AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet con...AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.展开更多
AIM: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema(CME) without and with internal limiting membrane(ILM) detachment...AIM: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema(CME) without and with internal limiting membrane(ILM) detachment and to discuss the presumed role of the glial scaffold for foveal structure stabilization. METHODS: A retrospective case series of 38 eyes of 35 patients is described. Of these, 17 eyes of 16 patients displayed foveal regeneration after resolution of CME, and 6 eyes of 6 patients displayed CME with ILM detachment. Eleven eyes of 9 patients displayed other kinds of foveal and retinal disorders associated with ILM detachment. RESULTS: The pattern of edematous cyst distribution, with or without a large cyst in the foveola and preferred location of cysts in the inner nuclear layer or Henle fiber layer(HFL), may vary between different eyes with CME or in one eye during different CME episodes. Large cysts in the foveola may be associated with a tractional elevation of the inner foveal layers and the formation of a foveoschisis in the HFL. Edematous cysts are usually not formed in the ganglion cell layer. Eyes with CME and ILM detachment display a schisis between the detached ILM and nerve fiber layer(NFL) which is traversed by Müller cell trunks. ILM detachment was also found in single eyes with myopic traction maculopathy, macular pucker, full-thickness macular holes, outer lamellar holes, and glaucomatous parapapillary retinoschisis, and in 3 eyes with Müller cell sheen dystrophy(MCSD). As observed in eyes with MCSD, cellophane maculopathy, and macular pucker, respectively, fundus light reflections can be caused by different highly reflective membranes or layers: the thickened and tightened ILM which may or may not be detached from the NFL, the NFL, or idiopathic epiretinal membranes. In eyes with short single or multiple CME episodes, the central fovea regenerated either completely, which included the disappearance of irregularities of the photoreceptor layer lines and the reformation of a fovea externa, or with remaining irregularities of the photoreceptor layer lines. CONCLUSION: The examples of a complete regeneration of the foveal morphology after transient CME show that the fovea may withstand even large tractional deformations and has a conspicuous capacity of structural regeneration as long as no cell degeneration occurs. It is suggested that the regenerative capacity depends on the integrity of the threedimensional glial scaffold for foveal structure stabilization composed of Müller cell and astrocyte processes. The glial scaffold may also maintain the retinal structure after loss of most retinal neurons as in late-stage MCSD.展开更多
AIM: To explore a more accurate quantifying diagnosis method of diabetic macular edema(DME) by displaying detailed 3D morphometry beyond the gold-standard quantification indicator-central retinal thickness(CRT) and ap...AIM: To explore a more accurate quantifying diagnosis method of diabetic macular edema(DME) by displaying detailed 3D morphometry beyond the gold-standard quantification indicator-central retinal thickness(CRT) and apply it in follow-up of DME patients.METHODS: Optical coherence tomography(OCT) scans of 229 eyes from 160 patients were collected.We manually annotated cystoid macular edema(CME), subretinal fluid(SRF) and fovea as ground truths.Deep convolution neural networks(DCNNs) were constructed including U-Net, sASPP, HRNetV2-W48, and HRNetV2-W48+Object-Contextual Representation(OCR) for fluid(CME+SRF) segmentation and fovea detection respectively, based on which the thickness maps of CME, SRF and retina were generated and divided by Early Treatment Diabetic Retinopathy Study(ETDRS) grid.RESULTS: In fluid segmentation, with the best DCNN constructed and loss function, the dice similarity coefficients(DSC) of segmentation reached 0.78(CME), 0.82(SRF), and 0.95(retina).In fovea detection, the average deviation between the predicted fovea and the ground truth reached 145.7±117.8 μm.The generated macular edema thickness maps are able to discover center-involved DME by intuitive morphometry and fluid volume, which is ignored by the traditional definition of CRT>250 μm.Thickness maps could also help to discover fluid above or below the fovea center ignored or underestimated by a single OCT B-scan.CONCLUSION: Compared to the traditional unidimensional indicator-CRT, 3D macular edema thickness maps are able to display more intuitive morphometry and detailed statistics of DME, supporting more accurate diagnoses and follow-up of DME patients.展开更多
