Aim: Review of presentation, management and outcome of patients admitted with Diabetic Ketoacidosis (DKA) to an emergency department short stay unit with expedited discharge. Methods: All admitted patients with a disc...Aim: Review of presentation, management and outcome of patients admitted with Diabetic Ketoacidosis (DKA) to an emergency department short stay unit with expedited discharge. Methods: All admitted patients with a discharge diagnosis of “Diabetic Ketoacidosis”, were identified by the file auditing section in the Emergency Department. Data obtained from the medical records were collected using an explicit chart review from January 2012 to June 2013. Data included clinical monitoring, investigations performed, the type and amount of intravenous fluids given, the insulin regime, potassium supplementation and outcome. Results: Out of a total of 120 patients labelled as DKA or hyperglycaemia on arrival, hundred patients fulfilled the criteria for DKA. In the population studied the mean age was 25 years with a male predominance. Eighty-two patients suffered from Type 1 Diabetes Mellitus (T1DM) whilst eighteen patients had Type 2 Diabetes Mellitus (T2DM). Sixteen patients were newly diagnosed during the present admission. Seventy-six (76%) patients were on insulin. The insulin regimen and potassium supplementation were followed as per protocol in all patients. All the patients except one were given intravenous fluid according to protocol. Parameters were monitored adequately except fluid input and output monitoring. The median length of stay in the short stay unit was 1.5833 days. There was no return visit within one week of discharge. Conclusion: The median length of stay was short and there were no documented complications or deaths during the stay. There was poor compliance with documentation of fluid input and output. In this population, the short stay model of care appeared to be safe and efficient.展开更多
SUMMARIES OF TOP NEWS STORIES 42nd Antarctic Expedition Kicked Off China’s 42nd Antarctic expedition team set sail from Shanghai on 1 November.During this expedition,a suite of new technologies will be deployed and t...SUMMARIES OF TOP NEWS STORIES 42nd Antarctic Expedition Kicked Off China’s 42nd Antarctic expedition team set sail from Shanghai on 1 November.During this expedition,a suite of new technologies will be deployed and tested in the icy wilderness of the Antarctic.展开更多
On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more...On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more than 160 mountain climbing enthusiasts from all over the country.展开更多
China's research-oriented icebreaker Xuelong,or Snow Dragon,arrived in Shanghai on April 8,marking the completion of key missions in the country's 41st Antarctic expedition.The expedition involves 516 members ...China's research-oriented icebreaker Xuelong,or Snow Dragon,arrived in Shanghai on April 8,marking the completion of key missions in the country's 41st Antarctic expedition.The expedition involves 516 members from 118 domestic and international institutions and is being carried out by three vessels.展开更多
On December 12,2020,I cast off with Argo,my trusty boat,for a solo voyage across the Atlantic.As we departed San Sebastian at dawn,the exhaustion from preparation already had me longing for sleep,which was a strange d...On December 12,2020,I cast off with Argo,my trusty boat,for a solo voyage across the Atlantic.As we departed San Sebastian at dawn,the exhaustion from preparation already had me longing for sleep,which was a strange desire on the very first day of what was to be a 70⁃day expedition.展开更多
This review compiles studies on paleoceanographic and paleoenvironmental changes in the high-latitude Southern Ocean during the late Quaternary based on Chinese Antarctic Expeditions.Four major findings are summarized...This review compiles studies on paleoceanographic and paleoenvironmental changes in the high-latitude Southern Ocean during the late Quaternary based on Chinese Antarctic Expeditions.Four major findings are summarized as follows.(1)Diatom compositions in sediment record sea surface condition changes in the Bransfield Strait and Cosmonaut Sea,indicating an increase in sea ice cover since the Mid-Holocene for both areas,possibly linked to cold water mass injection from the Weddell Sea ice shelf.(2)Export productivity records from Antarctic marginal seas show a glacial-interglacial variation pattern,with higher and lower productivity during the interglacial and glacial periods,respectively,controlled by both the intensity of Circumpolar Deep Water upwelling and sea ice cover.An overall increase of export productivity from Marine Isotope Stage(MIS)12 to MIS 6 is noticed.(3)Ventilation state of the abyssal Southern Ocean is closely related to global climate change and atmospheric CO_(2) concentrations,with elevated ventilation efficiency during deglacial periods responsible for elevated atmospheric CO_(2) concentrations.(4)Antarctic marine-based ice sheets/glaciers wax and wane in line with global and regional ice volume changes,predominantly subject to oceanic forcing,while land-based ice sheets might only reorganize in specific glacial intervals.Despite significant progress in understanding the role of the Southern Ocean and the Antarctic Ice Sheet within the global climate system,challenges remain in sample collection and research methods.Future studies should aim to collect samples from a broader range of latitudes,ensure higher quality and longer temporal span,resolve dating issues,reconstruct seawater temperature,and focus on reconstructions of Southern Ocean carbon cycling and changes of intermediate to deep water masses.展开更多
