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Human-Robot Interaction-Based Model Predictive Control for Exoskeleton Robots Driven by Series Elastic Actuators
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作者 Changxian Xu Keping Liu Zhongbo Sun 《IEEE/CAA Journal of Automatica Sinica》 2026年第2期486-488,共3页
Dear Editor,This letter presents a model predictive control(MPC)scheme for human-robot interaction(HRI)in a multi-joint exoskeleton robot(ER)driven by series elastic actuator(SEA).The proposed scheme in robot-in-charg... Dear Editor,This letter presents a model predictive control(MPC)scheme for human-robot interaction(HRI)in a multi-joint exoskeleton robot(ER)driven by series elastic actuator(SEA).The proposed scheme in robot-in-charge(RIC)mode facilitates the ER driven by SEA to provide the required assistance and support for the subject. 展开更多
关键词 human robot interaction model predictive assistance support series elastic actuator model predictive control series elastic actuator sea exoskeleton robot robot charge mode
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A Novel Passive Neck and Trunk Exoskeleton for Surgeons:Design and Validation
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作者 Ce Zhang Juha M.Hijmans +3 位作者 Christian Greve Han Houdijk Gijsbertus Jacob Verkerke Charlotte Christina Roossien 《Journal of Bionic Engineering》 2025年第1期226-237,共12页
Musculoskeletal Symptoms(MSS)often arise from prolonged maintenance of bent postures in the neck and trunk during surgical procedures.To prevent MSS,a passive exoskeleton utilizing carbon fiber beams to offer support ... Musculoskeletal Symptoms(MSS)often arise from prolonged maintenance of bent postures in the neck and trunk during surgical procedures.To prevent MSS,a passive exoskeleton utilizing carbon fiber beams to offer support to the neck and trunk was proposed.The application of support force is intended to reduce muscle forces and joint compression forces.A nonlinear mathematical model for the neck and trunk support beam is presented to estimate the support force.A validation test is subsequently conducted to assess the accuracy of the mathematical model.Finally,a preliminary functional evaluation test is performed to evaluate movement capabilities and support provided by the exoskeleton.The mathematical model demonstrates an accuracy for beam support force within a range of 0.8–1.2 N Root Mean Square Error(RMSE).The exoskeleton was shown to allow sufficient Range of Motion(ROM)for neck and trunk during open surgery training.While the exoskeleton showed potential in reducing musculoskeletal load and task difficulty during simulated surgery tasks,the observed reduction in perceived task difficulty was deemed non-significant.This prompts the recommendation for further optimization in personalized adjustments of beams to facilitate improvements in task difficulty and enhance comfort. 展开更多
关键词 Neck exoskeleton Trunk exoskeleton Passive exoskeleton Surgeon support Nonlinear modeling
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Active Disturbance Rejection Control Based on Twin-Delayed Deep Deterministic Policy Gradient for an Exoskeleton
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作者 Zhong Li Xiaorong Guan +4 位作者 Chunyang Liu Dingzhe Li Long He Yanfeng Cao Yi Long 《Journal of Bionic Engineering》 2025年第3期1211-1230,共20页
