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可成药全基因组预测腰椎椎管狭窄症治疗靶基因:DgiDB与Finn数据库数据分析
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作者 李涵玉 王超逸 +4 位作者 杨敬言 黄仁俊 赵余炀 郝华焘 于栋 《中国组织工程研究》 北大核心 2026年第12期3171-3181,共11页
背景:腰椎椎管狭窄症是一种常见且严重的退行性脊柱疾病,目前相关的治疗和预防仍具有一定的局限性,筛选腰椎椎管狭窄症的治疗靶基因、探索药物更广泛的应用范围、明确药物的作用机制有着重要的临床意义。目的:通过可成药全基因组的孟德... 背景:腰椎椎管狭窄症是一种常见且严重的退行性脊柱疾病,目前相关的治疗和预防仍具有一定的局限性,筛选腰椎椎管狭窄症的治疗靶基因、探索药物更广泛的应用范围、明确药物的作用机制有着重要的临床意义。目的:通过可成药全基因组的孟德尔随机化分析探讨腰椎椎管狭窄症的潜在治疗靶点。方法:使用收录了50万名芬兰人的基因组和健康信息的芬兰数据库、eQTLGen联盟、药物特征数据库、药物-基因相互作用数据库、蛋白互作数据库、有机小分子生物活性数据库及蛋白质结构数据库,将可成药基因的数据与腰椎椎管狭窄症全基因组关联研究数据进行双样本孟德尔随机化分析和共定位分析,以确定与腰椎椎管狭窄症高度相关的基因。此外,还进行了基因本体论与京都基因与基因组百科全书富集分析、蛋白质网络构建、药物预测和分子对接,为开发更有效、更有针对性的治疗药物提供了有价值的指导。结果与结论:(1)确定了32个与腰椎椎管狭窄症显著相关的可成药基因,其中CCDC77通过孟德尔随机化和共定位分析表现出与腰椎椎管狭窄症结果共享遗传效应的证据;(2)而差异基因主要参与细胞运动的正向调节、血管生成、适应性免疫应答等生物过程,上调基因主要富集在细胞黏附分子通路、缺氧诱导因子1信号通路、白细胞跨内皮迁移信号通路等作用途径;(3)药物富集结果显示大黄素及前列腺素E2为有潜力的治疗腰椎椎管狭窄症的药物;(4)这些发现可为针对腰椎椎管狭窄症的治疗提供有希望的线索,为药物研发提供新的方向,促进基础与临床研究结合,为国内相关领域的研究提供了参考。 展开更多
关键词 腰椎椎管狭窄症 孟德尔随机化 DgiDB数据库 可成药基因 finn数据库 大黄素 前列腺素E2
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饱和砂土液化Finn模型的关键参数 被引量:1
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作者 关振长 张浩浩 +2 位作者 苏拯弘 黄博洋 宁茂权 《地下空间与工程学报》 CSCD 北大核心 2024年第2期419-425,共7页
以闽江中细砂层为对象,开展三因素三水平正交设计的小型振动台试验,定性探讨闽江砂土液化特性;同时基于Finn模型,在FLAC3D数值平台上对典型试验过程开展动力时程数值模拟。结果表明:Finn模型可有效模拟地震动作用下饱和砂土孔压的增长... 以闽江中细砂层为对象,开展三因素三水平正交设计的小型振动台试验,定性探讨闽江砂土液化特性;同时基于Finn模型,在FLAC3D数值平台上对典型试验过程开展动力时程数值模拟。结果表明:Finn模型可有效模拟地震动作用下饱和砂土孔压的增长与有效应力的降低,能较为准确地反映饱和砂土的液化效应,Finn模型中的关键参数C_(1)、C_(2)对计算结果影响显著。以超孔压比峰值及超孔压比稳定值为指标,通过大量数值模拟结果与试验结果的对比,对上述关键参数进行标定,建议闽江饱和砂土液化Finn模型的关键参数取值为C_(1)=1.30、C_(2)=0.31。饱和砂土激振过程中呈现出轻微剪胀趋势,大致与液化现象同步出现。 展开更多
关键词 砂土液化finn模型 振动台试验 数值模拟 关键参数标定
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基于卫星火点排放清单(FINN)的我国东北三省生物质户外燃烧网格化清单建立及时空演变特征分析 被引量:1
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作者 王贺 赵鹏雷 +3 位作者 秦思达 李志东 李红梅 刘一鸣 《环境科学研究》 CAS CSCD 北大核心 2024年第2期278-288,共11页
生物质户外燃烧是影响环境空气质量的重要污染源,东北三省作为我国的重要农业产区,分析其生物质户外燃烧情况能够为当地秸秆资源综合利用和环境质量改善等提供依据.该研究基于卫星火点排放清单(Fire INventory from NCAR,FINN),分析了... 生物质户外燃烧是影响环境空气质量的重要污染源,东北三省作为我国的重要农业产区,分析其生物质户外燃烧情况能够为当地秸秆资源综合利用和环境质量改善等提供依据.该研究基于卫星火点排放清单(Fire INventory from NCAR,FINN),分析了我国东北三省2016-2020年生物质户外燃烧火点的时空分布特征,结合空气质量监测数据进行了重污染天气成因分析,并建立了可用于数值模拟的生物质户外燃烧源网格化清单.结果表明:①东北三省2018-2019年火点数量较2016-2017年大幅减少,2020年有所增加.年内火点主要出现在春秋两季,春季相对更多.火点主要分布在东北平原,即黑龙江省的东部和西部,以及吉林省西部等,其他地区火点数量相对较少,呈零散式分布的特点.②该研究搭建了东北三省2016-2020年生物质户外燃烧源网格化清单,清单空间分辨率为3km,污染物种类包括SO_(2)、NOx、CO、NMVOC、NH_(3)、PM_(10)、PM_(2.5)、BC和OC等,2016-2020年污染物排放量总体上呈下降趋势,2020年NOx、SO_(2)、PM_(2.5)和PM_(10)的排放总量分别为3479.81、13418.5、215702.87和235495.21 t.③将2019年和2020年生物质户外燃烧污染物排放数据与空气质量数据进行时间拟合,发现部分城市在两个年份的春季秸秆集中燃烧时段均发生了重污染天气事件,且大气污染物浓度峰值与生物质户外燃烧排放污染物峰值出现的时间一致.研究显示,近年来东北三省生物质户外燃烧管控工作成效明显,大气污染物排放量总体上呈下降趋势,但仍然是东北三省部分城市春季发生重污染天气事件的重要原因之一,对部分生物质户外燃烧污染物排放量较大的城市应进一步严格秸秆禁烧等防控措施.该研究建立的生物质户外燃烧源网格化清单,可以更好地服务于区域空气质量数值模拟研究,应用在大气污染成因分析等多个方面,为制定更为精准的大气污染防治措施提供技术支撑. 展开更多
关键词 卫星火点排放清单(finn) 生物质燃烧 时空分布特征 网格化清单 东北三省
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基于Finn本构模型的饱和砂土地震液化分析 被引量:29
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作者 王根龙 林玮 蔡晓光 《地震工程与工程振动》 CSCD 北大核心 2010年第3期178-184,共7页
天然地震作用下的饱和砂土液化问题是岩土地震工程研究的重要课题之一。目前,国内推荐使用的规范法是基于实际地震液化调查而建立的判别方法,方法本身缺乏理论基础。采用Finn液化本构关系建立了砂土液化数值分析模型,运用有限差分法的... 天然地震作用下的饱和砂土液化问题是岩土地震工程研究的重要课题之一。目前,国内推荐使用的规范法是基于实际地震液化调查而建立的判别方法,方法本身缺乏理论基础。采用Finn液化本构关系建立了砂土液化数值分析模型,运用有限差分法的动力时程分析模块,分析了饱和砂土地基的地震液化问题。结果表明,将Finn本构模型应用于砂土液化分析,可以较好地给出地震作用过程中孔隙水压力和有效应力变化的规律。 展开更多
关键词 砂土液化 地震 finn本构模型 有效应力 孔隙水压力
