P omegranate(Punica granatum L.)has attracted considerable attention in world markets due to its valuable nutrients and highly appreciated sensory properties.The aroma profiles of 4 varieties of pomegranate juice,incl...P omegranate(Punica granatum L.)has attracted considerable attention in world markets due to its valuable nutrients and highly appreciated sensory properties.The aroma profiles of 4 varieties of pomegranate juice,including Dahongtian(DP),Jingpitian(JP),Luyudan(LP),and Tianhonngdan(TP),were investigated via gas chromatography-mass spectrometry(GC-MS)and gas chromatography-olfactometry(GC-O)analyses.A total of 43 volatile compounds were identified by using GC-MS.Among these compounds,16 were considered as potential aroma-active compounds as detected by GC-O.These compounds belonged to the classes of terpinenes,alcohols,and aldehydes.Eleven volatile compounds were defined as the main contributors to the overall aroma of pomegranate juice due to their high odor activity values(OAVs≥1).Aroma recombination and omission tests confirmed thatβ-myrcene,1-hexanol,and(Z)-3-hexen-1-ol were the key aroma compounds,and limonene,1-octen-3-ol,linalool,and hexanal were important aroma-active compounds in DP samples.展开更多
Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. Methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analy...Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. Methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analysis, eosin-nigrosin (EN) staining and the HOS test. A further EN stain was then performed on a HOS pre-treated aliquot and a total of 2000 further sperm examined. Results: The median sperm density was 5.1 million/mL (IQR 4.3-13.1) and the median motility was 3.0 % (IQR 0-7). Seven samples showed complete asthenozoospermia. Initial EN staining showed 59 % viability (range 48-69) despite the poor standard parameters and 47 % (range 33-61) in the complete asthenozoospermia subgroup. The HOS test showed 49.9 % reacted overall (range 40-59) and 41.7 % (range 22-61) in the complete asthenozoospermia subgroup. The combined HOS/EN stain showed the positive predictive value of the HOS test to identify viable sperm was 84.2 % overall and 79.7 % in the complete asthenozoospermia subgroup. Conclusion: The HOS test can effectively predict sperm viability in patients with severe and complete asthenozoospermia.展开更多
This paper clarifies the essence of the significance test of singular value decomposition analysis （SVD）, and investigates four rules for testing the significance of coupled modes of SVD, including parallel analysis...This paper clarifies the essence of the significance test of singular value decomposition analysis （SVD）, and investigates four rules for testing the significance of coupled modes of SVD, including parallel analysis, nonparametric bootstrap, random-phase test, and a new rule named modified parallel analysis. A numerical experiment is conducted to quantitatively compare the performance of the four rules in judging whether a coupled mode of SVD is significant as parameters such as the sample size, the number of grid points, and the signal-to-noise ratio vary. The results show that the four rules perform better with lower ratio of the number of grid points to sample size. Modified parallel analysis and nonparametric bootstrap perform best to abandon the spurious coupled modes, but the latter is better than the former to retain the significant coupled modes when the sample size is not much larger than the number of grid points. Parallel analysis and random-phase test are robust to abandon the spurious coupled modes only when either （1） the observations at the grid points are spatially uncorrelated, or （2） the coupled signal is very strong for parallel analysis and is not weak for random-phase test. The reasons affecting the accuracy of the test rules are discussed.展开更多
<p> <span style="font-family:Verdana;">To address the drawbacks of the traditional Parker test in multivariate linear</span><span style="font-family:;" "=""> ...<p> <span style="font-family:Verdana;">To address the drawbacks of the traditional Parker test in multivariate linear</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">models:</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">the process is cumbersome and computationally intensive,</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">we propose a new heteroscedasticity test.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">A new heteroskedasticity test is proposed using the fitted values of the samples as new explanatory variables, reconstructing the regression model, and giving a new heteroskedasticity test based on the significance test of the coefficients, it is also compared with the existing Parker test which is improved using the principal component idea. Numerical simulations and empirical analyses show that the improved Parker test with the fitted values of the samples proposed in this paper is superior.</span> </p>展开更多
This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the...This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the initial cutoff point,correspondingly Se’and Sp’ at a new cutoff point:A=Se’/Se:B-(1-Sp’)/(1-Sp):C=Sp’/Sp;D=(I-Se’)/(I-Se).Moving the cutoff point from the initial point to the new point,if the contrary variationsof the sensitivity and specificity satisfy the inequality A】B,then the positive predictivevalue increases,otherwise it decreases or remains unchanged.If the variations satisfy theinequality C】D,then the negative prcdictive value increases,otherwise it decreasses or re-mains unchanged.展开更多