The study of exoskeletons has been a popular topic worldwide.However,there is still a long way to go before exoskeletons can be widely used.One of the major challenges is control,and there is no specific research tren... The study of exoskeletons has been a popular topic worldwide.However,there is still a long way to go before exoskeletons can be widely used.One of the major challenges is control,and there is no specific research trend for controlling exoskeletons.In this paper,we propose a novel exoskeleton control strategy that combines Active Disturbance Rejection Control(ADRC)and Deep Reinforcement Learning(DRL).The dynamic model of the exoskeleton is constructed,followed with the design of the ADRC.To automatically adjust the control parameters of the ADRC,the Twin-Delayed Deep Deterministic Policy Gradient(TD3)is utilized.Then a reward function is defined in terms of the joint angle,angular velocity,and their errors to the desired values,to maximize the accuracy of the joint angle.In the simulations and experiments,a conventional ADRC,and ADRC based on Genetic Algorithm(GA)and Particle Swarm Optimization(PSO)were carried out for comparison with the proposed control method.The results of the tests show that TD3-ADRC has a rapid response,small overshoot,and low Mean Absolute Error(MAE)and Root Mean Square Error(RMSE)followed with the desired,demonstrating the superiority of the proposed control method for the self-learning control of exoskeleton. 展开更多
关键词 exoskeleton ADRC TD3 Parameter tuning
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Structural Design and Analysis of Lower Limb Exoskeleton Robotics
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作者 Mingshuo ZHANG Yutong LI +2 位作者 Sheng ZHANG Yuanhai DING Chuanqi LI 《Mechanical Engineering Science》 2025年第1期20-25,共6页
With the acceleration of the global aging process and the increase of cardiovascular ancerebrovascular diseases,more and more patients are paralyzed due to accidents,so theexoskeleton robot began to appear in people&#... With the acceleration of the global aging process and the increase of cardiovascular ancerebrovascular diseases,more and more patients are paralyzed due to accidents,so theexoskeleton robot began to appear in people's sight,and the lower limb exoskeleton robot withrehabilitation training is also favored by more and more people.In this paper,the structural designand analysis of the lower limb exoskeleton robot are carried out in view of the patients'expectation ofnormal walking.First,gait analysis and structural design of lower limb exoskeleton robot.Based onthe analysis of the walking gait of normal people,the freedom of the three key joints of the lower limbexoskeleton robot hip joint,knee joint and ankle joint is determined.at the same time,according tothe structuralcharacteristics of each joint,the three key joints are modeled respectively,and theoverall model assembly of the lower limb exoskeleton robot is completed.Secondly,the kinematicsanalysis of the lower limb exoskeleton robot was carried out to obtain the relationship between thelinear displacement,linear speed and acceleration of each joint,so as to ensure the coordination ofthe model with the human lower limb movement.Thirdly,the static analysis of typical gait of hipjoint,knee joint and ankle joint is carried out to verify the safety of the design model under thepremise of ensuring the structural strength requirements.Finally,the parts of the model were 3Dprinted,and the rationality of the design was further verified in the process of assembling the model. 展开更多
关键词 exoskeleton Robots Mechanical Structure Design Finite Element Analysis Motion Simulation
