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基于FOCUS-PDCA循环提升医护一体化协作质量的实践研究
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作者 杨子晴 李颖雅 +3 位作者 何海艳 陈华丽 陈文雨 胡晓莹 《现代医院》 2026年第1期56-60,共5页
目的通过科学的方法构建医护一体化协作管理模式并实践,旨在提升医护一体化协作质量,进一步提升医疗服务的质量。方法选取2024年1-2月与2024年11-12月的病房护士作为改善前组与改善后组,观察组运用FOCUS-PDCA循环理论为指导,以量性和质... 目的通过科学的方法构建医护一体化协作管理模式并实践,旨在提升医护一体化协作质量,进一步提升医疗服务的质量。方法选取2024年1-2月与2024年11-12月的病房护士作为改善前组与改善后组,观察组运用FOCUS-PDCA循环理论为指导,以量性和质性相结合的研究方法对医护一体化工作现状进行调查,深入分析现存问题,识别协作中的关键问题和薄弱环节,提出针对性改进措施,包括建立制度、规范流程、长效培训及监督机制等举措,比较实施前后的效果。结果455名病房护士对医护一体化协作的总体评价为(75.46±9.87)分(满分85分)。改善前后护士对医护一体化协作的满意度从(3.93±0.80)分提升至(4.35±0.68)分(满分5分),差异具有统计学意义(P<0.05)。结论医护一体化协作现状不佳,基于FOCUS-PDCA循环构建医护一体化协作管理模式可有效改善医护一体化协作质量,改善医-护-患沟通,提升护士职业价值感,提高工作效率和医疗质量。 展开更多
关键词 focus-pdca循环 医护一体化 协作质量 医疗服务流程优化
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FMEA联合FOCUS-PDCA模式在改善门诊患者预约诊疗服务质量与就诊体验中的应用
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作者 黄元琦 梁波 +2 位作者 闭艳艳 赵小乐 刘国源 《右江民族医学院学报》 2026年第1期142-146,共5页
目的探讨失效模式与效应分析(FMEA)结合基于PDCA循环的持续质量改进管理模型(FOCUS-PDCA)模式在提升门诊预约服务质量及改善患者就诊体验中的应用效果。方法选取2024年6月至2025年7月广西某三甲医院门诊患者400例,将接受常规服务的200... 目的探讨失效模式与效应分析(FMEA)结合基于PDCA循环的持续质量改进管理模型(FOCUS-PDCA)模式在提升门诊预约服务质量及改善患者就诊体验中的应用效果。方法选取2024年6月至2025年7月广西某三甲医院门诊患者400例,将接受常规服务的200例患者设为对照组,将接受FMEA联合FOCUS-PDCA管理的200例患者设为观察组。比较两组的预约挂号率、就诊意愿率、挂号及候诊时长、门诊服务质量评分及患者满意度。结果与对照组相比,观察组的预约挂号率、就诊意愿率、门诊服务质量评分及患者满意度评分均更高,挂号及候诊时长更短,差异均有统计学意义(P<0.05)。结论FMEA联合FOCUS-PDCA管理模式能有效改善门诊预约诊疗服务质量、患者就诊体验及满意度,从而提高预约就诊率。 展开更多
关键词 门诊 预防诊疗 失效模式与效应分析 focus-pdca
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浅谈基于FOCUS-PDCA的医疗设备临床试用规范化管理实践与风险控制策略
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作者 于军 高婧颖 +2 位作者 陆风旗 余徐栋 夏慧 《中国设备工程》 2026年第1期62-64,共3页
目的:探讨FOCUS-PDCA模型在医疗设备临床试用规范化管理中的应用效果。方法:利用FOCUS-PDCA模型对医疗设备临床试用制度建设、需求申请、过程管理、终止试用及供应商管理等各个环节的规范化管理进行分析,采取有效措施实施改进,查验其效... 目的:探讨FOCUS-PDCA模型在医疗设备临床试用规范化管理中的应用效果。方法:利用FOCUS-PDCA模型对医疗设备临床试用制度建设、需求申请、过程管理、终止试用及供应商管理等各个环节的规范化管理进行分析,采取有效措施实施改进,查验其效果。并结合持续质量改进,提出医疗设备试用的风险控制策略。结果:执行措施后医疗设备临床试用申请全部通过审批,且未产生不良事件,显著提升了医疗安全。结论:基于FOCUS-PDCA可不断强化医疗设备临床试用的规范化管理,为降低医院运营成本和满足临床救治需要发挥积极作用。 展开更多
关键词 focus-pdca 医疗设备 试用 规范化管理 风险控制
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Agri-Eval:Multi-level Large Language Model Valuation Benchmark for Agriculture
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作者 WANG Yaojun GE Mingliang +2 位作者 XU Guowei ZHANG Qiyu BIE Yuhui 《农业机械学报》 北大核心 2026年第1期290-299,共10页
Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLM... Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLMs.Therefore,in order to better assess the capability of LLMs in the agricultural domain,Agri-Eval was proposed as a benchmark for assessing the knowledge and reasoning ability of LLMs in agriculture.The assessment dataset used in Agri-Eval covered seven major disciplines in the agricultural domain:crop science,horticulture,plant protection,animal husbandry,forest science,aquaculture science,and grass science,and contained a total of 2283 questions.Among domestic general-purpose LLMs,DeepSeek R1 performed best with an accuracy rate of 75.49%.In the realm of international general-purpose LLMs,Gemini 2.0 pro exp 0205 standed out as the top performer,achieving an accuracy rate of 74.28%.As an LLMs in agriculture vertical,Shennong V2.0 outperformed all the LLMs in China,and the answer accuracy rate of agricultural knowledge exceeded that of all the existing general-purpose LLMs.The launch of Agri-Eval helped the LLM developers to comprehensively evaluate the model's capability in the field of agriculture through a variety of tasks and tests to promote the development of the LLMs in the field of agriculture. 展开更多
关键词 large language models assessment systems agricultural knowledge agricultural datasets
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Ecological Dynamics of a Logistic Population Model with Impulsive Age-selective Harvesting
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作者 DAI Xiangjun JIAO Jianjun 《应用数学》 北大核心 2026年第1期72-79,共8页
In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asy... In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting. 展开更多
关键词 The logistic population model Selective harvesting Asymptotic stability EXTINCTION
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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Stability of k-ε model in Kolmogorov flow
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作者 Jiashuo GUO Le FANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期165-184,共20页