Dear Editor,I am Dr.Shan-Shan Li,from Northern Jiangsu People’s Hospital,Yangzhou,China.I write to present the case of formation of choroidal neovascularization(CNV)under the fovea after high-power laser irradiation....Dear Editor,I am Dr.Shan-Shan Li,from Northern Jiangsu People’s Hospital,Yangzhou,China.I write to present the case of formation of choroidal neovascularization(CNV)under the fovea after high-power laser irradiation.Currently,there is an increasing availability and accessibility to laser instruments,but improper use of these tools can lead to macular damage and irreversible visual impairment.展开更多
Detection of abnormalities in human eye is one of the wellestablished research areas of Machine Learning.Deep Learning techniques are widely used for the diagnosis of RetinalDiseases(RD).Fovea is one of the significan...Detection of abnormalities in human eye is one of the wellestablished research areas of Machine Learning.Deep Learning techniques are widely used for the diagnosis of RetinalDiseases(RD).Fovea is one of the significant parts of retina which would be prevented before the involvement of Perforated Blood Vessels(PBV).Retinopathy Images(RI)contains sufficient information to classify structural changes incurred upon PBV but Macular Features(MF)and Fovea Features(FF)are very difficult to detect because features ofMFand FF could be found with Similar Color Movements(SCM)with minor variations.This paper presents novel method for the diagnosis of Irregular Fovea(IF)to assist the doctors in diagnosis of irregular fovea.By considering all above problems this paper proposes a three-layer decision support system to explore the hindsight knowledge of RI and to solve the classification problem of IF.The first layer involves data preparation,the second layer builds the decision model to extract the hidden patterns of fundus images by using Deep Belief Neural Network(DBN)and the third layer visualizes the results by using confusion matrix.This paper contributes a data preparation algorithm for irregular fovea and a highest estimated classification accuracy measured about 96.90%.展开更多
<strong>Purpose:</strong> To investigate the foveal avascular zone (FAZ) in obese by optical coherence tomography angiography (OCT-A) and to evaluate the findings of structural optical coherence tomography...<strong>Purpose:</strong> To investigate the foveal avascular zone (FAZ) in obese by optical coherence tomography angiography (OCT-A) and to evaluate the findings of structural optical coherence tomography (OCT) and their relations with comorbidities. <strong>Methods:</strong> It was included 35 obese (study group) and 30 normal individuals (control group). Patients with retinal diseases and retinal treatments were excluded. The images were obtained using the Topcon<span style="color:#FFFFFF;font-family:Roboto, " white-space:normal;background-color:#d46399;"=""><span style="color:#000000;"><sup><span style="color:#000000;font-family:Roboto, " white-space:normal;background-color:#d46399;"=""><span style="white-space:nowrap;">®</span></span></sup></span>;</span>. <strong>Results:</strong> The mean areas of FAZ in superficial plexus (FAZ-SP) and deep plexus (FAZ-DP) were significantly greater in the study group: FAZ-SP was 405.0 ± 136.4 μm<sup>2</sup> in the obese group and 307.3 ± 78.6 μm<sup>2</sup> in the control group and in the left eye (LE) 477.1 ± 124.4 μm<sup>2</sup> in the obese group and 384.0 ± 88.7 μm<sup>2</sup> in the control group. This difference was statistically significant (RE: p = 0.0014 and LE: p = 0.0012). The mean area of the FAZ-DP was 491.0 ± 124.4 μm<sup>2</sup> (Right eye—RE) in the obese group and 384.4 ± 88.7 μm2 in the control group and in the left eye (LE) was 497.9 ± 124.1 μm<sup>2</sup> in the obese group and 484.9 ± 92.7 μm<sup>2</sup> in the control group. There were no correlations regarding FAZ-SP and FAZ-DP in both eyes with fasting blood glucose, glycated hemoglobin, total cholesterol and fractions and triglycerides. A significant association between enlargement of FAZ-DP and type 2 diabetes mellitus (p = 0.0160) was observed. <strong>Conclusion:</strong> The FAZ areas in superficial and deep plexus achieved significantly greater values in the study group. There was a significant association between a larger deep FAZ area and type 2 diabetes mellitus. It is necessary an evaluation with a larger sample size to corroborate the findings.展开更多
