Lubrication is an important prerequisite and foundation for the organism to protect biological tissues from mechanical friction damage and to maintain their normal life functions[1,2].After mechanical friction trauma,...Lubrication is an important prerequisite and foundation for the organism to protect biological tissues from mechanical friction damage and to maintain their normal life functions[1,2].After mechanical friction trauma,the lubrication matrix repairs damaged tissue by protecting the host from external impact and promotes the restoration of lubrication balance in the body.The process of lubrication typically unfolds in a series of events,beginning with a rapid response phase where lubricating fluids flow within the organism,reducing wear between tissues.This is followed by a gradual transition into a lubrication phase involving various lubrication mechanisms,such as fluid lubrication(The load is fully sustained by lubricant due to viscous forces in the space or gap between the components that are moving in relation to another object,while preventing solid-to-solid contact),boundary lubrication(The load is carried by surface high points rather than by lubricant),hydration lubrication(Hydration layers are tightly bound by the surrounding charges,allowing them to withstand significant pressure without being displaced,while also being able to quickly relax,resulting in a fluid-like response to shear forces),and mixed lubrication(This regime exists between full film lubrication and boundary lubrication,where the lubricant film generated is inadequate to fully separate the surfaces in contact,yet the hydrodynamic effect is significant)[3-5].Thus,lubrication plays a vital role in protecting living beings.However,if this well-coordinated wear reduction process is disrupted,lubrication can become uncontrolled or deteriorate,potentially leading to a range of lubrication-related diseases,including osteoarthritis,tendon adhesion,intervertebral disc degeneration,femoral head necrosis,cardiovascular blockages,tooth wear,and implant infections[1].展开更多
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0500700)the National Natural Science Foundation of China(52305206)the Shanghai Pujiang Programme(23PJD056)。
文摘Lubrication is an important prerequisite and foundation for the organism to protect biological tissues from mechanical friction damage and to maintain their normal life functions[1,2].After mechanical friction trauma,the lubrication matrix repairs damaged tissue by protecting the host from external impact and promotes the restoration of lubrication balance in the body.The process of lubrication typically unfolds in a series of events,beginning with a rapid response phase where lubricating fluids flow within the organism,reducing wear between tissues.This is followed by a gradual transition into a lubrication phase involving various lubrication mechanisms,such as fluid lubrication(The load is fully sustained by lubricant due to viscous forces in the space or gap between the components that are moving in relation to another object,while preventing solid-to-solid contact),boundary lubrication(The load is carried by surface high points rather than by lubricant),hydration lubrication(Hydration layers are tightly bound by the surrounding charges,allowing them to withstand significant pressure without being displaced,while also being able to quickly relax,resulting in a fluid-like response to shear forces),and mixed lubrication(This regime exists between full film lubrication and boundary lubrication,where the lubricant film generated is inadequate to fully separate the surfaces in contact,yet the hydrodynamic effect is significant)[3-5].Thus,lubrication plays a vital role in protecting living beings.However,if this well-coordinated wear reduction process is disrupted,lubrication can become uncontrolled or deteriorate,potentially leading to a range of lubrication-related diseases,including osteoarthritis,tendon adhesion,intervertebral disc degeneration,femoral head necrosis,cardiovascular blockages,tooth wear,and implant infections[1].