The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpec... The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpected non-physical phase points in practice.We conduct an analysis on the phase-space characteristics and the fixed-point theory underlying the k-ε turbulence model,and employ the classical Kolmogorov flow as a framework,leveraging its direct numerical simulation(DNS)data to construct a one-dimensional(1D)system under periodic/fixed boundary conditions.The RANS results demonstrate that under periodic boundary conditions,the k-ε model exhibits only a unique trivial fixed point,with asymptotes capturing the phase portraits.The stability of this trivial fixed point is determined by a mathematically derived stability phase diagram,indicating the fact that the k-ε model will never converge to correct values under periodic conditions.In contrast,under fixed boundary conditions,the model can yield a stable non-trivial fixed point.The evolutionary mechanisms and their relationship with boundary condition settings systematically explain the inherent limitations of the k-ε model,i.e.,its deficiency in computing the flow field under periodic boundary conditions and sensitivity to boundary-value specifications under fixed boundary conditions.These conclusions are finally validated with the open-source code OpenFOAM. 展开更多
关键词 k-εmodel Kolmogorov flow INSTABILITY turbulence model
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Design optimization and FEA of B-6 and B-7 levels ballistics armor:A modelling approach
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作者 Muhammad Naveed CHU Jinkui +1 位作者 Atif Ur Rehman Arsalan Hyder 《大连理工大学学报》 北大核心 2026年第1期66-77,共12页
Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is empl... Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is employed to simulate the ballistic impact of 7.62 mm armor-piercing projectiles on Aluminum AA5083-H116 and Steel Secure 500 armors,focusing on the evaluation of material deformation and penetration resistance at varying impact points.While the D-shaped armor plate is penetrated by the armor-piercing projectiles,the combination of the perforated D-shaped and base armor plates successfully halts penetration.A numerical model based on the finite element method is developed using software such as SolidWorks and ANSYS to analyze the interaction between radiator armor and bullet.The perforated design of radiator armor is to maintain airflow for radiator function,with hole sizes smaller than the bullet core diameter to protect radiator assemblies.Predictions are made regarding the brittle fracture resulting from the projectile core′s bending due to asymmetric impact,and the resulting fragments failed to penetrate the perforated base armor plate.Craters are formed on the surface of the perforated D-shaped armor plate due to the impact of projectile fragments.The numerical model accurately predicts hole growth and projectile penetration upon impact with the armor,demonstrating effective protection of the radiator assemblies by the radiator armor. 展开更多
关键词 radiator armor ballistics simulation Johnson-Cook model armor-piercing projectile perforated D-shaped armor plate
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CIT-Rec:Enhancing Sequential Recommendation System with Large Language Models
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作者 Ziyu Li Zhen Chen +2 位作者 Xuejing Fu Tong Mo Weiping Li 《Computers, Materials & Continua》 2026年第3期2328-2343,共16页
Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interact... Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations. 展开更多
关键词 Large language models vision language models sequential recommendation instruction tuning
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Lithospheric magnetic variations on the Tibetan Plateau based on a 3D surface spline model,compared with strong earthquake occurrences
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作者 PengTao Zhang Jun Yang +3 位作者 LiLi Feng Xia Li YuHong Zhao YingFeng Ji 《Earth and Planetary Physics》 2026年第1期30-43,共14页
The National Geophysical Data Center(NGDC)of the United States has collected aeromagnetic data for input into a series of geomagnetic models to improve model resolution;however,in the Tibetan Plateau region,ground-bas... The National Geophysical Data Center(NGDC)of the United States has collected aeromagnetic data for input into a series of geomagnetic models to improve model resolution;however,in the Tibetan Plateau region,ground-based observations remain insufficient to clearly reflect the characteristics of the region’s lithospheric magnetism.In this study,we evaluate the lithospheric magnetism of the Tibetan Plateau by using a 3D surface spline model based on observations from>200 newly constructed repeat stations(portable stations)to determine the spatial distribution of plateau geomagnetism,as well as its correlation with the tectonic features of the region.We analyze the relationships between M≥5 earthquakes and lithospheric magnetic field variations on the Tibetan Plateau and identify regions susceptible to strong earthquakes.We compare the geomagnetic results with those from an enhanced magnetic model(EMM2015)developed by the NGDC and provide insights into improving lithospheric magnetic field calculations in the Tibetan Plateau region.Further research reveals that these magnetic anomalies exhibit distinct differences from the magnetic-seismic correlation mechanisms observed in other tectonic settings;here,they are governed primarily by the combined effects of compressional magnetism,thermal magnetism,and deep thermal stress.This study provides new evidence of geomagnetic anomalies on the Tibetan Plateau,interprets them physically,and demonstrates their potential for identifying seismic hazard zones on the Plateau. 展开更多
