Exposure therapy, an effective treatment for fear disorders, requires memory retrieval of previous horror experiences in controllable environment. However, it remains unknown whether previous fear memories have been u...Exposure therapy, an effective treatment for fear disorders, requires memory retrieval of previous horror experiences in controllable environment. However, it remains unknown whether previous fear memories have been updated [1] or inhibited [2] during the formation of new memories, as well as the underlying neural mechanisms involved (eg. the type of cells engaged in this process).展开更多
On January 28,a Chinese-run road construction site in South Kordofan State,Sudan,was attacked by local rebels.Twenty-nine workers were kidnapped in the assault,and held until February 7 when their captors freed them.I...On January 28,a Chinese-run road construction site in South Kordofan State,Sudan,was attacked by local rebels.Twenty-nine workers were kidnapped in the assault,and held until February 7 when their captors freed them.Incidents similar to this one around Africa have increased in recent years,prompting a belief that security for Chinese nationals and展开更多
Colonoscopy is the reference method in the secondary prevention,diagnosis and,in some cases,treatment of colorectal cancer.It can often cause pain associated with embarrassment,anxiety,and physical and emotional disco...Colonoscopy is the reference method in the secondary prevention,diagnosis and,in some cases,treatment of colorectal cancer.It can often cause pain associated with embarrassment,anxiety,and physical and emotional discomfort.Pain intensity is influenced by a lot of factors,and there is a strict relationship among pain,pain perception,and mind.Several methods can be used to break the trinomial colonoscopy,pain and fear.Sedoanalgesia is recommended by several guidelines.If no sedation is offered,the patient must accept a higher chance of unacceptable discomfort and the endoscopist a lower chance of completing the procedure because of patient discomfort.Other non-pharmacologic methods such as acupuncture,music,and hydrocolonoscopy can be used as alternatives to pharmacologic sedoanalgesia.Furthermore,new endoscopic technologies such as variable-stiffness colonoscopes and ultrathin colonoscopes,or the use of carbon dioxide instead of air for colon insufflation,can reduce the pain caused by colonoscopy.In the future,technical improvements such as wireless capsules or robotic probes,will probably enable to overcome the present concept of colonoscopy,avoiding the use of traditional endoscopes.However,at present the poor attention paid by endoscopists to the pain and discomfort caused by colonoscopy can not be justified.There are several methods to reduce pain and anxiety and to break the trinomial colonoscopy,pain and fear.We must use them.展开更多
BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their...BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.展开更多
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B pathway.CYLD is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly expressed.Emerging studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like behaviors.However,the precise role of CYLD in glutamatergic neurons is largely unknown.Here,we first proposed involvement of CYLD in cued fear expression.We next constructed transgenic model mice with specific deletion of Cyld from glutamatergic neurons.Our results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male mice.Further,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male mice.Altogether,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial activation.This may contribute,at least in part,to cued fear expression.展开更多
Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear me...Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).展开更多
The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurr...The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurrence of a traumatic event[1].Fear generalization within the normal range represents an adaptive evolutionary mechanism to facilitate prompt reactions to potential threats and to enhance the likelihood of survival.展开更多
Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can...Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can significantly contribute to emotional disabilities and mental disorders,including panic disorder,phobias,social anxiety disorder,and post-traumatic stress disorder(PTSD).展开更多
Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patien...Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patients admitted to the hospital from July 2023 to September 2024 were enrolled.These patients were randomly assigned to a control group and an intervention group,with 52 patients in each group.The control group received routine nursing care,while the intervention group received an“Internet+”nursing intervention based on user profilingin addition to routine care.The intervention period lasted for one month following discharge.Before and one month after the intervention,the Fear of Progression Questionnaire-Short Form(FOP-Q-SF),the Fear of Cancer Recurrence Inventory-Short Form(FCRI-SF),Chinese Posttraumatic Growth Inventory(C-PTGI),and the Functional Assessment of Cancer Therapy-Breast(FACT-B)were applied to assess the effects of interventions.Results:A total of 104 patients were analyzed.After the intervention,FOP-Q-SF and FCRI-SF scores were significantlylower in the intervention group compared to the control group,with statistical significance(t=3.98,P<0.001;t=-7.59,P<0.001),and Cohen’s d of 0.781 and 1.49,respectively.Additionally,CPTGI and FACT-B scores in the intervention group were significantly higher than those in the control group(t=-6.534,P<0.001;t=-4.579,P<0.001),with Cohen’s d of 0.585 and 0.656.Conclusions:An“Internet+”nursing model based on user profilingcould reduce postoperative breast cancer patients fear of disease progression and cancer recurrence,also enhancing posttraumatic growth and overall quality of life.展开更多
BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited researc...BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited research on the prevalence of FoC among Australian pregnant women.AIM To investigate the prevalence of FoC,its risk factors and birth outcomes in Aust-ralian multiparous women.METHODS In this prospective cohort quantitative study,212 multiparous women were re-cruited from antenatal clinics at Westmead Hospital in western Sydney from 2019 to 2022.Pregnant women who attended antenatal visits and met the inclusion criteria signed the consent forms and completed several online questionnaires at baseline.After they gave birth,their birth outcomes were collected from the hospital’s medical record database.The data were analyzed using SPSS software and descriptive statistics,χ^(2)test,independent samples t-test,and multivariable logistic regression analysis.RESULTS Out of 212 participants,24%experienced a high level of FoC and 7%experienced severe FoC.Theχ^(2)test results revealed that a family income of≤$100000,no alcohol intake during pregnancy,pre-existing health problems,previous caesarean section(emergency or planned),and previous neutral/traumatic childbirth experiences were significantly associated with higher levels of FoC(P<0.05).Other risk factors included being moderately to very worried and fearful about the upcoming birth,having severe to extremely severe anxiety throughout pregnancy,and expressing low relationship satisfaction.According to multivariable logistic regression,the odds of a high level of FoC were higher in women with anxiety,a history of traumatic childbirth experience,a history of sexual assault during childhood,pre-existing health problems,and lower relationship satisfaction(P<0.05).CONCLUSION High-severe levels of FoC are experienced by pregnant multiparous women and are affected by several demo-graphic factors.However,due to the small sample size in the present study,further studies with larger sample sizes are required to draw a firm conclusion on the prevalence of severe FoC among multiparous women and its associated risk factors and birth outcomes.展开更多
Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forget...Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forgetting,suggesting the potential to erase fear memories through timely interventions.Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects.This review explores how fear memory may be erased,particularly focusing on the mnemonic phases of reconsolidation and extinction.Reconsolidation strengthens memory,while extinction weakens it.Interfering with memory reconsolidation could diminish the fear response.Alternatively,the extinction of acquired memory could reduce the fear memory response.This review summarizes experimental animal models of PTSD,examines the nature and epidemiology of reconsolidation to extinction,and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD.In sum,understanding how fear memory updates holds significant promise for PTSD treatment.展开更多
The present study explores the importance of developing metaphorical thinking skills in students within the framework of English as a Foreign Language(EFL)reading courses at the tertiary educational level.Metaphorical...The present study explores the importance of developing metaphorical thinking skills in students within the framework of English as a Foreign Language(EFL)reading courses at the tertiary educational level.Metaphorical thinking is viewed as the ability to envisage the world figuratively,perceive associatively,and express oneself creatively.It is crucial to recognize metaphors in texts,interpret the complex images they evoke,and generate new metaphors.It is especially needful in the current era of clip thinking and fragmented information processing when students often approach content superficially rather than comprehensively,leading to decreased cognitive activity and a diminished capacity to understand literature.To foster metaphorical thinking,the paper suggests building a text associative-semantic field focusing on metaphors.Due to its hierarchical structure,which can be envisioned as a dense nucleus surrounded by a central region of synonyms and further enveloped by a periphery of more loosely associated linguistic units,the text associative-semantic field is seen as a potent solution for facilitating improved visualization and more holistic comprehension of information,allowing students for expanding their vocabulary and strengthening associative connections.Notably,the study highlights analyzing the metaphors of emotional states as they contribute significantly to a more profound interpretation of the text,understanding the writer’s unique style,deepening the students’engagement with the book,and expanding their emotional experiences.展开更多
