On 29 April 2005, Ministry of Finance P.R.C. and State dministration of Taxation issued "Export Rebate Rate djustment of Partial Products". Export rebate of three types f rare earth products was cancelled (T...On 29 April 2005, Ministry of Finance P.R.C. and State dministration of Taxation issued "Export Rebate Rate djustment of Partial Products". Export rebate of three types f rare earth products was cancelled (Table 1).展开更多
At present, China's corporate business management is limited by many factors such as the cultural environment, imperfect management system, staff quality, social environment and so on, which are related to the com...At present, China's corporate business management is limited by many factors such as the cultural environment, imperfect management system, staff quality, social environment and so on, which are related to the company's economic activities. It cannot effectively prove the effectiveness of corporate business management, which limits the company's commercial activities and affects the performance of its management performance. In this paper, through clarifying the limiting factors in the company's business management, we have worked out an effective solution to improve the efficiency of business management.展开更多
Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of sys...Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of systemic metabolism.This is achieved through the secretion of a variety of hormones,cytokines,metal ions,extracellular vesicles,and other proteins/peptides,collectively referred to as bone-derived factors(BDFs).BDFs act as a medium through which bones can exert targeted regulatory functions upon various organs,thereby underscoring the profound and concrete implications of bone in human physiology.Nevertheless,there remains a pressing need for further investigations to elucidate the underlying mechanisms that inform the effects of bone on other body systems.This review aims to summarize the current findings related to the roles of these significant modulators across different organs and metabolic contexts by regulating critical genes and signaling pathways in vivo.It also addresses their involvement in the pathogenesis of various diseases affecting the musculoskeletal system,circulatory system,glucose and lipid metabolism,central nervous system,urinary system,and reproductive system.The insights gained from this review may contribute to the development of innovative therapeutic strategies through a focused approach to bone secretomes.Continued research into BDFs is expected to enhance our understanding of bone as a multifunctional organ with diverse regulatory roles in human health.展开更多
Gut microbiota(GM)exerts an indispensable effect in human health,especially in metabolism regulation.^(1)Recent studies have identified a potential association with osteoporosis.^(2–5)At the same time,GM intervention...Gut microbiota(GM)exerts an indispensable effect in human health,especially in metabolism regulation.^(1)Recent studies have identified a potential association with osteoporosis.^(2–5)At the same time,GM intervention,such as antibiotic treatment,^(6)fecal microbiota transplantation(FMT),^(7–8)supplement of probiotics^(9–10)and other means,will also subsequently affect bone metabolism.Further,GM dysbiosis was also mentioned as one of pathophysiological mechanism of osteoporosis,even written in the clinical diagnosis and treatment guidelines^(11)[Fig.1,based on Guidelines for the diagnosis and treatment of primary osteoporosis in China(2022)].展开更多
Marching band(MB)artists are often part of the general student population and not required to complete a preparticipation health screening to identify predisposing medical conditions or risks for injury/illness.Anecdo...Marching band(MB)artists are often part of the general student population and not required to complete a preparticipation health screening to identify predisposing medical conditions or risks for injury/illness.Anecdotally,exertional heat illnesses(EHI)are a concern for MB artists.As more athletic trainers provide MB healthcare,research is needed on EHI occurrence and MB associated EHI risk factors.We utilized an exploratory crosssectional study design to determine EHI risk factors,including previous EHI occurrence,among collegiate MB artists.MB artists(n=1207;age=[19.6±1.3]years)actively participating in their college/university's MB during the 2019 football season completed an online survey to characterize demographics,medical history,medication and supplement use,and nutrition behaviors.Chi-square and binomial logistical regressions assessed associations between categorical variables.Previous EHI was reported by 50.6%of MB artists,with 466(76.3%)experiencing exertional heat exhaustion and 31(5.1%)exertional heat stroke.More females reported exertional heat exhaustion overall(68.2%,p<0.001)and in the previous year(73.3%,p<0.001).Experiencing a previous EHI was significantly associated with having a mood/neurological condition(63.5%,p<0.001),diagnosed(74.3%,p=0.004)or perceived eating disorder(66.7%,p<0.001),and taking prescription medications(59.4%,p<0.001),over-the-counter medications(58.9%,p=0.002),and supplements(55.4%,p=0.037).Half of collegiate MB artists reported experiencing previous EHIs and engaged in behaviors known to increase EHI risk.MB artists should complete pre-participation examinations to identify pre-existing medical conditions and risks for adverse medical events.Healthcare providers working with MB artists should develop policies and procedures to mitigate EHI risks and occurrence.展开更多