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Flatness Control with Cascaded Filtered High-Gain and Disturbance Observers for Rehabilitation Exoskeletons
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作者 Sahbi Boubaker Salim Hadj Said +1 位作者 Souad Kamel Habib Dimassi 《Computers, Materials & Continua》 2025年第12期5703-5721,共19页
Accurate trajectory tracking in lower-limb exoskeletons is challenged by the nonlinear,time-varying dynamics of human-robot interaction,limited sensor availability,and unknown external disturbances.This study proposes... Accurate trajectory tracking in lower-limb exoskeletons is challenged by the nonlinear,time-varying dynamics of human-robot interaction,limited sensor availability,and unknown external disturbances.This study proposes a novel control strategy that combines flatness-based control with two cascaded observers:a high-gain observer to estimate unmeasured joint velocities,and a nonlinear disturbance observer to reconstruct external torque disturbances in real time.These estimates are integrated into the control law to enable robust,state-feedback-based trajectory tracking.The approach is validated through simulation scenarios involving partial state measurements and abrupt external torque perturbations,reflecting realistic rehabilitation conditions.Results confirm that the proposed method significantly enhances tracking accuracy and disturbance rejection capability,demonstrating its strong potential for reliable and adaptive rehabilitation assistance. 展开更多
关键词 exoskeleton control rehabilitation robot trajectory tracking state and disturbance estimation cascade observer
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Snow Leopard-inspired Lower Limb Exoskeleton for Adaptive Multi-terrain Locomotion:Design and Preliminary Experimental Evaluation
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作者 Yi Long Xiaofeng Luo +3 位作者 Tianqi Zhou Xiaopeng Hu Long He Wei Dong 《Journal of Bionic Engineering》 2025年第3期1249-1264,共16页
To overcome the limitations of traditional exoskeletons in complex outdoor terrains,this study introduces a novel lower limb exoskeleton inspired by the snow leopard’s forelimb musculoskeletal structure.It features a... To overcome the limitations of traditional exoskeletons in complex outdoor terrains,this study introduces a novel lower limb exoskeleton inspired by the snow leopard’s forelimb musculoskeletal structure.It features a non-fully anthropomorphic design,attaching only at the thigh and ankle with a backward-knee configuration to mimic natural human knee movement.The design incorporates a single elastic element at the hip for gravity compensation and dual elastic elements at the knee for terrain adaptability,which adjust based on walking context.The design’s effectiveness was assessed by measuring metabolic cost reduction and motor output torque under various walking conditions.Results showed significant metabolic cost savings of 5.8–8.8%across different speeds and a 7.9%reduction during 9°incline walking on a flat indoor surface.Additionally,the spring element decreased hip motor output torque by 7–15.9%and knee torque by 8.1–14.2%.Outdoor tests confirmed the design’s robustness and effectiveness in reducing motor torque across terrains,highlighting its potential to advance multi-terrain adaptive exoskeleton research. 展开更多
关键词 Lower limb exoskeleton Bionic structure Multi-terrain adaptive structure Backward-knee configuration Non-exhaustive anthropomorphism
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AES-SEA and Bionic Knee Based Lower Limb Exoskeleton Design and LQR-virtual Tunnel Control
