along the riverbanks,posing significant risks for the upcoming construction of hydropower stations.In order to identify potential rockfalls that could endanger the Zixia hydropower project,a comprehensive analysis employing various methods was conducted to investigate the kinematic characteristics and dynamic fragmentation of such precarious rocks.Initially,UAV oblique photography and field survey were used to create a digital elevation model with a resolution of 0.25 m and map the spatial distribution of precarious rocks.Subsequently,the development characteristics of joints within rock masses were analyzed through an adit investigation.Following these preliminary steps,a transportation simulation utilizing RocPro3D,considering stochastic initiation orientation,was employed to predict the trajectories of 18 precarious rocks.As a result,two hazardous rocks that pose a direct threat to the cofferdam were identified.Finally,considering the influence of internal structure planes,a discrete element method was applied for accurately simulating the kinematic characteristics and dynamic fragmentation of these hazardous rocks.The findings underscore several key observations:(1)Slopeparallel structure planes within these hazardous rocks play a pivotal role in both the progressive failure during initiation and dynamic fragmentation during transportation;(2)Hazardous rocksⅢ-1 andⅣ-1 would pose a direct threat to the cofferdam.Notably,block b4 from hazardous rockⅢ-1,could potentially impact the cofferdam with an energy of 4598.65 kJ and an impact force of 3007.5 kN;and(3)Continuous collisions encountered during transportation facilitate the disintegration of rock masses along structure planes and generate substantial high-velocity fragments.Finally,to cope with the impact risk of collapsing blocks,a reinforced retaining wall as the mitigation measure is recommended.
文摘Objective:To evaluate how DNA fragmentation index(DFI)and chromatin denaturation index(CDI)relate to semen parameters across different types of male infertility,thereby improving the understanding and assessment of sperm quality.Methods:A prospective and descriptive cohort study was conducted over two years at the Integrated Physiology Laboratory of the University of Carthage in collaboration with the Alyssa Fertility Group,Tunisia.A total of 163 participants were classified into five groups based on their semen parameters:normozoospermia,oligozoospermia,asthenozoospermia,teratozoospermia,and oligoastheno-teratozoospermia.The normozoospermia group was selected from volunteers who had children.Semen samples were analyzed according to WHO guidelines.DFI was measured using Halosperm®and CDI was tested using aniline blue staining.Results:Both DFI and CDI were significantly higher in all infertility groups,with the oligozoospermia group showing the highest DFI and CDI.Negative correlations were found between DFI/CDI and sperm motility,concentration,and morphology in the affected groups.The normozoospermia group served as a control with the lowest DFI and CDI values.Conclusions:DFI and CDI are increasingly recognized as important biomarkers for evaluating sperm quality in cases of male infertility.Their elevated levels in patients with oligozoospermia,asthenozoospermia,teratozoospermia,and oligo-asthenoteratozoospermia underscore their potential role in not only diagnosing male infertility but also in assessing the overall reproductive outcomes for affected individuals,thus guiding more effective treatment strategies.
基金supported by the National Natural Science Foundation of China(No.22273038 and No.22033004).
文摘Electronic circular dichroism(ECD)spectrum is an important tool for as-sessing molecular chirality.Tradition-al methods,like linear response time-dependent density functional theory(LR-TDDFT),predict ECD spectra well for small or medium-sized molecules,but struggle with large sys-tems due to high computational costs,making it a significant challenge to ac-curately and efficiently predict the ECD properties of complex systems.Within the framework of the generalized energy-based fragmentation(GEBF)method for localized excited states(ESs)calculation,we propose a combination algorithm for calculating rotatory strengths of ESs in condensed phase systems.This algorithm estimates the rotatory strength of the total system by calculating and combin-ing the transition electric and magnetic dipole moments of subsystems.We have used the GEBF method to calculate the ECD properties of chiral drug molecule derivatives,green fluo-rescent protein,and cyclodextrin derivatives,and compared their results with traditional methods or experimental data.The results show that this method can efficiently and accu-rately predict the ECD spectra of these systems.Thus,the GEBF method for ECD spectra demonstrates great potential in the chiral analysis of complex systems and chiral material design,promising to become a powerful theoretical tool in chiral chemistry.
基金the National Natural Science Foundation of China(Grant Nos.52371342,52271338,52101378 and 51979277)。
文摘This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabricated fragments are employed to examine the damage under blast shock waves and combined blast and fragments loading on various liquid-filled cylindrical shell structures.The test results are compared to numerical calculations and theoretical analysis for the structure's deformation,the liquid medium's movement,and the pressure waves'propagation characteristics under different liquid-filling methods.The results showed that the filling method influences the blast protection and the struc-ture's energy absorption performance.The external filling method reduces the structural deformation,and the internal filling method increases the damage effect.The gapped internal filling method improves the structure's energy absorption efficiency.The pressure wave loading on the liquid-filled cylindrical shell structure differs depending on filling methods.Explosive shock waves and high-speed fragments show a damage enhancement effect on the liquid-filled cylindrical shell structure,depending on the thickness of the internal liquid container layer.The specific impulse on the inner surface of the cylindrical shell positively correlates to the radial deformation of the cylindrical shell structure,and the external liquid layer limits the radial structural deformation.