In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental ...In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental component of treatment,its efficacy varies considerably among individuals.DNA methylation plays a pivotal role in the extinction of fear memories,providing a promising molecular mechanism that could enhance the success of exposure-based interventions.Extensive studies have consistently demonstrated a substantial association between DNA methylation and neuronal plasticity.While DNA methylation holds potential regulatory effects on the effectiveness of exposure therapy,the bidirectional regulatory relationship between it and neuronal activity necessitates addressing several challenges before its widespread clinical application for mental disorders.First,excessive DNA methylation may suppress neural function,and non-selective enhancement of methylation could be counterproductive.Furthermore,due to potential systemic side effects,the use of methylation-modulating agents might disrupt the physiological balance and functionality of other organs and systems.Despite the dynamic interplay between DNA methylation and neuronal activity offering novel insights into the treatment of mental disorders, the strict consideration of target specificity and an appropriate dosing window requirescautious implementation in clinical practice.展开更多
BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge...BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge.Fear conditioning and extinction in animal models offer insights into its mechanisms.Our previous research indi-cates that DNA methyltransferases play a role in fear memory renewal.AIM To investigate the role of DNA methylation in the extinction of fear memory,with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.METHODS This study investigated the role of DNA methylation in fear memory extinction in mice.DNA methylation was manipulated using N-phthalyl-L-tryptophan(RG108)to reduce methylation and L-methionine injections to enhance it.Neuronal activity,and dendritic spine density was measured following extinction training.RESULTS RG108 suppressed extinction,reduced spine density,and inhibited neuronal activity.Methionine injections facilitated extinction.CONCLUSION DNA methylation is crucial for fear memory extinction.Enhancing methylation may improve the efficacy of exposure therapy,offering a potential strategy to treat fear-related disorders.展开更多
Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were...Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were divided into routine nursing group,emotional release technology group and aromatherapy combined with emotional release technology group.Routine nursing group received routine nursing;Emotional release technology group implemented emotional release technology for one month on the basis of routine nursing group;Aromatherapy combined with emotional release technology group used lavender aromatherapy on the basis of emotional release technology group.Results:After one month of intervention,there were statistically significant differences in the scores of fear of disease progression and sleep quality among the three groups.Conclusion:Aromatherapy combined with emotional release technology can improve the sleep quality of lung cancer survivors and reduce the economic toxicity of cancer to some extent.展开更多
The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations of...The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations often sound“noisy”because vocal production systems are over-blown when animals are highly aroused.While much is known about the conditions under which animals produce vocalizations containing NLP and how species respond to them,there is little research about the heritability of such behavioral traits.Using the quantitative genetic animal model,we estimated the genetic basis of“noise”in alarm calls produced by females and found significant heritability in call entropy-our measure of the noisiness.About 9%of the variance in noisiness can be accounted for by genetic differences.Taken together,these findings suggest that the degree to which marmots produce noisy calls is modestly heritable and can be thus subject to further evolution via natural selection.展开更多
Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content ...Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content and an active form of memory processing that induces memory reconsolidation,has attracted increasing attention in recent years.Although the molecular mechanisms specifc to memory retrievalinduced reconsolidation have been gradually revealed,an understanding of the time-dependent regulatory mechanisms of this process is still lacking.In this study,we applied a transcriptome analysis of memory retrieval at diferent time points in the recent memory stage.Diferential expression analysis and Short Time-series Expression Miner(STEM)depicting temporal gene expression patterns indicated that most diferential gene expression occurred at 48 h,and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant diference.We then screened the diferentially-expressed genes associated with that met the expression patterns of those cluster-identifed genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9(DPP9).Further quantitative polymerase chain reaction verifcation and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory.Taken together,our fndings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.展开更多
Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psyc...Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psychological security(PS)and FoMO by analyzing the mediating role of social networking addiction(SNA)and the moderating role of social self-efficacy(SSE).Methods:We collected a sample of 1181 college students(with a mean age of 19.671.38 years)from five universities in a province of China's Mainland through cluster sampling.Data±were gathered using the psychological security questionnaire(PSQ),the FoMO scale,the SNA scale,and the perceived social self-efficacy(PSSE)scale.Data analysis employed independent-sample t-tests,one-way analysis of variance(ANOVA),Harman’s single-factor test,confirmatory factor analysis,and moderated mediation analysis.Results:The results of the mediation model and moderated mediation model analyses showed the following key findings:(1)PS is significantly negatively correlated with FoMO;(2)SNA mediates the relationship between PS and FoMO;(3)SSE positively moderates the relationship between PS and FoMO;and(4)SSE also positively moderates the relationship between PS and SNA.Conclusion:University students’PS not only directly impacts FoMO but also indirectly influences it through SNA.Additionally,SSE positively moderates both the direct path and the first half of the mediation path,indicating that enhancing students’PS and SSE can help alleviate their SNA and FoMO,promoting their psychological and behavioral well-being.展开更多
Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenie...Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenience sampling,228 elderly people were selected as the research subjects,and the general demographic characteristics questionnaire,elderly loneliness scale,dementia fear scale,and simplified intelligence status check scale were used for investigation.SPSS 28.0 statistical software was used for data analysis.Results:The total score of loneliness was 96.21±21.83 points,and the total score of dementia fear was 59.34±13.50 points.There were statistically significant differences in dementia fear scores among elderly people in the community in terms of age,gender,marital status,family history of dementia,and number of chronic diseases(P<0.05).Person correlation analysis showed a positive correlation between the total score of dementia fear and loneliness in elderly people in the community(r=0.162,P<0.05).Conclusion:The level of loneliness and dementia fear among elderly people in the community is at a moderate level.Age,gender,marital status,family history of dementia,and number of chronic diseases are important influencing factors of dementia fear among elderly people in the community.The sense of loneliness among elderly people in the community is positively correlated with dementia fear,meaning that the greater the degree of loneliness,the higher the degree of dementia fear among elderly people in the community.展开更多
文摘Exposure therapy, an effective treatment for fear disorders, requires memory retrieval of previous horror experiences in controllable environment. However, it remains unknown whether previous fear memories have been updated [1] or inhibited [2] during the formation of new memories, as well as the underlying neural mechanisms involved (eg. the type of cells engaged in this process).
文摘On January 28,a Chinese-run road construction site in South Kordofan State,Sudan,was attacked by local rebels.Twenty-nine workers were kidnapped in the assault,and held until February 7 when their captors freed them.Incidents similar to this one around Africa have increased in recent years,prompting a belief that security for Chinese nationals and
文摘Colonoscopy is the reference method in the secondary prevention,diagnosis and,in some cases,treatment of colorectal cancer.It can often cause pain associated with embarrassment,anxiety,and physical and emotional discomfort.Pain intensity is influenced by a lot of factors,and there is a strict relationship among pain,pain perception,and mind.Several methods can be used to break the trinomial colonoscopy,pain and fear.Sedoanalgesia is recommended by several guidelines.If no sedation is offered,the patient must accept a higher chance of unacceptable discomfort and the endoscopist a lower chance of completing the procedure because of patient discomfort.Other non-pharmacologic methods such as acupuncture,music,and hydrocolonoscopy can be used as alternatives to pharmacologic sedoanalgesia.Furthermore,new endoscopic technologies such as variable-stiffness colonoscopes and ultrathin colonoscopes,or the use of carbon dioxide instead of air for colon insufflation,can reduce the pain caused by colonoscopy.In the future,technical improvements such as wireless capsules or robotic probes,will probably enable to overcome the present concept of colonoscopy,avoiding the use of traditional endoscopes.However,at present the poor attention paid by endoscopists to the pain and discomfort caused by colonoscopy can not be justified.There are several methods to reduce pain and anxiety and to break the trinomial colonoscopy,pain and fear.We must use them.
基金Supported by the Chongqing Medical University Program for Youth Innovation in Future Medicine,No.W0019Chongqing Municipal Education Commission’s 14th Five-Year Key Discipline Support Project,No.20240101 and No.20240102。
文摘BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.
基金supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY)the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL)the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
文摘Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B pathway.CYLD is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly expressed.Emerging studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like behaviors.However,the precise role of CYLD in glutamatergic neurons is largely unknown.Here,we first proposed involvement of CYLD in cued fear expression.We next constructed transgenic model mice with specific deletion of Cyld from glutamatergic neurons.Our results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male mice.Further,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male mice.Altogether,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial activation.This may contribute,at least in part,to cued fear expression.
基金supported by the National Natural Science Foundation of China(82104138)the Zhejiang Provincial Natural Science Foundation of China(LY24H310003).
文摘Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).