Affective valence is typically positive at exercise intensities below the lactate threshold,yet more aversive responses occur at supra-threshold intensities.Nevertheless,the physiological and psychological predictors ...Affective valence is typically positive at exercise intensities below the lactate threshold,yet more aversive responses occur at supra-threshold intensities.Nevertheless,the physiological and psychological predictors of affective valence during supramaximal intensities including short sprint interval training(sSIT)have not yet been elucidated.Seventeen(7 women/10 men)moderately active young adults(age=[28.2±5.6]years;VO2max[maximum oxygen consumption]=[52.9±8.1]mL·kg^(-1)·min^(-1);BMI[body mass index]=[242]kg·m^(-2))completed four low-volume running sSIT sessions(10^(-4)s efforts with 30 s of passive recovery).We recorded participants’heart rate(HR),root mean square of successive differences of normal RR intervals(RMSSD),heart rate recovery(HRR),ratings of perceived exertion(RPE),feeling scale(FS),intention and self-efficacy during,and after each session.Overall,no significant correlation(p>0.05)was found between FS and baseline clinical outcomes.No significant correlation(p>0.05)was detected between FS and any training parameter.No significant correlations were noted between FS and exercise task self-efficacy and intentions(p>0.05).The regression model was significant(F_(3,61)=5.57;p=0.002)and only three variables significantly entered the generated model:ΔHRR_(end-120s end)(p=0.002;VIF=2.58;40.8%),time≥90%HR_(peak)(p=0.001;VIF=1.26;31.6%),and RMSSD_(end)(p=0.025;VIF=2.23;27.6%).These findings suggest that HR-based measures,particularly those related to in-task stress(time≥90%HR_(peak))and acute recovery(ΔHRR_(end-120s end),and RMSSD_(end)),may predict affective valence during real-world sSIT.展开更多
Dear Editor,The most serious heat related injury is exertional heat stroke(EHS).EHS occurs when healthy individuals perform physical activity in a hot and humid environment[1].A disrupted balance between heat producti...Dear Editor,The most serious heat related injury is exertional heat stroke(EHS).EHS occurs when healthy individuals perform physical activity in a hot and humid environment[1].A disrupted balance between heat production and dissipation in the human body results in excessive body heat storage in cases.It occurs frequently in the military population because of work characteristics such as the requirements to perform essential duties under prolonged heat stress,the need to achieve mission objectives during deployment operations,or the opportunities for training and selection for elite units[2].The pathophysiology of EHS is complex,which often results in thermoregulation failure,hemodynamic disturbance,and endotoxin release,and further causes multiple organ failure,probably increasing myocardial enzymes and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels.Rhabdomyolysis caused by EHS often results from mechanical and metabolic injury to the striated muscle fibers accompanied with the release of muscle contents into the circulation[3].Liu et al.展开更多
Exertional heat stroke (EHS) is a life-threatening condition characterized by profound central nervous system (CNS)dysfunction and core temperature typically>40°C.^([1])This condition involves complex pathophy...Exertional heat stroke (EHS) is a life-threatening condition characterized by profound central nervous system (CNS)dysfunction and core temperature typically>40°C.^([1])This condition involves complex pathophysiological processes in which heat triggers a cascade of dysregulated inflammatory responses,endothelial dysfunction,coagulation abnormalities,and muscle damage.These processes can lead to multiorgan failure,significantly increasing the risk of mortality.^([2])Given the severity of EHS,early identification and timely intervention are crucial.However,there are no specific diagnostic markers for EHS,^([1])highlighting the need to identify reliable clinical parameters that can assist early decision-making.展开更多
