Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited ...Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited by the need for wound exposure and by increased pain.Our preliminary study demonstrated the innovative application of remote NMES(rNMES)to the skeletal muscle of the distal calf,which showed the potential to accelerate wound healing in remote areas.rNMES was effective in human clinical trials in our previous work,although the underlying mechanisms remain unclear.As rNMES is often used to stimulate muscle contraction in long-term bedridden patients,we analyzed data from the Gene Expression Omnibus(GEO)database and found that exercise promotes midkine(MDK)expression in muscle.MDK is a small secreted heparin-binding protein that interacts with multiple cell surface receptors to promote growth.In the present study,we found that MDK significantly enhanced macrophage efferocytosis in a low-density lipoprotein receptor-related protein 1(LRP1)-dependent manner.Our findings demonstrate that rNMES upregulates MDK expression in skeletal muscles through the AMPK-ERK axis,facilitating its delivery to wounds through the circulatory system and promoting LRP1-mediated efferocytosis of apoptotic cells,thereby expediting wound healing.展开更多
Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short...Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short time remains a major challenge.In this study,a multifunctional mussel-inspired hydrogel was synthesized in only 5 min,with polydopamine(PDA)-polypyrrole(Ppy)-polyaniline(PANi)and poly(vinyl alcohol)(PVA)nanoparticles incorporated into the polyacrylamide(PAM)network.The resulting hydrogel exhibited high transparency(about 90% light transmission in the range of 400-800 nm),high conductivity((95.4±0.4)×10^(-4)S/cm),tensile strength(32.60±1.03 k Pa),strain at break(904.46%±11.50%),and adhesive strength(30-60 k Pa).It also demonstrated rapid self-healing properties(about 48% strength recovery within 1h at 50℃)and water-dependent shape memory behavior.As a wearable strain sensor,the hydrogel successfully detected finger flexion,wrist movements,facial expression changes,and breathing with high sensitivity and stability.The calculated gauge factor(GF)was 7.44±0.31,which is higher than that of many previously reported hydrogels.Compared with previous oyster-inspired or Ppy-based hydrogels,our system showed a much shorter synthesis time,higher transparency,and enhanced multifunctionality.These findings highlight the potential of the proposed hydrogel for next-generation flexible electronics,e-skin,and biomedical monitoring devices.展开更多
Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,thi...Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,this study applied a non-inva-sive Transcutaneous Electrical Nerve Stimulation(TENS)to elicit tactile sensations in the hand,which involved median nerve,ulnar nerve,and radial nerve.Ten able-bodied subjects(8 males,2 females)were recruited to participate in the study.An array of 4×2 electrodes was positioned on the medial aspect of the brachii muscle's short head in the upper arm,which is in proximity to the median nerve,ulnar nerve,and radial nerve.Different electrode pairs were randomly selected to elicit distinct sensations at various positions on the hand,and the subjects reported the sensory areas.Then,the sensory areas and sensory thresholds were confirmed through psychophysical methods.According to the experimental results,tactile sensations were elicited at different locations on the subjects'hand through TENS of different electrode pairs.All subjects reported extensive and detailed sensory areas in the fingers,palm,and dorsum,corresponding to the sensory innervation areas of different nerves.The study effectively demonstrated the ability of TENS in evoking tactile feedback in the hand,paving the way for future optimization and development of prosthetic hands.展开更多
Hydrochloric acid(HCl)extensively exists in deep underground projects,arising from the transportation of industrial raw materials or fracturing fluids of petroleum engineering.It results in corrosion,which can signifi...Hydrochloric acid(HCl)extensively exists in deep underground projects,arising from the transportation of industrial raw materials or fracturing fluids of petroleum engineering.It results in corrosion,which can significantly impact the stability of surrounding rock structures.Therefore,in-depth analysis of the degradation of rock corroded by the HCl solution is an essential task for underground engineering.In this study,the granite specimens are initially treated with the HCl solution with various concentrations.Then,the tests and analyses,such as electrical conductivity(EC)measurements,mineral composition assays,and Brazilian splitting tests,are employed to investigate the corrosion mechanism of the HCl solution.Our results and findings are generally as follows:(1)As the immersion time increases,the EC exhibits a relatively high level at pH value of 1,a decreasing trend at pH value of 3,and an increasing trend at pH value of 5 and 7.(2)The HCl solutions with various concentration have different effect on mineral composition,characterized by an increase in proportion of SiO_(2) and a reduction in proportion of Na_(2)O,Al_(2)O_(3),K_(2)O,MgO,and CaO,as the solution pH value decreases.(3)After immersion in the solutions with pH values of 1,3,and 5,the tensile strength of the granite decreases by 23.85%,20.84%,and 20.24%;the average stiffness of the specimen decreases by 29.29%,23.43%,and 11.97%;the proportion of releasable energy increases by 6%,4%,and -2%;the releasable energy decreases by 54.96%,26.09%,and 14.52%;and the dissipated energy decreases by approximately 68.85%,41.39%,and 5.41%,respectively.(4)The evolution of physical and mechanical properties of the immersed granite specimen can be analyzed from a chemical aspect.The corrosive action of HCl cleaves Si–O and Al–O chemical bonds within the granite,particularly altering the tetrahedral structures of its silicate components.This process involves breaking existing chemical bonds and the formation of new ones,ultimately destroying the silicate molecular structures.As the concentration of HCl increases,the rate of these reactions accelerates,progressively weakening the chemical bonds and consequently deteriorating the mechanical characteristics of the granite.These findings can deepen our knowledge about the corrosion effect of HCI solutions on natural surrounding rocks and serve as references for further research on rock corrosion mechanisms in underground engineering.展开更多