The year,2024,marks the 40th anniversary of Chinese research expeditions in the polar regions and the 25th anniversary of its Arctic research expeditions.China has conducted 14 national Arctic research expeditions.Wit...The year,2024,marks the 40th anniversary of Chinese research expeditions in the polar regions and the 25th anniversary of its Arctic research expeditions.China has conducted 14 national Arctic research expeditions.With the increase of understandings on the global impacts of the changes of Arctic climate system,especially on China’s weather and climate,and demands for commercial utilization of the Arctic sea routes,Chinese scientists have made great progresses on in site and remote sensing observation technologies for Arctic Ocean,interaction mechanisms between atmosphere,sea ice,and ocean,the connection mechanism between the Arctic Ocean and other regions,and have achieved a series of research results.This study summarizes the research achievements by Chinese scientists in the above-mentioned aspects or beyond,identifies knowledge gaps,and based on this,discusses prospects and provides suggestions.From a perspective of observation,improving the observation capabilities of the Arctic Ocean in winter and the ocean under the ice,as well as floe-scale processes of sea ice and mesoscale and submesoscale processes of the ocean,is an urgent task to be addressed.Strengthening international cooperation is necessary for building a monitoring network for the Arctic marine environment.From a perspective of numerical simulation,the descriptive ability and parameterization scheme of sub-grid processes based on observational evidence need to be developed.From a perspective of cross-sphere interactions,in addition to the multi-media coupling within the Arctic Ocean that this review focuses on,the interaction between the Arctic Ocean and land or ice sheet(Greenland),especially the water cycle process,is also a scientific domain that needs to be considered,in the context of Arctic warming and humidification.From a perspective of climate effects,the physical mechanisms that affect the robustness of teleconnection need to be clarified.展开更多
Dear Readers:Antarctica,with its unparalleled atmospheric transparency,extended polar nights,and unique geographical position,has become a premier site for modern astronomical observation.Two decades ago,the Chinese A...Dear Readers:Antarctica,with its unparalleled atmospheric transparency,extended polar nights,and unique geographical position,has become a premier site for modern astronomical observation.Two decades ago,the Chinese Antarctic Research Expedition(CHINARE)team reached Dome A,the highest point of the Antarctic ice sheet,marking the beginning of a new era for astro-nomical research from the Antarctic plateau.展开更多
Black carbon (BC) aerosols are considered key factors that contribute to rapid climate warming and ice melt in the Arctic region.However,compared with long-term observations from land-based stations,observational data...Black carbon (BC) aerosols are considered key factors that contribute to rapid climate warming and ice melt in the Arctic region.However,compared with long-term observations from land-based stations,observational data over the Arctic Ocean remain relatively scarce.Four Arctic scientific expeditions were conducted in the summer and early autumn of 2010,2012,2016,and 2018 via the Chinese research vessel Xue Long,during which the BC concentrations along the routes were measured via light absorption methods.In this work,the spatiotemporal distribution characteristics of BC over the Arctic Ocean were examined on the basis of these observations.The potential sources of BC along the various routes were analyzed via the weighted potential source contribution function and weighted concentrationweighted trajectory methods of the hybrid single-particle Lagrangian integrated trajectory model in conjunction with Arctic transport potential climate model simulations.The analysis results indicated that wildfires in the western Aleutian Islands,Siberia,and Far East regions were the primary contributors to the BC aerosol concentration observed along the Arctic expedition routes in summer,identifying these regions as major potential source areas.展开更多
Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was us...Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was used to study the content and implementation effect of BTD system in China and the relevant policies and implementation of the same procedures of drug regulatory authorities in the United States,Japan and the European Union.Then,the differences in policies and implementation results among these countries were analyzed to provide suggestions for the implementation and optimization of this system in China.Results and Conclusion China’s BTD system is implemented late and a small number of drugs has been approved.At the same time,there are problems such as insufficient guidance and communication from the agency to applicants,a broad application condition,single review mode,and lack of full-time personnel.Both the agencies and the applicants have limited experience due to the short implementation time of BTD system in China.There are still some problems despite we have learned a lot from the experience of other drug regulatory agencies.Therefore,based on our national conditions,we should strengthen the guidance of evaluation agency to applicants,optimize the eligibility criteria of BTD system,introduce the rolling review,and increase the number of professional liaisons,which can accelerate the development and marketing process of drugs with obvious clinical value,and finally to address unmet medical need.展开更多
Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling opera...Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling operations and it is a fundamental input for well design,and mud weight estimation for wellbore stability.However,the pore pressure trend prediction in complex geological provinces is challenging particularly at oceanic slope setting,where sedimentation rate is relatively high and PP can be driven by various complex geo-processes.To overcome these difficulties,an advanced machine learning(ML)tool is implemented in combination with empirical methods.The empirical method for PP prediction is comprised of data pre-processing and model establishment stage.Eaton's method and Porosity method have been used for PP calculation of the well U1517A located at Tuaheni Landslide Complex of Hikurangi Subduction zone of IODP expedition 372.Gamma-ray,sonic travel time,bulk density and sonic derived porosity are extracted from well log data for the theoretical framework construction.The normal compaction trend(NCT)curve analysis is used to check the optimum fitting of the low permeable zone data.The statistical analysis is done using the histogram analysis and Pearson correlation coefficient matrix with PP data series to identify potential input combinations for ML-based predictive model development.The dataset is prepared and divided into two parts:Training and Testing.The PP data and well log of borehole U1517A is pre-processed to scale in between[-1,+1]to fit into the input range of the non-linear activation/transfer function of the decision tree regression model.The Decision Tree Regression(DTR)algorithm is built and compared to the model performance to predict the PP and identify the overpressure zone in Hikurangi Tuaheni Zone of IODP Expedition 372.展开更多
During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which...During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi Sea.The buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 d.After returning to the Mendeleev Ridge,it continued to drift toward the pole.Overall,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time intervals.The results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).展开更多
The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oce...The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oceanography, marine meteorology, sea ice, marine chemistry,marine biology, marine ecology, geology, and geophysics in the Bering Sea, Chukchi Sea, Chukchi Plateau, Mendeleev Ridge, and Canada Basin. This paper gives an overview of the main achievements of this expedition and highlights the scientific achievements.展开更多
Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo so...Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work.展开更多
Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for...Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for the expedition teams.Several countries have tested the UAV technology to support Antarctic research and logistics.In this trend paper,we provide insightful reviews and discussions on such a prospective topic.Based on a comprehensive literature survey,we firstly summarize the key research progress of UAV in Antarctic studies.Then the examples of risk scenarios during the field exploration are given,after which several promising applications of the UAVs in safety guarantee are illustrated.In particular,we present a case of site-selection for the Chinese first ice sheet airfield,using the data collected in the 34th Chinese National Antarctic Research Expedition(CHINARE).In the end,we highlight the unique value of the UAVs in the popularization of polar science before concluding the advantages and limitations.Considering their excellent performance,we expect more innovations for UAV’s applications in the following Antarctic expeditions.展开更多
The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expeditio...The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expedition： new/recent snow, melt-fi＇eeze crust, icy layer, depth hoar, coarse-grained, and chains of depth hoar. Across most measurement areas, the snow surface was covered by a melt-freeze crust 2-3 cm thick, which was produced by alternate strong solar radiation and the sharp temperature decrease over the summer Arctic Ocean. There was an intermittent layer of snow and ice at the base of the snow pack. The mean bulk density of the snow was 304.01~29.00 kg/m3 along the expedition line, and the surface values were generally smaller than those of the sub- surface, confirming the principle of snow densification. In addition, the thicknesses and water equivalents of the new/recent and total-layer snow showed a decreasing trend with latitude, suggesting that the amount of snow cover and its spatial variations were mainly determined by precipitation. Snow temperature also presented significant variations in the vertical profile, and ablation and evaporation were not the primary factors in the snow assessment in late summer. The mean temperature of the surface snow was -2.01±0.96℃, which was much higher than that observed in the interface of snow and sea ice.展开更多
文摘Aim: Review of presentation, management and outcome of patients admitted with Diabetic Ketoacidosis (DKA) to an emergency department short stay unit with expedited discharge. Methods: All admitted patients with a discharge diagnosis of “Diabetic Ketoacidosis”, were identified by the file auditing section in the Emergency Department. Data obtained from the medical records were collected using an explicit chart review from January 2012 to June 2013. Data included clinical monitoring, investigations performed, the type and amount of intravenous fluids given, the insulin regime, potassium supplementation and outcome. Results: Out of a total of 120 patients labelled as DKA or hyperglycaemia on arrival, hundred patients fulfilled the criteria for DKA. In the population studied the mean age was 25 years with a male predominance. Eighty-two patients suffered from Type 1 Diabetes Mellitus (T1DM) whilst eighteen patients had Type 2 Diabetes Mellitus (T2DM). Sixteen patients were newly diagnosed during the present admission. Seventy-six (76%) patients were on insulin. The insulin regimen and potassium supplementation were followed as per protocol in all patients. All the patients except one were given intravenous fluid according to protocol. Parameters were monitored adequately except fluid input and output monitoring. The median length of stay in the short stay unit was 1.5833 days. There was no return visit within one week of discharge. Conclusion: The median length of stay was short and there were no documented complications or deaths during the stay. There was poor compliance with documentation of fluid input and output. In this population, the short stay model of care appeared to be safe and efficient.
