Extreme weather events,such as floods and droughts,are expected to rise significantly worldwide as a result of climate change.Investigating future drought patterns is therefore a key approach for elaborating anticipat...Extreme weather events,such as floods and droughts,are expected to rise significantly worldwide as a result of climate change.Investigating future drought patterns is therefore a key approach for elaborating anticipatory water resources management responses to climate change.In this paper,future meteorological drought conditions are investigated based on the SPEI(Standardised Precipitation Evapotranspiration Index).This study makes use of observed and projected data.The simulated data were retrieved from the CMIP6(Coupled Model Intercomparison Project Phase 6)over the period 2025-2050,and the Delta change method was adopted to remove the bias in the dataset.Then SPEI at various scales has been estimated under four future scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5).The trend analysis of the projected SPEI was performed at p<0.05 using the MMK(Modified Mann-Kendall)test in order to detect the statistically significant trend of the drought against the null hypothesis of no trend.Results show large variability in the magnitude of drought in the past and future.Based on SPEI at 24 months accumulation,the result shows that under SSP1-2.6,the basin will experience a wet period during the first decade(SPEI=0.60),the second decade will be dry(SPEI24=-0.43).The remaining years will be also dry(SPEI=-0.34).Under SSP2-4.5,SSP3-7.0 and SSP5-8.5 scenarios,the district will experience a wet period during the first two decades with SPEI ranging from 0.38 to 0.59.This wet period will be followed by a dry period under these scenarios ranging from-0.14 to-0.06.Overall,under SSPs scenarios,two main periods characterized by a rainfall recovery spanning from followed by a moderately prolonged drought are identified within the study area.The findings of this study may provide valuable information for developing proactive measures to reduce water insecurity in Fada N’Gourma through effective drought mitigation.展开更多
Colorectal cancer(CRC)screening and early diagnosis is an effective strategy for reducing CRC mortality.However,the current detection methods involve exorbitant costs and complex procedures,which are inconvenient for ...Colorectal cancer(CRC)screening and early diagnosis is an effective strategy for reducing CRC mortality.However,the current detection methods involve exorbitant costs and complex procedures,which are inconvenient for large-scale screening.Given its high prevalence inmalignant tissues and feces of CRC patients,Fusobacterium nucleatum(F.nucleatum)has emerged as a crucial biomarker for the early detection of CRC.Herein,we propose an F.nucleatum-specific recognition strategy for CRC screening and diagnosis.A novel nanobioprobe(AIE-Pep)with aggregation-induced emission(AIE)characteristics was synthesized by conjugating a red/near-infrared(NIR)emissive AIE luminogen(AIEgen)with a FadA-targeting peptide(ASANWTIQYND).The robust binding affinity between the peptide and FadA on F.nucleatum allows AIE-Pep NPs to adhere selectively to F.nucleatum,and emits strong red/NIR fluorescence.In the model of the orthotopic CRC,AIE-Pep NPs can precisely localize F.nucleatum around CRC.Moreover,AIE-Pep NPs demonstrated a limit of detection(LOD)of 82.97 CFU/mL for F.nucleatum,which could significantly differentiate the feces of CRC mice from those of normal mice.Overall,this study presents a pivotal approach to specifically identifying F.nucleatum and holds immense potential for CRC diagnosis.展开更多
文摘Extreme weather events,such as floods and droughts,are expected to rise significantly worldwide as a result of climate change.Investigating future drought patterns is therefore a key approach for elaborating anticipatory water resources management responses to climate change.In this paper,future meteorological drought conditions are investigated based on the SPEI(Standardised Precipitation Evapotranspiration Index).This study makes use of observed and projected data.The simulated data were retrieved from the CMIP6(Coupled Model Intercomparison Project Phase 6)over the period 2025-2050,and the Delta change method was adopted to remove the bias in the dataset.Then SPEI at various scales has been estimated under four future scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5).The trend analysis of the projected SPEI was performed at p<0.05 using the MMK(Modified Mann-Kendall)test in order to detect the statistically significant trend of the drought against the null hypothesis of no trend.Results show large variability in the magnitude of drought in the past and future.Based on SPEI at 24 months accumulation,the result shows that under SSP1-2.6,the basin will experience a wet period during the first decade(SPEI=0.60),the second decade will be dry(SPEI24=-0.43).The remaining years will be also dry(SPEI=-0.34).Under SSP2-4.5,SSP3-7.0 and SSP5-8.5 scenarios,the district will experience a wet period during the first two decades with SPEI ranging from 0.38 to 0.59.This wet period will be followed by a dry period under these scenarios ranging from-0.14 to-0.06.Overall,under SSPs scenarios,two main periods characterized by a rainfall recovery spanning from followed by a moderately prolonged drought are identified within the study area.The findings of this study may provide valuable information for developing proactive measures to reduce water insecurity in Fada N’Gourma through effective drought mitigation.
基金supported by the National Natural Science Foundation of China(U20A20260 and 22075209)National Key R&D Program of China(2024YFE0104000)+1 种基金the Key Program of Tianjin Municipal Natural Science Foundation(22JCZDJC00570)a distinguished professor of Tianjin,the Training Project of Innovation Team of Colleges and Universities in Tianjin(TD13-5020).
文摘Colorectal cancer(CRC)screening and early diagnosis is an effective strategy for reducing CRC mortality.However,the current detection methods involve exorbitant costs and complex procedures,which are inconvenient for large-scale screening.Given its high prevalence inmalignant tissues and feces of CRC patients,Fusobacterium nucleatum(F.nucleatum)has emerged as a crucial biomarker for the early detection of CRC.Herein,we propose an F.nucleatum-specific recognition strategy for CRC screening and diagnosis.A novel nanobioprobe(AIE-Pep)with aggregation-induced emission(AIE)characteristics was synthesized by conjugating a red/near-infrared(NIR)emissive AIE luminogen(AIEgen)with a FadA-targeting peptide(ASANWTIQYND).The robust binding affinity between the peptide and FadA on F.nucleatum allows AIE-Pep NPs to adhere selectively to F.nucleatum,and emits strong red/NIR fluorescence.In the model of the orthotopic CRC,AIE-Pep NPs can precisely localize F.nucleatum around CRC.Moreover,AIE-Pep NPs demonstrated a limit of detection(LOD)of 82.97 CFU/mL for F.nucleatum,which could significantly differentiate the feces of CRC mice from those of normal mice.Overall,this study presents a pivotal approach to specifically identifying F.nucleatum and holds immense potential for CRC diagnosis.
