It has been argued that the human brain,as an information-processing machine,operates near a phase transition point in a non-equilibrium state,where it violates detailed balance leading to entropy production.Thus,the ...It has been argued that the human brain,as an information-processing machine,operates near a phase transition point in a non-equilibrium state,where it violates detailed balance leading to entropy production.Thus,the assessment of irreversibility in brain networks can provide valuable insights into their non-equilibrium properties.In this study,we utilized an open-source whole-brain functional magnetic resonance imaging(fMRI)dataset from both resting and task states to evaluate the irreversibility of large-scale human brain networks.Our analysis revealed that the brain networks exhibited significant irreversibility,violating detailed balance,and generating entropy.Notably,both physical and cognitive tasks increased the extent of this violation compared to the resting state.Regardless of the state(rest or task),interactions between pairs of brain regions were the primary contributors to this irreversibility.Moreover,we observed that as global synchrony increased within brain networks,so did irreversibility.The first derivative of irreversibility with respect to synchronization peaked near the phase transition point,characterized by the moderate mean synchronization and maximized synchronization entropy of blood oxygenation level-dependent(BOLD)signals.These findings deepen our understanding of the non-equilibrium dynamics of large-scale brain networks,particularly in relation to their phase transition behaviors,and may have potential clinical applications for brain disorders.展开更多
脑卒中后吞咽障碍是脑卒中患者常见的并发症,发生率高达30%~65%^([1-2])。吞咽困难会让患者同时遭遇营养不良与吸入性肺炎的严峻挑战,还影响其生活品质与康复进程^([3-4])。近年来,功能磁共振成像(functional magnetic resonance imagin...脑卒中后吞咽障碍是脑卒中患者常见的并发症,发生率高达30%~65%^([1-2])。吞咽困难会让患者同时遭遇营养不良与吸入性肺炎的严峻挑战,还影响其生活品质与康复进程^([3-4])。近年来,功能磁共振成像(functional magnetic resonance imaging,fMRI)技术的快速发展为研究脑卒中后吞咽障碍的神经机制提供了新的视角。fMRI能够无创观察大脑活动,揭示吞咽过程中不同脑区的激活模式和功能连接变化^([5])。展开更多
目的 基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗前后的酒精使用障碍(alcohol use disorder,AUD)患者冲动...目的 基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗前后的酒精使用障碍(alcohol use disorder,AUD)患者冲动行为脑网络改变。方法 选取2022年12月至2024年12月于我院就诊的AUD患者为AUD组,同时选取同期在我院进行体检的健康者为对照组,每组初始计划纳入61例。根据纳排标准,AUD组和对照组分别排除15例,最终两组各纳入46例。通过SPSS23.0软件进行数据分析。运用双重差分(DID)模型评估效果。结果 两组患者BIS-Ⅱ总评分和RBANS总评分均比干预前有明显下降(P<0.05)。State1状态下,AUD组DMN和ECN间功能连接以增强为主;state2状态下,DMN和ECN间功能连接以减弱为主。AUD组state2状态平均持续时间与冲动行为评分呈负相关、与认知功能评分呈正相关(P<0.05)。结论 rs-fMRI发现,rTMS治疗后的AUD患者,其冲动行为相关脑区中DMN和ECN的动态功能连接模式发生改变,该连接可反映大脑活动的瞬时变化,为AUD画着精准诊疗提供临床依据。展开更多
基金supported by the Fundamental Research Funds for the Central Universities(Grant Nos.lzujbky-2021-62 and lzujbky-2024-jdzx06)the National Natural Science Foundation of China(Grant No.12247101)+1 种基金the Natural Science Foundation of Gansu Province,China(Grant Nos.22JR5RA389 and 23JRRA1740)the‘111 Center’Fund(Grant No.B20063).
文摘It has been argued that the human brain,as an information-processing machine,operates near a phase transition point in a non-equilibrium state,where it violates detailed balance leading to entropy production.Thus,the assessment of irreversibility in brain networks can provide valuable insights into their non-equilibrium properties.In this study,we utilized an open-source whole-brain functional magnetic resonance imaging(fMRI)dataset from both resting and task states to evaluate the irreversibility of large-scale human brain networks.Our analysis revealed that the brain networks exhibited significant irreversibility,violating detailed balance,and generating entropy.Notably,both physical and cognitive tasks increased the extent of this violation compared to the resting state.Regardless of the state(rest or task),interactions between pairs of brain regions were the primary contributors to this irreversibility.Moreover,we observed that as global synchrony increased within brain networks,so did irreversibility.The first derivative of irreversibility with respect to synchronization peaked near the phase transition point,characterized by the moderate mean synchronization and maximized synchronization entropy of blood oxygenation level-dependent(BOLD)signals.These findings deepen our understanding of the non-equilibrium dynamics of large-scale brain networks,particularly in relation to their phase transition behaviors,and may have potential clinical applications for brain disorders.
文摘脑卒中后吞咽障碍是脑卒中患者常见的并发症,发生率高达30%~65%^([1-2])。吞咽困难会让患者同时遭遇营养不良与吸入性肺炎的严峻挑战,还影响其生活品质与康复进程^([3-4])。近年来,功能磁共振成像(functional magnetic resonance imaging,fMRI)技术的快速发展为研究脑卒中后吞咽障碍的神经机制提供了新的视角。fMRI能够无创观察大脑活动,揭示吞咽过程中不同脑区的激活模式和功能连接变化^([5])。
文摘目的 基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗前后的酒精使用障碍(alcohol use disorder,AUD)患者冲动行为脑网络改变。方法 选取2022年12月至2024年12月于我院就诊的AUD患者为AUD组,同时选取同期在我院进行体检的健康者为对照组,每组初始计划纳入61例。根据纳排标准,AUD组和对照组分别排除15例,最终两组各纳入46例。通过SPSS23.0软件进行数据分析。运用双重差分(DID)模型评估效果。结果 两组患者BIS-Ⅱ总评分和RBANS总评分均比干预前有明显下降(P<0.05)。State1状态下,AUD组DMN和ECN间功能连接以增强为主;state2状态下,DMN和ECN间功能连接以减弱为主。AUD组state2状态平均持续时间与冲动行为评分呈负相关、与认知功能评分呈正相关(P<0.05)。结论 rs-fMRI发现,rTMS治疗后的AUD患者,其冲动行为相关脑区中DMN和ECN的动态功能连接模式发生改变,该连接可反映大脑活动的瞬时变化,为AUD画着精准诊疗提供临床依据。
