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Nonlinear dynamics of a circular curved cantilevered pipe conveying pulsating fluid based on the geometrically exact model
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作者 Runqing CAO Zilong GUO +2 位作者 Wei CHEN Huliang DAI Lin WANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第2期261-276,共16页
Due to the novel applications of flexible pipes conveying fluid in the field of soft robotics and biomedicine,the investigations on the mechanical responses of the pipes have attracted considerable attention.The fluid... Due to the novel applications of flexible pipes conveying fluid in the field of soft robotics and biomedicine,the investigations on the mechanical responses of the pipes have attracted considerable attention.The fluid-structure interaction(FSI)between the pipe with a curved shape and the time-varying internal fluid flow brings a great challenge to the revelation of the dynamical behaviors of flexible pipes,especially when the pipe is highly flexible and usually undergoes large deformations.In this work,the geometrically exact model(GEM)for a curved cantilevered pipe conveying pulsating fluid is developed based on the extended Hamilton's principle.The stability of the curved pipe with three different subtended angles is examined with the consideration of steady fluid flow.Specific attention is concentrated on the large-deformation resonance of circular pipes conveying pulsating fluid,which is often encountered in practical engineering.By constructing bifurcation diagrams,oscillating shapes,phase portraits,time traces,and Poincarémaps,the dynamic responses of the curved pipe under various system parameters are revealed.The mean flow velocity of the pulsating fluid is chosen to be either subcritical or supercritical.The numerical results show that the curved pipe conveying pulsating fluid can exhibit rich dynamical behaviors,including periodic and quasi-periodic motions.It is also found that the preferred instability type of a cantilevered curved pipe conveying steady fluid is mainly in the flutter of the second mode.For a moderate value of the mass ratio,however,a third-mode flutter may occur,which is quite different from that of a straight pipe system. 展开更多
关键词 curved pipe conveying fluid pulsating fluid geometrically exact model(GEM) nonlinear dynamics parametric vibration FLUTTER
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THREE-DIMENSIONAL EXACT MODELING OF GEOMETRIC AND MECHANICAL PROPERTIES OF WOVEN COMPOSITES
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作者 Zhangjian Wu 《Acta Mechanica Solida Sinica》 SCIE EI 2009年第5期479-486,共8页
A formulation for the prediction of the influence of various parameters on the elastic moduli of three-dimensional (3D) orthogonally woven composites has been given. These parameters can be classified into different... A formulation for the prediction of the influence of various parameters on the elastic moduli of three-dimensional (3D) orthogonally woven composites has been given. These parameters can be classified into different groups according to their properties, such as input design and material parameters, structural parameters etc. Some, by their nature, can be well controlled during the design and manufacture of the composite. The composite is assumed to be homogeneous and orthotropic macroscopically. With a selected representative unit cell and the stiffness model developed by author in 2000, the influence of all of these parameters can be determined. Results showing the influence of the main design geometric parameters are presented. They demonstrate that an optimal design is possible for the through-the-thickness stiffness of the composites. The methodology used can be generalized to predict the behavior of other kinds of 3D woven structures. 展开更多
关键词 woven composites 3D modelling mechanical property exact solution
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Conservation Laws and Particular Solutions for a Keller-Segel Model