基金supported by the Shandong Provincial Natural Science Foundation(ZR2022QH144).
文摘The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurrence of a traumatic event[1].Fear generalization within the normal range represents an adaptive evolutionary mechanism to facilitate prompt reactions to potential threats and to enhance the likelihood of survival.
文摘Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can significantly contribute to emotional disabilities and mental disorders,including panic disorder,phobias,social anxiety disorder,and post-traumatic stress disorder(PTSD).
基金funded by the 2023 Hospital Management Innovation Research Project by the Jiangsu Hospital Association(No.JSYGY-2-2023-551)。
文摘Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patients admitted to the hospital from July 2023 to September 2024 were enrolled.These patients were randomly assigned to a control group and an intervention group,with 52 patients in each group.The control group received routine nursing care,while the intervention group received an“Internet+”nursing intervention based on user profilingin addition to routine care.The intervention period lasted for one month following discharge.Before and one month after the intervention,the Fear of Progression Questionnaire-Short Form(FOP-Q-SF),the Fear of Cancer Recurrence Inventory-Short Form(FCRI-SF),Chinese Posttraumatic Growth Inventory(C-PTGI),and the Functional Assessment of Cancer Therapy-Breast(FACT-B)were applied to assess the effects of interventions.Results:A total of 104 patients were analyzed.After the intervention,FOP-Q-SF and FCRI-SF scores were significantlylower in the intervention group compared to the control group,with statistical significance(t=3.98,P<0.001;t=-7.59,P<0.001),and Cohen’s d of 0.781 and 1.49,respectively.Additionally,CPTGI and FACT-B scores in the intervention group were significantly higher than those in the control group(t=-6.534,P<0.001;t=-4.579,P<0.001),with Cohen’s d of 0.585 and 0.656.Conclusions:An“Internet+”nursing model based on user profilingcould reduce postoperative breast cancer patients fear of disease progression and cancer recurrence,also enhancing posttraumatic growth and overall quality of life.
文摘BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited research on the prevalence of FoC among Australian pregnant women.AIM To investigate the prevalence of FoC,its risk factors and birth outcomes in Aust-ralian multiparous women.METHODS In this prospective cohort quantitative study,212 multiparous women were re-cruited from antenatal clinics at Westmead Hospital in western Sydney from 2019 to 2022.Pregnant women who attended antenatal visits and met the inclusion criteria signed the consent forms and completed several online questionnaires at baseline.After they gave birth,their birth outcomes were collected from the hospital’s medical record database.The data were analyzed using SPSS software and descriptive statistics,χ^(2)test,independent samples t-test,and multivariable logistic regression analysis.RESULTS Out of 212 participants,24%experienced a high level of FoC and 7%experienced severe FoC.Theχ^(2)test results revealed that a family income of≤$100000,no alcohol intake during pregnancy,pre-existing health problems,previous caesarean section(emergency or planned),and previous neutral/traumatic childbirth experiences were significantly associated with higher levels of FoC(P<0.05).Other risk factors included being moderately to very worried and fearful about the upcoming birth,having severe to extremely severe anxiety throughout pregnancy,and expressing low relationship satisfaction.According to multivariable logistic regression,the odds of a high level of FoC were higher in women with anxiety,a history of traumatic childbirth experience,a history of sexual assault during childhood,pre-existing health problems,and lower relationship satisfaction(P<0.05).CONCLUSION High-severe levels of FoC are experienced by pregnant multiparous women and are affected by several demo-graphic factors.However,due to the small sample size in the present study,further studies with larger sample sizes are required to draw a firm conclusion on the prevalence of severe FoC among multiparous women and its associated risk factors and birth outcomes.
基金supported by the National Key Research and Development Project of China(2021ZD0202800)the National Natural Science Foundation of China(U21A20418,82003727).
文摘Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forgetting,suggesting the potential to erase fear memories through timely interventions.Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects.This review explores how fear memory may be erased,particularly focusing on the mnemonic phases of reconsolidation and extinction.Reconsolidation strengthens memory,while extinction weakens it.Interfering with memory reconsolidation could diminish the fear response.Alternatively,the extinction of acquired memory could reduce the fear memory response.This review summarizes experimental animal models of PTSD,examines the nature and epidemiology of reconsolidation to extinction,and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD.In sum,understanding how fear memory updates holds significant promise for PTSD treatment.
