目的探索超声心动图在鉴别诊断Fabry病和肥厚型心肌病(hypertrophic cardiomyopathy,HCM中的应用价值。方法选择西安交通大学第一附属医院2022年1月—2024年1月收治的Fabry病患者和同期HCM患者基线资料和超声心动图参数并进行组间比较...目的探索超声心动图在鉴别诊断Fabry病和肥厚型心肌病(hypertrophic cardiomyopathy,HCM中的应用价值。方法选择西安交通大学第一附属医院2022年1月—2024年1月收治的Fabry病患者和同期HCM患者基线资料和超声心动图参数并进行组间比较。筛选具有诊断价值的参数,并用受试者操作特征曲线及曲线下面积(area under the curve,AUC)分析有价值的参数以评价对2种疾病的鉴别诊断能力。结果共纳入Fabry病患者16例、HCM患者41例。Fabry病组年龄、体质量指数、心电图异常比例、吸烟史低于HCM组(P<0.05);Fabry病组病史久于HCM组(P<0.05)。Fabry病组左心室心肌最厚处厚度、升主动脉宽度小于HCM组(P<0.05),而e峰值大于HCM组(P<0.05)。e峰的鉴别诊断价值AUC为0.698[95%置信区间(0.502,0.894),P<0.05],灵敏度为41.7%,特异度为100%,Youden指数为41.7%。3者联合应用后,其灵敏度和准确度均较e峰值提高,鉴别诊断价值AUC为0.773[95%置信区间(0.585,0.961),P<0.05],灵敏度为100%,特异度为45.5%。两组患者二维斑点追踪技术超声其他参数(左心室整体纵向应变、心尖段应变、基底段应变等)比较,差异均无统计学意义(P>0.05)。结论超声心动图可能对Fabry病和HCM的鉴别诊断具有一定意义。展开更多
In recent years,machine learning(ML)techniques have been shown to be effective in accelerating the development process of optoelectronic devices.However,as"black box"models,they have limited theoretical inte...In recent years,machine learning(ML)techniques have been shown to be effective in accelerating the development process of optoelectronic devices.However,as"black box"models,they have limited theoretical interpretability.In this work,we leverage symbolic regression(SR)technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot(FP)laser and its optical field distribution,which greatly improves model transparency compared to ML.We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models,which suggests that the expressions have better fitting and generalization capabilities.展开更多
A compact and highly sensitive gas pressure and temperature sensor based on Fabry-Pérot interferometer(FPI)and fiber Bragg grating(FBG)is proposed and demonstrated experimentally in this paper.The theoretical mod...A compact and highly sensitive gas pressure and temperature sensor based on Fabry-Pérot interferometer(FPI)and fiber Bragg grating(FBG)is proposed and demonstrated experimentally in this paper.The theoretical model for pressure and temperature sensing is established.Building on this foundation,a novel micro silicon cavity sensor structure sensitive to pressure is devised downstream of an FBG.The concept of separate measurement and the mechanisms enhancing pressure sensitivity are meticulously analyzed,and the corresponding samples are fabricated.The experimental results indicate that the pressure sensitivity of the sensor is-747.849 nm/MPa in 0—100 k Pa and its linearity is 99.7%and it maintains good stability in 150 min.The sensor offers the advantages of compact size,robust construction,easy fabrication,and high sensitivity,making it potentially valuable for micro-pressure application.展开更多
文摘目的探索超声心动图在鉴别诊断Fabry病和肥厚型心肌病(hypertrophic cardiomyopathy,HCM中的应用价值。方法选择西安交通大学第一附属医院2022年1月—2024年1月收治的Fabry病患者和同期HCM患者基线资料和超声心动图参数并进行组间比较。筛选具有诊断价值的参数,并用受试者操作特征曲线及曲线下面积(area under the curve,AUC)分析有价值的参数以评价对2种疾病的鉴别诊断能力。结果共纳入Fabry病患者16例、HCM患者41例。Fabry病组年龄、体质量指数、心电图异常比例、吸烟史低于HCM组(P<0.05);Fabry病组病史久于HCM组(P<0.05)。Fabry病组左心室心肌最厚处厚度、升主动脉宽度小于HCM组(P<0.05),而e峰值大于HCM组(P<0.05)。e峰的鉴别诊断价值AUC为0.698[95%置信区间(0.502,0.894),P<0.05],灵敏度为41.7%,特异度为100%,Youden指数为41.7%。3者联合应用后,其灵敏度和准确度均较e峰值提高,鉴别诊断价值AUC为0.773[95%置信区间(0.585,0.961),P<0.05],灵敏度为100%,特异度为45.5%。两组患者二维斑点追踪技术超声其他参数(左心室整体纵向应变、心尖段应变、基底段应变等)比较,差异均无统计学意义(P>0.05)。结论超声心动图可能对Fabry病和HCM的鉴别诊断具有一定意义。
文摘Fabry病(FD)因GLA致病性变异,导致溶酶体α-半乳糖苷酶A(α-Gal A)缺乏和鞘脂类酰基鞘鞍醇三己糖(Gb3)堆积,进一步发生严重的肾脏和心血管等器官并发症。肾脏主要影响足细胞。FD是一种多系统疾病,起源于细胞水平,但Gb3诱导细胞功能障碍的机制还不清楚。澳大利亚学者Sharon D.Ricardo教授团队近期开展了一项工作,旨在明确FD潜在的驱动因素,并探索了FD患者诱导多能干细胞(iPSC)衍生足细胞的潜在细胞病理学。研究结果发表于近期《Kidney International Reports》。
基金supported by the National Natural Science Foundation of China(No.92370117)the CAS Project for Young Scientists in Basic Research(No.YSBR-090)。
文摘In recent years,machine learning(ML)techniques have been shown to be effective in accelerating the development process of optoelectronic devices.However,as"black box"models,they have limited theoretical interpretability.In this work,we leverage symbolic regression(SR)technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot(FP)laser and its optical field distribution,which greatly improves model transparency compared to ML.We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models,which suggests that the expressions have better fitting and generalization capabilities.
基金supported in part by the National Natural Science Foundation of China(Nos.61735014 and 61927812)the Shaanxi Provincial Education Department(No.18JS093)+2 种基金the Natural Science Basic Research Program of Shaanxi Province(No.2024JC-YBMS-530)the Operation Fund of Logging Key Laboratory of Group Company(No.2021DQ0107-11)the Graduate Student Innovation Fund of Xi’an Shiyou University(No.YCS23213193)。
文摘A compact and highly sensitive gas pressure and temperature sensor based on Fabry-Pérot interferometer(FPI)and fiber Bragg grating(FBG)is proposed and demonstrated experimentally in this paper.The theoretical model for pressure and temperature sensing is established.Building on this foundation,a novel micro silicon cavity sensor structure sensitive to pressure is devised downstream of an FBG.The concept of separate measurement and the mechanisms enhancing pressure sensitivity are meticulously analyzed,and the corresponding samples are fabricated.The experimental results indicate that the pressure sensitivity of the sensor is-747.849 nm/MPa in 0—100 k Pa and its linearity is 99.7%and it maintains good stability in 150 min.The sensor offers the advantages of compact size,robust construction,easy fabrication,and high sensitivity,making it potentially valuable for micro-pressure application.