文摘SUMMARIES OF TOP NEWS STORIES 42nd Antarctic Expedition Kicked Off China’s 42nd Antarctic expedition team set sail from Shanghai on 1 November.During this expedition,a suite of new technologies will be deployed and tested in the icy wilderness of the Antarctic.
文摘On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more than 160 mountain climbing enthusiasts from all over the country.
文摘China's research-oriented icebreaker Xuelong,or Snow Dragon,arrived in Shanghai on April 8,marking the completion of key missions in the country's 41st Antarctic expedition.The expedition involves 516 members from 118 domestic and international institutions and is being carried out by three vessels.
文摘On December 12,2020,I cast off with Argo,my trusty boat,for a solo voyage across the Atlantic.As we departed San Sebastian at dawn,the exhaustion from preparation already had me longing for sleep,which was a strange desire on the very first day of what was to be a 70⁃day expedition.
基金The National Natural Science Foundation of China under contract Nos 42030401 and 42276077the Open Foundation of State Key Laboratory of Marine Geology,Tongji University under contract No.MGK202207+1 种基金the Open Foundation Project of the Key Laboratory of Polar Geology and Marine Mineral Resources of Ministry of Education,China University of Geosciences (Beijing),under contract Nos PGMR-2024-102 and PGMR-2023-304the Start-up Foundation of Guangdong Ocean University under contract No.060302032110
文摘This review compiles studies on paleoceanographic and paleoenvironmental changes in the high-latitude Southern Ocean during the late Quaternary based on Chinese Antarctic Expeditions.Four major findings are summarized as follows.(1)Diatom compositions in sediment record sea surface condition changes in the Bransfield Strait and Cosmonaut Sea,indicating an increase in sea ice cover since the Mid-Holocene for both areas,possibly linked to cold water mass injection from the Weddell Sea ice shelf.(2)Export productivity records from Antarctic marginal seas show a glacial-interglacial variation pattern,with higher and lower productivity during the interglacial and glacial periods,respectively,controlled by both the intensity of Circumpolar Deep Water upwelling and sea ice cover.An overall increase of export productivity from Marine Isotope Stage(MIS)12 to MIS 6 is noticed.(3)Ventilation state of the abyssal Southern Ocean is closely related to global climate change and atmospheric CO_(2) concentrations,with elevated ventilation efficiency during deglacial periods responsible for elevated atmospheric CO_(2) concentrations.(4)Antarctic marine-based ice sheets/glaciers wax and wane in line with global and regional ice volume changes,predominantly subject to oceanic forcing,while land-based ice sheets might only reorganize in specific glacial intervals.Despite significant progress in understanding the role of the Southern Ocean and the Antarctic Ice Sheet within the global climate system,challenges remain in sample collection and research methods.Future studies should aim to collect samples from a broader range of latitudes,ensure higher quality and longer temporal span,resolve dating issues,reconstruct seawater temperature,and focus on reconstructions of Southern Ocean carbon cycling and changes of intermediate to deep water masses.
基金The National Natural Science Foundation of China under contract Nos 42325604 and 42276253the Program of Shanghai Academic/Technology Research Leader under contract No.22XD1403600the Fund of the Ministry of Industry and Information Technology of China under contract No.CBG2N21-2-1.