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作者 Yi Long Zhibin Cai Hexiao Guo 《Journal of Bionic Engineering》 2025年第3期1231-1248,共18页
The lower limb assisted exoskeleton is a prominent area of research within the field of exoskeleton technology.However,several challenges remain,including the development of flexible actuators,high battery consumption... The lower limb assisted exoskeleton is a prominent area of research within the field of exoskeleton technology.However,several challenges remain,including the development of flexible actuators,high battery consumption,the risk of joint misalignment,and limited assistive capabilities.This paper proposes a compact flexible actuator incorporating two elastic elements named Adjustable Energy Storage Series Elastic Actuator(AES-SEA),which combining an adjustable energy storage device with a series elastic actuator for application in exoskeleton hip joints.This design aims to enhance energy efficiency and improve assistive effects.Subsequently,we introduce a novel knee joint bionic structure based on a pulley-groove configuration and a four-link mechanism,designed to replicate human knee joint motion and prevent joint misalignment.Additionally,we propose an innovative controller that integrates concepts from Linear Quadratic Regulator(LQR)control and virtual tunnel for level walking assistance.This controller modulates the assisted reference trajectory using the virtual tunnel concept,enabling different levels of assistance both inside and outside the tunnel by adjusting the parameters Q and R.This approach enhances the assisting force while ensuring the safety of human-computer interaction.Finally,metabolic experiments were conducted to evaluate the effectiveness of the exoskeleton assistance. 展开更多
关键词 Bioinspired joint Energy storage Human-exoskeleton Interaction Lower limb exoskeleton LQR control Series elastic actuation(SEA)
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Radial Basis Function Neural Network Adaptive Controller for Wearable Upper-Limb Exoskeleton with Disturbance Observer
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作者 Mohammad Soleimani Amiri Sahbi Boubaker +1 位作者 Rizauddin Ramli Souad Kamel 《Computer Modeling in Engineering & Sciences》 2025年第9期3113-3133,共21页
Disability is defined as a condition that makes it difficult for a person to perform certain vital activities.In recent years,the integration of the concepts of intelligence in solving various problems for disabled pe... Disability is defined as a condition that makes it difficult for a person to perform certain vital activities.In recent years,the integration of the concepts of intelligence in solving various problems for disabled persons has become more frequent.However,controlling an exoskeleton for rehabilitation presents challenges due to their nonlinear characteristics and external disturbances caused by the structure itself or the patient wearing the exoskeleton.To remedy these problems,this paper presents a novel adaptive control strategy for upper-limb rehabilitation exoskeletons,addressing the challenges of nonlinear dynamics and external disturbances.The proposed controller integrated a Radial Basis Function Neural Network(RBFNN)with a disturbance observer and employed a high-dimensional integral Lyapunov function to guarantee system stability and trajectory tracking performance.In the control system,the role of the RBFNN was to estimate uncertain signals in the dynamic model,while the disturbance observer tackled external