We present here an alternative definition of the P-value for statistical hypothesis test of a real-valued parameter for a continuous random variable X. Our approach uses neither the notion of Type I error nor the assu...We present here an alternative definition of the P-value for statistical hypothesis test of a real-valued parameter for a continuous random variable X. Our approach uses neither the notion of Type I error nor the assumption that null hypothesis is true. Instead, the new P-value involves the maximum likelihood estimator, which is usually available for a parameter such as the mean μ or standard deviation σ of a random variable X with a common distribution.展开更多
The interpretation and application of CPT(cone penetration test)results is characterized by considerable variability of data,either in measured or correlated parameters.According to the requirements of Eurocode 7 the ...The interpretation and application of CPT(cone penetration test)results is characterized by considerable variability of data,either in measured or correlated parameters.According to the requirements of Eurocode 7 the existing variability in soil properties has to be taken into account statistically during the determination of the characteristic values of each parameter.This should be done by selecting a cautious estimate of the value affecting the limit state.Obtaining the characteristic values of CPT measurements is not an easy task and on this aspect nor clear neither unified guidelines exist.This paper focuses in several approaches to characterize the cone resistance and the sleeve friction using simple statistical analysis,in order for these parameters to be applicable in design.Similar procedures are then applied to determine the characteristic values of correlated parameters from CPT such as the effective friction angle for sands and the undrained shear strength for clays.The resulting characteristic values of the considered parameters emphasize the fact that the prediction and the interpretation of characteristic values of soil properties is a complicated and biased procedure.展开更多
Objective: this paper mainly analyzes the practical value of biochemical tests in the current diagnosis of liver cirrhosis diseases. Methods: 60 patients were diagnosed in January 2019-2-2020 and were divided into obs...Objective: this paper mainly analyzes the practical value of biochemical tests in the current diagnosis of liver cirrhosis diseases. Methods: 60 patients were diagnosed in January 2019-2-2020 and were divided into observation and control groups. Biochemical tests were performed for all patients, such as total cholesterol, cholinesterase, total bile acid, and serum albumin. Results: Chinesterase and total cholesterol and serum albumin were lower than control and higher total bile acid, with statistically significant P <0.05. Conclusion: the use of biochemical test items in patients with cirrhosis disease can improve diagnostic accuracy and promote promotion.展开更多
Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control...Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.展开更多
Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this ...Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this experiment. The treatment period was from April 2018 to June 2019. According to the disease of diabetes, they were divided into general diabetes group (experimental group) and observation group (diabetes complications group) for analysis. At the same time, normal patients receiving biochemical tests were selected as the detection objects. Among them, the concentrations of fasting blood glucose (FPG), OGTT(oral glucose tolerance test) and glycosylated hemoglobin (HbAlc) were compared. Results: the FPG, OGTT and HbAlc of the experimental group were significantly higher than those of the observation group and the healthy group (P<0.05), and the difference was statistically significant. Conclusion: in the clinical test, the biochemical test for the diagnosis of diabetes is helpful to distinguish the blood glucose of diabetes, and has the value of promotion.展开更多
Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in Septemb...Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in September 2019 ~ 2020, 9 months were a total of 70 patients with adrenocortical disease in diagnosis experiment, will be more patients were divided into two groups, control group (n = 35) adopts the method of routine inspection, observation group (n = 35) are taking biochemical testing method, finally compare two groups of patients with the diagnosis accuracy. Results: the test accuracy of observation group was much higher than control group, and P < 0.05. Conclusion: compared with the conventional examination method, the application of biochemical examination technology in adrenal cortical diseases can effectively improve the accuracy of disease diagnosis, provide effective guidance for clinical treatment, has higher application value, and is worthy of popularization and application.展开更多
Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were ra...Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were randomly divided into control group and observation group. Each group has 50 cases and use different inspection methods. The control group used routine prenatal examination. The observation group used immune test items on the basis of control group. The incidences of high-risk pregnancy were compared. Results: there were high-risk pregnancies in both groups, but the observation group took corresponding measures to control the pregnant women’s condition in time after the immune test. And its incidence of high-risk pregnancy was 4%, while the incidence of high-risk pregnancy of the conventional group was 30%, which was significantly higher than that of the observation group (P < 0.05). Conclusion: the clinical application value of immune test items in prenatal examination is significant. Immunization test is conducive to timely detect maternal high-risk pregnancy to a large extent, provides an important reference basis for the control of maternal high-risk pregnancy factors and helps to reduce the incidence of high-risk pregnancy.展开更多
Objective: to study the effect of improved standard collection method in sputum bacterial test. Methods: 82 patients with acute attack of bronchitis received in our hospital from October 2018 to October 2019 were sele...Objective: to study the effect of improved standard collection method in sputum bacterial test. Methods: 82 patients with acute attack of bronchitis received in our hospital from October 2018 to October 2019 were selected for sputum bacterial test.Based on the order of admission, 41 cases in the reference group were given routine expectoration collection method;41 cases in the observation group were treated with improved standard collection method, and the test results of the two groups were compared. Results: ① The qualified rate of sputum samples in the observation group was statistically different from that in the reference group (P < 0.05).② The positive rate of sputum culture in the observation group was significantly different from that in the reference group (P < 0.05).③ There were differences in the collection time of samples and the operation time of sputum bacteriological test between the two groups (P < 0.05).Conclusion: the application of improved standard collection method in sputum bacterial test can improve the positive rate and shorten the time of practical operation.展开更多
To compare the diagnostic value of four signs for superior labrum anterior and posterior (SLAP) lesions of the shoulder.Methods The physical examination was performed randomly on 81 cases with abnormalities of the sho...To compare the diagnostic value of four signs for superior labrum anterior and posterior (SLAP) lesions of the shoulder.Methods The physical examination was performed randomly on 81 cases with abnormalities of the shoulder.There were four tests,including Kibler anterior sliding test,Liu crank test,O’Brien active compression test and Kim biceps load test Ⅱ.The arthroscopic examination were also performed.The result of the arthroscopic examination was considered as a golden standard,so that we could estimate the diagnosis value of the four tests according to the method of evaluation of diagnosis test on clinical epidemiology,their sensitivity,specificity,positive and negative predictive value,accuracy.Results There were 21 cases diagnosed as SLAP lesions by arthroscopy.The diagnosis value of Kim biceps load test Ⅱ was the highest among the four tests,in which 19 of true positive,59 of true negative,1 of false positive,only 2 of false negative cases;while the sensitivity was 90.48%,specificity was 98.33%,positive predictive value was 95.00%,negative predictive value was 96.72%,and accuracy was 96.30%.However the sensitivity,specificity,positive predicitive value,negative predictive vale and accuracy of Kibler anterior sliding test were 76.19%,96.67%,88.89%,92.06%,91.33%;and those of Liu crank test were 85.71%,93.33%,81.82%,94.92%,91.35%;those of O’Brien active compression test were 80.95%,91.66%,77.27%,93.22%,88.89%.Conclusion Kim Biceps load test Ⅱ may be the best for clinical diagnosis of SLAP lesions of the shoulder.9 refs,4 figs,2 tabs.展开更多
This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical labo...This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical laboratory results. Reference interval development has classically relied on concepts elaborated by the International Federation of Clinical Chemistry Expert Panel on Reference Values during the 1980s. These guidelines involve obtaining and classifying samples from a healthy population of at least 120 individuals and then identifying the outermost 5% of observations to use in defining limits for two-sided or one-sided reference intervals. More recently, decision limits based on epidemiological outcome analysis have also been introduced to aid in test interpretation. The reference population must be carefully defined on the basis of the intended clinical use of the underlying test. To determine appropriate reference intervals for use in male fertility assessment, a reference population of men with documented time to pregnancy of 〈 12 months would be most suitable. However, for epidemiological assessment of semen testing results, a reference population made up ofunselected healthy men would be preferred. Although reference and decision limits derived for individual semen analysis test results will undoubtedly be the interpretational tools of choice in the near future, in the long term, multivariate methods for the interpretation of semen analysis alone or in combination with information from the female partner seem to represent better means for assessing the likelihood of achieving a successful pregnancy in a subfertile couple.展开更多
AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) an...AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China.展开更多
Calorific value of plants is an important parameter for evalu- ating and indexing material cycles and energy conversion in forest eco- systems. Based on mensuration data of 150 sample sets, we analyzed the calorific v...Calorific value of plants is an important parameter for evalu- ating and indexing material cycles and energy conversion in forest eco- systems. Based on mensuration data of 150 sample sets, we analyzed the calorific value （CV） and ash content （AC） of different parts of Masson pine （Pinus massoniana） trees in southern China using hypothesis testing and regression analysis. CV and AC of different tree parts were almost significantly different （P〈0.05）. In descending order, ash-free calorific value （AFCV） ranked as foliage 〉 branch 〉 stem bark 〉 root 〉 stem wood, and AC ranked as foliage 〉 stem bark 〉 root 〉 branch 〉 stem wood. CV and AC of stem wood from the top, middle and lower sections of trees differed significantly. CV increased from the top to the lower sections of the tnmk while AC decreased. Mean gross calorific value （GCV） and AFCV of aboveground parts were significantly higher than those of belowground parts （roots）. The mean GCV, AFCV and AC of a whole tree of Masson pine were 21.54 kJ/g, 21.74 kJ/g and 0.90%, re- spectively. CV and AC of different tree parts were, to some extent, cor- related with tree diameter, height and origin.展开更多
Objective: To determine hydrophilic–lipophilic balance(HLB) value, stability of formulate emulsion and properties of sacha inchi oil.Methods: The physiochemical characteristics of sacha inchi oil were first investiga...Objective: To determine hydrophilic–lipophilic balance(HLB) value, stability of formulate emulsion and properties of sacha inchi oil.Methods: The physiochemical characteristics of sacha inchi oil were first investigated.Free radical scavenging property was studied by DPPH assay. HLB value of sacha inchi oil was experimentally determined by preparing the emulsion using emulsifiers at different HLB value. Sacha inchi oil emulsion was prepared using the obtained HLB and its stability was conducted by centrifugation, temperature cycling, and accelerated stability test. The efficiency of the prepared emulsion was clinically investigated by 15 volunteers. The primary skin irritation was performed using closed patch test. Subjective sensory assessment was evaluated by using 5-point hedonic scale method.Results: Peroxide value of sacha inchi oil was 18.40 meq O2/kg oil and acid value was1.86 KOH/g oil. The major fatty acids are omega-3(44%), omega-6(35%) and omega-9(9%). The vitamin E content was 226 mg/100 g oil. Moreover, sacha inchi oil(167 ppm)and its emulsion showed 85% and 89% DPPH inhibition, respectively. The experimental HLB value of sacha inchi oil was 8.5. The sacha inchi oil emulsion exhibited good stability after stability test. The emulsion was classified as non-irritant after tested by primary skin irritation method. The skin hydration value significantly increased from38.59 to 45.21(P < 0.05) after applying sacha inchi oil emulsion for 1 month and the overall product satisfaction of volunteers after use was with score of 4.2.Conclusions: This work provides information on HLB value and emulsion properties of sacha inchi oil which is useful for cosmetic and pharmaceutical application.展开更多
The noise as an undesired phenomenon often appears in the pulsed eddy current testing(PECT)signal, and it is difficult to recognize the character of the testing signal. One of the most common noises presented in the P...The noise as an undesired phenomenon often appears in the pulsed eddy current testing(PECT)signal, and it is difficult to recognize the character of the testing signal. One of the most common noises presented in the PECT signal is the Gaussian noise, since it is caused by the testing environment. A new denoising approach based on singular value decomposition(SVD) is proposed in this paper to reduce the Gaussian noise of PECT signal. The approach first discusses the relationship between signal to noise ratio(SNR) and negentropy of PECT signal. Then the Hankel matrix of PECT signal is constructed for noise reduction, and the matrix is divided into noise subspace and signal subspace by a singular valve threshold. Based on the theory of negentropy, the optimal matrix dimension and threshold are chosen to improve the performance of denoising. The denoised signal Hankel matrix is reconstructed by the singular values of signal subspace, and the denoised signal is finally extracted from this matrix. Experiment is performed to verify the feasibility of the proposed approach, and the results indicate that the proposed approach can reduce the Gaussian noise of PECT signal more effectively compared with other existing approaches.展开更多