AIM:To describe the optical coherence tomography(OCT)features in the fellow eyes of individuals with full-thickness macular holes(FTMHs).METHODS:This multicenter retrospective study included observational and validati...AIM:To describe the optical coherence tomography(OCT)features in the fellow eyes of individuals with full-thickness macular holes(FTMHs).METHODS:This multicenter retrospective study included observational and validation groups,incorporating fellow eyes of patients diagnosed with idiopathic FTMH.OCT images were categorized according to International Vitreomacular Traction Study(IVTS)and Gass classification.Age-and sex-related cataract patients were served as control groups.Vertical and horizontal OCT images were chosen for further measurement.OCT parameters including foveal floor width(FFW),central foveal thickness(CFT)and FFW/CFT ratio were assessed and compared between observational and control groups and were validated by validation group.Receiver operating characteristic(ROC)curves were plotted for OCT parameters in identifying macular holes(MHs).RESULTS:A total of 73 patients were included in the observational group,comprising 51 females and 22 males,with an average age of 65.5±7.3y and an axial length of 23.9±0.8 mm.The validated group consisted of 47 patients,including 31 females and 16 males,with an average age of 65.0±7.4y and an average axial length of 23.6±0.8 mm.In the observational group,16.4%of the fellow eyes associated with FTMHs also exhibited MHs,while in the validated group,this prevalence was 12.7%.The 45.2%in the observational group and 44.6%in validated group of these fellow eyes displayed abnormalities including vitreomacular adhesion(VMA),vitreomacular traction(VMT),and MHs.Statistically significant differences were observed in FFW,CFT,and FFW/CFT ratio between control and observational group,as well as validated group(P<0.01),no matter in the vertical or horizontal layer.ROC curves revealed the area under the curve(AUC)for FFW and the FFW/CFT ratio was 0.85 and 0.90,respectively.CONCLUSION:In the case of unilateral idiopathic MHs,it was important to carefully monitor the condition of the fellow eye.The FFW and FFW/CFT ratio may be good metrics for predicting MHs.展开更多
AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ...AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ophthalmoscopy(AOSLO)systems were utilized for retinal imaging with a large sampling window of 700μm×700μm.The study cohort included 14 emmetropic[spherical equivalent(SE)ranged+0.5 to-0.5 D],15 low myopic(SE ranged-0.5 to-3 D)and 21 moderate myopic(SE ranged-3 to-6 D)healthy young adults.Photoreceptors at 3°temporal,6°superior and inferior 6°were captured.Statistical analysis was then performed to obtain PCPD and cell spacing.RESULTS:The average age of participants was 22.54±2.86(ranged 20–30y)with no difference among 3 groups.At 3°temporal,the emmetropic group exhibited the highest PCPD of 15186.16±2050.54 cells/mm^(2),while the low and moderate myopic groups had PCPD of 14009.15±1073.01 and 13466.92±1121.71 cells/mm2,respectively.At 3°temporal,the emmetropic group also had the smallest cell spacing at 6.66±0.26 mm,compared to 6.85±0.26 and 6.91±0.28 mm for the low and moderate myopic groups,respectively.Compared to the emmetropic group,at 3°temporal,the myopic groups showed significantly reduced PCPD(low myopia:P=0.032;moderate myopia:P=0.001).At 6°inferior,the moderate myopic group exhibited a significant decrease in PCPD(P=0.013),while at 6°superior,there were no significant statistical differences in PCPD for the low and moderate myopic groups(P>0.05).In comparison to the emmetropic group,only the moderate myopic group showed significantly increased cell spacing at all three positions(temporal 3°:P=0.011,superior 6°:P=0.046,inferior 6°:P=0.013).Correlation analysis revealed a positive correlation between PCPD and axial length changes(P<0.05).CONCLUSION:Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes,especially at 6°inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be associated with increased axial lengthinduced retinal stretching.展开更多
目的:基于光学相干断层扫描血管成像(OCTA)技术分析悬吊式人工晶状体(IOL)植入术对患者术后黄斑区血管变化的影响。方法:选取2022年1月—2023年10月上饶市中心医院收治的无晶状体眼患者共计74例。检测患者术前及术后1 d、1周、1个月、3...目的:基于光学相干断层扫描血管成像(OCTA)技术分析悬吊式人工晶状体(IOL)植入术对患者术后黄斑区血管变化的影响。方法:选取2022年1月—2023年10月上饶市中心医院收治的无晶状体眼患者共计74例。检测患者术前及术后1 d、1周、1个月、3个月、6个月眼压(IOP)、裸眼视力(UCVA)、最佳矫正视力(BCVA)及OCTA指标[浅层视网膜毛细血管丛(SCP)密度、深层视网膜毛细血管丛(DCP)密度、黄斑中心凹无灌注区(FAZ)面积],采用Pearson相关分析术后1 d黄斑中心凹血管密度变化值与术后1 d BCVA的相关性。结果:术后各时段患者UCVA、BCVA较术前均改善(P<0.05),且术后1个月后达到最佳,术后3、6个月达到稳定;在黄斑中心凹旁颞侧、上方、鼻侧、下方四个方向,患者术后1 d SCP密度较术前下降,且术后1周较术后1 d增加(P<0.05)。患者术前术后各位点DCP密度及FAZ面积比较,差异无统计学意义(P>0.05);Pearson分析显示,术后1 d的SCP密度、DCP密度均与术后1 d BCVA呈正相关性(r=0.361、0.417,P<0.05)。结论:OCTA技术能用于无晶状体眼患者悬吊式IOL植入术治疗后的效果评估,并为临床干预提供理论依据。展开更多
文摘AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.