disturbances during trajectory tracking.Artificially created scenarios for Human-Robot interactive experiments and periodically repeated reference trajectory experiments validated the controller’s performance,demonstrating efficient tracking.The proposed controller is found to achieve superior tracking accuracy with Root-Mean-Squared(RMS)errors of 0.022-0.026 rad for all joints,outperforming conventional Proportional-Integral-Derivative(PID)by 73%and Neural-Fuzzy Adaptive Control(NFAC)by 389.47%lower error.These results suggested that the RBFNN adaptive controller,coupled with disturbance compensation,could serve as an effective rehabilitation tool for upper-limb exoskeletons.These results demonstrate the superiority of the proposed method in enhancing rehabilitation accuracy and robustness,offering a promising solution for the control of upper-limb assistive devices.Based on the obtained results and due to their high robustness,the proposed control schemes can be extended to other motor disabilities,including lower limb exoskeletons. 展开更多
关键词 Adaptive neural network controller disturbance observer upper-limb exoskeleton rehabilitation robotics Lyapunov stability radial basis function network
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Virtual Impedance Adaptation of Lower-Limb Exoskeleton for Human Performance Augmentation Based on Deep Reinforcement Learning
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作者 Ranran Zheng Zhiyuan Yu +3 位作者 Hongwei Liu Junqin Lin Bo Zeng Longfei Jia 《Chinese Journal of Mechanical Engineering》 2025年第6期189-207,共19页
This paper proposes virtual impedance adaptation of the lower-limb exoskeleton for human performance augmentation(LEHPA) based on deep reinforcement learning(VIADRL) to mitigate reliance on model accuracy and address ... This paper proposes virtual impedance adaptation of the lower-limb exoskeleton for human performance augmentation(LEHPA) based on deep reinforcement learning(VIADRL) to mitigate reliance on model accuracy and address the ever-changing human-exoskeleton interaction(HEI) dynamics. The classical sensitivity amplification control strategy is expanded to the virtual impedance control strategy with more learnable virtual impedance parameters. The adjustment of these virtual impedance parameters is formalized as finding the optimal policy for a Markov Decision Process and can then be effectively resolved using deep reinforcement learning algorithms. To ensure safe and efficient policy training, a multibody simulation environment is established to facilitate the training process, supplemented by the innovative hybrid inverse-forward dynamics simulation approach for executing the simulation. For comparison purposes, the SADRL strategy is introduced as a benchmark. A novel control performance evaluation method based on the HEI forces at the back, thighs, and shanks is proposed to quantitatively evaluate the performance of our proposed VIADRL strategy. The VIADRL controller is systematically compared with the SADRL controller at five selected walking speeds. The lumped ratio of HEI forces under the SADRL strategy relative to those under the SADRL strategy is as low as 0.81 in simulation and approximately 0.89 on the LEHPA prototype. The overall reduction of HEI forces demonstrates the superiority of the VIADRL strategy in comparison to the SADRL strategy. 展开更多
关键词 Lower-limb exoskeleton for human performance augmentation(LEHPA) Virtual impedance adaptation Deep reinforcement learning Control performance evaluation