Objective： This study compared the performance of the immunochromatographic strip （ICS） to the Venereal Disease Research Laboratory （VDRL） test and Treponema pallidum haemagglutination assay （TPHA） at a primary...Objective： This study compared the performance of the immunochromatographic strip （ICS） to the Venereal Disease Research Laboratory （VDRL） test and Treponema pallidum haemagglutination assay （TPHA） at a primary health care setting. Methods： The study group was comprised of 150 females randomly drawn from a population of pregnant women attending their first antenatal visit or follow-up visits at West Maternity Hospital in Eldoret Kenya, but without a previous syphilis test during that pregnancy. On-site VDRL, ICS and TPHA tests were performed and immediate treatment provided where appropriate. The performance of the three tests was compared, Results： The sero-prevalence of syphilis as determined by the VDRL test was 3%. There was no significant difference between the ICS and the VDRL test （P 〉 0.05）. The sensitivity and specificity of the ICS test were 80% and 98.6% respectively, while the negative predictive value （NPV） and positive predictive value （PPV） were both 100%. On the other hand, the sensitivity and specificity of the VDRL test were 66.7% and 99.3%, while the NPV and PPV were 80% and 98.6% respectively. The Treponema pallidum haemagglutination assay was used as a reference test and had sensitivity, specificity, NPV and PPV of 100%. Conclusion： The diagnostic accuracy of the ICS compared favorably with theVDRL gold standard. The use of the ICS in Kenya can improve the diagnosis of syphilis in health facilities both with and without laboratories and allow community health care workers to make a rapid diagnosis of the disease, and consequently make immediate therapeutic decisions.展开更多
基金funded by Shaanxi Natural Science Foundation (2019JQ-665)Xi’an Agricultural Science and Technology Project (20NYYF0021)supported by the Open Project Program of Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University (BTBU), Beijing 100048, China (SPFW2020YB12)
文摘P omegranate(Punica granatum L.)has attracted considerable attention in world markets due to its valuable nutrients and highly appreciated sensory properties.The aroma profiles of 4 varieties of pomegranate juice,including Dahongtian(DP),Jingpitian(JP),Luyudan(LP),and Tianhonngdan(TP),were investigated via gas chromatography-mass spectrometry(GC-MS)and gas chromatography-olfactometry(GC-O)analyses.A total of 43 volatile compounds were identified by using GC-MS.Among these compounds,16 were considered as potential aroma-active compounds as detected by GC-O.These compounds belonged to the classes of terpinenes,alcohols,and aldehydes.Eleven volatile compounds were defined as the main contributors to the overall aroma of pomegranate juice due to their high odor activity values(OAVs≥1).Aroma recombination and omission tests confirmed thatβ-myrcene,1-hexanol,and(Z)-3-hexen-1-ol were the key aroma compounds,and limonene,1-octen-3-ol,linalool,and hexanal were important aroma-active compounds in DP samples.
文摘Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. Methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analysis, eosin-nigrosin (EN) staining and the HOS test. A further EN stain was then performed on a HOS pre-treated aliquot and a total of 2000 further sperm examined. Results: The median sperm density was 5.1 million/mL (IQR 4.3-13.1) and the median motility was 3.0 % (IQR 0-7). Seven samples showed complete asthenozoospermia. Initial EN staining showed 59 % viability (range 48-69) despite the poor standard parameters and 47 % (range 33-61) in the complete asthenozoospermia subgroup. The HOS test showed 49.9 % reacted overall (range 40-59) and 41.7 % (range 22-61) in the complete asthenozoospermia subgroup. The combined HOS/EN stain showed the positive predictive value of the HOS test to identify viable sperm was 84.2 % overall and 79.7 % in the complete asthenozoospermia subgroup. Conclusion: The HOS test can effectively predict sperm viability in patients with severe and complete asthenozoospermia.
基金This work was supported by the National Natural Science Foundation of China under Grant No. 40233027.
文摘This paper clarifies the essence of the significance test of singular value decomposition analysis （SVD）, and investigates four rules for testing the significance of coupled modes of SVD, including parallel analysis, nonparametric bootstrap, random-phase test, and a new rule named modified parallel analysis. A numerical experiment is conducted to quantitatively compare the performance of the four rules in judging whether a coupled mode of SVD is significant as parameters such as the sample size, the number of grid points, and the signal-to-noise ratio vary. The results show that the four rules perform better with lower ratio of the number of grid points to sample size. Modified parallel analysis and nonparametric bootstrap perform best to abandon the spurious coupled modes, but the latter is better than the former to retain the significant coupled modes when the sample size is not much larger than the number of grid points. Parallel analysis and random-phase test are robust to abandon the spurious coupled modes only when either （1） the observations at the grid points are spatially uncorrelated, or （2） the coupled signal is very strong for parallel analysis and is not weak for random-phase test. The reasons affecting the accuracy of the test rules are discussed.