The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can b...The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can be harnessed to promote diabetic wound healing remains unexplored.Here,we investigate the impact of a bone injury strategy on diabetic wound healing,leveraging the body’s innate regenerative capacity to stimulate osteokine release and influence remote skin wound repair.This study demonstrates that the tibial defect significantly accelerates ipsilateral diabetic foot skin wound healing.Mechanistically,we identify osteokines,platelet-derived growth factor-BB(PDGF-BB),as the key to initiating this process.Bone defect triggers a substantial release of PDGF-BB,which reaches the skin wound site via peripheral circulation.At the skin wound site,PDGF-BB mediates the secretion of keratinocyte growth factor(KGF)from fibroblasts via the PDGFRβsignaling pathway,thereby promoting the rapid re-epithelialization of epidermal cells through a paracrine pathway.Additionally,elevated PDGF-BB levels enhance the regeneration of CD31hi Emcnhi blood vessels within the wound.展开更多
Prodrugs need to be converted to active drugs to exert their pharmacological activities.Identifying the direct targets of active drugs is essential to elucidate the pharmacological mechanisms of prodrugs,but remains c...Prodrugs need to be converted to active drugs to exert their pharmacological activities.Identifying the direct targets of active drugs is essential to elucidate the pharmacological mechanisms of prodrugs,but remains challenging,especially for active drugs with low stability.展开更多
Purpose The primary aim of this study was to investigate the acute dose response of 4 different individualized high intensity interval training(HIIT)prescriptions on upright standing postural control.Further,due to th...Purpose The primary aim of this study was to investigate the acute dose response of 4 different individualized high intensity interval training(HIIT)prescriptions on upright standing postural control.Further,due to the similarity between the factors contributing to the change in postural control and fatiguability,the secondary aim of this study was to evaluate the correlation between upright standing postural control and parameters of performance[electromyographic fatigue threshold(EMG_(FT))]and perceived fatiguability[rate of perceived exertion(RPE),motivation,muscle soreness]in endurance athletes.Methods For this purpose,a sample of 40 trained endurance athletes(age:21.47±2.61 years;height:164.77±7.3 cm;weight:57.53±6.3 kg;BMI:21.18±7.4 kg/m^(2))was recruited for the study and randomly allocated into 4 groups.After assessing the demographic,physiological[height,weight,heart rate,blood pressure,maximal oxygen consumption(VO_(2max)),velocity at onset of blood lactate accumulation(vOBLA)]and fatigability parameters,different groups were assigned indi-vidualized HIIT sessions with varied recovery interval intensity and duration in between the pre-and post-postural control assessments.Results All HIIT protocols caused a significant increment in the postural sway in all four directions(front,back,left,and right)which was not significantly different from each other.A strong negative correlation between the change in postural control was reported with VO_(2max),EMG_(FT)and a strong positive correlation with height,weight,body mass index,RPE,while the correlation coefficient revealed a moderate positive correlation with vOBLA.Conclusion This study concludes that all the four HIIT prescriptions have similar acute effect on the upright standing postural control and it is strongly correlated with fatiguability.展开更多
The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can b...The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can be harnessed to promote diabetic wound healing remains unexplored.Here,we investigate the impact of a bone injury strategy on diabetic wound healing,leveraging the body's innate regenerative capacity to stimulate osteokine release and influence remote skin wound repair.This study demonstrates that the tibial defect significantly accelerates ipsilateral diabetic foot skin wound healing.Mechanistically,we identify osteokines,platelet-derived growth factor-BB(PDGF-BB),as the key to initiating this process.Bone defect triggers a substantial release of PDGF-BB,which reaches the skin wound site via peripheral circulation.At the skin wound site,PDGF-BB mediates the secretion of keratinocyte growth factor(KGF)from fibroblasts via the PDGFRβsignaling pathway,thereby promoting the rapid reepithelialization of epidermal cells through a paracrine pathway.Additionally,elevated PDGF-BB levels enhance the regeneration of CD31^(h i)Emcn^(h i)blood vessels within the wound.Importantly,we demonstrate the therapeutic potential of osteokines by showing that a collagen hydrogel loaded with osteokines promotes wound healing in diabetic mice.Our findings reveal a clear link between bone and skin wound healing,providing a therapeutic inspiration for chronic wounds that are difficult to treat locally.展开更多