Cement paste backfill(CPB)technology is a key method for mine waste treatment,and pipeline transport is critical for safe and efficient waste transfer.Variations in raw material properties can cause slurry segregation...Cement paste backfill(CPB)technology is a key method for mine waste treatment,and pipeline transport is critical for safe and efficient waste transfer.Variations in raw material properties can cause slurry segregation,increase pipeline wear and resistance,raise the risk of blockages or bursts,and disrupt operations.To study CPB slurry segregation during transport,CPB was prepared using cement as the cementitious material and unclassified tailings as inert materials.A small annular-tube device using an electrical resistance tomography system was developed to analyze its flow characteristics,and quantitative segregation assessment methods were developed.The results indicated that CPB conductivity increases with transport time but decreases with higher solid mass content,with the latter having a greater impact.At a low solid content,solid particles migrated toward the bottom of the pipe as the flow time increased,and the migratory behavior of the particles diminished as the solid content increased.At a flow rate of 1.25 m/s,the heterogeneity index for CPB with 58wt% solid content increased by 1.24 in 20 min,whereas that for CPB with 62wt% solid content increased by 2.17.Higher solid mass content amplifies the effect of conveying time on segregation,emphasizing the need to balance these factors for minimizing segregation.These insights can guide the optimization of mine pipeline transport systems.展开更多
An in-built N^(+)pocket electrically doped tunnel field-effect transistor(ED-TFET)-based biosensor has been reported for the first time.The proposed device begins with a PN junction structure with a control gate(CG)an...An in-built N^(+)pocket electrically doped tunnel field-effect transistor(ED-TFET)-based biosensor has been reported for the first time.The proposed device begins with a PN junction structure with a control gate(CG)and two polarity gates(PG1 and PG2).Utilizing the polarity bias concept,a narrow N^(+)pocket is formed between the source and channel without the need for additional doping steps,achieved through biasing PG1 and PG2 at-1.2 V and 1.2 V,respectively.This method not only addresses issues related to doping control but also eliminates constraints associated with thermal budgets and simplifies the fabrication process compared to traditional TFETs.To facilitate biomolecule sensing within the device,a nanogap cavity is formed in the gate dielectric by selectively etching a section of the polarity gate dielectric layer toward the source side.The investigation into the presence of neutral and charged molecules within the cavities has been conducted by examining variations in the electrical properties of the proposed biosensor.Key characteristics assessed include drain current,energy band,and electric field distribution.The performance of the biosensor is measured using various metrics such as drain current(I_(DS)),subthreshold swing(SS),threshold voltage(V_(TH)),drain current ratio(I_(ON)/I_(OFF)).The proposed in-built N^(+)pocket ED-TFET-based biosensor reaches a peak sensitivity of 1.08×10~(13)for a neutral biomolecule in a completely filled nanogap with a dielectric constant of 12.Additionally,the effects of cavity geometry and different fill factors(FFs)on sensitivity are studied.展开更多
Electrically controlled solid propellant(ECSP)offers multiple ignition and adjustable burning rate,serving as fuel for next-generation intelligent propulsion systems.To further enhance the combustion performance of EC...Electrically controlled solid propellant(ECSP)offers multiple ignition and adjustable burning rate,serving as fuel for next-generation intelligent propulsion systems.To further enhance the combustion performance of ECSP,a method utilizing electrochemical and thermal decomposition catalysts has been proposed.In this work,we investigated the combustion characteristics of hydroxylamine nitrate(HAN)-based ECSP incorporating cerium oxide(CeO_(2))and graphene oxide(GO)by using an electrically controlled combustion test system.Electrochemical impedance spectroscopy(EIS)and linear sweep voltammetry(LSV)were used to measure the electrical conductibility and overpotential of ECSP with various additives,and Tafel curves were calculated.Thermogravimetric analysis coupled with differential scanning calorimetry(TG-DSC)was employed to investigate the thermal decomposition behavior of ECSP.While the addition of CeO_(2) and GO reduced the conductivity of ECSP,both catalysts exhibited strong electrocatalytic properties and facilitated the thermal decomposition of ECSP.Between two catalysts,GO demonstrated superior electrochemical catalytic performance but weaker thermal decomposition catalytic ability than CeO_(2).The addition of catalysts significantly enhanced the combustion performance of HAN-based ECSP.Specifically,the ignition delay time was shortened by 10%~20%.CeO_(2) raised the burning rate by approximately 20%but GO exhibited a remarkable boost of 40%in burning rate at high voltage.The combination of GO and PVA produced a flame-retardant substance that negatively impacted the ignition delay of ECSP and resulted in a smaller increase in the burning rate of ECSP at low ignition voltages.展开更多
To elucidate the accelerated degradation mechanisms of metallic interconnects in operational solid oxide fuel cells,the oxidation behavior of FSS430 ferritic stainless steel under the coupling of simultaneous electric...To elucidate the accelerated degradation mechanisms of metallic interconnects in operational solid oxide fuel cells,the oxidation behavior of FSS430 ferritic stainless steel under the coupling of simultaneous electrical current and high-temperature exposure is investigated.Isothermal thermogravimetric analysis was employed to quantify oxidation kinetics,complemented by microstructural characterization using X-ray diffraction,scanning electron microscopy with energy-dispersive spectroscopy and transmission electron microscopy.Experimental results demonstrate that the applied current dramatically enhances oxidation rates,increasing specific mass gain from 0.25 mg/cm^(2)(0 A/cm^(2))to 5.20 mg/cm^(2)(0.2 A/cm^(2))and oxide scale thickness from 1.87 to 15.62μm after 200 h.This acceleration originates from current-induced electromigration forces that promote cationic transport through the oxide layer.The quantitative relationships between current density and oxidation parameters are established,enabling predictive modeling of interconnector degradation in solid oxide fuel cell(SOFC)systems.展开更多
The Electrical Power System(EPS)is one of the spacecraft’s key subsystems,and its operational status directly affects the lifespan and performance of the entire spacecraft.The corresponding fault diagnosis has always...The Electrical Power System(EPS)is one of the spacecraft’s key subsystems,and its operational status directly affects the lifespan and performance of the entire spacecraft.The corresponding fault diagnosis has always been the discussion focus to ensure spacecraft reliability.In this paper,a few-shot unsupervised fault diagnosis method based on the improved Newman community division algorithm is proposed,to approach the scarcity of fault data samples and the inconspicuous characteristics of abnormal data.Firstly,aiming to capture the overall relevance of the fault dataset,a complex network model is built by adopting the K-Dynamic time warping distance Adjacent Nodes(KDAN)method.Based on the complex network model,the Newman community divisions algorithm is improved by using the Quantum-behaved Particle Swarm Optimization(QPSO).Subsequently,in order to evaluate the feasibility of the proposed method,experimental validation was conducted using an open-source dataset.The results indicate that the average accuracy can reach 96.43% for fault data diagnosis,and an F1_score of 97.76%with only 17.65%of the dataset used for training.The proposed method can accurately classify abnormal data by identifying the community structure in the data network,significantly improve the efficiency of the community divisions algorithm and reduce its complexity,and provide a new solution for fault diagnosis in large-scale complex systems.展开更多