文摘<p> <span style="font-family:Verdana;">To address the drawbacks of the traditional Parker test in multivariate linear</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">models:</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">the process is cumbersome and computationally intensive,</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">we propose a new heteroscedasticity test.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">A new heteroskedasticity test is proposed using the fitted values of the samples as new explanatory variables, reconstructing the regression model, and giving a new heteroskedasticity test based on the significance test of the coefficients, it is also compared with the existing Parker test which is improved using the principal component idea. Numerical simulations and empirical analyses show that the improved Parker test with the fitted values of the samples proposed in this paper is superior.</span> </p>
文摘This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the initial cutoff point,correspondingly Se’and Sp’ at a new cutoff point:A=Se’/Se:B-(1-Sp’)/(1-Sp):C=Sp’/Sp;D=(I-Se’)/(I-Se).Moving the cutoff point from the initial point to the new point,if the contrary variationsof the sensitivity and specificity satisfy the inequality A】B,then the positive predictivevalue increases,otherwise it decreases or remains unchanged.If the variations satisfy theinequality C】D,then the negative prcdictive value increases,otherwise it decreasses or re-mains unchanged.
文摘We present here an alternative definition of the P-value for statistical hypothesis test of a real-valued parameter for a continuous random variable X. Our approach uses neither the notion of Type I error nor the assumption that null hypothesis is true. Instead, the new P-value involves the maximum likelihood estimator, which is usually available for a parameter such as the mean μ or standard deviation σ of a random variable X with a common distribution.
文摘The interpretation and application of CPT(cone penetration test)results is characterized by considerable variability of data,either in measured or correlated parameters.According to the requirements of Eurocode 7 the existing variability in soil properties has to be taken into account statistically during the determination of the characteristic values of each parameter.This should be done by selecting a cautious estimate of the value affecting the limit state.Obtaining the characteristic values of CPT measurements is not an easy task and on this aspect nor clear neither unified guidelines exist.This paper focuses in several approaches to characterize the cone resistance and the sleeve friction using simple statistical analysis,in order for these parameters to be applicable in design.Similar procedures are then applied to determine the characteristic values of correlated parameters from CPT such as the effective friction angle for sands and the undrained shear strength for clays.The resulting characteristic values of the considered parameters emphasize the fact that the prediction and the interpretation of characteristic values of soil properties is a complicated and biased procedure.
文摘Objective: this paper mainly analyzes the practical value of biochemical tests in the current diagnosis of liver cirrhosis diseases. Methods: 60 patients were diagnosed in January 2019-2-2020 and were divided into observation and control groups. Biochemical tests were performed for all patients, such as total cholesterol, cholinesterase, total bile acid, and serum albumin. Results: Chinesterase and total cholesterol and serum albumin were lower than control and higher total bile acid, with statistically significant P <0.05. Conclusion: the use of biochemical test items in patients with cirrhosis disease can improve diagnostic accuracy and promote promotion.
文摘Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.
文摘Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this experiment. The treatment period was from April 2018 to June 2019. According to the disease of diabetes, they were divided into general diabetes group (experimental group) and observation group (diabetes complications group) for analysis. At the same time, normal patients receiving biochemical tests were selected as the detection objects. Among them, the concentrations of fasting blood glucose (FPG), OGTT(oral glucose tolerance test) and glycosylated hemoglobin (HbAlc) were compared. Results: the FPG, OGTT and HbAlc of the experimental group were significantly higher than those of the observation group and the healthy group (P<0.05), and the difference was statistically significant. Conclusion: in the clinical test, the biochemical test for the diagnosis of diabetes is helpful to distinguish the blood glucose of diabetes, and has the value of promotion.
文摘Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in September 2019 ~ 2020, 9 months were a total of 70 patients with adrenocortical disease in diagnosis experiment, will be more patients were divided into two groups, control group (n = 35) adopts the method of routine inspection, observation group (n = 35) are taking biochemical testing method, finally compare two groups of patients with the diagnosis accuracy. Results: the test accuracy of observation group was much higher than control group, and P < 0.05. Conclusion: compared with the conventional examination method, the application of biochemical examination technology in adrenal cortical diseases can effectively improve the accuracy of disease diagnosis, provide effective guidance for clinical treatment, has higher application value, and is worthy of popularization and application.
文摘Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were randomly divided into control group and observation group. Each group has 50 cases and use different inspection methods. The control group used routine prenatal examination. The observation group used immune test items on the basis of control group. The incidences of high-risk pregnancy were compared. Results: there were high-risk pregnancies in both groups, but the observation group took corresponding measures to control the pregnant women’s condition in time after the immune test. And its incidence of high-risk pregnancy was 4%, while the incidence of high-risk pregnancy of the conventional group was 30%, which was significantly higher than that of the observation group (P < 0.05). Conclusion: the clinical application value of immune test items in prenatal examination is significant. Immunization test is conducive to timely detect maternal high-risk pregnancy to a large extent, provides an important reference basis for the control of maternal high-risk pregnancy factors and helps to reduce the incidence of high-risk pregnancy.