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基于PL-Finn模型的饱和砂土液化数值分析 被引量:11
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作者 张向东 张晋 苏伟林 《辽宁工程技术大学学报(自然科学版)》 CAS 北大核心 2017年第7期724-728,共5页
为研究地震作用下沉箱式码头的砂土液化特征,基于包含动孔压上升的PL-Finn模型,结合现场实测和大型有限差分软件FLAC^(3D),采用完全非线性的动力分析方法,同时考虑地震动载荷与渗流的耦合作用,对置换砂和回填砂土的超孔压比进行了分析,... 为研究地震作用下沉箱式码头的砂土液化特征,基于包含动孔压上升的PL-Finn模型,结合现场实测和大型有限差分软件FLAC^(3D),采用完全非线性的动力分析方法,同时考虑地震动载荷与渗流的耦合作用,对置换砂和回填砂土的超孔压比进行了分析,并将现场实测结果与有限差分模拟结果进行对比分析.结果表明:码头最大水平残余位移为3.47 m,最大残余沉降为1.86 m;回填砂土在地震动载荷施加第6~9 s时已经发生了液化,且超孔压比接近1;置换砂土基本没有发生液化现象,残余超孔压比稳定在0.25~0.30;模拟计算所得的沉箱沉降量比现场实测值低7%,即有限差分模拟结果与实测数据基本吻合,认为采用FLAC^(3D)有限差分方法可以很好地模拟地震砂土液化过程. 展开更多
关键词 沉箱式码头 动载荷 饱和砂土液化 PL-finn本构模型 超孔压比
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职业能力测评中评分者信度FINN系数与ICC的计算与MATLAB实现 被引量:5
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作者 钟韬 魏庆曜 《西南民族大学学报(自然科学版)》 CAS 2015年第4期489-493,共5页
对FINN系数与组内相关系数ICC进行研究和分析,详细介绍了FINN系数与组内相关系数ICC的数学原理与计算方法.将FINN系数与组内相关系数应用于职业能力测评,结果显示FINN系数更能得到较好的信度值.而ICC更依赖评分点平均值的方差,在职业能... 对FINN系数与组内相关系数ICC进行研究和分析,详细介绍了FINN系数与组内相关系数ICC的数学原理与计算方法.将FINN系数与组内相关系数应用于职业能力测评,结果显示FINN系数更能得到较好的信度值.而ICC更依赖评分点平均值的方差,在职业能力测评中容易得到较低的信度值,从而测量不出重要的信度.文章例解了FINN系数与组内相关系数ICC的MATLAB计算程序. 展开更多
关键词 finn系数 组内相关系数ICC 评分者信度
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P2PSand和Finn本构模型在水库土石坝液化模拟中对比
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作者 牛金帝 张西文 +2 位作者 邱宇 扈萍 陈子俊 《华北地震科学》 2023年第4期66-71,共6页
为了研究地震作用下水库土石坝饱和砂土坝基可液化土层的影响规律,以某水库土石坝为背景,运用FLAC3D分析Practical Two-surface Plastic Sand(简称P2PSand)本构模型和Finn本构模型下的水库土石坝可液化粉砂层的液化分布规律、坝体变形... 为了研究地震作用下水库土石坝饱和砂土坝基可液化土层的影响规律,以某水库土石坝为背景,运用FLAC3D分析Practical Two-surface Plastic Sand(简称P2PSand)本构模型和Finn本构模型下的水库土石坝可液化粉砂层的液化分布规律、坝体变形特点以及坝坡的稳定性。计算结果表明:P2PSand模型下可液化粉砂层的液化程度、范围以及水库土石坝坝体位移均大于Finn模型,水平位移较显著;两种本构模型下水库土石坝坝体均出现两条明显的滑动面,稳定性降低。 展开更多
关键词 水库土石坝 动力响应 P2PSand本构模型 finn本构模型
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On the Americans'National Traits Reflected in The Adventures of Huckleberry Finn from the Perspective of History and Culture
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作者 金辉 唐岩 《海外英语》 2013年第15期186-187,共2页
The Adventures of Huckleberry Finn is Mark Twain's masterpiece,the one book from which,as Ernest Hemingway noted," All modern American literature comes ".It accounts the adventures of white Huck helping ... The Adventures of Huckleberry Finn is Mark Twain's masterpiece,the one book from which,as Ernest Hemingway noted," All modern American literature comes ".It accounts the adventures of white Huck helping black slave Jim escape and pursue freedom.Through their long journey along the Mississippi River,we can see panorama of America,such as its slavery,racial conflicts and integration,American Puritanism,and Westward Movement,etc.This thesis mainly deals with Americans'national traits reflected in The Adventures of Huckleberry Finn from the perspective of American developmental history and American culture. 展开更多
关键词 The Adventures of Huckleberry finn MARK TWAIN Amer
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Understanding Mark Twain's Opinion of Anti-slavery—Analysis on Jim in Huckleberry Finn
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作者 杨乐 《海外英语》 2014年第21期221-222,共2页