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作者 Luyun Chen Jie Lou 《Advances in Pure Mathematics》 2025年第2期107-118,共12页
This work focuses on a Keller-Segel chemotaxis model, with an emphasis on its conservation laws. Through a new approach combined with the multiplier method, called the mixed method, we obtain conservation vectors that... This work focuses on a Keller-Segel chemotaxis model, with an emphasis on its conservation laws. Through a new approach combined with the multiplier method, called the mixed method, we obtain conservation vectors that are related and unrelated to symmetric information. In addition, some exact solutions with particular forms are obtained according to the method of conservation laws. These particular solutions are different from the group-invariant solutions. 展开更多
关键词 Keller-Segel model Conservation Laws Mixed Method exact Solutions
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一种新型测量瓦里安碳纤维Exact IGRT Couch HU值的方法及临床应用
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作者 王广善 张同梅 +2 位作者 邢彦 牛亦婷 金见悦 《中国医学物理学杂志》 2025年第9期1130-1135,共6页
目的:寻找一种新方法测量瓦里安Exact IGRT Couch表面碳纤维材料的HU值,并在计划系统中创建治疗床模型,以修正治疗床对射线剂量的衰减。方法:通过两种不同的射野组合对瓦里安Exact IGRT Couch床头薄端和中间中等厚度处对射线剂量的衰减... 目的:寻找一种新方法测量瓦里安Exact IGRT Couch表面碳纤维材料的HU值,并在计划系统中创建治疗床模型,以修正治疗床对射线剂量的衰减。方法:通过两种不同的射野组合对瓦里安Exact IGRT Couch床头薄端和中间中等厚度处对射线剂量的衰减进行测量,得到射线穿治疗床和不穿治疗床两种情况下的剂量偏差。在治疗计划系统(TPS)中定义多组不同的床表面材料的HU值,按照与测量相同的条件计算射线穿床和不穿床两种情况下剂量差异。通过数据比对分析,找到与实测相对应的治疗床材料的HU值。结果:两对穿射野在薄端处的衰减为-2.49%~-1.69%,在中等厚度处的衰减为-3.43%~-2.23%;多个斜入射射野在薄端处的衰减为-3.12%~-2.17%,在中等厚度处的衰减为-3.59%~-2.86%。当TPS中床模型表面和内部HU值分别定义为-500和-960时,两对穿射野在薄端处的衰减为-2.57%~-1.53%,在中等厚度处的衰减为-3.28%~-2.18%,多个斜入射射野在薄端处的衰减为-3.12%~-2.21%,在中等厚度处的衰减为-3.42%~-2.43%,与实测数值比较吻合。40个验证计划在薄端和中等厚度处实测点剂量与TPS计算剂量平均差异分别为0.90%和0.89%。结论:该新型测量方法可以预测Exact IGRT Couch表面碳纤维材料和内部泡沫材料的HU值,在TPS中定义床模型两种材料的HU值为-500和-960校正治疗床对射线的衰减,从而提高靶区和危及器官的剂量精度。 展开更多
关键词 exact IGRT Couch 治疗床 衰减 HU值 床模型
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On dynamics of elastic rod based on exact Cosserat model 被引量:11
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作者 刘延柱 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第1期1-8,共8页
The analysis of kinematics and dynamics of an elastic rod with circular cross section is studied on the basis of exact Cosserat model under consideration of the tension and shear deformation of the rod. The dynamical ... The analysis of kinematics and dynamics of an elastic rod with circular cross section is studied on the basis of exact Cosserat model under consideration of the tension and shear deformation of the rod. The dynamical equations of a rod with arbitrary initial shape are established in general form. The dynamics of a straight rod under axial tension and torsion is discussed as an example. In discussion of static stability in the space domain the Greenhill criteria of stability and the Euler load are corrected by the influence of tension and shear strain. In analysis of dynamical stability in the time domain it is shown that the Lyapunov and Euler stability conditions of the rod in space domain are the necessary conditions of Lyapunov's stability in the time domain. The longitudinal, torsional and lateral vibrations of a straight rod based on exact model are discussed, and an exact formula of free frequency of lateral vibration is obtained. The free frequency formulas of various simplified models, such as the Rayleigh beam, the Kirchhoff rod, and the Timoshenko beam, can be seen as special cases of the exact formula under different conditions of simplification. 展开更多
关键词 dynamics of elastic rod exact Cosserat model lateral vibration of rod
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A search-free near-field source localization method with exact signal model 被引量:2
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作者 PAN Jingjing SINGH Parth Raj MEN Shaoyang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第4期756-763,共8页