A 64-year-old woman who presented with progressive exertional dyspnea(NYHA class IIb)over the previous month,unresponsive to adjustments in diuretic therapy.She denied chest pain or palpitations.On physical examinatio...A 64-year-old woman who presented with progressive exertional dyspnea(NYHA class IIb)over the previous month,unresponsive to adjustments in diuretic therapy.She denied chest pain or palpitations.On physical examination,bilateral lower extremity edema and a right parasternal systolic murmur were noted.Electrocardiography showed sinus rhythm with first-degree atrioventricular block and complete right bundle branch block.展开更多
Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigat...Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigate the inheritance of stigma exertion. K239 S and K92 S are TPSGMS lines with higher and lower stigma exertion rates（SER）, respectively. The SERs of parents, reciprocal crosses and the DH population were evaluated for two consecutive years. The results showed that no significant difference was observed in SER between F1 s of K239S/K92 S and K92S/K239 S,implying that stigma exertion was a trait controlled by nuclear gene（s）. In the DH population, the segregation of low and high SERs fitted to a ratio of 3 ∶1 by Chisquare test, suggesting that the stigma exertion of K239 S was controlled by one pair of recessive genes. In addition, the effects of temperature and humidity on the expression of stigma exertion were also discussed.展开更多
Heat stroke(HS)is a fatal disease caused by thermal damage in the body,and it has a very high mortality rate.In 2015,the People’s Liberation Army Professional Committee of Critical Care Medicine published the first e...Heat stroke(HS)is a fatal disease caused by thermal damage in the body,and it has a very high mortality rate.In 2015,the People’s Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China,Expert consensus on standardized diagnosis and treatment for heat stroke.With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years,the 2015 consensus no longer meet the requirements for HS prevention and treatment.It is necessary to update the consensus to include the latest research evidence and establish a new consensus that has broader coverage,is more practical and is more in line with China’s national conditions.This new expert consensus includes new concept of HS,recommendations for laboratory tests and auxiliary examinations,new understanding of diagnosis and differential diagnosis,On-site emergency treatment and In-hospital treatment,translocation of HS patients and prevention of HS.展开更多
OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport schoo...OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters.展开更多
The results of treatment of 54 cases of rheumatoid arthritis(RA)by warm needling(WN)and point-injection(PI)with Zhuifengsu are reported.Good clinical results were observedwith an effective rate of 100%.At the same tim...The results of treatment of 54 cases of rheumatoid arthritis(RA)by warm needling(WN)and point-injection(PI)with Zhuifengsu are reported.Good clinical results were observedwith an effective rate of 100%.At the same time,changes in cellular and humoral immunityand other parameters in peripheral blood were noted before and after treatment.The NK ac-tivity and IL-2 value in RA patients were found to be lower than those of normalindividuals;both increased after treatment(P【0.01).This suggests that the WN and PIwith Zhuifengsu exert a regulatory effect on the cellular immunological function.展开更多
OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared w...OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.展开更多
5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor...5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor,could partially inhibit the EAA,abolish the effects ofEA’s increasing the 5-HT content in the medulla oblongata plus pons and the DA level in thebrain stem,and decrease the NA level in the diencephalon after EA.These results indicate thatEA may mediate the metabolism of the central monoamine neurotransmitters partially via opiatereceptor to exert its analgesic effect.展开更多
文摘On 29 April 2005, Ministry of Finance P.R.C. and State dministration of Taxation issued "Export Rebate Rate djustment of Partial Products". Export rebate of three types f rare earth products was cancelled (Table 1).
文摘At present, China's corporate business management is limited by many factors such as the cultural environment, imperfect management system, staff quality, social environment and so on, which are related to the company's economic activities. It cannot effectively prove the effectiveness of corporate business management, which limits the company's commercial activities and affects the performance of its management performance. In this paper, through clarifying the limiting factors in the company's business management, we have worked out an effective solution to improve the efficiency of business management.
