Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both t...Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available thera- peutics. This therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experi- mental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. This short review will consider relevant background and poten- tial solutions to this problem in the axon regeneration domain.展开更多
Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for repro...Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for reproduction of experiments to con- firm results, 2） promote thorough analyses of data, and 3） foster the incremental advancement of valid approaches. Unfortunately, most would also agree we have far to go to reach this vital goal （Hackam and Redelmeier, 2006; Prinz et al., 2011; Baker et al., 2014）.展开更多
Wiley Open Access journals are supported by a network of authoritative journals and societies as well as internationally renowned editorial board members.All research articles published in Wiley Open Access journals a...Wiley Open Access journals are supported by a network of authoritative journals and societies as well as internationally renowned editorial board members.All research articles published in Wiley Open Access journals are immediately freely available to read,download and share.Wiley Open Access journals are a group of high-quality open access journals offering authors a great venue to publish their work.展开更多
2018 is the ＂forum year＂ for China-Arica cooperation. The Forum on China-Africa Cooperation （hereinafter referred to as the forum） is a plat-form for collective dialogue and mechanism of practical cooperation join...2018 is the ＂forum year＂ for China-Arica cooperation. The Forum on China-Africa Cooperation （hereinafter referred to as the forum） is a plat-form for collective dialogue and mechanism of practical cooperation jointly created by China and African countries at the turn of the century, with the aim of establishing a new type of China-Africa strategic partnership for long-term stability and mutual benefits in the 21st century The Chinese government＇s promotion of the strategic importance of relations with Africa is due to a variety of factors, the most important of which is the change in demand for Africa triggered by the sustained and rapid growth of China＇s economy against the backdrop of globalization. Thanks to the effective operation of the forum mechanism, China-Africa relations have shown a good trend of comprehensive and rapid development.展开更多
Clinical Ladder Programs is to develop different training programs according to different levels of nurses’management.The purpose is to improve nurses’sense of professional identity,professional and technical capabi...Clinical Ladder Programs is to develop different training programs according to different levels of nurses’management.The purpose is to improve nurses’sense of professional identity,professional and technical capabilities,and determine salary levels,so as to fully mobilize nurses’enthusiasm.This article reviews the current status of the application of Clinical Ladder Programs in clinical nursing around the world,and understands the obstacles and facilitating factors that affect the implementation of Clinical Ladder Programs,in order to provide a reference for establishing a perfect hierarchical nurse training model in China.展开更多
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).展开更多
This paper reports a study on a Chinese English major＇s argumentative English writings focusing on the development of her thinking capacities and factors that facilitate or constrain such development. The data came f...This paper reports a study on a Chinese English major＇s argumentative English writings focusing on the development of her thinking capacities and factors that facilitate or constrain such development. The data came from three sources： her essays, reflective journals, and my semi-structured interviews with her. Major findings can be summed up as follows： 1） at the initial stage, the participant was weak in rational thinking; 2） as she had more writing practice, she made progress in ideas and organization of ideas but not in expression of ideas; and 3） factors facilitating or constraining her development primarily include language input, cultural identification, teacher feedback and motivation.展开更多
The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the gl...The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.展开更多
Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potenti...Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potential risk to groundwater due to colloid-facilitated transport.However,the extent to which soil colloidsmay enhance the spreading of PBDEs in groundwater is largely unknown.Herein,we report the co-transport of decabromodiphenyl ester(BDE-209)and soil colloids in saturated porous media.The colloids released froma soil sample collected at an e-waste recycling site in Tianjin,China,contain high concentration of PBDEs,with BDE-209 being the most abundant conger(320±30 mg/kg).The colloids exhibit relatively high mobility in saturated sand columns,under conditions commonly observed in groundwater environments.Notably,under all the tested conditions(i.e.,varying flow velocity,pH,ionic species and ionic strength),the mass of eluted BDE-209 correlates linearly with that of eluted soil colloids,even though the mobility of the colloids varies markedly depending on the specific hydrodynamic and solution chemistry conditions involved.Additionally,the mass of BDE-209 retained in the columns also correlates strongly with themass of retained colloids.Apparently,the PBDEs remain bound to soil colloids during transport in porous media.Findings in this study indicate that soil colloidsmay significantly promote the transport of PBDEs in groundwater by serving as an effective carrier.This might be the reason why the highly insoluble and adsorptive PBDEs are found in groundwater at some PBDE-contaminated sites.展开更多
Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to...Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.展开更多
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.展开更多
It has been commonplace for students to com-plain about their oral lessons.This paper arises froma thought of concrete problems facing Chinese high-school graduates who are unable to speak English well.Based on three ...It has been commonplace for students to com-plain about their oral lessons.This paper arises froma thought of concrete problems facing Chinese high-school graduates who are unable to speak English well.Based on three elements that are crucial to languagelearning,the paper will focus on developing students’speaking abilities.In the paper,the teachers’ role ishighlighted.The students will find it the most effec-tive way to improve their speaking abilities if themethod is applied under the proper direction of aqualified teacher.展开更多
Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has s...Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.展开更多
Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for...Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for Implementation Research(CFIR).Methods The sample consisted of 17 nurses from three urology wards at a tertiary hospital in Beijing,China,who had participated in the EBP.Guided by the CFIR,we identified constructs influencing the sustainability of implementation by conducting a directed content analysis of the 17 individual in-depth interviews.By rating,the valence and magnitude of each construct were determined.Results This study identified 19 factors across the five domains of the CFIR.Among these determinants,16 were identified as barriers,while three were recognized as facilitators.Common barriers across different contexts were identified,such as delayed evidence updating,the complexity of intervention components and steps,and incompatibility between the implementation process and clinical practices.In contrast,facilitators of intervention implementation were regular communication and feedback,support and drive from principals and a positive cultural atmosphere.In addition,we identified“regular evidence updating”as an independent construct outside of the CFIR,a finding that will provide key information for updating the CFIR framework.Conclusions Regular evidence updating is crucial for the sustainability of EBP implementation.Researchers should receive consistent feedback from practitioners and adjust or modify the EBP as necessary.Additionally,researchers must consider the compatibility or adaptability of the EBP’s content with clinical practice in formulating it rather than adding additional complexity to the original workflow.展开更多
Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Sem...Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Semi-structured interviews were conducted with 10 frail KTRs who participated in a 3-month Baduanjin practice.The Colaizzi seven-step analysis method was used to analyze,summarize,and extract themes from the interview data.Results:Two themes were extracted:facilitators and barriers.Facilitators included intrinsic motivation and perceived benefits,while barriers included conflicts with practice time,worsening physical condition,lack of immediate benefits,and difficulty integrating into daily life.Conclusion:The practice of Baduanjin by frail KTRs is influenced by various factors.Healthcare professionals should develop personalized intervention plans that take into account these factors and the needs of the patients.展开更多
Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive dise...Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive disease on lichi,litchi downy blight.PlM90 was reported as a key oosporogenesis regulator.Here,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 mutant.To investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing technology.Compared with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and pathogenicity.Furthermore,PlMFS1 deletion significantly affected P.litchii utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial growth.PlMFS1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired P.litchii pathogenicity.To our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.展开更多
Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their fu...Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their functions have not yet been confirmed,especially for SULTR3 in rice.In this study,we analyzed the expression patterns,subcellular localization,and inorganic phosphate(Pi)transporter activity of SULTR3 proteins in yeast.Except for OsSULTR3.4,which localized to the plasma membrane,other OsSULTR3 members were localized to the endoplasmic reticulum(ER)membrane in rice protoplast cells.展开更多
BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts betwee...BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.展开更多
In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a sha...In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a shared future.展开更多
基金Research in the Lemmon/Bixby lab is supported by NIH grants NS080145 and NS059866by the Miami Project to Cure Paralysis
文摘Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available thera- peutics. This therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experi- mental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. This short review will consider relevant background and poten- tial solutions to this problem in the axon regeneration domain.
文摘Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for reproduction of experiments to con- firm results, 2） promote thorough analyses of data, and 3） foster the incremental advancement of valid approaches. Unfortunately, most would also agree we have far to go to reach this vital goal （Hackam and Redelmeier, 2006; Prinz et al., 2011; Baker et al., 2014）.
文摘Wiley Open Access journals are supported by a network of authoritative journals and societies as well as internationally renowned editorial board members.All research articles published in Wiley Open Access journals are immediately freely available to read,download and share.Wiley Open Access journals are a group of high-quality open access journals offering authors a great venue to publish their work.
文摘2018 is the ＂forum year＂ for China-Arica cooperation. The Forum on China-Africa Cooperation （hereinafter referred to as the forum） is a plat-form for collective dialogue and mechanism of practical cooperation jointly created by China and African countries at the turn of the century, with the aim of establishing a new type of China-Africa strategic partnership for long-term stability and mutual benefits in the 21st century The Chinese government＇s promotion of the strategic importance of relations with Africa is due to a variety of factors, the most important of which is the change in demand for Africa triggered by the sustained and rapid growth of China＇s economy against the backdrop of globalization. Thanks to the effective operation of the forum mechanism, China-Africa relations have shown a good trend of comprehensive and rapid development.