文摘The year,2024,marks the 40th anniversary of Chinese research expeditions in the polar regions and the 25th anniversary of its Arctic research expeditions.China has conducted 14 national Arctic research expeditions.With the increase of understandings on the global impacts of the changes of Arctic climate system,especially on China’s weather and climate,and demands for commercial utilization of the Arctic sea routes,Chinese scientists have made great progresses on in site and remote sensing observation technologies for Arctic Ocean,interaction mechanisms between atmosphere,sea ice,and ocean,the connection mechanism between the Arctic Ocean and other regions,and have achieved a series of research results.This study summarizes the research achievements by Chinese scientists in the above-mentioned aspects or beyond,identifies knowledge gaps,and based on this,discusses prospects and provides suggestions.From a perspective of observation,improving the observation capabilities of the Arctic Ocean in winter and the ocean under the ice,as well as floe-scale processes of sea ice and mesoscale and submesoscale processes of the ocean,is an urgent task to be addressed.Strengthening international cooperation is necessary for building a monitoring network for the Arctic marine environment.From a perspective of numerical simulation,the descriptive ability and parameterization scheme of sub-grid processes based on observational evidence need to be developed.From a perspective of cross-sphere interactions,in addition to the multi-media coupling within the Arctic Ocean that this review focuses on,the interaction between the Arctic Ocean and land or ice sheet(Greenland),especially the water cycle process,is also a scientific domain that needs to be considered,in the context of Arctic warming and humidification.From a perspective of climate effects,the physical mechanisms that affect the robustness of teleconnection need to be clarified.
文摘Dear Readers:Antarctica,with its unparalleled atmospheric transparency,extended polar nights,and unique geographical position,has become a premier site for modern astronomical observation.Two decades ago,the Chinese Antarctic Research Expedition(CHINARE)team reached Dome A,the highest point of the Antarctic ice sheet,marking the beginning of a new era for astro-nomical research from the Antarctic plateau.
基金supported by the National Natural Science Foundation of China (No.42201151)the Basic Research Fund of the Chinese Academy of Meteorological Sciences (Nos.2023Z004 and 2024Z007)。
文摘Black carbon (BC) aerosols are considered key factors that contribute to rapid climate warming and ice melt in the Arctic region.However,compared with long-term observations from land-based stations,observational data over the Arctic Ocean remain relatively scarce.Four Arctic scientific expeditions were conducted in the summer and early autumn of 2010,2012,2016,and 2018 via the Chinese research vessel Xue Long,during which the BC concentrations along the routes were measured via light absorption methods.In this work,the spatiotemporal distribution characteristics of BC over the Arctic Ocean were examined on the basis of these observations.The potential sources of BC along the various routes were analyzed via the weighted potential source contribution function and weighted concentrationweighted trajectory methods of the hybrid single-particle Lagrangian integrated trajectory model in conjunction with Arctic transport potential climate model simulations.The analysis results indicated that wildfires in the western Aleutian Islands,Siberia,and Far East regions were the primary contributors to the BC aerosol concentration observed along the Arctic expedition routes in summer,identifying these regions as major potential source areas.
基金Special Fund for Academy of Pharmaceutical Regulatory Sciences of Research Base for Drug Regulatory Science of National Medical Products Administration-Shenyang Pharmaceutical University(2021jgkx004).
文摘Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was used to study the content and implementation effect of BTD system in China and the relevant policies and implementation of the same procedures of drug regulatory authorities in the United States,Japan and the European Union.Then,the differences in policies and implementation results among these countries were analyzed to provide suggestions for the implementation and optimization of this system in China.Results and Conclusion China’s BTD system is implemented late and a small number of drugs has been approved.At the same time,there are problems such as insufficient guidance and communication from the agency to applicants,a broad application condition,single review mode,and lack of full-time personnel.Both the agencies and the applicants have limited experience due to the short implementation time of BTD system in China.There are still some problems despite we have learned a lot from the experience of other drug regulatory agencies.Therefore,based on our national conditions,we should strengthen the guidance of evaluation agency to applicants,optimize the eligibility criteria of BTD system,introduce the rolling review,and increase the number of professional liaisons,which can accelerate the development and marketing process of drugs with obvious clinical value,and finally to address unmet medical need.