文摘Objective: to study the effect of improved standard collection method in sputum bacterial test. Methods: 82 patients with acute attack of bronchitis received in our hospital from October 2018 to October 2019 were selected for sputum bacterial test.Based on the order of admission, 41 cases in the reference group were given routine expectoration collection method;41 cases in the observation group were treated with improved standard collection method, and the test results of the two groups were compared. Results: ① The qualified rate of sputum samples in the observation group was statistically different from that in the reference group (P < 0.05).② The positive rate of sputum culture in the observation group was significantly different from that in the reference group (P < 0.05).③ There were differences in the collection time of samples and the operation time of sputum bacteriological test between the two groups (P < 0.05).Conclusion: the application of improved standard collection method in sputum bacterial test can improve the positive rate and shorten the time of practical operation.
文摘To compare the diagnostic value of four signs for superior labrum anterior and posterior (SLAP) lesions of the shoulder.Methods The physical examination was performed randomly on 81 cases with abnormalities of the shoulder.There were four tests,including Kibler anterior sliding test,Liu crank test,O’Brien active compression test and Kim biceps load test Ⅱ.The arthroscopic examination were also performed.The result of the arthroscopic examination was considered as a golden standard,so that we could estimate the diagnosis value of the four tests according to the method of evaluation of diagnosis test on clinical epidemiology,their sensitivity,specificity,positive and negative predictive value,accuracy.Results There were 21 cases diagnosed as SLAP lesions by arthroscopy.The diagnosis value of Kim biceps load test Ⅱ was the highest among the four tests,in which 19 of true positive,59 of true negative,1 of false positive,only 2 of false negative cases;while the sensitivity was 90.48%,specificity was 98.33%,positive predictive value was 95.00%,negative predictive value was 96.72%,and accuracy was 96.30%.However the sensitivity,specificity,positive predicitive value,negative predictive vale and accuracy of Kibler anterior sliding test were 76.19%,96.67%,88.89%,92.06%,91.33%;and those of Liu crank test were 85.71%,93.33%,81.82%,94.92%,91.35%;those of O’Brien active compression test were 80.95%,91.66%,77.27%,93.22%,88.89%.Conclusion Kim Biceps load test Ⅱ may be the best for clinical diagnosis of SLAP lesions of the shoulder.9 refs,4 figs,2 tabs.
文摘This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical laboratory results. Reference interval development has classically relied on concepts elaborated by the International Federation of Clinical Chemistry Expert Panel on Reference Values during the 1980s. These guidelines involve obtaining and classifying samples from a healthy population of at least 120 individuals and then identifying the outermost 5% of observations to use in defining limits for two-sided or one-sided reference intervals. More recently, decision limits based on epidemiological outcome analysis have also been introduced to aid in test interpretation. The reference population must be carefully defined on the basis of the intended clinical use of the underlying test. To determine appropriate reference intervals for use in male fertility assessment, a reference population of men with documented time to pregnancy of 〈 12 months would be most suitable. However, for epidemiological assessment of semen testing results, a reference population made up ofunselected healthy men would be preferred. Although reference and decision limits derived for individual semen analysis test results will undoubtedly be the interpretational tools of choice in the near future, in the long term, multivariate methods for the interpretation of semen analysis alone or in combination with information from the female partner seem to represent better means for assessing the likelihood of achieving a successful pregnancy in a subfertile couple.
基金Supported by 11th 5-Year Key Programs for Science and Technology Development of China,No.2006BAI02A08
文摘AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China.
基金initiated as part of the National Biomass Modeling Program in Continuous Forest Inventory(NBMP-CFI)funded by the State Forestry Administration of China
文摘Calorific value of plants is an important parameter for evalu- ating and indexing material cycles and energy conversion in forest eco- systems. Based on mensuration data of 150 sample sets, we analyzed the calorific value （CV） and ash content （AC） of different parts of Masson pine （Pinus massoniana） trees in southern China using hypothesis testing and regression analysis. CV and AC of different tree parts were almost significantly different （P〈0.05）. In descending order, ash-free calorific value （AFCV） ranked as foliage 〉 branch 〉 stem bark 〉 root 〉 stem wood, and AC ranked as foliage 〉 stem bark 〉 root 〉 branch 〉 stem wood. CV and AC of stem wood from the top, middle and lower sections of trees differed significantly. CV increased from the top to the lower sections of the tnmk while AC decreased. Mean gross calorific value （GCV） and AFCV of aboveground parts were significantly higher than those of belowground parts （roots）. The mean GCV, AFCV and AC of a whole tree of Masson pine were 21.54 kJ/g, 21.74 kJ/g and 0.90%, re- spectively. CV and AC of different tree parts were, to some extent, cor- related with tree diameter, height and origin.