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Development and Control of an Upper-Limb Exoskeleton CASIA-EXO for Motor Learning in Post-Stroke Rehabilitation
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作者 Chen Wang Liang Peng Zeng-Guang Hou 《IEEE/CAA Journal of Automatica Sinica》 2025年第8期1733-1735,共3页
Dear Editor,This letter investigates the system development of a multi-joint rehabilitation exoskeleton,and highlights the subject-adaptive control factors for efficient motor learning.In order to enable the natural m... Dear Editor,This letter investigates the system development of a multi-joint rehabilitation exoskeleton,and highlights the subject-adaptive control factors for efficient motor learning.In order to enable the natural mobility of the human upper extremity,we design the shoulder mechanism by arranging three rotational joints with acute angles,and adopt a serial chain structure for the fully constructed system.After the kinematics and dynamics of CASIA-EXO are modelled,the patient-in-the-loop control strategy is proposed for rehabilitation training,consisting of the intention-based trajectory planning and performance-based intervention adaptation.Finally,we conduct experiments to validate the efficacy of the control system,and further demonstrate the potential of CASIA-EXO in neurorehabilitation.Introduction:Neurological diseases are the leading cause of nontraumatic disability worldwide,and stroke is one of the most common encountered neurological injury,which is suffered by over 15 million individuals each year,and about 70%−80%of these individuals have varying degrees of functional impairments[1].In order to facilitate the motor relearning in central nervous system,post-stroke patients need to undergo long-term rehabilitation training to promote neural plasticity,thereby enhancing the recovery of motor function in activities of daily living(ADLs).Evidence in the clinical studies suggests that robot-assisted rehabilitation integrating neuroscience,biomechanics,and automation control can improve the patients’motivation for active participation while improving the treatment efficiency,therefore,be expected to become the most promising means for neurorehabilitation[2]. 展开更多
关键词 upper limb exoskeleton motor learning post stroke rehabilitation natural mobility system development serial chain structure shoulder mechanism arranging three rotational joints
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CPG-based gait planning and model-independent adaptive time-delay control for lower limb rehabilitation exoskeleton robots
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作者 Zhe Sun Weixin Chen +3 位作者 Bo Chen Hai Wang Jinchuan Zheng Zhihong Man 《Control Theory and Technology》 2025年第4期650-662,共13页
Focusing on the rehabilitation training of hemiplegia patients,this paper proposes a gait-planning strategy based on a central pattern generator and an adaptive time-delay control scheme that utilizes recursive termin... Focusing on the rehabilitation training of hemiplegia patients,this paper proposes a gait-planning strategy based on a central pattern generator and an adaptive time-delay control scheme that utilizes recursive terminal sliding mode for lower limb rehabilitation exoskeleton robots.The central pattern generator network plans a reference gait trajectory for the affected leg,synchronized with the movement of the healthy leg.The proposed adaptive time-delay control scheme possesses a model-independent property due to the mechanism of time-delay estimation,with adaptive control gains that enhance the resilience against system perturbations and a recursive terminal sliding mode control component to achieve a fast convergence rate.According to the Lyapunov stability criterion,it is proved that the gait trajectory-tracking error is uniformly ultimately bounded.Experiments are conducted on a lower limb exoskeleton experimental platform,and the experimental results demonstrate the effectiveness and superiority of the proposed strategies. 展开更多