文摘AIM: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema(CME) without and with internal limiting membrane(ILM) detachment and to discuss the presumed role of the glial scaffold for foveal structure stabilization. METHODS: A retrospective case series of 38 eyes of 35 patients is described. Of these, 17 eyes of 16 patients displayed foveal regeneration after resolution of CME, and 6 eyes of 6 patients displayed CME with ILM detachment. Eleven eyes of 9 patients displayed other kinds of foveal and retinal disorders associated with ILM detachment. RESULTS: The pattern of edematous cyst distribution, with or without a large cyst in the foveola and preferred location of cysts in the inner nuclear layer or Henle fiber layer(HFL), may vary between different eyes with CME or in one eye during different CME episodes. Large cysts in the foveola may be associated with a tractional elevation of the inner foveal layers and the formation of a foveoschisis in the HFL. Edematous cysts are usually not formed in the ganglion cell layer. Eyes with CME and ILM detachment display a schisis between the detached ILM and nerve fiber layer(NFL) which is traversed by Müller cell trunks. ILM detachment was also found in single eyes with myopic traction maculopathy, macular pucker, full-thickness macular holes, outer lamellar holes, and glaucomatous parapapillary retinoschisis, and in 3 eyes with Müller cell sheen dystrophy(MCSD). As observed in eyes with MCSD, cellophane maculopathy, and macular pucker, respectively, fundus light reflections can be caused by different highly reflective membranes or layers: the thickened and tightened ILM which may or may not be detached from the NFL, the NFL, or idiopathic epiretinal membranes. In eyes with short single or multiple CME episodes, the central fovea regenerated either completely, which included the disappearance of irregularities of the photoreceptor layer lines and the reformation of a fovea externa, or with remaining irregularities of the photoreceptor layer lines. CONCLUSION: The examples of a complete regeneration of the foveal morphology after transient CME show that the fovea may withstand even large tractional deformations and has a conspicuous capacity of structural regeneration as long as no cell degeneration occurs. It is suggested that the regenerative capacity depends on the integrity of the threedimensional glial scaffold for foveal structure stabilization composed of Müller cell and astrocyte processes. The glial scaffold may also maintain the retinal structure after loss of most retinal neurons as in late-stage MCSD.
文摘AIM: To explore a more accurate quantifying diagnosis method of diabetic macular edema(DME) by displaying detailed 3D morphometry beyond the gold-standard quantification indicator-central retinal thickness(CRT) and apply it in follow-up of DME patients.METHODS: Optical coherence tomography(OCT) scans of 229 eyes from 160 patients were collected.We manually annotated cystoid macular edema(CME), subretinal fluid(SRF) and fovea as ground truths.Deep convolution neural networks(DCNNs) were constructed including U-Net, sASPP, HRNetV2-W48, and HRNetV2-W48+Object-Contextual Representation(OCR) for fluid(CME+SRF) segmentation and fovea detection respectively, based on which the thickness maps of CME, SRF and retina were generated and divided by Early Treatment Diabetic Retinopathy Study(ETDRS) grid.RESULTS: In fluid segmentation, with the best DCNN constructed and loss function, the dice similarity coefficients(DSC) of segmentation reached 0.78(CME), 0.82(SRF), and 0.95(retina).In fovea detection, the average deviation between the predicted fovea and the ground truth reached 145.7±117.8 μm.The generated macular edema thickness maps are able to discover center-involved DME by intuitive morphometry and fluid volume, which is ignored by the traditional definition of CRT>250 μm.Thickness maps could also help to discover fluid above or below the fovea center ignored or underestimated by a single OCT B-scan.CONCLUSION: Compared to the traditional unidimensional indicator-CRT, 3D macular edema thickness maps are able to display more intuitive morphometry and detailed statistics of DME, supporting more accurate diagnoses and follow-up of DME patients.