文摘The present study explores the importance of developing metaphorical thinking skills in students within the framework of English as a Foreign Language(EFL)reading courses at the tertiary educational level.Metaphorical thinking is viewed as the ability to envisage the world figuratively,perceive associatively,and express oneself creatively.It is crucial to recognize metaphors in texts,interpret the complex images they evoke,and generate new metaphors.It is especially needful in the current era of clip thinking and fragmented information processing when students often approach content superficially rather than comprehensively,leading to decreased cognitive activity and a diminished capacity to understand literature.To foster metaphorical thinking,the paper suggests building a text associative-semantic field focusing on metaphors.Due to its hierarchical structure,which can be envisioned as a dense nucleus surrounded by a central region of synonyms and further enveloped by a periphery of more loosely associated linguistic units,the text associative-semantic field is seen as a potent solution for facilitating improved visualization and more holistic comprehension of information,allowing students for expanding their vocabulary and strengthening associative connections.Notably,the study highlights analyzing the metaphors of emotional states as they contribute significantly to a more profound interpretation of the text,understanding the writer’s unique style,deepening the students’engagement with the book,and expanding their emotional experiences.
基金Supported by the General Program of the Joint Fund Project Under the Liaoning Provincial Science and Technology Plan,No.2024-MSLH-104Research Project Plan of the Qingpu Branch of Zhongshan Hospital,No.QYT2023-02Research Topic of the Shanghai Qingpu District Health Commission,No.QWJ2024-10.
文摘In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental component of treatment,its efficacy varies considerably among individuals.DNA methylation plays a pivotal role in the extinction of fear memories,providing a promising molecular mechanism that could enhance the success of exposure-based interventions.Extensive studies have consistently demonstrated a substantial association between DNA methylation and neuronal plasticity.While DNA methylation holds potential regulatory effects on the effectiveness of exposure therapy,the bidirectional regulatory relationship between it and neuronal activity necessitates addressing several challenges before its widespread clinical application for mental disorders.First,excessive DNA methylation may suppress neural function,and non-selective enhancement of methylation could be counterproductive.Furthermore,due to potential systemic side effects,the use of methylation-modulating agents might disrupt the physiological balance and functionality of other organs and systems.Despite the dynamic interplay between DNA methylation and neuronal activity offering novel insights into the treatment of mental disorders, the strict consideration of target specificity and an appropriate dosing window requirescautious implementation in clinical practice.
基金Supported by National Natural Science Foundation of China,No.82360231Yunnan Basic Research Program General Project,No.202401AT070075+1 种基金Dali Basic Research Program Key Project,No.202301A020021Youth Special Project for Basic Research of Local Universities in Yunnan Province,No.202301BA070001-127.
文摘BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge.Fear conditioning and extinction in animal models offer insights into its mechanisms.Our previous research indi-cates that DNA methyltransferases play a role in fear memory renewal.AIM To investigate the role of DNA methylation in the extinction of fear memory,with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.METHODS This study investigated the role of DNA methylation in fear memory extinction in mice.DNA methylation was manipulated using N-phthalyl-L-tryptophan(RG108)to reduce methylation and L-methionine injections to enhance it.Neuronal activity,and dendritic spine density was measured following extinction training.RESULTS RG108 suppressed extinction,reduced spine density,and inhibited neuronal activity.Methionine injections facilitated extinction.CONCLUSION DNA methylation is crucial for fear memory extinction.Enhancing methylation may improve the efficacy of exposure therapy,offering a potential strategy to treat fear-related disorders.
基金Guiding Science and Technology Program Project of Yichang City in 2024(Project No.:B24-2-002)。
文摘Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were divided into routine nursing group,emotional release technology group and aromatherapy combined with emotional release technology group.Routine nursing group received routine nursing;Emotional release technology group implemented emotional release technology for one month on the basis of routine nursing group;Aromatherapy combined with emotional release technology group used lavender aromatherapy on the basis of emotional release technology group.Results:After one month of intervention,there were statistically significant differences in the scores of fear of disease progression and sleep quality among the three groups.Conclusion:Aromatherapy combined with emotional release technology can improve the sleep quality of lung cancer survivors and reduce the economic toxicity of cancer to some extent.