关键词 Lower limb rehabilitation exoskeleton robot(LLRER) Central pattern generator(CPG) Time-delay estimation(TDE) Sliding mode control(SMC)
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基于转录组解析水体高亚硝态氮导致凡纳对虾外骨骼软化机制
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作者 王洋 单洪伟 +1 位作者 陈朝通 王芳 《渔业科学进展》 北大核心 2026年第1期24-36,共13页
亚硝态氮对对虾具有较强毒性,是影响对虾生长、生存的主要环境胁迫因子之一。水体高亚硝态氮环境往往伴随着对虾外骨骼软化(软皮)的现象。为揭示水体亚硝态氮对凡纳对虾(Penaeus vannamei)外骨骼影响的作用机制,本研究从3个亚硝态氮浓度... 亚硝态氮对对虾具有较强毒性,是影响对虾生长、生存的主要环境胁迫因子之一。水体高亚硝态氮环境往往伴随着对虾外骨骼软化(软皮)的现象。为揭示水体亚硝态氮对凡纳对虾(Penaeus vannamei)外骨骼影响的作用机制,本研究从3个亚硝态氮浓度为(4.35±1.07)mg/L的凡纳对虾养殖池随机取硬壳虾(CH)为对照组,从另外3个亚硝态氮浓度为(21.05±0.84)mg/L的对虾养殖池中取硬壳虾(NH)和软壳虾(NS)作为实验组,对肝胰腺组织进行转录组学以及生理指标测定分析。转录组学结果显示,NS组几丁质降解途径关键基因的表达水平显著上调,而几丁质合成、矿物质吸收以及角质层蛋白合成途径中的关键基因的表达水平显著下调。生理指标结果显示,NS组几丁质酶、β-N-乙酰氨基葡萄糖苷酶活性显著高于NH组和CH组(P<0.05)。CH组海藻糖酶活性显著高于NS组,Ca^(2+)-ATPase的活性显著高于NH组(P<0.05)。NH组肝胰腺中Ca^(2+)含量显著高于NS组和CH组(P<0.05)。以上结果提示,水体中高浓度的亚硝态氮可能通过降低几丁质的含量、损伤角质层构象以及减少矿物质的沉积影响凡纳对虾的外骨骼硬度。本研究为进一步探究亚硝态氮对对虾外骨骼的影响提供了理论基础。 展开更多
关键词 凡纳对虾 亚硝态氮 外骨骼 几丁质 矿物质
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最优模糊理论的下肢机器人自适应鲁棒控制
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作者 陈元富 贺元成 《机械设计与制造》 北大核心 2026年第2期298-308,共11页
为了解决不确定性和外部干扰,提出了一种基于最优模糊理论的下肢外骨骼机器人自适应鲁棒控制方法。首先提出一种自适应鲁棒控制,保证系统的一致有界性和一致最终有界性。然后采用模糊集理论来描述不确定性和干扰,并用隶属函数确定这些... 为了解决不确定性和外部干扰,提出了一种基于最优模糊理论的下肢外骨骼机器人自适应鲁棒控制方法。首先提出一种自适应鲁棒控制,保证系统的一致有界性和一致最终有界性。然后采用模糊集理论来描述不确定性和干扰,并用隶属函数确定这些不确定性和干扰的界。在此基础上,构造一个包含平均模糊系统性能和控制代价的模糊性能指标,求出自适应鲁棒控制的最优控制增益,并从理论上验证了最优控制增益的存在性。最后,通过仿真结果证明了提出方法可以同时实现高精度跟踪控制和良好的不确定性鲁棒控制。 展开更多
关键词 不确定性 下肢外骨骼机器人 鲁棒控制 模糊集理论
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呼吸控制联合外骨骼机器人步行训练对脊髓损伤患儿康复的影响
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作者 李金铭 吴英英 +2 位作者 王向丽 韩亮 石彩晓 《护理学杂志》 北大核心 2026年第5期11-15,共5页
目的探讨呼吸控制联合外骨骼机器人步行训练对脊髓损伤患儿肺功能及运动功能的影响。方法将60例脊髓损伤患儿按照入院时间分为呼吸组、机器人组及联合组各20例。三组患儿均接受常规康复治疗护理,呼吸组增加呼吸控制训练,机器人组增加外... 目的探讨呼吸控制联合外骨骼机器人步行训练对脊髓损伤患儿肺功能及运动功能的影响。方法将60例脊髓损伤患儿按照入院时间分为呼吸组、机器人组及联合组各20例。三组患儿均接受常规康复治疗护理,呼吸组增加呼吸控制训练,机器人组增加外骨骼机器人步行训练,联合组实施呼吸控制训练联合外骨骼机器人步行训练。于干预前、干预4周、8周比较患儿的肺功能、平衡功能、10米步行测试及儿童功能独立性评定表评分。结果干预4周与8周后,三组患儿的肺功能、平衡功能、10米步行时间及儿童功能独立性评分较干预前均显著改善,联合组效果最佳(干预主效应、时间主效应及交互效应均P<0.05)。结论呼吸控制联合外骨骼机器人步行训练可以有效改善脊髓损伤患儿的肺功能,增强其运动能力,进而提高日常生活活动能力。 展开更多
关键词 脊髓损伤 儿童 外骨骼机器人 步行训练 呼吸控制训练 肺功能 平衡功能 康复护理
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一种基于运动状态机的搬运助力外骨骼
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作者 韩亚丽 徐闽海 +2 位作者 韩子瑒 周磊 陈志阳 《机器人》 北大核心 2026年第1期66-76,88,共12页
为减轻搬运作业人员的肌肉损伤,针对现有外骨骼灵活性低、人机耦合性差的问题,提出了一种基于套索驱动的搬运助力外骨骼。外骨骼通过电机带动线轮转动,完成套索的灵活收放,实现辅助搬运的功能,从而减轻穿戴者的肌肉损伤。首先,基于多传... 为减轻搬运作业人员的肌肉损伤,针对现有外骨骼灵活性低、人机耦合性差的问题,提出了一种基于套索驱动的搬运助力外骨骼。外骨骼通过电机带动线轮转动,完成套索的灵活收放,实现辅助搬运的功能,从而减轻穿戴者的肌肉损伤。首先,基于多传感器信息融合进行穿戴者的运动意图识别,并对外骨骼采用分层控制策略,分别采用有限运动状态机和力/位混合控制作为控制系统的上层和下层控制;其次,进行了外骨骼性能测试及助力评估。实验结果显示,在10 kg重物搬运提举过程中,肱二头肌的肌肉激活度降低约11.7%,腰竖脊肌的肌肉激活度降低约37.3%;在以0.8 m/s的速度搬运10 kg重物行走时,肱二头肌的肌肉激活度降低约31.9%。结果表明该外骨骼对手臂及腰部具有良好的助力效果。 展开更多
关键词 搬运助力外骨骼 套索驱动 运动意图识别 有限状态机
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分割树遗传算法的不规则物流园区布局研究
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作者 张思奇 郑一明 李冠洋 《机械设计与制造》 北大核心 2026年第1期71-76,83,共7页