基金supported, in part, by the National Natural Science Foundation of China Grants (82430078, 82261160395, 82230081, 82004395, 82302767)the Shenzhen Medical Research Funds (B2402033, C2401029)+5 种基金the Shenzhen Fundamental Research Program (JCYJ20220818100617036)the National Key Research and Development Program of China Grants (2019YFA0906004)the Guangdong Provincial Science and Technology Innovation Council Grant (2017B030301018)the Shenzhen Key Laboratory of Cell Microenvironment Grant (ZDSYS20140509142721429)the Hubei Provincial Natural Science Foundation of China (2024AFB610)the Science Foundation of Wuhan Union Hospital (2022xhyn032)
文摘Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of systemic metabolism.This is achieved through the secretion of a variety of hormones,cytokines,metal ions,extracellular vesicles,and other proteins/peptides,collectively referred to as bone-derived factors(BDFs).BDFs act as a medium through which bones can exert targeted regulatory functions upon various organs,thereby underscoring the profound and concrete implications of bone in human physiology.Nevertheless,there remains a pressing need for further investigations to elucidate the underlying mechanisms that inform the effects of bone on other body systems.This review aims to summarize the current findings related to the roles of these significant modulators across different organs and metabolic contexts by regulating critical genes and signaling pathways in vivo.It also addresses their involvement in the pathogenesis of various diseases affecting the musculoskeletal system,circulatory system,glucose and lipid metabolism,central nervous system,urinary system,and reproductive system.The insights gained from this review may contribute to the development of innovative therapeutic strategies through a focused approach to bone secretomes.Continued research into BDFs is expected to enhance our understanding of bone as a multifunctional organ with diverse regulatory roles in human health.
基金supported by the National Key Research and Development Program(2021YFC2501700)the National Natural Science Foundation of China(82330078,82272554)Beijing Natural Science Foundation(7232214,L241067)。
文摘Gut microbiota(GM)exerts an indispensable effect in human health,especially in metabolism regulation.^(1)Recent studies have identified a potential association with osteoporosis.^(2–5)At the same time,GM intervention,such as antibiotic treatment,^(6)fecal microbiota transplantation(FMT),^(7–8)supplement of probiotics^(9–10)and other means,will also subsequently affect bone metabolism.Further,GM dysbiosis was also mentioned as one of pathophysiological mechanism of osteoporosis,even written in the clinical diagnosis and treatment guidelines^(11)[Fig.1,based on Guidelines for the diagnosis and treatment of primary osteoporosis in China(2022)].
文摘Marching band(MB)artists are often part of the general student population and not required to complete a preparticipation health screening to identify predisposing medical conditions or risks for injury/illness.Anecdotally,exertional heat illnesses(EHI)are a concern for MB artists.As more athletic trainers provide MB healthcare,research is needed on EHI occurrence and MB associated EHI risk factors.We utilized an exploratory crosssectional study design to determine EHI risk factors,including previous EHI occurrence,among collegiate MB artists.MB artists(n=1207;age=[19.6±1.3]years)actively participating in their college/university's MB during the 2019 football season completed an online survey to characterize demographics,medical history,medication and supplement use,and nutrition behaviors.Chi-square and binomial logistical regressions assessed associations between categorical variables.Previous EHI was reported by 50.6%of MB artists,with 466(76.3%)experiencing exertional heat exhaustion and 31(5.1%)exertional heat stroke.More females reported exertional heat exhaustion overall(68.2%,p<0.001)and in the previous year(73.3%,p<0.001).Experiencing a previous EHI was significantly associated with having a mood/neurological condition(63.5%,p<0.001),diagnosed(74.3%,p=0.004)or perceived eating disorder(66.7%,p<0.001),and taking prescription medications(59.4%,p<0.001),over-the-counter medications(58.9%,p=0.002),and supplements(55.4%,p=0.037).Half of collegiate MB artists reported experiencing previous EHIs and engaged in behaviors known to increase EHI risk.MB artists should complete pre-participation examinations to identify pre-existing medical conditions and risks for adverse medical events.Healthcare providers working with MB artists should develop policies and procedures to mitigate EHI risks and occurrence.