文摘Objective: To determine hydrophilic–lipophilic balance(HLB) value, stability of formulate emulsion and properties of sacha inchi oil.Methods: The physiochemical characteristics of sacha inchi oil were first investigated.Free radical scavenging property was studied by DPPH assay. HLB value of sacha inchi oil was experimentally determined by preparing the emulsion using emulsifiers at different HLB value. Sacha inchi oil emulsion was prepared using the obtained HLB and its stability was conducted by centrifugation, temperature cycling, and accelerated stability test. The efficiency of the prepared emulsion was clinically investigated by 15 volunteers. The primary skin irritation was performed using closed patch test. Subjective sensory assessment was evaluated by using 5-point hedonic scale method.Results: Peroxide value of sacha inchi oil was 18.40 meq O2/kg oil and acid value was1.86 KOH/g oil. The major fatty acids are omega-3(44%), omega-6(35%) and omega-9(9%). The vitamin E content was 226 mg/100 g oil. Moreover, sacha inchi oil(167 ppm)and its emulsion showed 85% and 89% DPPH inhibition, respectively. The experimental HLB value of sacha inchi oil was 8.5. The sacha inchi oil emulsion exhibited good stability after stability test. The emulsion was classified as non-irritant after tested by primary skin irritation method. The skin hydration value significantly increased from38.59 to 45.21(P < 0.05) after applying sacha inchi oil emulsion for 1 month and the overall product satisfaction of volunteers after use was with score of 4.2.Conclusions: This work provides information on HLB value and emulsion properties of sacha inchi oil which is useful for cosmetic and pharmaceutical application.
文摘The noise as an undesired phenomenon often appears in the pulsed eddy current testing(PECT)signal, and it is difficult to recognize the character of the testing signal. One of the most common noises presented in the PECT signal is the Gaussian noise, since it is caused by the testing environment. A new denoising approach based on singular value decomposition(SVD) is proposed in this paper to reduce the Gaussian noise of PECT signal. The approach first discusses the relationship between signal to noise ratio(SNR) and negentropy of PECT signal. Then the Hankel matrix of PECT signal is constructed for noise reduction, and the matrix is divided into noise subspace and signal subspace by a singular valve threshold. Based on the theory of negentropy, the optimal matrix dimension and threshold are chosen to improve the performance of denoising. The denoised signal Hankel matrix is reconstructed by the singular values of signal subspace, and the denoised signal is finally extracted from this matrix. Experiment is performed to verify the feasibility of the proposed approach, and the results indicate that the proposed approach can reduce the Gaussian noise of PECT signal more effectively compared with other existing approaches.
文摘Objective： This study compared the performance of the immunochromatographic strip （ICS） to the Venereal Disease Research Laboratory （VDRL） test and Treponema pallidum haemagglutination assay （TPHA） at a primary health care setting. Methods： The study group was comprised of 150 females randomly drawn from a population of pregnant women attending their first antenatal visit or follow-up visits at West Maternity Hospital in Eldoret Kenya, but without a previous syphilis test during that pregnancy. On-site VDRL, ICS and TPHA tests were performed and immediate treatment provided where appropriate. The performance of the three tests was compared, Results： The sero-prevalence of syphilis as determined by the VDRL test was 3%. There was no significant difference between the ICS and the VDRL test （P 〉 0.05）. The sensitivity and specificity of the ICS test were 80% and 98.6% respectively, while the negative predictive value （NPV） and positive predictive value （PPV） were both 100%. On the other hand, the sensitivity and specificity of the VDRL test were 66.7% and 99.3%, while the NPV and PPV were 80% and 98.6% respectively. The Treponema pallidum haemagglutination assay was used as a reference test and had sensitivity, specificity, NPV and PPV of 100%. Conclusion： The diagnostic accuracy of the ICS compared favorably with theVDRL gold standard. The use of the ICS in Kenya can improve the diagnosis of syphilis in health facilities both with and without laboratories and allow community health care workers to make a rapid diagnosis of the disease, and consequently make immediate therapeutic decisions.