基金supported by the National Geographic Society,the University of California Los Angeles(Faculty Senate and Division of Life Sciences)an RMBL research fellowship and the U.S.National Science Foundation(NSF IDBR-0754247 and DEB-1119660 and 1557130 to D.T.B.,as well as DBI 0242960,07211346 and 1226713 to RMBL).
文摘The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations often sound“noisy”because vocal production systems are over-blown when animals are highly aroused.While much is known about the conditions under which animals produce vocalizations containing NLP and how species respond to them,there is little research about the heritability of such behavioral traits.Using the quantitative genetic animal model,we estimated the genetic basis of“noise”in alarm calls produced by females and found significant heritability in call entropy-our measure of the noisiness.About 9%of the variance in noisiness can be accounted for by genetic differences.Taken together,these findings suggest that the degree to which marmots produce noisy calls is modestly heritable and can be thus subject to further evolution via natural selection.
基金supported by the STI2030-Major Projects(2022ZD0204900)the National Natural Science Foundation of China(32071029 and 32271080)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32020200)the Yunnan Provincial Science and Technology Department(202402AA310014).
文摘Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content and an active form of memory processing that induces memory reconsolidation,has attracted increasing attention in recent years.Although the molecular mechanisms specifc to memory retrievalinduced reconsolidation have been gradually revealed,an understanding of the time-dependent regulatory mechanisms of this process is still lacking.In this study,we applied a transcriptome analysis of memory retrieval at diferent time points in the recent memory stage.Diferential expression analysis and Short Time-series Expression Miner(STEM)depicting temporal gene expression patterns indicated that most diferential gene expression occurred at 48 h,and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant diference.We then screened the diferentially-expressed genes associated with that met the expression patterns of those cluster-identifed genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9(DPP9).Further quantitative polymerase chain reaction verifcation and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory.Taken together,our fndings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.
基金supported by the Jiangxi Province Think Tank Research Project(ZK202406)the 2023 Jiangxi Provincial Health Commission Research Project(52524010)。
文摘Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psychological security(PS)and FoMO by analyzing the mediating role of social networking addiction(SNA)and the moderating role of social self-efficacy(SSE).Methods:We collected a sample of 1181 college students(with a mean age of 19.671.38 years)from five universities in a province of China's Mainland through cluster sampling.Data±were gathered using the psychological security questionnaire(PSQ),the FoMO scale,the SNA scale,and the perceived social self-efficacy(PSSE)scale.Data analysis employed independent-sample t-tests,one-way analysis of variance(ANOVA),Harman’s single-factor test,confirmatory factor analysis,and moderated mediation analysis.Results:The results of the mediation model and moderated mediation model analyses showed the following key findings:(1)PS is significantly negatively correlated with FoMO;(2)SNA mediates the relationship between PS and FoMO;(3)SSE positively moderates the relationship between PS and FoMO;and(4)SSE also positively moderates the relationship between PS and SNA.Conclusion:University students’PS not only directly impacts FoMO but also indirectly influences it through SNA.Additionally,SSE positively moderates both the direct path and the first half of the mediation path,indicating that enhancing students’PS and SSE can help alleviate their SNA and FoMO,promoting their psychological and behavioral well-being.
文摘Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenience sampling,228 elderly people were selected as the research subjects,and the general demographic characteristics questionnaire,elderly loneliness scale,dementia fear scale,and simplified intelligence status check scale were used for investigation.SPSS 28.0 statistical software was used for data analysis.Results:The total score of loneliness was 96.21±21.83 points,and the total score of dementia fear was 59.34±13.50 points.There were statistically significant differences in dementia fear scores among elderly people in the community in terms of age,gender,marital status,family history of dementia,and number of chronic diseases(P<0.05).Person correlation analysis showed a positive correlation between the total score of dementia fear and loneliness in elderly people in the community(r=0.162,P<0.05).Conclusion:The level of loneliness and dementia fear among elderly people in the community is at a moderate level.Age,gender,marital status,family history of dementia,and number of chronic diseases are important influencing factors of dementia fear among elderly people in the community.The sense of loneliness among elderly people in the community is positively correlated with dementia fear,meaning that the greater the degree of loneliness,the higher the degree of dementia fear among elderly people in the community.