关键词 Tibetan Plateau magnetic variation SEISMICITY surface spline model enhanced magnetic model
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UAV-to-Ground Channel Modeling:(Quasi-)Closed-Form Channel Statistics and Manual Parameter Estimation
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作者 Zeng Linzhou Liao Xuewen +3 位作者 Xie Wenwu Ma Zhangfeng Xiong Baiping Jiang Hao 《China Communications》 2026年第1期47-66,共20页
(Quasi-)closed-form results for the statistical properties of unmanned aerial vehicle(UAV)airto-ground channels are derived for the first time using a novel spatial-vector-based method from a threedimensional(3-D)arbi... (Quasi-)closed-form results for the statistical properties of unmanned aerial vehicle(UAV)airto-ground channels are derived for the first time using a novel spatial-vector-based method from a threedimensional(3-D)arbitrary-elevation one-cylinder model.The derived results include a closed-form expression for the space-time correlation function and some quasi-closed-form ones for the space-Doppler power spectrum density,the level crossing rate,and the average fading duration,which are shown to be the generalizations of those previously obtained from the two-dimensional(2-D)one-ring model and the 3-D low-elevation one-cylinder model for terrestrial mobile-to-mobile channels.The close agreements between the theoretical results and the simulations as well as the measurements validate the utility of the derived channel statistics.Based on the derived expressions,the impacts of some parameters on the channel characteristics are investigated in an effective,efficient,and explicable way,which leads to a general guideline on the manual parameter estimation from the measurement description. 展开更多
关键词 channel characteristics geometry-based stochastic model manual parameter estimation UAV channel modeling
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Ecological restoration model selection for abandoned mines in the Luo River Basin,Eastern Qinling Mountains
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作者 HUANG Yuming GAO Ningze +1 位作者 ZHANG Hanyuan ZHENG Wenlong 《Journal of Mountain Science》 2026年第1期358-369,共12页
Effective management of mining areas in the Luo River Basin,located in the eastern Qinling Mountains,is vital for the integrated protection and restoration needed to support the high-quality development of the Yellow ... Effective management of mining areas in the Luo River Basin,located in the eastern Qinling Mountains,is vital for the integrated protection and restoration needed to support the high-quality development of the Yellow River Basin.Using the‘cupball'model,this study analyzes the limiting factors and restoration characteristics across four mining areas and proposes a conceptual model for selecting appropriate restoration approaches.A second conceptual model is then introduced to address regional development needs,incorporating ecological conservation,safety protection,and people's wellbeing.The applicability of the integrated model selection framework is demonstrated through a case study on the south bank of the Qinglongjian River.The results indicate that:(1)The key limiting factors are similar across cases,but the degree of ecological degradation varies.(2)Mildly degraded areas are represented by a shallower and narrower‘cup',where natural recovery is the preferred approach,whereas moderately and severely degraded systems call for assisted regeneration and ecological reconstruction,respectively.(3)When the restoration models determined based on limiting factors and development needs are consistent,the model is directly applicable;if they differ,the option involving less artificial intervention is preferred;(4)Monitoring of the restored mining area on the Qinglongjian River's south bank confirms significant improvements in soil erosion control and vegetation coverage.This study provides a transferable methodology for balancing resource extraction with ecosystem conservation,offering practical insights for other ecologically vulnerable mining regions. 展开更多
关键词 Luo River Basin Cup-ball model Mine restoration Ecological degradation Conceptual model Development needs
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Do Higher Horizontal Resolution Models Perform Better?