The Adventures of Huckleberry Finn is one of the most famous works of Mark Twain. Huck has become the antihero in American literature. In addition, this kind of rebellion of spirit even has a realistic sense at presen... The Adventures of Huckleberry Finn is one of the most famous works of Mark Twain. Huck has become the antihero in American literature. In addition, this kind of rebellion of spirit even has a realistic sense at present. This paper discusses Jim's anti-slavery from its source and conception. At last, the author concludes the indelible artistic value of Jim. 展开更多
关键词 The Adventures of Huckleberry finn MARK TWAIN Slav
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Romanticism in The Adventures of Huckleberry Finn
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作者 李琳 《海外英语》 2013年第4X期177-180,202,共5页
The Adventures of Huckleberry Finn has been studied as a realistic work widely.Although The Adventures of Huckleberry Finn mainly work for the realism,there are also spark notes of romanticism in the book.So this essa... The Adventures of Huckleberry Finn has been studied as a realistic work widely.Although The Adventures of Huckleberry Finn mainly work for the realism,there are also spark notes of romanticism in the book.So this essay discusses the romanticism from its source and its conception,and the third part of this essay analyzes which parts and which points in the book show the romanticism,and analyzes the romanticism in the book from the general following aspects:description of the environment,the friendship between the main characters,the plots,and themes.At last,the author concludes the indelible artistic value in The Adventures of Huckleberry Finn. 展开更多
关键词 The Adventures of Huckleberry finn ROMANTICISM DIF
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The Mississippi River in The Adventures of Huckleberry Finn
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作者 欧阳 《海外英语》 2014年第8X期199-200,共2页
In The Adventures of Huckleberry Finn,The Mississippi River is not just to provide a general background,but to constitute the center image of the novel.It gives"form"to the whole novel,all the adventures in ... In The Adventures of Huckleberry Finn,The Mississippi River is not just to provide a general background,but to constitute the center image of the novel.It gives"form"to the whole novel,all the adventures in the book begins with the river and ends with the river.This paper talks about the important river.It is a symbol of freedom and maternity,and it has deep meaning of life and regeneration,purification and sublimation.The symbols and senses of this river deepen the theme of the novel,and prop up its broad and profound metaphorical world. 展开更多
关键词 The Adventures of Huckleberry finn The MISSISSIPPI
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Fluidization Prediction of Liquefiable Cargo: Based on FINN and UBCSAND Constitutive Models
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作者 Jianwei Zhang Weiwen Qian +1 位作者 Jinshu Lu Gechuan Chen 《Journal of Marine Science and Application》 CSCD 2022年第2期210-227,共18页
Fluidization mechanism of liquefiable cargo is similar to that of sand liquefaction.But the cargo is subjected to more complex external loads during sea transportation.Based on two different constitutive models,numeri... Fluidization mechanism of liquefiable cargo is similar to that of sand liquefaction.But the cargo is subjected to more complex external loads during sea transportation.Based on two different constitutive models,numerical predictions were conducted in this study.And the effects of ship motions including motion acceleration,frequency and relative density of cargo on fluidization was investigated.By comparing with available the experimental data,validation is carried out.Results show that the roll motion is the most important one related to cargo fluidization.When the motion acceleration increases,the possibility of cargo fluidization increases.The higher of the cargo density the lower of the possibility of cargo fluidization.The effect of frequency on cargo fluidization is not unique,and it exists a critical value.The fluidization behavior of cargo could be described both by UBCSAND and FINN models.And the comparisons were discussed and summed up. 