Twinning-induced plasticity(TWIP)steel was processed using electrically assisted friction stir welding(EFSW).The microstructure,mechanical properties,and deformation behavior of the welded joints were systematically i...Twinning-induced plasticity(TWIP)steel was processed using electrically assisted friction stir welding(EFSW).The microstructure,mechanical properties,and deformation behavior of the welded joints were systematically investigated.The results show that the average grain size was refined from 3.67μm in the base material(BM)to 1.39μm in the stir zone(SZ),while it increased to 4.19μm in the heat-affected zone(HAZ).The fraction of twin boundaries(TBs)decreased from 20.7%in the BM to 6.9%in the SZ and increased to24.5%in the HAZ.The ultimate tensile strength,yield strength,and elongation of the BM were 1021 MPa,505 MPa,and 65.8%,respectively.In comparison,the EFSW joint exhibited values of 1055 MPa,561 MPa,and 60.8%,corresponding to 103.3%,111.1%,and 92.4%of those of the BM,respectively.During tensile testing,plastic deformation was primarily concentrated in the BM,although both the SZ and HAZ also exhibited notable plastic deformation.Fracture ultimately occurred in the BM.展开更多
BACKGROUND:Individualized positive end-expiratory pressure(PEEP)titration is a crucial technique in mechanical ventilation therapy for acute respiratory distress syndrome(ARDS)patients with intra-abdominal hypertensio...BACKGROUND:Individualized positive end-expiratory pressure(PEEP)titration is a crucial technique in mechanical ventilation therapy for acute respiratory distress syndrome(ARDS)patients with intra-abdominal hypertension(IAH).This study aimed to evaluate the eff ectiveness of electrical impedance tomography(EIT)-guided PEEP titration in this population.METHODS:This prospective study enrolled 36 ARDS patients,including 22 patients with IAH and 14 without IAH.All the patients underwent EIT-guided PEEP titration at the intersection point between alveolar overdistension and collapse during a decremental PEEP trial.The changes in pulmonary ventilation distribution,respiratory mechanics and hemodynamics during the titration process were observed.RESULTS:After EIT-guided PEEP titration was performed,the PEEP,peak inspiratory pressure and plateau pressure increased significantly(P<0.05).Furthermore,no significant differences were observed in respiratory system compliance,tidal volume,driving pressure,or the 4*DP+RR index between the two groups(P>0.05).The mechanical power increased in the non-IAH(NIAH)group after PEEP titration(P<0.05).Ventilation in gravity-dependent lung regions significantly increased(P<0.05),and the oxygenation index(PaO2/FiO2)improved signifi cantly(P<0.05)in both groups.However,blood pressure,heart rate,respiratory rate,central venous pressure,and lactate levels did not signifi cantly change.In the IAH group,the PaO2/FiO2 ratio improved less than that in the NIAH group did(P<0.05).CONCLUSION:In our study,individualized PEEP titration guided by EIT improved oxygenation in ARDS patients with concomitant IAH without signifi cantly aff ecting hemodynamics.The presence of IAH may limit the improvement of oxygenation during EIT-guided PEEP titration.展开更多
The rapid development of wind energy in the power sectors raises the question about the reliability of wind turbines for power system planning and operation.The electrical subsystem of wind turbines(ESWT),which is one...The rapid development of wind energy in the power sectors raises the question about the reliability of wind turbines for power system planning and operation.The electrical subsystem of wind turbines(ESWT),which is one of the most vulnerable parts of the wind turbine,is investigated in this paper.The hygrothermal aging of power electronic devices(PEDs)is modeled for the first time in the comprehensive reliability evaluation of ESWT,by using a novel stationary“circuit-like”approach.First,the failure mechanism of the hygrothermal aging,which includes the solder layer fatigue damage and packaging material performance degradation,is explained.Then,a moisture diffusion resistance concept and a hygrothermal equivalent circuit are proposed to quantitate the hygrothermal aging behavior.A conditional probability function is developed to calculate the time-varying failure rate of PEDs.At last,the stochastic renewal process is simulated to evaluate the reliability for ESWT through the sequential Monte Carlo simulation,in which failure,repair,and replacement states of devices are all included.The effectiveness of our proposed reliability evaluation method is verified on an ESWT in a 2 MW wind turbine use time series data collected from a wind farm in China.展开更多
Laser-induced aerosols,predominantly submicron in size,pose significant environmental and health risks during the decommissioning of nuclear reactors.This study experimentally investigated the removal of laser-generat...Laser-induced aerosols,predominantly submicron in size,pose significant environmental and health risks during the decommissioning of nuclear reactors.This study experimentally investigated the removal of laser-generated aerosol particles using a water spray system integrated with an innovative system for pre-injecting electrically charged mist in our facility.To simulate aerosol generation in reactor decommissioning,a high-power laser was used to irradiate various materials(including stainless steel,carbon steel,and concrete),generating aerosol particles that were agglomerated with injected water mist and subsequently scavenged by water spray.Experimental results demonstrate enhanced aerosol removal via aerosol-mist agglomeration,with charged mist significantly improving particle capture by increasing wettability and size.The average improvements for the stainless steel,carbon steel,and concrete were 40%,44%,and 21%,respectively.The results of experiments using charged mist with different polarities(both positive and negative)and different surface coatings reveal that the dominant polarity of aerosols varies with the irradiated materials,influenced by their crystal structure and electron emission properties.Notably,surface coatings such as ZrO_(2)and CeO_(2)were found to possibly alter aerosol charging characteristics,thereby affecting aerosol removal efficiency with charged mist configurations.The innovative aerosol-mist agglomeration approach shows promise in mitigating radiation exposure,ensuring environmental safety,and reducing contaminated water during reactor dismantling.This study contributes critical knowledge for the development of advanced aerosol management strategies for nuclear reactor decommissioning.The understanding obtained in this work is also expected to be useful for various environmental and chemical engineering applications such as gas decontamination,air purification,and pollution control.展开更多