文摘Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling operations and it is a fundamental input for well design,and mud weight estimation for wellbore stability.However,the pore pressure trend prediction in complex geological provinces is challenging particularly at oceanic slope setting,where sedimentation rate is relatively high and PP can be driven by various complex geo-processes.To overcome these difficulties,an advanced machine learning(ML)tool is implemented in combination with empirical methods.The empirical method for PP prediction is comprised of data pre-processing and model establishment stage.Eaton's method and Porosity method have been used for PP calculation of the well U1517A located at Tuaheni Landslide Complex of Hikurangi Subduction zone of IODP expedition 372.Gamma-ray,sonic travel time,bulk density and sonic derived porosity are extracted from well log data for the theoretical framework construction.The normal compaction trend(NCT)curve analysis is used to check the optimum fitting of the low permeable zone data.The statistical analysis is done using the histogram analysis and Pearson correlation coefficient matrix with PP data series to identify potential input combinations for ML-based predictive model development.The dataset is prepared and divided into two parts:Training and Testing.The PP data and well log of borehole U1517A is pre-processed to scale in between[-1,+1]to fit into the input range of the non-linear activation/transfer function of the decision tree regression model.The Decision Tree Regression(DTR)algorithm is built and compared to the model performance to predict the PP and identify the overpressure zone in Hikurangi Tuaheni Zone of IODP Expedition 372.
基金The Fundamental Research Fund Project of the First Institute of OceanographyMinistry of Natural Resources+1 种基金under contract No.GY022Y07the National Natural Science Foundation of China under contract No.42106232。
文摘During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi Sea.The buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 d.After returning to the Mendeleev Ridge,it continued to drift toward the pole.Overall,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time intervals.The results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).
文摘The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oceanography, marine meteorology, sea ice, marine chemistry,marine biology, marine ecology, geology, and geophysics in the Bering Sea, Chukchi Sea, Chukchi Plateau, Mendeleev Ridge, and Canada Basin. This paper gives an overview of the main achievements of this expedition and highlights the scientific achievements.
基金financially supported by the National Natural Science Foundation of China (Grant nos. 41776186, 41730102 and 41571407)the Chinese Polar Environmental Comprehensive Investigation and Assessment Programs (Grant no. CHINARE-02-02)
文摘Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work.
基金the National Natural Science Foundation of China(Grant nos.41830536,41676176 and 41676182)the Chinese Polar Environment Comprehensive Investigation and Assessment ProgramTeng Li is also funded by the UK-China Joint Research and Innovation Partnership Fund PhD Placement Program.
文摘Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for the expedition teams.Several countries have tested the UAV technology to support Antarctic research and logistics.In this trend paper,we provide insightful reviews and discussions on such a prospective topic.Based on a comprehensive literature survey,we firstly summarize the key research progress of UAV in Antarctic studies.Then the examples of risk scenarios during the field exploration are given,after which several promising applications of the UAVs in safety guarantee are illustrated.In particular,we present a case of site-selection for the Chinese first ice sheet airfield,using the data collected in the 34th Chinese National Antarctic Research Expedition(CHINARE).In the end,we highlight the unique value of the UAVs in the popularization of polar science before concluding the advantages and limitations.Considering their excellent performance,we expect more innovations for UAV’s applications in the following Antarctic expeditions.
基金funded by the Opening Founding of the State Key Laboratory of Cryospheric Sciences (SKLCS 09-07)the Special Polar Program of the Ministry of Finance (CHINARE2012-02-02)the National Natural Science Foundation of China (NSFC) (41121001)
文摘The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expedition： new/recent snow, melt-fi＇eeze crust, icy layer, depth hoar, coarse-grained, and chains of depth hoar. Across most measurement areas, the snow surface was covered by a melt-freeze crust 2-3 cm thick, which was produced by alternate strong solar radiation and the sharp temperature decrease over the summer Arctic Ocean. There was an intermittent layer of snow and ice at the base of the snow pack. The mean bulk density of the snow was 304.01~29.00 kg/m3 along the expedition line, and the surface values were generally smaller than those of the sub- surface, confirming the principle of snow densification. In addition, the thicknesses and water equivalents of the new/recent and total-layer snow showed a decreasing trend with latitude, suggesting that the amount of snow cover and its spatial variations were mainly determined by precipitation. Snow temperature also presented significant variations in the vertical profile, and ablation and evaporation were not the primary factors in the snow assessment in late summer. The mean temperature of the surface snow was -2.01±0.96℃, which was much higher than that observed in the interface of snow and sea ice.