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作者 Shoji KUSUNOKI 《Advances in Atmospheric Sciences》 2026年第1期259-262,共4页
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(... Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)]. 展开更多
关键词 enhancing model resolution refinement data assimilation systems section climate model climate projection higher horizontal resolution seasonal forecasting simulation seasonal migration rain bands model resolution
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A peridynamics modeling approach for pre-cracked rock cracking processes under impact by integrating Drucker-Prager plasticity model and efficient contact model
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作者 Jingzhi Tu Nengxiong Xu Gang Mei 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期179-195,共17页
In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical propert... In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical properties of rocks,the cracking processes of pre-cracked rocks have been extensively studied using numerical modeling methods.The peridynamics(PD)exhibits advantages over other numerical methods due to the absence of the requirements for remeshing and external crack growth criterion.However,for modeling pre-cracked rock cracking processes under impact,current PD implementations lack generally applicable rock constitutive models and impact contact models,which leads to difficulties in determining rock material parameters and efficiently calculating impact loads.This paper proposes a non-ordinary state-based peridynamics(NOSBPD)modeling method integrating the Drucker-Prager(DP)plasticity model and an efficient contact model to address the above problems.In the proposed method,the Drucker-Prager plasticity model is integrated into the NOSBPD,thereby equipping NOSBPD with the capability to accurately characterize the nonlinear stress-strain relationship inherent in rocks.An efficient contact model between particles and meshes is designed to calculate the impact loads,which is essentially a coupling method of PD with the finite element method(FEM).The effectiveness of the proposed NOSBPD modeling method is verified by comparison with other numerical methods and experiments.Experimental results indicate that the proposed method can effectively and accurately predict the 3D cracking processes of pre-cracked cracks under impact loading,and the maximum principal stress is the key driver behind wing crack formation in pre-cracked rocks. 展开更多
关键词 Pre-cracked rocks Cracking processes Non-ordinary state-based peridynamics (NOSBPD) Drucker-Prager plasticity model Efficient contact model
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Secured-FL:Blockchain-Based Defense against Adversarial Attacks on Federated Learning Models
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作者 Bello Musa Yakubu Nor Shahida Mohd Jamail +1 位作者 Rabia Latif Seemab Latif 《Computers, Materials & Continua》 2026年第3期734-757,共24页
Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work pr... Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments. 展开更多
关键词 Federated learning(FL) blockchain FL based privacy model defense FL model security ethereum smart contract
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Three-Dimensional Hybrid Model for Wave Interaction with Porous Layer
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作者 Divya Ramesh Sriram Venkatachalam 《Computer Modeling in Engineering & Sciences》 2026年第1期577-603,共27页
A hybrid model combining Fully Non-Linear Potential Flow Theory(FNPT)based on the Finite Element Method(FEM)and the Unified Navier-Stokes equation,using the 3D Improved Meshless Local Petrov Galerkin method with Ranki... A hybrid model combining Fully Non-Linear Potential Flow Theory(FNPT)based on the Finite Element Method(FEM)and the Unified Navier-Stokes equation,using the 3D Improved Meshless Local Petrov Galerkin method with Rankine Source(IMLPG_R),is developed to study wave interactions with a porous layer.In previous studies,the above formulations are applied to wave interaction with fixed cylindrical structures.The present study extends this framework by integrating a unified governing equation within the hybrid modeling approach to capture the dynamics of wave interaction with porous media.The porous layers are employed to replicate the wave-dissipating behavior of the structure.A weak coupling strategy is implemented within a designated buffer zone,wherein field variables from the 2D Fully Nonlinear Potential Theory(FNPT)simulations are transferred to the 3D Improved Moving Least Squares-based Petrov-Galerkin(IMLPG_R)model at each time step.This domain decomposition significantly reduces computational cost compared to a full 3D simulation by partitioning the domain into two subregions:the FNPT domain representing the far-field without