In this paper,electrically excited synchronous machines(EESMs)using copper(Cu)and aluminum(Al)windings are compared for the feasibility of replacing Cu windings with Al windings in electric vehicle(EV)applications sin...In this paper,electrically excited synchronous machines(EESMs)using copper(Cu)and aluminum(Al)windings are compared for the feasibility of replacing Cu windings with Al windings in electric vehicle(EV)applications since Al windings have lower mass density and cost per weight,but higher resistivity and lower thermal conductivity than Cu windings.The EESMs with four winding configurations are optimized with an electromagnetic-thermal co-optimization method.The optimized EESM with only Cu windings is considered as the baseline in this study.Results show that the EESM with stator-Cu/rotor-Al windings has the least torque reduction(12.1%)compared to the baseline among the three EESMs with Al windings and the highest torque mass density among all EESMs.Meanwhile,although the new European driving cycle efficiency of the stator-Cu/rotor-Al EESM is 1.8%lower than that of the baseline,the torque per cost is 71%higher,and the maximum rotor mechanical stress is 8%lower.Therefore,the EESMs with stator-Cu/rotor-Al windings are prospective substitutions of those with only Cu windings for EV applications considering the trade-off between performance and cost.展开更多
The electrode structures in ignition devices for Electrically Controlled Solid Propellants(ECSP) can be classified into fixed and movable types. In movable electrode structures, springs are typically used to push the ...The electrode structures in ignition devices for Electrically Controlled Solid Propellants(ECSP) can be classified into fixed and movable types. In movable electrode structures, springs are typically used to push the electrodes and the propellant. The effects of spring pressure on the ignition and combustion of propellants have not yet been studied. In this paper, a universal testing machine and an electrochemical workstation were firstly utilized to investigate the compressive mechanical property and conductivity of Hydroxylamine Nitrate(HAN)-ECSP. The maximum pressure at which the propellant undergoes elastic deformation is 65 kPa. When the spring pressure increased from 5.1 k Pa to 20.4 kPa, the propellant resistance decreased from 56.8 Ω to 36.8 Ω.Various observation methods were employed to study the process of electrical energy injection and the ignition and combustion characteristics under constant voltage. Appropriately increasing the spring pressure can accelerate the injection of electrical energy into the propellant, increase the electrification current, and thus reduce the initial ignition delay time of the propellant. When the spring pressure is 20.4 kPa, the squeezing speed of the propellant is too fast, making it difficult for the propellant to be adequately heated at the electrode interface, which is unfavorable for ignition. Excessive spring pressure also leads to the accumulation of a large amount of combustion residue on the electrode plate, hindering the mixing and diffusion of hot gases during the second ignition process, preventing the gaseous flame of the propellant. When the spring pressure is 5.1 kPa, improving the working voltage can enhance the repeated ignition characteristics of the propellant.展开更多
With the widespread application of combined heat and power(CHP)units,the economic dispatch of integrated electric and district heating systems(IEHSs)has drawn increasing attention.Because the electric power system(EPS...With the widespread application of combined heat and power(CHP)units,the economic dispatch of integrated electric and district heating systems(IEHSs)has drawn increasing attention.Because the electric power system(EPS)and district heating system(DHS)are generally managed separately,the decentralized dispatch pattern is preferable for the IEHS dispatch problem.However,many common decentralized methods suffer from the drawbacks of slow and local convergence.Moreover,the uncertainties of renewable generation cannot be ignored in a decentralized pattern.Additionally,the most commonly used individual chance constraints in distributionally robust optimization cannot consider safety constraints simultaneously,so the safe operation of an IEHS cannot be guaranteed.Thus,distributionally robust joint chance constraints and robust constraints are jointly introduced into the IEHS dispatch problem in this paper to obtain a stronger safety guarantee,and a method combined with Bonferroni and conditional value at risk(CVaR)approximation is presented to transform the original model into a quadratic program.Additionally,a dynamic boundary response(DBR)-based distributed algorithm based on multiparametric programming is proposed for a fast solution.Case studies showcase the necessity of using mixed distributionally robust joint chance constraints and robust constraints,as well as the effectiveness of the DBR algorithm.展开更多
In this paper,a precise and computationally efficient method for estimating multiparameter of permanent magnet synchronous motors(PMSMs)is proposed.This method can realize decoupling estimation with a small amount of ...In this paper,a precise and computationally efficient method for estimating multiparameter of permanent magnet synchronous motors(PMSMs)is proposed.This method can realize decoupling estimation with a small amount of data at a single speed,and considers the inductance correlation to improve the estimation accuracy.The saturation in the stator frame is first modeled,and then the related inductance model in the rotating frame is derived.The estimation model is established based on the related inductance model,which is modeled by polynomials of d-axis current(I_(d))for a given q-axis current(I_(q)).Then,the influence of permanent magnet(PM)flux linkage on inductance estimation can be eliminated by using the partial derivative of the correlated inductance model.The estimation model fully explores the inductance correlation and can realize the decoupling of PM flux linkage(λ_(0))and inductance,which greatly improves the inductance estimation accuracy,especially when Id is small.Moreover,this paper realizes the estimation of distortion voltage,PM flux linkage,and stator resistance based on the derived electrical model and mechanical model.Compared with the existing method,this method can use a small amount of data at a single speed to model voltage,which can effectively reduce the influence of measurement noise and improve the calculation efficiency.Experimental verification on a laboratory PMSM prototype shows that the method’s performance of the proposed method is better than existing methods under various working conditions.展开更多
Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance to...Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke.展开更多
The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly f...The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.展开更多
提出一种改进的ELECTRE(elimination et choix traduisant la réalité)动态模糊多属性决策方法。首先,对动态决策矩阵运用熵权法获得客观的时间权重;其次,提出改进的ELECTRE方法,针对直觉模糊数不可直接比较的问题,根据隶属...提出一种改进的ELECTRE(elimination et choix traduisant la réalité)动态模糊多属性决策方法。首先,对动态决策矩阵运用熵权法获得客观的时间权重;其次,提出改进的ELECTRE方法,针对直觉模糊数不可直接比较的问题,根据隶属度、非隶属度值不同的物理含义,分别构造其级别优先的一致性和矛盾性动态指标函数,再融合为各属性的一致性和矛盾性动态指标;随后,根据其相反的赋值意义,利用时间权重分别进行集成,获得综合各时间段的一致性和矛盾性指标并进行耦合,从而得到各方案的赋值级别优先关系,最终完成方案排序。实验数据验证了方法的有效性与可行性。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82271252 to W.L.,No.8217091029 to T.W.and No.82204542 to L.H.)the Key Medical Research Projects of Jiangsu Health and Health Commission(Grant No.K2023066 to L.Z.)the Taishan Industrial Talent Project(Grant No.2020-371722-73-03-097290 to W.L.).