文摘Dear Editor,I am Dr.Shan-Shan Li,from Northern Jiangsu People’s Hospital,Yangzhou,China.I write to present the case of formation of choroidal neovascularization(CNV)under the fovea after high-power laser irradiation.Currently,there is an increasing availability and accessibility to laser instruments,but improper use of these tools can lead to macular damage and irreversible visual impairment.
文摘Detection of abnormalities in human eye is one of the wellestablished research areas of Machine Learning.Deep Learning techniques are widely used for the diagnosis of RetinalDiseases(RD).Fovea is one of the significant parts of retina which would be prevented before the involvement of Perforated Blood Vessels(PBV).Retinopathy Images(RI)contains sufficient information to classify structural changes incurred upon PBV but Macular Features(MF)and Fovea Features(FF)are very difficult to detect because features ofMFand FF could be found with Similar Color Movements(SCM)with minor variations.This paper presents novel method for the diagnosis of Irregular Fovea(IF)to assist the doctors in diagnosis of irregular fovea.By considering all above problems this paper proposes a three-layer decision support system to explore the hindsight knowledge of RI and to solve the classification problem of IF.The first layer involves data preparation,the second layer builds the decision model to extract the hidden patterns of fundus images by using Deep Belief Neural Network(DBN)and the third layer visualizes the results by using confusion matrix.This paper contributes a data preparation algorithm for irregular fovea and a highest estimated classification accuracy measured about 96.90%.
文摘<strong>Purpose:</strong> To investigate the foveal avascular zone (FAZ) in obese by optical coherence tomography angiography (OCT-A) and to evaluate the findings of structural optical coherence tomography (OCT) and their relations with comorbidities. <strong>Methods:</strong> It was included 35 obese (study group) and 30 normal individuals (control group). Patients with retinal diseases and retinal treatments were excluded. The images were obtained using the Topcon<span style="color:#FFFFFF;font-family:Roboto, " white-space:normal;background-color:#d46399;"=""><span style="color:#000000;"><sup><span style="color:#000000;font-family:Roboto, " white-space:normal;background-color:#d46399;"=""><span style="white-space:nowrap;">®</span></span></sup></span>;</span>. <strong>Results:</strong> The mean areas of FAZ in superficial plexus (FAZ-SP) and deep plexus (FAZ-DP) were significantly greater in the study group: FAZ-SP was 405.0 ± 136.4 μm<sup>2</sup> in the obese group and 307.3 ± 78.6 μm<sup>2</sup> in the control group and in the left eye (LE) 477.1 ± 124.4 μm<sup>2</sup> in the obese group and 384.0 ± 88.7 μm<sup>2</sup> in the control group. This difference was statistically significant (RE: p = 0.0014 and LE: p = 0.0012). The mean area of the FAZ-DP was 491.0 ± 124.4 μm<sup>2</sup> (Right eye—RE) in the obese group and 384.4 ± 88.7 μm2 in the control group and in the left eye (LE) was 497.9 ± 124.1 μm<sup>2</sup> in the obese group and 484.9 ± 92.7 μm<sup>2</sup> in the control group. There were no correlations regarding FAZ-SP and FAZ-DP in both eyes with fasting blood glucose, glycated hemoglobin, total cholesterol and fractions and triglycerides. A significant association between enlargement of FAZ-DP and type 2 diabetes mellitus (p = 0.0160) was observed. <strong>Conclusion:</strong> The FAZ areas in superficial and deep plexus achieved significantly greater values in the study group. There was a significant association between a larger deep FAZ area and type 2 diabetes mellitus. It is necessary an evaluation with a larger sample size to corroborate the findings.
基金Supported by Jiangsu Provincial Medical Innovation Team(No.CXTDA2017039)the Soochow Scholar Project of Soochow University(No.R5122001).