展开更多
关键词 Liquefiable cargo FLUIDIZATION finn UBCSAND Ship motion Relative density
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An Analysis of Mark Twain’s Humor in The Adventures of Huckleberry Finn
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作者 YU Chen 《Journal of Literature and Art Studies》 2022年第4期328-333,共6页
Mark Twain is a famous writer and orator in America.Being distinguished from many greatest American writers,Mark Twain is noted for his language.Humor and satire are the best generalizations of his writing style.He is... Mark Twain is a famous writer and orator in America.Being distinguished from many greatest American writers,Mark Twain is noted for his language.Humor and satire are the best generalizations of his writing style.He is superior to other contemporary writers in that he not only makes use of humorous language to create a ridiculous atmosphere,but also to raise the curtain over the darkness of American society.The Adventures of Huckleberry Finn is one of the most typical one that can show his unique language.The author makes a humorous effect through the application of exaggerated language,expands the effect through the explicit and implicit contrast of the discourse,and creates a humorous atmosphere through the use of vernacular and dialect.Based on the discussion of humor and its characteristics,this paper analyzes and arranges the humorous language of Mark Twain in The Adventures of Huckleberry Finn,and then discusses how Mark Twain achieves the humorous effect by violating the Cooperative Principle,thus revealing the theme. 展开更多
关键词 Mark Twain The Adventures of Huckleberry finn HUMOR the cooperative principle
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Ambiguous Freedom in The Adventures of Huckleberry Finn
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作者 辛婕 《海外英语》 2019年第13期206-207,210,共3页
Mark Twain’s The Adventures of Huckleberry Finn tells the story of Huck and Jim,a white boy and a black slave,who run away in search of freedom.The first part of this thesis is the literature review.Focus is put on t... Mark Twain’s The Adventures of Huckleberry Finn tells the story of Huck and Jim,a white boy and a black slave,who run away in search of freedom.The first part of this thesis is the literature review.Focus is put on the review of the freedom theme and analysis.The main body starts from the second part which divides Huck’s escape into three stages:Huck’s aversion and tolerance to the civilized society before escape,his decayed initiative in the pursuit of freedom during the escape and his return to search for freedom at the end.Through above analysis,the conclusion is reached:Mark Twain’s view of freedom in this novel is vague and ambiguous,and there are many paradoxes in it.He longs for personal freedom but cannot escape from the secular society.He is willing to resist repressing civilization but unable to revolt its invasion. 展开更多