文摘Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited by the need for wound exposure and by increased pain.Our preliminary study demonstrated the innovative application of remote NMES(rNMES)to the skeletal muscle of the distal calf,which showed the potential to accelerate wound healing in remote areas.rNMES was effective in human clinical trials in our previous work,although the underlying mechanisms remain unclear.As rNMES is often used to stimulate muscle contraction in long-term bedridden patients,we analyzed data from the Gene Expression Omnibus(GEO)database and found that exercise promotes midkine(MDK)expression in muscle.MDK is a small secreted heparin-binding protein that interacts with multiple cell surface receptors to promote growth.In the present study,we found that MDK significantly enhanced macrophage efferocytosis in a low-density lipoprotein receptor-related protein 1(LRP1)-dependent manner.Our findings demonstrate that rNMES upregulates MDK expression in skeletal muscles through the AMPK-ERK axis,facilitating its delivery to wounds through the circulatory system and promoting LRP1-mediated efferocytosis of apoptotic cells,thereby expediting wound healing.
文摘Conducting hydrogels have garnered significant interest in the field of wearable electronics.However,simultaneously achieving high transparency,high conductivity,strong adhesion,and self-healing ability within a short time remains a major challenge.In this study,a multifunctional mussel-inspired hydrogel was synthesized in only 5 min,with polydopamine(PDA)-polypyrrole(Ppy)-polyaniline(PANi)and poly(vinyl alcohol)(PVA)nanoparticles incorporated into the polyacrylamide(PAM)network.The resulting hydrogel exhibited high transparency(about 90% light transmission in the range of 400-800 nm),high conductivity((95.4±0.4)×10^(-4)S/cm),tensile strength(32.60±1.03 k Pa),strain at break(904.46%±11.50%),and adhesive strength(30-60 k Pa).It also demonstrated rapid self-healing properties(about 48% strength recovery within 1h at 50℃)and water-dependent shape memory behavior.As a wearable strain sensor,the hydrogel successfully detected finger flexion,wrist movements,facial expression changes,and breathing with high sensitivity and stability.The calculated gauge factor(GF)was 7.44±0.31,which is higher than that of many previously reported hydrogels.Compared with previous oyster-inspired or Ppy-based hydrogels,our system showed a much shorter synthesis time,higher transparency,and enhanced multifunctionality.These findings highlight the potential of the proposed hydrogel for next-generation flexible electronics,e-skin,and biomedical monitoring devices.
基金National Natural Science Foundation of China(Grant No.52525504)Emerging Frontiers Cultivation Program of Tianjin University Interdisciplinary Center.
文摘Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,this study applied a non-inva-sive Transcutaneous Electrical Nerve Stimulation(TENS)to elicit tactile sensations in the hand,which involved median nerve,ulnar nerve,and radial nerve.Ten able-bodied subjects(8 males,2 females)were recruited to participate in the study.An array of 4×2 electrodes was positioned on the medial aspect of the brachii muscle's short head in the upper arm,which is in proximity to the median nerve,ulnar nerve,and radial nerve.Different electrode pairs were randomly selected to elicit distinct sensations at various positions on the hand,and the subjects reported the sensory areas.Then,the sensory areas and sensory thresholds were confirmed through psychophysical methods.According to the experimental results,tactile sensations were elicited at different locations on the subjects'hand through TENS of different electrode pairs.All subjects reported extensive and detailed sensory areas in the fingers,palm,and dorsum,corresponding to the sensory innervation areas of different nerves.The study effectively demonstrated the ability of TENS in evoking tactile feedback in the hand,paving the way for future optimization and development of prosthetic hands.
基金National Science Fund for Distinguished Young Scholars,Grant/Award Number:52225403State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering,Grant/Award Number:SDGZK2404Fundamental Research Funds for the Central Universities,Grant/Award Number:2023KYJD1006。
文摘Hydrochloric acid(HCl)extensively exists in deep underground projects,arising from the transportation of industrial raw materials or fracturing fluids of petroleum engineering.It results in corrosion,which can significantly impact the stability of surrounding rock structures.Therefore,in-depth analysis of the degradation of rock corroded by the HCl solution is an essential task for underground engineering.In this study,the granite specimens are initially treated with the HCl solution with various concentrations.Then,the tests and analyses,such as electrical conductivity(EC)measurements,mineral composition assays,and Brazilian splitting tests,are employed to investigate the corrosion mechanism of the HCl solution.Our results and findings are generally as follows:(1)As the immersion time increases,the EC exhibits a relatively high level at pH value of 1,a decreasing trend at pH value of 3,and an increasing trend at pH value of 5 and 7.(2)The HCl solutions with various concentration have different effect on mineral composition,characterized by an increase in proportion of SiO_(2) and a reduction in proportion of Na_(2)O,Al_(2)O_(3),K_(2)O,MgO,and CaO,as the solution pH value decreases.(3)After immersion in the solutions with pH values of 1,3,and 5,the tensile strength of the granite decreases by 23.85%,20.84%,and 20.24%;the average stiffness of the specimen decreases by 29.29%,23.43%,and 11.97%;the proportion of releasable energy increases by 6%,4%,and -2%;the releasable energy decreases by 54.96%,26.09%,and 14.52%;and the dissipated energy decreases by approximately 68.85%,41.39%,and 5.41%,respectively.(4)The evolution of physical and mechanical properties of the immersed granite specimen can be analyzed from a chemical aspect.The corrosive action of HCl cleaves Si–O and Al–O chemical bonds within the granite,particularly altering the tetrahedral structures of its silicate components.This process involves breaking existing chemical bonds and the formation of new ones,ultimately destroying the silicate molecular structures.As the concentration of HCl increases,the rate of these reactions accelerates,progressively weakening the chemical bonds and consequently deteriorating the mechanical characteristics of the granite.These findings can deepen our knowledge about the corrosion effect of HCI solutions on natural surrounding rocks and serve as references for further research on rock corrosion mechanisms in underground engineering.
基金supported by the National Natural ScienceFoundation of China(Nos.52427804 and 52574136).
文摘Cement paste backfill(CPB)technology is a key method for mine waste treatment,and pipeline transport is critical for safe and efficient waste transfer.Variations in raw material properties can cause slurry segregation,increase pipeline wear and resistance,raise the risk of blockages or bursts,and disrupt operations.To study CPB slurry segregation during transport,CPB was prepared using cement as the cementitious material and unclassified tailings as inert materials.A small annular-tube device using an electrical resistance tomography system was developed to analyze its flow characteristics,and quantitative segregation assessment methods were developed.The results indicated that CPB conductivity increases with transport time but decreases with higher solid mass content,with the latter having a greater impact.At a low solid content,solid particles migrated toward the bottom of the pipe as the flow time increased,and the migratory behavior of the particles diminished as the solid content increased.At a flow rate of 1.25 m/s,the heterogeneity index for CPB with 58wt% solid content increased by 1.24 in 20 min,whereas that for CPB with 62wt% solid content increased by 2.17.Higher solid mass content amplifies the effect of conveying time on segregation,emphasizing the need to balance these factors for minimizing segregation.These insights can guide the optimization of mine pipeline transport systems.
