A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy...A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy-4-（pyridine-3-yl）benzyl]-2,4-diamino pyrimidine,had an IC50 of 1.45μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice （NFS-60）,which was similar with GW2580,a selective inhibitor of c-Fms kinase.展开更多
A key issue of practical importance in the two-dimensional (2-D) discrete system is stability analysis. Linear state-space models describing 2-D discrete systems have been proposed by several researchers. A popular mo...A key issue of practical importance in the two-dimensional (2-D) discrete system is stability analysis. Linear state-space models describing 2-D discrete systems have been proposed by several researchers. A popular model, called Forna- sini-Marchesini (FM) second model was proposed by Fornasini and Marchesini in 1978. The aim of this paper is to present a survey of the existing literature on the stability of FM second model.展开更多
基金financially supported by the National High-Tech Research and Development Program of China(863 Program)(No.2006AA10A201)National Natural Science Foundation(No.30472093)
文摘A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy-4-（pyridine-3-yl）benzyl]-2,4-diamino pyrimidine,had an IC50 of 1.45μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice （NFS-60）,which was similar with GW2580,a selective inhibitor of c-Fms kinase.
文摘A key issue of practical importance in the two-dimensional (2-D) discrete system is stability analysis. Linear state-space models describing 2-D discrete systems have been proposed by several researchers. A popular model, called Forna- sini-Marchesini (FM) second model was proposed by Fornasini and Marchesini in 1978. The aim of this paper is to present a survey of the existing literature on the stability of FM second model.