structures,and the IMLPG_R domain encompassing the porous region.The Unified Navier-Stokes formulation is extended by incorporating additional drag forces governed by Darcy’s law to model the resistance introduced by the porous medium.A stationary background node framework is utilized for interpolation by fluid particles at each time step to accommodate the porous representation.To enhance numerical stability and accuracy,particularly in the presence of sloping boundaries,the Particle Shifting Technique(PST)is integrated into the IMLPG_R model.This implementation involves a modified version of the PST algorithm,where key parameters such as the weight function,velocity ratio,and radius of influence are optimized for IMLPG_R.This is the first time the application of 3D IMLPG_R for porous structure has been reported.Further,the model is subsequently validated against experimental data. 展开更多
关键词 FNPT IMLPG_R hybrid model PST
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Review of machine learning tight-binding models:Route to accurate and scalable electronic simulations
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作者 Jijie Zou Zhanghao Zhouyin +1 位作者 Shishir Kumar Pandey Qiangqiang Gu 《Chinese Physics B》 2026年第1期2-12,共11页
The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-ti... The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-time scenarios.This review begins with a concise overview of traditional tight-binding(TB)models,including both(semi-)empirical and first-principles approaches,establishing the foundation for understanding MLTB developments.We then present a systematic classification of existing MLTB methodologies,grouped into two major categories:direct prediction of TB Hamiltonian elements and inference of empirical parameters.A comparative analysis with other ML-based electronic structure models is also provided,highlighting the advancement of MLTB approaches.Finally,we explore the emerging MLTB application ecosystem,highlighting how the integration of MLTB models with a diverse suite of post-processing tools from linear-scaling solvers to quantum transport frameworks and molecular dynamics interfaces is essential for tackling complex scientific problems across different domains.The continued advancement of this integrated paradigm promises to accelerate materials discovery and open new frontiers in the predictive simulation of complex quantum phenomena. 展开更多
关键词 machine learning tight-binding model electronic simulations
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Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis
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作者 Yewei Jia Yuhuai Guo +10 位作者 Yusheng Yang Jie Zhang Ziyang Zhang Ying Qu Jiulin Tan Jie Shen Nathachit Limjunyawong Jianzhong Xu Zehua Zhang Fei Luo Ce Dou 《Animal Models and Experimental Medicine》 2026年第1期5-20,共16页
Background:Skeletal tuberculosis(TB)remains a persistent clinical and research chal-lenge due to its chronic course,osteolytic destruction,and the limitations of existing animal models,which often require high-level b... Background:Skeletal tuberculosis(TB)remains a persistent clinical and research chal-lenge due to its chronic course,osteolytic destruction,and the limitations of existing animal models,which often require high-level biosafety containment or fail to repli-cate human skeletal pathology.Methods:This study developed a biosafe,accessible,and versatile murine model of skeletal TB using Mycobacterium smegmatis,a fast-growing,nonpathogenic myco-bacterial species with high genomic homology to Mycobacterium tuberculosis.Three infection routes-subperiosteal calvarial injection,intratibial injection,and intra-cardiac inoculation-were systematically evaluated for their ability to induce lo-calized versus disseminated bone infection under standard biosafety level(BSL)-1 conditions.Results:Subperiosteal calvarial and intratibial injection of M.smegmatis induced local-ized bone lesions characterized by osteolysis,sequestrum formation,granulomatous inflammation,and increased osteoclast activity.Intratibial infection additionally trig-gered compartment-specific immune responses,including neutrophil and macrophage expansion,transient B-cell depletion,and activation of interferon-γ^(+)(IFN-γ^(+))T cells,reflecting active immune remodeling at the infection site.Systemic dissemination via intracardiac injection reproducibly generated progressive vertebral and tibial bone destruction with organized granuloma formation and immune cell infiltration but without prominent sequestrum formation.Compared to intratibial infection,intracar-diac delivery exhibited lower intragroup variability and more closely recapitulated the diffuse progression of extrapulmonary skeletal tuberculosis.Conclusions:This M.smegmatis-based murine model provides a straightforward,reliable,and immunopathologically relevant platform for exploring host-pathogen dynamics,immune-driven bone destruction,and early-stage therapeutic testing in skeletal TB,all within standard BSL-1 laboratories.This model fills a critical gap by enabling BSL-1 research into skeletal TB mechanisms and drug development. 展开更多