Most of the near-field source localization methods are developed with the approximated signal model,because the phases of the received near-field signal are highly non-linear.Nevertheless,the approximated signal model... Most of the near-field source localization methods are developed with the approximated signal model,because the phases of the received near-field signal are highly non-linear.Nevertheless,the approximated signal model based methods suffer from model mismatch and performance degradation while the exact signal model based estimation methods usually involve parameter searching or multiple decomposition procedures.In this paper,a search-free near-field source localization method is proposed with the exact signal model.Firstly,the approximative estimates of the direction of arrival(DOA)and range are obtained by using the approximated signal model based method through parameter separation and polynomial rooting operations.Then,the approximative estimates are corrected with the exact signal model according to the exact expressions of phase difference in near-field observations.The proposed method avoids spectral searching and parameter pairing and has enhanced estimation performance.Numerical simulations are provided to demonstrate the effectiveness of the proposed method. 展开更多
关键词 NEAR-FIELD source localization polynomial rooting approximation error exact signal model
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Stability analysis of helical rod based on exact Cosserat model 被引量:1
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作者 刘延柱 薛纭 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2011年第5期603-612,共10页
Helical equilibrium of a thin elastic rod has practical backgrounds, such as DNA, fiber, sub-ocean cable, and oil-well drill string. Kirchhoff's kinetic analogy is an effective approach to the stability analysis of e... Helical equilibrium of a thin elastic rod has practical backgrounds, such as DNA, fiber, sub-ocean cable, and oil-well drill string. Kirchhoff's kinetic analogy is an effective approach to the stability analysis of equilibrium of a thin elastic rod. The main hypotheses of Kirchhoff's theory without the extension of the centerline and the shear deformation of the cross section are not adoptable to real soft materials of biological fibers. In this paper, the dynamic equations of a rod with a circular cross section are established on the basis of the exact Cosserat model by considering the tension and the shear deformations. Euler's angles are applied as the attitude representation of the cross section. The deviation of the normal axis of the cross section from the tangent of the centerline is considered as the result of the shear deformation. Lyapunov's stability of the helical equilibrium is discussed in static category. Euler's critical values of axial force and torque are obtained. Lyapunov's and Euler's stability conditions in the space domain are the necessary conditions of Lyapunov's stability of the helical rod in the time domain. 展开更多
关键词 exact Cosserat model Kirchhoff's rod Lyapunov's stability Euler's load
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THE EXACT ANALYTICAL SOLUTIONS TO THE NEW MODEL OF RESERVOIR FILTRATION PROBLEM 被引量:1
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作者 李笑萍 赵子刚 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1993年第7期615-626,共12页
The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtra... The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtration and consequently has got, through various forms of limits, the exact analytical solutions of the three common reservoirs (fissure, homogeneous and the two-layered) pressure distribution under the conditions of three boundaries, i.e., infinite boundary, sealed finite boundary and the finite boundary at constant pressures. 展开更多
关键词 reservoir filtration new model exact analytical solutions
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An exact solution for flow past an accelerated horizontal plate in a rotating fluid with the generalized Oldroyd-B model 被引量:1