基金founded by Proyectos I+D,Comision Sectorial de Investigacion Científica,Universidad de la República,Uruguay 2018,grant number 192supported by Grant RYC2021-031098-I funded by MCIN/AEI/10.13039/501100011033,by“European Union Next Generation EU/PRTR”by a productivity research grant PQ1-D(317126/2021-0)by CNPq(Brazil).
文摘Affective valence is typically positive at exercise intensities below the lactate threshold,yet more aversive responses occur at supra-threshold intensities.Nevertheless,the physiological and psychological predictors of affective valence during supramaximal intensities including short sprint interval training(sSIT)have not yet been elucidated.Seventeen(7 women/10 men)moderately active young adults(age=[28.2±5.6]years;VO2max[maximum oxygen consumption]=[52.9±8.1]mL·kg^(-1)·min^(-1);BMI[body mass index]=[242]kg·m^(-2))completed four low-volume running sSIT sessions(10^(-4)s efforts with 30 s of passive recovery).We recorded participants’heart rate(HR),root mean square of successive differences of normal RR intervals(RMSSD),heart rate recovery(HRR),ratings of perceived exertion(RPE),feeling scale(FS),intention and self-efficacy during,and after each session.Overall,no significant correlation(p>0.05)was found between FS and baseline clinical outcomes.No significant correlation(p>0.05)was detected between FS and any training parameter.No significant correlations were noted between FS and exercise task self-efficacy and intentions(p>0.05).The regression model was significant(F_(3,61)=5.57;p=0.002)and only three variables significantly entered the generated model:ΔHRR_(end-120s end)(p=0.002;VIF=2.58;40.8%),time≥90%HR_(peak)(p=0.001;VIF=1.26;31.6%),and RMSSD_(end)(p=0.025;VIF=2.23;27.6%).These findings suggest that HR-based measures,particularly those related to in-task stress(time≥90%HR_(peak))and acute recovery(ΔHRR_(end-120s end),and RMSSD_(end)),may predict affective valence during real-world sSIT.
基金supported by the Natural Science Foundation of Hainan Province(821QN389,821MS112,822MS198,820MS126,820QN383)the Military Medical Science and Technology Youth Incubation Program(20QNPY110,19QNP060)+6 种基金the Excellent Youth Incubation Program of Chinese PLA General Hospital(2020-YQPY-007)the Heatstroke Treatment and Research Center of Chinese PLA(413EGZ1D10)the Simulation Training for Treatment of Heatstroke,the Major Science and Technology Programme of Hainan Province(ZDKJ2019012)the National Key Research and Development Program of China(2018YFC2000400)the National S&T Resource Sharing Service Platform Project of China(YCZYPT[2018]07)the Specific Research Fund of Innovation Platform for Academicians of Hainan Province(YSPTZX202216)the Medical Big Data Research and Development Project of Chinese PLA General Hospital(MBD2018030).
文摘Dear Editor,The most serious heat related injury is exertional heat stroke(EHS).EHS occurs when healthy individuals perform physical activity in a hot and humid environment[1].A disrupted balance between heat production and dissipation in the human body results in excessive body heat storage in cases.It occurs frequently in the military population because of work characteristics such as the requirements to perform essential duties under prolonged heat stress,the need to achieve mission objectives during deployment operations,or the opportunities for training and selection for elite units[2].The pathophysiology of EHS is complex,which often results in thermoregulation failure,hemodynamic disturbance,and endotoxin release,and further causes multiple organ failure,probably increasing myocardial enzymes and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels.Rhabdomyolysis caused by EHS often results from mechanical and metabolic injury to the striated muscle fibers accompanied with the release of muscle contents into the circulation[3].Liu et al.
基金funded by Research Fund of Zhejiang Provincial Health Commission (2025KY8662025)。
文摘Exertional heat stroke (EHS) is a life-threatening condition characterized by profound central nervous system (CNS)dysfunction and core temperature typically>40°C.^([1])This condition involves complex pathophysiological processes in which heat triggers a cascade of dysregulated inflammatory responses,endothelial dysfunction,coagulation abnormalities,and muscle damage.These processes can lead to multiorgan failure,significantly increasing the risk of mortality.^([2])Given the severity of EHS,early identification and timely intervention are crucial.However,there are no specific diagnostic markers for EHS,^([1])highlighting the need to identify reliable clinical parameters that can assist early decision-making.