基金This research was supported by Yunnan Province Science and Technology Project(No.2017FE467(-204)).
文摘Clinical Ladder Programs is to develop different training programs according to different levels of nurses’management.The purpose is to improve nurses’sense of professional identity,professional and technical capabilities,and determine salary levels,so as to fully mobilize nurses’enthusiasm.This article reviews the current status of the application of Clinical Ladder Programs in clinical nursing around the world,and understands the obstacles and facilitating factors that affect the implementation of Clinical Ladder Programs,in order to provide a reference for establishing a perfect hierarchical nurse training model in China.
基金funded by NIH grants HL154720-03S1, AG057587, AG074283, DK122708-03S1, BrightFocus ADR A20183775Brown Foundation 2020 Healthy Aging Initiative (to WC)
文摘Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).
基金sponsored by the Social Science Planning Project from Beijing Municipal Commission of Education(SM201310038009)
文摘This paper reports a study on a Chinese English major＇s argumentative English writings focusing on the development of her thinking capacities and factors that facilitate or constrain such development. The data came from three sources： her essays, reflective journals, and my semi-structured interviews with her. Major findings can be summed up as follows： 1） at the initial stage, the participant was weak in rational thinking; 2） as she had more writing practice, she made progress in ideas and organization of ideas but not in expression of ideas; and 3） factors facilitating or constraining her development primarily include language input, cultural identification, teacher feedback and motivation.
基金supported by the Major Subject of the National Social Science Foundation of China(21&ZD093)the Basic Research Funds of Chinese Academy of Agricultural Sciences(16100520240017)+1 种基金the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAASCSAERD-202402,10-IAED-04-2024)the earmarked fund for China Agriculture Research System(CARS-08).
文摘The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.
基金supported by the National Key Research and Development Program of China(No.2019YFC1804202)the National Natural Science Foundation of China(No.22020102004)+1 种基金the Tianjin Municipal Science and Technology Bureau(No.21JCZDJC00280)the Fundamental Research Funds for the Central Universities by the Ministry of Education of China(No.T2017002).
文摘Polybromodiphenyl ethers(PBDEs),the widely used flame retardants,are common contaminants in surface soils at e-waste recycling sites.The association of PBDEs with soil colloids has been observed,indicating the potential risk to groundwater due to colloid-facilitated transport.However,the extent to which soil colloidsmay enhance the spreading of PBDEs in groundwater is largely unknown.Herein,we report the co-transport of decabromodiphenyl ester(BDE-209)and soil colloids in saturated porous media.The colloids released froma soil sample collected at an e-waste recycling site in Tianjin,China,contain high concentration of PBDEs,with BDE-209 being the most abundant conger(320±30 mg/kg).The colloids exhibit relatively high mobility in saturated sand columns,under conditions commonly observed in groundwater environments.Notably,under all the tested conditions(i.e.,varying flow velocity,pH,ionic species and ionic strength),the mass of eluted BDE-209 correlates linearly with that of eluted soil colloids,even though the mobility of the colloids varies markedly depending on the specific hydrodynamic and solution chemistry conditions involved.Additionally,the mass of BDE-209 retained in the columns also correlates strongly with themass of retained colloids.Apparently,the PBDEs remain bound to soil colloids during transport in porous media.Findings in this study indicate that soil colloidsmay significantly promote the transport of PBDEs in groundwater by serving as an effective carrier.This might be the reason why the highly insoluble and adsorptive PBDEs are found in groundwater at some PBDE-contaminated sites.
文摘Facilitated transport membranes for post-combustion carbon capture are one of the technologies to achieve efficient and large-scale capture.The central principle is to utilize the affinity of CO_(2) for the carrier to achieve efficient separation and to break the Robson upper bound.This paper reviews the progress of facilitated transport membranes research regarding polymer materials,principles,and problems faced at this stage.Firstly,we briefly introduce the transport mechanism of the facilitated transport membranes.Then the research progress of several major polymers used for facilitated transport membranes for CO_(2)/N_(2) separation was presented in the past five years.Additionally,we analyze the primary challenges of facilitated transport membranes,including the influence of water,the effect of temperature,the saturation effect of the carrier,and the process configuration.Finally,we also delve into the challenges and competitiveness of facilitated transport membranes.
基金supported by the National Natural Science Foundation of China,No.82104412(to TD)Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD)+1 种基金the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM)Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
文摘The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.