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作者 Jianhong Kang Mingyu Xu Institute of Applied Mathematics,School of Mathematics and System Science,Shandong University, 250100 Jinan, China 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2009年第4期463-469,共7页
In this paper, the generalized Oldroyd-B with fractional calculus approach is used. An exact solution in terms of Fox-H function for flow past an accelerated horizontal plate in a rotating fluid is obtained by using d... In this paper, the generalized Oldroyd-B with fractional calculus approach is used. An exact solution in terms of Fox-H function for flow past an accelerated horizontal plate in a rotating fluid is obtained by using discrete Laplace transform method. A comparison among the influence of various parameters in the Oldroyd-B model and the angular velocity of the fluid on the velocity profiles is made through numerical method in graphic form. 展开更多
关键词 Generalized Oldroyd-B model Rotating fluid Accelerated plate exact solution
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Exact analytical solutions to the mean-field model depicting microcavity containing semiconductor quantum wells
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作者 宋佩君 吕新友 +1 位作者 刘继兵 郝向英 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第5期85-91,共7页
By using a two-mode mean-field approximation, we study the dynamics of the microcavities containing semiconductor quantum wells. The exact analytical solutions are obtained in this study. Based on these solutions, we ... By using a two-mode mean-field approximation, we study the dynamics of the microcavities containing semiconductor quantum wells. The exact analytical solutions are obtained in this study. Based on these solutions, we show that the emission from the microcavity manifests periodic oscillation behaviour and the oscillation can be suppressed under a certain condition. 展开更多
关键词 mean-field model MICROCAVITY exact analytical solutions
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细长输流管道大变形动力学研究进展 被引量:3
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作者 陈伟 曹润青 +2 位作者 胡嘉纯 代胡亮 王琳 《力学进展》 北大核心 2025年第1期113-174,共62页
细长输流管道是发动机液压装置、航空加油机、核工业热交换器、海洋钻井平台等工程装备系统的一类重要结构.当流速较高时,细长管道可能会发生屈曲或颤振等流致失稳现象,严重时可酿成重大安全事故.输流管道的流致失稳及其非线性振动是典... 细长输流管道是发动机液压装置、航空加油机、核工业热交换器、海洋钻井平台等工程装备系统的一类重要结构.当流速较高时,细长管道可能会发生屈曲或颤振等流致失稳现象,严重时可酿成重大安全事故.输流管道的流致失稳及其非线性振动是典型的流固耦合力学行为,已成为结构动力学、流固耦合力学等研究领域的一个普遍性范例.在建立动力学方程、明确稳定性机理和分析非线性振动规律之后,近年来人们极其关注输流管道的大变形/大位移动力学问题.本文系统介绍了细长输流管道非线性振动,特别是其弯曲大变形动力学的研究进展.首先,概述了输流管系统的非线性特征及其分类,简要分析了一些常用假设的合理性.其次,重点介绍了泰勒展开近似模型、几何精确理论模型、绝对节点坐标描述计算模型、数据驱动模型及相关的其他建模与求解方法.然后,针对两端支撑管道和悬臂管道两类有本质区别的动力学系统,回顾了其非线性动力学机理与演化规律,重点介绍了悬臂管道从小变形假设到大变形响应的一些新近研究进展.在此基础上,还介绍了提高输流管稳定性、抑制输流管非线性振动和利用输流管大变形响应的主要方法.最后,对细长输流管道大变形动力学的研究现状进行了归纳总结,并指出值得关注的几个基础性科学问题. 展开更多
关键词 输流管道 流固耦合 大变形动力学 几何精确模型 绝对节点坐标法
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Exact solutions to drift-flux multiphase flow models through Lie group symmetry analysis
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作者 B.BIRA T.R.SEKHAR 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2015年第8期1105-1112,共8页
In the present paper, Lie group symmetry method is used to obtain some exact solutions for a hyperbolic system of partial differential equations (PDEs), which governs an isothermal no-slip drift-flux model for multi... In the present paper, Lie group symmetry method is used to obtain some exact solutions for a hyperbolic system of partial differential equations (PDEs), which governs an isothermal no-slip drift-flux model for multiphase flow problem. Those sym- metries are used for the governing system of equations to obtain infinitesimal transforma- tions, which consequently reduces the governing system of PDEs to a system of ODEs. Further, the solutions of the system of ODEs which in turn produces some exact solutions for the PDEs are presented. Finally, the evolutionary behavior of weak discontinuity is discussed. 展开更多