基金Project supported by the Ministry of Education’s Supply and Demand Matching Employment and Education Project(Grant No.2024110776329)。
文摘An in-built N^(+)pocket electrically doped tunnel field-effect transistor(ED-TFET)-based biosensor has been reported for the first time.The proposed device begins with a PN junction structure with a control gate(CG)and two polarity gates(PG1 and PG2).Utilizing the polarity bias concept,a narrow N^(+)pocket is formed between the source and channel without the need for additional doping steps,achieved through biasing PG1 and PG2 at-1.2 V and 1.2 V,respectively.This method not only addresses issues related to doping control but also eliminates constraints associated with thermal budgets and simplifies the fabrication process compared to traditional TFETs.To facilitate biomolecule sensing within the device,a nanogap cavity is formed in the gate dielectric by selectively etching a section of the polarity gate dielectric layer toward the source side.The investigation into the presence of neutral and charged molecules within the cavities has been conducted by examining variations in the electrical properties of the proposed biosensor.Key characteristics assessed include drain current,energy band,and electric field distribution.The performance of the biosensor is measured using various metrics such as drain current(I_(DS)),subthreshold swing(SS),threshold voltage(V_(TH)),drain current ratio(I_(ON)/I_(OFF)).The proposed in-built N^(+)pocket ED-TFET-based biosensor reaches a peak sensitivity of 1.08×10~(13)for a neutral biomolecule in a completely filled nanogap with a dielectric constant of 12.Additionally,the effects of cavity geometry and different fill factors(FFs)on sensitivity are studied.
基金supported by the National Natural Science Foundation of China(Grant No.12074187).
文摘Electrically controlled solid propellant(ECSP)offers multiple ignition and adjustable burning rate,serving as fuel for next-generation intelligent propulsion systems.To further enhance the combustion performance of ECSP,a method utilizing electrochemical and thermal decomposition catalysts has been proposed.In this work,we investigated the combustion characteristics of hydroxylamine nitrate(HAN)-based ECSP incorporating cerium oxide(CeO_(2))and graphene oxide(GO)by using an electrically controlled combustion test system.Electrochemical impedance spectroscopy(EIS)and linear sweep voltammetry(LSV)were used to measure the electrical conductibility and overpotential of ECSP with various additives,and Tafel curves were calculated.Thermogravimetric analysis coupled with differential scanning calorimetry(TG-DSC)was employed to investigate the thermal decomposition behavior of ECSP.While the addition of CeO_(2) and GO reduced the conductivity of ECSP,both catalysts exhibited strong electrocatalytic properties and facilitated the thermal decomposition of ECSP.Between two catalysts,GO demonstrated superior electrochemical catalytic performance but weaker thermal decomposition catalytic ability than CeO_(2).The addition of catalysts significantly enhanced the combustion performance of HAN-based ECSP.Specifically,the ignition delay time was shortened by 10%~20%.CeO_(2) raised the burning rate by approximately 20%but GO exhibited a remarkable boost of 40%in burning rate at high voltage.The combination of GO and PVA produced a flame-retardant substance that negatively impacted the ignition delay of ECSP and resulted in a smaller increase in the burning rate of ECSP at low ignition voltages.
基金supported by Natural Science Foundation of Wuhan(2024040701010051)Natural Science Foundation of Hubei(2023AFB111)and National Natural Science Foundation of China(52401108).
文摘To elucidate the accelerated degradation mechanisms of metallic interconnects in operational solid oxide fuel cells,the oxidation behavior of FSS430 ferritic stainless steel under the coupling of simultaneous electrical current and high-temperature exposure is investigated.Isothermal thermogravimetric analysis was employed to quantify oxidation kinetics,complemented by microstructural characterization using X-ray diffraction,scanning electron microscopy with energy-dispersive spectroscopy and transmission electron microscopy.Experimental results demonstrate that the applied current dramatically enhances oxidation rates,increasing specific mass gain from 0.25 mg/cm^(2)(0 A/cm^(2))to 5.20 mg/cm^(2)(0.2 A/cm^(2))and oxide scale thickness from 1.87 to 15.62μm after 200 h.This acceleration originates from current-induced electromigration forces that promote cationic transport through the oxide layer.The quantitative relationships between current density and oxidation parameters are established,enabling predictive modeling of interconnector degradation in solid oxide fuel cell(SOFC)systems.
基金supported in part by the Natural Science Foundation of Shanghai,China(No.23ZR1432400)the Shanghai Pilot Program for Basic Research-Chinese Academy of Science(No.JCYJ-SHFY-2022-015).
文摘The Electrical Power System(EPS)is one of the spacecraft’s key subsystems,and its operational status directly affects the lifespan and performance of the entire spacecraft.The corresponding fault diagnosis has always been the discussion focus to ensure spacecraft reliability.In this paper,a few-shot unsupervised fault diagnosis method based on the improved Newman community division algorithm is proposed,to approach the scarcity of fault data samples and the inconspicuous characteristics of abnormal data.Firstly,aiming to capture the overall relevance of the fault dataset,a complex network model is built by adopting the K-Dynamic time warping distance Adjacent Nodes(KDAN)method.Based on the complex network model,the Newman community divisions algorithm is improved by using the Quantum-behaved Particle Swarm Optimization(QPSO).Subsequently,in order to evaluate the feasibility of the proposed method,experimental validation was conducted using an open-source dataset.The results indicate that the average accuracy can reach 96.43% for fault data diagnosis,and an F1_score of 97.76%with only 17.65%of the dataset used for training.The proposed method can accurately classify abnormal data by identifying the community structure in the data network,significantly improve the efficiency of the community divisions algorithm and reduce its complexity,and provide a new solution for fault diagnosis in large-scale complex systems.