基金supported by the Key Program of the National Natural Science Foundation of China grants 32230059the Basic Science Center Program T2288102+1 种基金the National Natural Science Foundation of China grants 32301123the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry JKVD1211002.
文摘The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can be harnessed to promote diabetic wound healing remains unexplored.Here,we investigate the impact of a bone injury strategy on diabetic wound healing,leveraging the body’s innate regenerative capacity to stimulate osteokine release and influence remote skin wound repair.This study demonstrates that the tibial defect significantly accelerates ipsilateral diabetic foot skin wound healing.Mechanistically,we identify osteokines,platelet-derived growth factor-BB(PDGF-BB),as the key to initiating this process.Bone defect triggers a substantial release of PDGF-BB,which reaches the skin wound site via peripheral circulation.At the skin wound site,PDGF-BB mediates the secretion of keratinocyte growth factor(KGF)from fibroblasts via the PDGFRβsignaling pathway,thereby promoting the rapid re-epithelialization of epidermal cells through a paracrine pathway.Additionally,elevated PDGF-BB levels enhance the regeneration of CD31hi Emcnhi blood vessels within the wound.
基金support from the National Natural Science Foundation of China(Grant Nos.:U21A20407 and 81973467).
文摘Prodrugs need to be converted to active drugs to exert their pharmacological activities.Identifying the direct targets of active drugs is essential to elucidate the pharmacological mechanisms of prodrugs,but remains challenging,especially for active drugs with low stability.
基金supported by the research grant under the Prime Minister Research Fellowship(PMRF)(Scheme code-3268)given by the Ministry of Education,Government of India.The funding agency had no role in the data analysis and interpretation,or the right to approve or disapprove publication of the finished manuscript.
文摘Purpose The primary aim of this study was to investigate the acute dose response of 4 different individualized high intensity interval training(HIIT)prescriptions on upright standing postural control.Further,due to the similarity between the factors contributing to the change in postural control and fatiguability,the secondary aim of this study was to evaluate the correlation between upright standing postural control and parameters of performance[electromyographic fatigue threshold(EMG_(FT))]and perceived fatiguability[rate of perceived exertion(RPE),motivation,muscle soreness]in endurance athletes.Methods For this purpose,a sample of 40 trained endurance athletes(age:21.47±2.61 years;height:164.77±7.3 cm;weight:57.53±6.3 kg;BMI:21.18±7.4 kg/m^(2))was recruited for the study and randomly allocated into 4 groups.After assessing the demographic,physiological[height,weight,heart rate,blood pressure,maximal oxygen consumption(VO_(2max)),velocity at onset of blood lactate accumulation(vOBLA)]and fatigability parameters,different groups were assigned indi-vidualized HIIT sessions with varied recovery interval intensity and duration in between the pre-and post-postural control assessments.Results All HIIT protocols caused a significant increment in the postural sway in all four directions(front,back,left,and right)which was not significantly different from each other.A strong negative correlation between the change in postural control was reported with VO_(2max),EMG_(FT)and a strong positive correlation with height,weight,body mass index,RPE,while the correlation coefficient revealed a moderate positive correlation with vOBLA.Conclusion This study concludes that all the four HIIT prescriptions have similar acute effect on the upright standing postural control and it is strongly correlated with fatiguability.
