运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100...运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100倍的基因共8个,下调50~100倍的基因共14个,同时按基因转录水平将这些基因进行了分类。运用KEGG(Kyoto Encyclopedia of Genes and Genomes)通路分析技术分析相关基因通路,结果显示松乳菇多糖主要抑制人喉癌Hep-2细胞中的MAPK信号转导通路和PI3K-AKT信号转导通路。在松乳菇多糖的刺激作用下,人喉癌Hep-2细胞的凋亡是多种基因共同作用的综合结果。用筛选出的基因进一步研究肿瘤凋亡的分子机制,对寻找潜在的抗肿瘤作用靶点具有重要生物学意义。展开更多
For 5G new radio(NR),there are two frequency bands:Frequency Range 1(FR‐1)(low frequency)and Frequency Range 2(FR‐2)(millimeter‐wave frequency).Millimeter‐wave has been officially utilized in mobile applications.T...For 5G new radio(NR),there are two frequency bands:Frequency Range 1(FR‐1)(low frequency)and Frequency Range 2(FR‐2)(millimeter‐wave frequency).Millimeter‐wave has been officially utilized in mobile applications.The wide bandwidth is the key for the millimeter-wave band.However,higher loss has become the major challenge for the wide use of this frequency range.Antenna array and beamforming technologies have been introduced to resolve the path loss and coverage problems.The key design considerations of the beamforming antenna array are low loss,compact system and small size.Antenna-in-package(AiP)has become the most attractive technology for millimeter-wave front-end system.For the design of AiP,many parameters such as RF transition,material and heat need to be considered and designed properly.The Over‐the‐Air(OTA)testing technology is also very critical for AiP mass production.In this paper,the detail of AiP design and new OTA testing technology are discussed and demonstrated.展开更多
文摘运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100倍的基因共8个,下调50~100倍的基因共14个,同时按基因转录水平将这些基因进行了分类。运用KEGG(Kyoto Encyclopedia of Genes and Genomes)通路分析技术分析相关基因通路,结果显示松乳菇多糖主要抑制人喉癌Hep-2细胞中的MAPK信号转导通路和PI3K-AKT信号转导通路。在松乳菇多糖的刺激作用下,人喉癌Hep-2细胞的凋亡是多种基因共同作用的综合结果。用筛选出的基因进一步研究肿瘤凋亡的分子机制,对寻找潜在的抗肿瘤作用靶点具有重要生物学意义。
文摘For 5G new radio(NR),there are two frequency bands:Frequency Range 1(FR‐1)(low frequency)and Frequency Range 2(FR‐2)(millimeter‐wave frequency).Millimeter‐wave has been officially utilized in mobile applications.The wide bandwidth is the key for the millimeter-wave band.However,higher loss has become the major challenge for the wide use of this frequency range.Antenna array and beamforming technologies have been introduced to resolve the path loss and coverage problems.The key design considerations of the beamforming antenna array are low loss,compact system and small size.Antenna-in-package(AiP)has become the most attractive technology for millimeter-wave front-end system.For the design of AiP,many parameters such as RF transition,material and heat need to be considered and designed properly.The Over‐the‐Air(OTA)testing technology is also very critical for AiP mass production.In this paper,the detail of AiP design and new OTA testing technology are discussed and demonstrated.