基金financially supported by the National Natural Science Foundation of China(Nos.52034005,52227807,52104383,and 52222410)the Shaanxi Province National Science Fund for Distinguished Young Scholars,China(No.2022JC-24)+1 种基金the Key Research and Development Program of Shaanxi Province,China(No.2022JBGS2-01)the Central Guidance on Local Science and TechnologyDevelopment Fund of Shaanxi Province,China(No.2024ZY-JCYJ-04-09).
文摘Twinning-induced plasticity(TWIP)steel was processed using electrically assisted friction stir welding(EFSW).The microstructure,mechanical properties,and deformation behavior of the welded joints were systematically investigated.The results show that the average grain size was refined from 3.67μm in the base material(BM)to 1.39μm in the stir zone(SZ),while it increased to 4.19μm in the heat-affected zone(HAZ).The fraction of twin boundaries(TBs)decreased from 20.7%in the BM to 6.9%in the SZ and increased to24.5%in the HAZ.The ultimate tensile strength,yield strength,and elongation of the BM were 1021 MPa,505 MPa,and 65.8%,respectively.In comparison,the EFSW joint exhibited values of 1055 MPa,561 MPa,and 60.8%,corresponding to 103.3%,111.1%,and 92.4%of those of the BM,respectively.During tensile testing,plastic deformation was primarily concentrated in the BM,although both the SZ and HAZ also exhibited notable plastic deformation.Fracture ultimately occurred in the BM.
基金PEEP titration in ARDS patients using EIT combined with lung ultrasound,Key Laboratory of Emergency Trauma Research,Ministry of Education (KLET-202201)airway clearance protocol in ICU mechanically ventilated patients based on electrical impedance imaging technology,Natural Science Foundation of Hunan Province (2024JJ9148)effects of end expiratory positive pressure on lung re-expansion in patients with ARDS and intra-abdominal hypertension monitored using lung ultrasound,Natural Science Foundation of Hunan Province (2023JJ60308)
文摘BACKGROUND:Individualized positive end-expiratory pressure(PEEP)titration is a crucial technique in mechanical ventilation therapy for acute respiratory distress syndrome(ARDS)patients with intra-abdominal hypertension(IAH).This study aimed to evaluate the eff ectiveness of electrical impedance tomography(EIT)-guided PEEP titration in this population.METHODS:This prospective study enrolled 36 ARDS patients,including 22 patients with IAH and 14 without IAH.All the patients underwent EIT-guided PEEP titration at the intersection point between alveolar overdistension and collapse during a decremental PEEP trial.The changes in pulmonary ventilation distribution,respiratory mechanics and hemodynamics during the titration process were observed.RESULTS:After EIT-guided PEEP titration was performed,the PEEP,peak inspiratory pressure and plateau pressure increased significantly(P<0.05).Furthermore,no significant differences were observed in respiratory system compliance,tidal volume,driving pressure,or the 4*DP+RR index between the two groups(P>0.05).The mechanical power increased in the non-IAH(NIAH)group after PEEP titration(P<0.05).Ventilation in gravity-dependent lung regions significantly increased(P<0.05),and the oxygenation index(PaO2/FiO2)improved signifi cantly(P<0.05)in both groups.However,blood pressure,heart rate,respiratory rate,central venous pressure,and lactate levels did not signifi cantly change.In the IAH group,the PaO2/FiO2 ratio improved less than that in the NIAH group did(P<0.05).CONCLUSION:In our study,individualized PEEP titration guided by EIT improved oxygenation in ARDS patients with concomitant IAH without signifi cantly aff ecting hemodynamics.The presence of IAH may limit the improvement of oxygenation during EIT-guided PEEP titration.
基金supported by the National Natural Science Foundation of China under Grant 52022016China Postdoctoral Science Foundation under grant 2021M693711Fundamental Research Funds for the Central Universities under grant 2021CDJQY-037.
文摘The rapid development of wind energy in the power sectors raises the question about the reliability of wind turbines for power system planning and operation.The electrical subsystem of wind turbines(ESWT),which is one of the most vulnerable parts of the wind turbine,is investigated in this paper.The hygrothermal aging of power electronic devices(PEDs)is modeled for the first time in the comprehensive reliability evaluation of ESWT,by using a novel stationary“circuit-like”approach.First,the failure mechanism of the hygrothermal aging,which includes the solder layer fatigue damage and packaging material performance degradation,is explained.Then,a moisture diffusion resistance concept and a hygrothermal equivalent circuit are proposed to quantitate the hygrothermal aging behavior.A conditional probability function is developed to calculate the time-varying failure rate of PEDs.At last,the stochastic renewal process is simulated to evaluate the reliability for ESWT through the sequential Monte Carlo simulation,in which failure,repair,and replacement states of devices are all included.The effectiveness of our proposed reliability evaluation method is verified on an ESWT in a 2 MW wind turbine use time series data collected from a wind farm in China.
基金financial support from the Nuclear Energy Science&Technology and Human Resource Development Project of the Japan Atomic Energy Agency/Collaborative Laboratories for Advanced Decommissioning Science(No.R04I034)The author Ruicong Xu appreciates the scholarship(financial support)from the China Scholarship Council(CSC,No.202106380073).
文摘Laser-induced aerosols,predominantly submicron in size,pose significant environmental and health risks during the decommissioning of nuclear reactors.This study experimentally investigated the removal of laser-generated aerosol particles using a water spray system integrated with an innovative system for pre-injecting electrically charged mist in our facility.To simulate aerosol generation in reactor decommissioning,a high-power laser was used to irradiate various materials(including stainless steel,carbon steel,and concrete),generating aerosol particles that were agglomerated with injected water mist and subsequently scavenged by water spray.Experimental results demonstrate enhanced aerosol removal via aerosol-mist agglomeration,with charged mist significantly improving particle capture by increasing wettability and size.The average improvements for the stainless steel,carbon steel,and concrete were 40%,44%,and 21%,respectively.The results of experiments using charged mist with different polarities(both positive and negative)and different surface coatings reveal that the dominant polarity of aerosols varies with the irradiated materials,influenced by their crystal structure and electron emission properties.Notably,surface coatings such as ZrO_(2)and CeO_(2)were found to possibly alter aerosol charging characteristics,thereby affecting aerosol removal efficiency with charged mist configurations.The innovative aerosol-mist agglomeration approach shows promise in mitigating radiation exposure,ensuring environmental safety,and reducing contaminated water during reactor dismantling.This study contributes critical knowledge for the development of advanced aerosol management strategies for nuclear reactor decommissioning.The understanding obtained in this work is also expected to be useful for various environmental and chemical engineering applications such as gas decontamination,air purification,and pollution control.