文摘It has been commonplace for students to com-plain about their oral lessons.This paper arises froma thought of concrete problems facing Chinese high-school graduates who are unable to speak English well.Based on three elements that are crucial to languagelearning,the paper will focus on developing students’speaking abilities.In the paper,the teachers’ role ishighlighted.The students will find it the most effec-tive way to improve their speaking abilities if themethod is applied under the proper direction of aqualified teacher.
文摘Since last year,China’s inbound tourism market has accelerated its recovery.With the introduction and optimization of various facilitation policies and the development of new products,the inbound tourism market has shown unlimited potential for growth.According to data from the Data Center of the Ministry of Culture and Tourism,the number of inbound tourists reached a new high during the Spring Festival in 2025.The UK became China's third largest source of inbound tourists after the Republic of Korea and Japan.
基金supported by the Peking University Nursing Discipline Research Development Fund(No.TYZH2023001)。
文摘Objectives To investigate the barriers and facilitators influencing the sustainable implementation of evidence-based practice(EBP)for Peristomal Irritant Contact Dermatitis(PICD)based on the Consolidated Framework for Implementation Research(CFIR).Methods The sample consisted of 17 nurses from three urology wards at a tertiary hospital in Beijing,China,who had participated in the EBP.Guided by the CFIR,we identified constructs influencing the sustainability of implementation by conducting a directed content analysis of the 17 individual in-depth interviews.By rating,the valence and magnitude of each construct were determined.Results This study identified 19 factors across the five domains of the CFIR.Among these determinants,16 were identified as barriers,while three were recognized as facilitators.Common barriers across different contexts were identified,such as delayed evidence updating,the complexity of intervention components and steps,and incompatibility between the implementation process and clinical practices.In contrast,facilitators of intervention implementation were regular communication and feedback,support and drive from principals and a positive cultural atmosphere.In addition,we identified“regular evidence updating”as an independent construct outside of the CFIR,a finding that will provide key information for updating the CFIR framework.Conclusions Regular evidence updating is crucial for the sustainability of EBP implementation.Researchers should receive consistent feedback from practitioners and adjust or modify the EBP as necessary.Additionally,researchers must consider the compatibility or adaptability of the EBP’s content with clinical practice in formulating it rather than adding additional complexity to the original workflow.
基金funded by the General Program of the National Natural Science Foundation of China(82072553)the Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-026).
文摘Objective:To understand the facilitators and barriers for frail kidney transplant recipients(KTRs)practicing Baduanjin,and to provide a theoretical basis for developing intervention strategies.Subjects and Methods:Semi-structured interviews were conducted with 10 frail KTRs who participated in a 3-month Baduanjin practice.The Colaizzi seven-step analysis method was used to analyze,summarize,and extract themes from the interview data.Results:Two themes were extracted:facilitators and barriers.Facilitators included intrinsic motivation and perceived benefits,while barriers included conflicts with practice time,worsening physical condition,lack of immediate benefits,and difficulty integrating into daily life.Conclusion:The practice of Baduanjin by frail KTRs is influenced by various factors.Healthcare professionals should develop personalized intervention plans that take into account these factors and the needs of the patients.
基金funded by the Natural Science Foundation of Guangdong Province,China(Grant Nos.2023A1515012617,2022A1515010458 and 2023A1515030267)Guangzhou Science&Technology Program(Grant No.202201010410)the earmarked fund for CARS-32。
文摘Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy metabolism.Peronophythora litchii causes the most destructive disease on lichi,litchi downy blight.PlM90 was reported as a key oosporogenesis regulator.Here,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 mutant.To investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing technology.Compared with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and pathogenicity.Furthermore,PlMFS1 deletion significantly affected P.litchii utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial growth.PlMFS1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired P.litchii pathogenicity.To our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.
基金supported by the National Natural Science Foundation of China(Grant Nos.32130096 and 32172667)the Central Public-Interest Scientific Institution Basal Research Fund,China(Grant No.Y2022QC14).
文摘Sulfate transporters(SULTRs)facilitate sulfate uptake and transport in plants.In plants,SULTRs can be classified into four distinct functional groups,among which SULTR3 members are the least characterized,and their functions have not yet been confirmed,especially for SULTR3 in rice.In this study,we analyzed the expression patterns,subcellular localization,and inorganic phosphate(Pi)transporter activity of SULTR3 proteins in yeast.Except for OsSULTR3.4,which localized to the plasma membrane,other OsSULTR3 members were localized to the endoplasmic reticulum(ER)membrane in rice protoplast cells.
文摘BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.
文摘In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a shared future.