结合物流工程中不规则物流园区功能区块布局中存在的问题,寻找合理的布局设计,为保证当前及未来持续时间内园区准确平稳运作,需要减少运作成本,以及提升运作效率。这里首先分析了物流园区的发展现状,同时对物流园区未来的发展需求进行... 结合物流工程中不规则物流园区功能区块布局中存在的问题,寻找合理的布局设计,为保证当前及未来持续时间内园区准确平稳运作,需要减少运作成本,以及提升运作效率。这里首先分析了物流园区的发展现状,同时对物流园区未来的发展需求进行了预测,并结合功能区块的物流量及面积,对物流园区的功能区块进行了划分。采用栅格结构,以物流成本最小及综合相关度最大为目标函数的集合划分模型,分析分割树遗传算法在不规则物流园区布局上的合理性,利用分割树的编码和解码方式,将遗传算法和分割树相结合。在此基础上,通过案例详细分析了分割树遗传算法在不规则物流园区布局中的具体实现方案。最后,通过实例上的运用,可以看到该模型和算法应用在不规则物流园区布局中存在的不足,并对物流园区布局的前景进行了展望。 展开更多
关键词 不规则物流园区 分割树 遗传算法 神经网络预测 矢量化模块 功能区布局
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支持ULE/MPE的IP over DVB-S接收系统在Linux下的设计与实现 被引量:2
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作者 白翔宇 叶新铭 +1 位作者 蒋海 李军 《内蒙古大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第4期463-468,共6页
IP over DVB-S是基于卫星实现IP数据广播的关键技术,在远程教育等领域广泛应用.ULE封装协议相比传统MPE协议更加简练、高效,对IP网络支持更好.设计了IP over DVB-S接收系统,并对其在Linux中实现时的关键技术予以介绍.该系统具有兼容ULE/... IP over DVB-S是基于卫星实现IP数据广播的关键技术,在远程教育等领域广泛应用.ULE封装协议相比传统MPE协议更加简练、高效,对IP网络支持更好.设计了IP over DVB-S接收系统,并对其在Linux中实现时的关键技术予以介绍.该系统具有兼容ULE/MPE两种封装方式、支持IPv4/IPv6双协议的特点,在实际环境中进行了部署. 展开更多
关键词 IP OVER DVB—S ule MPE 接收系统Linux
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灭活鸭肠炎病毒UL31基因定性标准样品研制及初步试用
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作者 姜怀玉 张媛 +11 位作者 史莉圆 穆颖 张晶晶 周梦棋 顾小雪 邵红霞 秦爱建 叶家美 王传彬 李琦 刘玉良 格日勒图 《中国家禽》 北大核心 2026年第4期61-68,共8页
为研制灭活鸭肠炎病毒(Duck enteritis virus,DEV)UL31基因定性标准样品,研究以DEV VAC株为原料,接种SPF鸭胚,经病毒鉴定、灭活处理以及冷冻干燥等技术流程,采用荧光定量PCR(qPCR)方法对所制备的标准样品进行均匀性检验、稳定性监测和评... 为研制灭活鸭肠炎病毒(Duck enteritis virus,DEV)UL31基因定性标准样品,研究以DEV VAC株为原料,接种SPF鸭胚,经病毒鉴定、灭活处理以及冷冻干燥等技术流程,采用荧光定量PCR(qPCR)方法对所制备的标准样品进行均匀性检验、稳定性监测和评估,并委托不同单位进行协作定值和试用。结果显示:该标准样品纯净、均匀,无外源病毒污染;稳定性良好,在4℃、25℃、37℃环境中可至少稳定保存14 d、7 d、5 d,在-20℃环境中可至少稳定保存12个月,且冻融10次后仍稳定;9家单位协作定值和3家试用结果均显示为鸭肠炎病毒UL31基因核酸阳性。研究表明,研制的灭活鸭肠炎病毒UL31基因定性标准样品可作为DEV核酸检测阳性质控品,用于DEV核酸检测质量控制、检测能力比对验证以及试剂盒检测效果评价等工作。 展开更多
关键词 鸭肠炎病毒 UL31基因 标准样品 核酸检测 荧光定量PCR 质量控制
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牛传染性鼻气管炎病毒UL18蛋白多克隆抗体的制备及鉴定
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作者 张含沛 刘益昆 +4 位作者 殷鑫欢 朱少睿 黄勇 童德文 杜谦 《动物医学进展》 北大核心 2026年第2期1-8,共8页
牛传染性鼻气管炎病毒(Infectious bovine rhinotracheitis virus,IBRV)是临床常见病原,UL18蛋白是IBRV衣壳蛋白,具有高度保守性,且在不同IBRV毒株中相对保守。研究旨在制备针对UL18蛋白的多克隆抗体,为IBRV的研究提供材料。参照GenBan... 牛传染性鼻气管炎病毒(Infectious bovine rhinotracheitis virus,IBRV)是临床常见病原,UL18蛋白是IBRV衣壳蛋白,具有高度保守性,且在不同IBRV毒株中相对保守。研究旨在制备针对UL18蛋白的多克隆抗体,为IBRV的研究提供材料。参照GenBank公布的IBRV全基因组序列,按照大肠埃希氏菌密码子偏好性合成UL18基因的CDS区域并连接至pET-32a载体,SDS-PAGE及Western blot鉴定目的蛋白的表达及其表达形式,对IPTG诱导浓度、温度和时间进行优化以确定最佳表达条件。利用Ni-NTA磁珠纯化蛋白并免疫Balb/c小鼠,通过酶联免疫吸附试验(ELISA)检测抗体效价,并用Western blot和间接免疫荧光验证抗体的特异性。将合成的pET-32a-UL18质粒成功转化BL21(DE3)大肠埃希氏菌,命名为pET-32a-UL18(BL21)。经诱导表达发现UL18重组蛋白表达在包涵体中,以0.1 mmol/L IPTG在30℃诱导pET-32a-UL18(BL21)表达4 h时,UL18重组蛋白表达量最高。免疫小鼠后采集血清,间接ELISA结果显示,获得的鼠抗UL18蛋白多克隆抗体效价可达1∶409600。Western blot和IFA试验结果显示,该多克隆抗体能特异性识别IBRV UL18蛋白。本研究成功制备了高效价且特异性好的鼠抗IBRV UL18蛋白多克隆抗体,为进一步开展IBRV相关研究提供了材料。 展开更多
关键词 牛传染性鼻气管炎病毒 UL18蛋白 蛋白纯化 多克隆抗体
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被动式踝关节助力外骨骼机构设计与仿真
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作者 仇志宇 朱松青 +1 位作者 韩亚丽 金壮壮 《机械科学与技术》 北大核心 2026年第1期57-65,共9页
研究了一种基于离合器和弹簧组成的踝关节助力外骨骼,该外骨骼为被动式设计,通过离合器在行走不同阶段的开合,串联弹簧实现能量的存储与释放,进而实现行走行走助力并减少代谢消耗的目的。首先,基于三维建模软件SolidWorks进行踝关节助... 研究了一种基于离合器和弹簧组成的踝关节助力外骨骼,该外骨骼为被动式设计,通过离合器在行走不同阶段的开合,串联弹簧实现能量的存储与释放,进而实现行走行走助力并减少代谢消耗的目的。首先,基于三维建模软件SolidWorks进行踝关节助力外骨骼结构设计;其次,基于Adams虚拟样机仿真,研究机构的合理性,并基于OpenSim进行人体穿戴踝关节外骨骼后的代谢能量变化研究;最后,进行行走实验,结果证明实验者穿戴踝关节助力外骨骼行走时,下肢肌肉的肌电信号减小,踝关节有较好的助力行走效果。 展开更多
关键词 踝关节 被动式外骨骼 助力行走 OpenSim仿真
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