基金supported by the Key Program of the National Natural Science Foundation of China grants 32230059the Basic Science Center Program T2288102,the National Natural Science Foundation of China grants 32301123the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry JKVD1211002。
文摘The treatment of severe diabetic foot remains a clinical challenge.While it is established that bone can exert systemic effects through the secretion of osteokines on other organs,whether this endocrine function can be harnessed to promote diabetic wound healing remains unexplored.Here,we investigate the impact of a bone injury strategy on diabetic wound healing,leveraging the body's innate regenerative capacity to stimulate osteokine release and influence remote skin wound repair.This study demonstrates that the tibial defect significantly accelerates ipsilateral diabetic foot skin wound healing.Mechanistically,we identify osteokines,platelet-derived growth factor-BB(PDGF-BB),as the key to initiating this process.Bone defect triggers a substantial release of PDGF-BB,which reaches the skin wound site via peripheral circulation.At the skin wound site,PDGF-BB mediates the secretion of keratinocyte growth factor(KGF)from fibroblasts via the PDGFRβsignaling pathway,thereby promoting the rapid reepithelialization of epidermal cells through a paracrine pathway.Additionally,elevated PDGF-BB levels enhance the regeneration of CD31^(h i)Emcn^(h i)blood vessels within the wound.Importantly,we demonstrate the therapeutic potential of osteokines by showing that a collagen hydrogel loaded with osteokines promotes wound healing in diabetic mice.Our findings reveal a clear link between bone and skin wound healing,providing a therapeutic inspiration for chronic wounds that are difficult to treat locally.
文摘A 64-year-old woman who presented with progressive exertional dyspnea(NYHA class IIb)over the previous month,unresponsive to adjustments in diuretic therapy.She denied chest pain or palpitations.On physical examination,bilateral lower extremity edema and a right parasternal systolic murmur were noted.Electrocardiography showed sinus rhythm with first-degree atrioventricular block and complete right bundle branch block.
基金Supported by Applied Basic Research Program of Yunnan Province(2010CD096)National High-tech Research and Development Program of China(863 Program)(2011AA10A106)Key New Products Development Program of Department of Science and Technology,Yunnan Province(2012BB015)~~
文摘Stigma exertion is one of the key factors for improving the outcrossing ability of wheat thermo-photo sensitive genic male sterile（TPSGMS） line. A DH population derived from K239S/K92 S was constructed to investigate the inheritance of stigma exertion. K239 S and K92 S are TPSGMS lines with higher and lower stigma exertion rates（SER）, respectively. The SERs of parents, reciprocal crosses and the DH population were evaluated for two consecutive years. The results showed that no significant difference was observed in SER between F1 s of K239S/K92 S and K92S/K239 S,implying that stigma exertion was a trait controlled by nuclear gene（s）. In the DH population, the segregation of low and high SERs fitted to a ratio of 3 ∶1 by Chisquare test, suggesting that the stigma exertion of K239 S was controlled by one pair of recessive genes. In addition, the effects of temperature and humidity on the expression of stigma exertion were also discussed.
文摘Heat stroke(HS)is a fatal disease caused by thermal damage in the body,and it has a very high mortality rate.In 2015,the People’s Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China,Expert consensus on standardized diagnosis and treatment for heat stroke.With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years,the 2015 consensus no longer meet the requirements for HS prevention and treatment.It is necessary to update the consensus to include the latest research evidence and establish a new consensus that has broader coverage,is more practical and is more in line with China’s national conditions.This new expert consensus includes new concept of HS,recommendations for laboratory tests and auxiliary examinations,new understanding of diagnosis and differential diagnosis,On-site emergency treatment and In-hospital treatment,translocation of HS patients and prevention of HS.
文摘OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters.
文摘The results of treatment of 54 cases of rheumatoid arthritis(RA)by warm needling(WN)and point-injection(PI)with Zhuifengsu are reported.Good clinical results were observedwith an effective rate of 100%.At the same time,changes in cellular and humoral immunityand other parameters in peripheral blood were noted before and after treatment.The NK ac-tivity and IL-2 value in RA patients were found to be lower than those of normalindividuals;both increased after treatment(P【0.01).This suggests that the WN and PIwith Zhuifengsu exert a regulatory effect on the cellular immunological function.
基金the National Natural Science Foundation of China(Research of the Biological Effects and Mechanism of Different Guasha Therapies,No.30672720)the National Natural Science Foundation of China(Comparative Research of Different Acupuncture Stimulation Methods on The Expression of Effects in Acupoint Areas,No.81674079)
文摘OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.
文摘5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor,could partially inhibit the EAA,abolish the effects ofEA’s increasing the 5-HT content in the medulla oblongata plus pons and the DA level in thebrain stem,and decrease the NA level in the diencephalon after EA.These results indicate thatEA may mediate the metabolism of the central monoamine neurotransmitters partially via opiatereceptor to exert its analgesic effect.