关键词 bone tuberculosis murine model Mycobacterium smegmatis TUBERCULOSIS
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A Predictive Model for the Elastic Modulus of High-Strength Concrete Based on Coarse Aggregate Characteristics
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作者 LI Liangshun LI Huajian +2 位作者 HUANG Fali YANG Zhiqiang DONG Haoliang 《Journal of Wuhan University of Technology(Materials Science)》 2026年第1期121-137,共17页
To investigate the influence of coarse aggregate parent rock properties on the elastic modulus of concrete,the mineralogical properties and stress-strain curves of granite and dolomite parent rocks,as well as the stre... To investigate the influence of coarse aggregate parent rock properties on the elastic modulus of concrete,the mineralogical properties and stress-strain curves of granite and dolomite parent rocks,as well as the strength and elastic modulus of mortar and concrete prepared with mechanism aggregates of the corresponding lithology,and the stress-strain curves of concrete were investigated.In this paper,a coarse aggregate and mortar matrix bonding assumption is proposed,and a prediction model for the elastic modulus of mortar is established by considering the lithology of the mechanism sand and the slurry components.An equivalent coarse aggregate elastic modulus model was established by considering factors such as coarse aggregate particle size,volume fraction,and mortar thickness between coarse aggregates.Based on the elastic modulus of the equivalent coarse aggregate and the remaining mortar,a prediction model for the elastic modulus of the two and three components of concrete in series and then in parallel was established,and the predicted values differed from the measured values within 10%.It is proposed that the coarse aggregate elastic modulus in highstrength concrete is the most critical factor affecting the elastic modulus of concrete,and as the coarse aggregate elastic modulus increases by 27.7%,the concrete elastic modulus increases by 19.5%. 展开更多
关键词 elastic modulus prediction model MINERALOGICAL influence mechanism
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Establishment of a mouse model of TMAO-induced cardiac injury and application of MICT intervention
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作者 Zhongping Xie Hong Zou +2 位作者 Lijing Gong Minghui Lin Caihua Huang 《Animal Models and Experimental Medicine》 2026年第1期142-153,共12页
Background:This study aims to explore the establishment of an animal model of car-diac injury induced by trimethylamine-N-oxide(TMAO),a metabolite secreted by gut microorganisms,and to investigate its application in m... Background:This study aims to explore the establishment of an animal model of car-diac injury induced by trimethylamine-N-oxide(TMAO),a metabolite secreted by gut microorganisms,and to investigate its application in moderate-intensity continuous training(MICT)intervention.Methods:C57BL6/J mice were randomly divided into four groups:normal mice(Nor,n=15);mice administered TMAO(TMAO,n=15);mice undergoing(Nor+MICT,n=15);mice undergoing(MICT)and administered TMAO(TMAO+MICT,n=15).Mice in the TMAO and TMAO+MICT groups received daily gavage of high-dose TMAO for 8 weeks,whereas those in the Nor+MICT and TMAO+MICT groups underwent MICT for 8 weeks(60 min per session,5 days per week,at 50%maximal running capacity).Cardiac function was evaluated using ultrasound,myocardial histology was examined using hematoxylin and eosin(HE)staining,and nuclear magnetic resonance(NMR)-based metabolomics was employed for multivariate statistical and metabolic pathway analyses.Results:Relative to the Nor group,TMAO-treated mice exhibited significant weight loss,elevated heart rate,and reduced ejection fraction and left ventricular fractional shortening,indicating cardiac impairment.Importantly,the TMAO+MICT group dem-onstrated significant improvements in these parameters compared to the TMAO group,alongside distinct alterations in myocardial metabolic profiles.TMAO altered five metabolic pathways relative to controls,whereas MICT induced significant changes in three pathways in TMAO-treated mice.Conclusion:Eight weeks of high-dose TMAO administration induced significant cardiac dysfunction in mice,which was effectively mitigated by MICT intervention.Consequently,this animal model serves as a valuable tool for investigating the mecha-nisms underlying the impact of MICT on cardiovascular diseases. 展开更多
关键词 animal model of injury HEART MICT TMAO
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