关键词 AMERICAN LITERATURE MarkTwain The Adventures of Huckleberry finn Huckleberry finn ESCAPE VIEW of FREEDOM
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Adventures of Huckleberry Finn:A Scrutiny of Racial Prejudice
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作者 Xue Zhou-tang 《外语研究》 1987年第2期75-81,共7页
James R.Dickenson once observed,“It is the fate of great literature to bmisread and misunderstood as well as savored and appreciated”(The Guardian,April 14,1985).A typical case in point is Mark Twain’s Adventures o... James R.Dickenson once observed,“It is the fate of great literature to bmisread and misunderstood as well as savored and appreciated”(The Guardian,April 14,1985).A typical case in point is Mark Twain’s Adventures of Huck-leberry Finn.Perhaps it is the most controversial book in American literaryhistory.On the one hand,it met with the most unfavorable reception after itsappearance.Many of its first readers and critics were shocked by its franknessin expression and its straightforward attacks on the existing institutions 展开更多
关键词 Adventures of Huckleberry finn
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The Margin Is not Marginal An Interpretation of Adventures of Huckleberry Finn
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作者 易雪容 《海外英语》 2018年第11期182-184,共3页
Adventures of Huckleberry Finn is one of the most greatest works of Mark Twain, an American literary giant in the 19th century, telling the story of fleeing and seeking for freedom along the Mississippi river. This pa... Adventures of Huckleberry Finn is one of the most greatest works of Mark Twain, an American literary giant in the 19th century, telling the story of fleeing and seeking for freedom along the Mississippi river. This paper will use the theory of core-periphery to analyze the encounter and mutual-helping of Huck and Jim.Their adventures reflect the fate of marginal characters, disclose some problems covered in the marginal spaces and make some marginal voices heard. What reflected behind is that the true,the good, and the beautiful of human nature and the righteousness of society are never absent. 展开更多
关键词 Adventures of Huckleberry finn marginal characters marginal spaces marginal voices
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Similarities in Terms of Humor in Characterization as Seen in Sunshine Sketches of a Little Town andThe Adventures of Huckleberry Finn
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作者 郭勇丽 《阴山学刊》 2013年第4期72-75,共4页
This thesis attempts to investigate the humor in characterization in two novels,Sunshine Sketches of a Little Town by a Canadian writer Stephen Leacock and The Adventures ofHuckleberry Finn by an American writer Mark ... This thesis attempts to investigate the humor in characterization in two novels,Sunshine Sketches of a Little Town by a Canadian writer Stephen Leacock and The Adventures ofHuckleberry Finn by an American writer Mark Twain.Through comparison of characterization inthese two great works,the lively and funny appearances,psychological development and humorousconducts of the characters come to life.It does help readers have a thorough understanding of thehumor created by these two masters of realism in the worldwide literature. 展开更多
关键词 英语 教材 文学作品 文学
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Finns Proved Best
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作者 郝昌明 《中学英语园地(八九年级适用)》 2005年第Z1期43-45,共3页
关键词 finns Proved Best
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