文摘AIM:To describe the optical coherence tomography(OCT)features in the fellow eyes of individuals with full-thickness macular holes(FTMHs).METHODS:This multicenter retrospective study included observational and validation groups,incorporating fellow eyes of patients diagnosed with idiopathic FTMH.OCT images were categorized according to International Vitreomacular Traction Study(IVTS)and Gass classification.Age-and sex-related cataract patients were served as control groups.Vertical and horizontal OCT images were chosen for further measurement.OCT parameters including foveal floor width(FFW),central foveal thickness(CFT)and FFW/CFT ratio were assessed and compared between observational and control groups and were validated by validation group.Receiver operating characteristic(ROC)curves were plotted for OCT parameters in identifying macular holes(MHs).RESULTS:A total of 73 patients were included in the observational group,comprising 51 females and 22 males,with an average age of 65.5±7.3y and an axial length of 23.9±0.8 mm.The validated group consisted of 47 patients,including 31 females and 16 males,with an average age of 65.0±7.4y and an average axial length of 23.6±0.8 mm.In the observational group,16.4%of the fellow eyes associated with FTMHs also exhibited MHs,while in the validated group,this prevalence was 12.7%.The 45.2%in the observational group and 44.6%in validated group of these fellow eyes displayed abnormalities including vitreomacular adhesion(VMA),vitreomacular traction(VMT),and MHs.Statistically significant differences were observed in FFW,CFT,and FFW/CFT ratio between control and observational group,as well as validated group(P<0.01),no matter in the vertical or horizontal layer.ROC curves revealed the area under the curve(AUC)for FFW and the FFW/CFT ratio was 0.85 and 0.90,respectively.CONCLUSION:In the case of unilateral idiopathic MHs,it was important to carefully monitor the condition of the fellow eye.The FFW and FFW/CFT ratio may be good metrics for predicting MHs.
基金Supported by National Natural Science Foundation of China(No.82271107).
文摘AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ophthalmoscopy(AOSLO)systems were utilized for retinal imaging with a large sampling window of 700μm×700μm.The study cohort included 14 emmetropic[spherical equivalent(SE)ranged+0.5 to-0.5 D],15 low myopic(SE ranged-0.5 to-3 D)and 21 moderate myopic(SE ranged-3 to-6 D)healthy young adults.Photoreceptors at 3°temporal,6°superior and inferior 6°were captured.Statistical analysis was then performed to obtain PCPD and cell spacing.RESULTS:The average age of participants was 22.54±2.86(ranged 20–30y)with no difference among 3 groups.At 3°temporal,the emmetropic group exhibited the highest PCPD of 15186.16±2050.54 cells/mm^(2),while the low and moderate myopic groups had PCPD of 14009.15±1073.01 and 13466.92±1121.71 cells/mm2,respectively.At 3°temporal,the emmetropic group also had the smallest cell spacing at 6.66±0.26 mm,compared to 6.85±0.26 and 6.91±0.28 mm for the low and moderate myopic groups,respectively.Compared to the emmetropic group,at 3°temporal,the myopic groups showed significantly reduced PCPD(low myopia:P=0.032;moderate myopia:P=0.001).At 6°inferior,the moderate myopic group exhibited a significant decrease in PCPD(P=0.013),while at 6°superior,there were no significant statistical differences in PCPD for the low and moderate myopic groups(P>0.05).In comparison to the emmetropic group,only the moderate myopic group showed significantly increased cell spacing at all three positions(temporal 3°:P=0.011,superior 6°:P=0.046,inferior 6°:P=0.013).Correlation analysis revealed a positive correlation between PCPD and axial length changes(P<0.05).CONCLUSION:Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes,especially at 6°inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be associated with increased axial lengthinduced retinal stretching.
文摘目的:基于光学相干断层扫描血管成像(OCTA)技术分析悬吊式人工晶状体(IOL)植入术对患者术后黄斑区血管变化的影响。方法:选取2022年1月—2023年10月上饶市中心医院收治的无晶状体眼患者共计74例。检测患者术前及术后1 d、1周、1个月、3个月、6个月眼压(IOP)、裸眼视力(UCVA)、最佳矫正视力(BCVA)及OCTA指标[浅层视网膜毛细血管丛(SCP)密度、深层视网膜毛细血管丛(DCP)密度、黄斑中心凹无灌注区(FAZ)面积],采用Pearson相关分析术后1 d黄斑中心凹血管密度变化值与术后1 d BCVA的相关性。结果:术后各时段患者UCVA、BCVA较术前均改善(P<0.05),且术后1个月后达到最佳,术后3、6个月达到稳定;在黄斑中心凹旁颞侧、上方、鼻侧、下方四个方向,患者术后1 d SCP密度较术前下降,且术后1周较术后1 d增加(P<0.05)。患者术前术后各位点DCP密度及FAZ面积比较,差异无统计学意义(P>0.05);Pearson分析显示,术后1 d的SCP密度、DCP密度均与术后1 d BCVA呈正相关性(r=0.361、0.417,P<0.05)。结论:OCTA技术能用于无晶状体眼患者悬吊式IOL植入术治疗后的效果评估,并为临床干预提供理论依据。
