Mg alloys have mechanical properties compatible with human bones.However,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human implants.In this study,thr...Mg alloys have mechanical properties compatible with human bones.However,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human implants.In this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat model.All three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital organs.Proteomics analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array analyses.Further,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured tissues.Structurally,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,respectively.This is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in vivo.In conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.展开更多
In order to evaluate the operational reliability of Japanese FBR （fast breeder reactor） MONJU, frequencies of important intermediate events and equipment failures resulting during reactor automatic trip are predicte...In order to evaluate the operational reliability of Japanese FBR （fast breeder reactor） MONJU, frequencies of important intermediate events and equipment failures resulting during reactor automatic trip are predicted using FTA （fault tree analysis） technique for the plant system model. The targeted devices are the following： PHTS （primary heat transport system）, SHTS （secondary heat transport system）, WS （water and steam system）, PPS （plant protection system） and PCS （plant control system）. In this paper, the frequency of automatic reactor trips was estimated by extracting and analyzing the important intermediate events and equipment failures covering all the derived fault trees of these systems. The analyses predicted 1.2/RY （reactor year） the value of unplanned shut down frequency by the internal factor of the system. The largest contributed event was function failure of SHTS accounting for 42.6% of total events followed by PHTS with 40.1%. The contribution factor of WS was only 4.4%.展开更多
基金supported in part by JSPS research grant(No.P16718)Natural Science Foundation of Guangdong Province(No.2020A1515010855)+2 种基金National Science Foundation of China(31971355)Genecology MCR Seed Funding of University of the Sunshine CoastDeng Feng Project of Foshan First People’s Hospital(2019A008)。
文摘Mg alloys have mechanical properties compatible with human bones.However,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human implants.In this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat model.All three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital organs.Proteomics analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array analyses.Further,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured tissues.Structurally,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,respectively.This is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in vivo.In conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.
文摘In order to evaluate the operational reliability of Japanese FBR （fast breeder reactor） MONJU, frequencies of important intermediate events and equipment failures resulting during reactor automatic trip are predicted using FTA （fault tree analysis） technique for the plant system model. The targeted devices are the following： PHTS （primary heat transport system）, SHTS （secondary heat transport system）, WS （water and steam system）, PPS （plant protection system） and PCS （plant control system）. In this paper, the frequency of automatic reactor trips was estimated by extracting and analyzing the important intermediate events and equipment failures covering all the derived fault trees of these systems. The analyses predicted 1.2/RY （reactor year） the value of unplanned shut down frequency by the internal factor of the system. The largest contributed event was function failure of SHTS accounting for 42.6% of total events followed by PHTS with 40.1%. The contribution factor of WS was only 4.4%.