基金supported in part by China Scholarship Council(CSC)under Grant 202206160023.
文摘In this paper,electrically excited synchronous machines(EESMs)using copper(Cu)and aluminum(Al)windings are compared for the feasibility of replacing Cu windings with Al windings in electric vehicle(EV)applications since Al windings have lower mass density and cost per weight,but higher resistivity and lower thermal conductivity than Cu windings.The EESMs with four winding configurations are optimized with an electromagnetic-thermal co-optimization method.The optimized EESM with only Cu windings is considered as the baseline in this study.Results show that the EESM with stator-Cu/rotor-Al windings has the least torque reduction(12.1%)compared to the baseline among the three EESMs with Al windings and the highest torque mass density among all EESMs.Meanwhile,although the new European driving cycle efficiency of the stator-Cu/rotor-Al EESM is 1.8%lower than that of the baseline,the torque per cost is 71%higher,and the maximum rotor mechanical stress is 8%lower.Therefore,the EESMs with stator-Cu/rotor-Al windings are prospective substitutions of those with only Cu windings for EV applications considering the trade-off between performance and cost.
基金supported by the National Natural Science Foundation of China(Nos.T222100,22205258,52302485 and 2024JJ5404).
文摘The electrode structures in ignition devices for Electrically Controlled Solid Propellants(ECSP) can be classified into fixed and movable types. In movable electrode structures, springs are typically used to push the electrodes and the propellant. The effects of spring pressure on the ignition and combustion of propellants have not yet been studied. In this paper, a universal testing machine and an electrochemical workstation were firstly utilized to investigate the compressive mechanical property and conductivity of Hydroxylamine Nitrate(HAN)-ECSP. The maximum pressure at which the propellant undergoes elastic deformation is 65 kPa. When the spring pressure increased from 5.1 k Pa to 20.4 kPa, the propellant resistance decreased from 56.8 Ω to 36.8 Ω.Various observation methods were employed to study the process of electrical energy injection and the ignition and combustion characteristics under constant voltage. Appropriately increasing the spring pressure can accelerate the injection of electrical energy into the propellant, increase the electrification current, and thus reduce the initial ignition delay time of the propellant. When the spring pressure is 20.4 kPa, the squeezing speed of the propellant is too fast, making it difficult for the propellant to be adequately heated at the electrode interface, which is unfavorable for ignition. Excessive spring pressure also leads to the accumulation of a large amount of combustion residue on the electrode plate, hindering the mixing and diffusion of hot gases during the second ignition process, preventing the gaseous flame of the propellant. When the spring pressure is 5.1 kPa, improving the working voltage can enhance the repeated ignition characteristics of the propellant.
基金supported by National Natural Science Foundation of China(52377107,52007105)and the Taishan Scholars Program.
文摘With the widespread application of combined heat and power(CHP)units,the economic dispatch of integrated electric and district heating systems(IEHSs)has drawn increasing attention.Because the electric power system(EPS)and district heating system(DHS)are generally managed separately,the decentralized dispatch pattern is preferable for the IEHS dispatch problem.However,many common decentralized methods suffer from the drawbacks of slow and local convergence.Moreover,the uncertainties of renewable generation cannot be ignored in a decentralized pattern.Additionally,the most commonly used individual chance constraints in distributionally robust optimization cannot consider safety constraints simultaneously,so the safe operation of an IEHS cannot be guaranteed.Thus,distributionally robust joint chance constraints and robust constraints are jointly introduced into the IEHS dispatch problem in this paper to obtain a stronger safety guarantee,and a method combined with Bonferroni and conditional value at risk(CVaR)approximation is presented to transform the original model into a quadratic program.Additionally,a dynamic boundary response(DBR)-based distributed algorithm based on multiparametric programming is proposed for a fast solution.Case studies showcase the necessity of using mixed distributionally robust joint chance constraints and robust constraints,as well as the effectiveness of the DBR algorithm.
基金sponsored by Ministry of Natural Resources in Guangdong Province(No.GDNRC[2024]52)。
文摘In this paper,a precise and computationally efficient method for estimating multiparameter of permanent magnet synchronous motors(PMSMs)is proposed.This method can realize decoupling estimation with a small amount of data at a single speed,and considers the inductance correlation to improve the estimation accuracy.The saturation in the stator frame is first modeled,and then the related inductance model in the rotating frame is derived.The estimation model is established based on the related inductance model,which is modeled by polynomials of d-axis current(I_(d))for a given q-axis current(I_(q)).Then,the influence of permanent magnet(PM)flux linkage on inductance estimation can be eliminated by using the partial derivative of the correlated inductance model.The estimation model fully explores the inductance correlation and can realize the decoupling of PM flux linkage(λ_(0))and inductance,which greatly improves the inductance estimation accuracy,especially when Id is small.Moreover,this paper realizes the estimation of distortion voltage,PM flux linkage,and stator resistance based on the derived electrical model and mechanical model.Compared with the existing method,this method can use a small amount of data at a single speed to model voltage,which can effectively reduce the influence of measurement noise and improve the calculation efficiency.Experimental verification on a laboratory PMSM prototype shows that the method’s performance of the proposed method is better than existing methods under various working conditions.
基金supported by the Fundamental Research Funds for the Central Universities,Nos.G2021KY05107,G2021KY05101the National Natural Science Foundation of China,Nos.32071316,32211530049+1 种基金the Natural Science Foundation of Shaanxi Province,No.2022-JM482the Education and Teaching Reform Funds for the Central Universities,No.23GZ230102(all to LL and HH).
文摘Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke.
基金supported by European Union Funding Programme,PNRR,No. 760058(to DMH)the UEFISCDI Project,No. PN-III-P4-IDPCE-2020-059(to APW)
文摘The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.
文摘提出一种改进的ELECTRE(elimination et choix traduisant la réalité)动态模糊多属性决策方法。首先,对动态决策矩阵运用熵权法获得客观的时间权重;其次,提出改进的ELECTRE方法,针对直觉模糊数不可直接比较的问题,根据隶属度、非隶属度值不同的物理含义,分别构造其级别优先的一致性和矛盾性动态指标函数,再融合为各属性的一致性和矛盾性动态指标;随后,根据其相反的赋值意义,利用时间权重分别进行集成,获得综合各时间段的一致性和矛盾性指标并进行耦合,从而得到各方案的赋值级别优先关系,最终完成方案排序。实验数据验证了方法的有效性与可行性。