关键词 multiphase flow drift-flux models Lie group analysis exact solution weakdiscontinuity
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AUTO-DARBOUX TRANSFORMATION AND EXACT SOLUTIONS OF THE BRUSSELATOR REACTION DIFFUSION MODEL 被引量:3
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作者 YAN Zhenya(闫振亚) +1 位作者 ZHANG Hongqing(张鸿庆) 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2001年第5期541-546,共6页
Firstly, using the improved homogeneous balance method, an auto-Darboux transformation (ADT) for the Brusselator reaction diffusion model is found. Based on the ADT, several exact solutions are obtained which contain ... Firstly, using the improved homogeneous balance method, an auto-Darboux transformation (ADT) for the Brusselator reaction diffusion model is found. Based on the ADT, several exact solutions are obtained which contain some authors' results known. Secondly, by using a series of transformations, the model is reduced into a nonlinear reaction diffusion equation and then through using sine-cosine method, more exact solutions are found which contain soliton solutions. 展开更多
关键词 brusselator reaction model Darboux transformation homogeneous balance method sine-cosine method exact solution
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Exact Solutions of a Power Law Fluid Model in Posttreatment Analysis of Wire Coating with Linearly Varying Boundary Temperature
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作者 Rehan Ali Shah Saeed Islam +1 位作者 Abdul Majeed Siddiqui Tahira Haroon 《Applied Mathematics》 2013年第2期330-337,共8页
In this paper, analysis of post-treatment of wire coating is presented. Coating material satisfies power law fluid model. Exact solutions for the velocity field, volume flow rate and average velocity are obtained. Mor... In this paper, analysis of post-treatment of wire coating is presented. Coating material satisfies power law fluid model. Exact solutions for the velocity field, volume flow rate and average velocity are obtained. Moreover, the heat transfer results are presented for different cases of linearly varying on the boundaries. The variations of velocity, volume flow rate, radius of coated wire, shear rate and the force on the total wire are presented graphically and discussed. 展开更多
关键词 exact Solution WIRE COATING Power Law Fluid model LINEARLY VARYING TEMPERATURE at Boundaries
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15 MW级风力机纵荡过程中的气弹耦合特性研究 被引量:1
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作者 周乐 李逸佳 +3 位作者 马璐 沈昕 欧阳华 杜朝辉 《工程热物理学报》 北大核心 2025年第7期2254-2260,共7页
基于升力线自由尾迹模型及几何精确梁模型,以IEA-15 MW风力机为对象研究了纵荡条件下风力机的气弹耦合特性。结果表明:纵荡工况下风力机的载荷会呈现出周期性波动,且受风轮尾迹的诱导作用、翼型的非定常气动特性及叶片形变运动的影响,... 基于升力线自由尾迹模型及几何精确梁模型,以IEA-15 MW风力机为对象研究了纵荡条件下风力机的气弹耦合特性。结果表明:纵荡工况下风力机的载荷会呈现出周期性波动,且受风轮尾迹的诱导作用、翼型的非定常气动特性及叶片形变运动的影响,载荷的响应存在一定的延迟。在考虑叶片柔性后,叶片的形变(尤其是扭转变形)会降低风力机的功率和推力。此外,纵荡工况下浮台运动和叶片自身重力影响的叠加会使叶片的形变特征较固定工况更加复杂。 展开更多
关键词 浮式风力机 纵荡运动 气弹耦合 自由尾迹模型 几何精确梁模型
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精确线性约束条件下众数回归模型的参数估计
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作者 王照良 张天乙 张航 《河南师范大学学报(自然科学版)》 北大核心 2025年第5期90-96,I0014,共8页
研究了众数线性回归模型中回归系数具有精确线性约束条件下的估计问题.提出了拉格朗日乘子的众数估计量,证明了所得估计量的相合性及渐近正态性,并给出了一个求解最大化目标函数的迭代算法.最后通过数值模拟研究了所提方法的良好有限样... 研究了众数线性回归模型中回归系数具有精确线性约束条件下的估计问题.提出了拉格朗日乘子的众数估计量,证明了所得估计量的相合性及渐近正态性,并给出了一个求解最大化目标函数的迭代算法.最后通过数值模拟研究了所提方法的良好有限样本性质. 展开更多
关键词 回归模型 最小二乘估计 众数 精确线性约束 拉格朗日乘子
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纵荡工况下叶片柔性对15 MW级浮式风力机气动特性影响研究
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作者 马璐 周乐 +3 位作者 张险峰 雷肖 沈昕 杜朝辉 《太阳能学报》 北大核心 2025年第6期667-675,共9页
以IEA-15 MW风力机为对象,基于涡尾迹模型和几何精确梁模型研究了纵荡工况下叶片形变对风力机性能的影响。结果表明,浮台的纵荡运动所带来的附加速度会改变风力机的入流速度,从而使风力机的载荷出现波动;而相比于固定工况,纵荡工况下风... 以IEA-15 MW风力机为对象,基于涡尾迹模型和几何精确梁模型研究了纵荡工况下叶片形变对风力机性能的影响。结果表明,浮台的纵荡运动所带来的附加速度会改变风力机的入流速度,从而使风力机的载荷出现波动;而相比于固定工况,纵荡工况下风力机的输出功率有所提升,且在考虑叶片柔性后风力机载荷有所下降。此外,在风力机纵荡运动过程中,风力机的载荷对入流速度变化的响应存在延迟,同时叶片柔性形变带来的附加速度会加剧载荷响应的延迟。 展开更多
关键词 浮式风力机 气动特性 柔性形变 自由尾迹模型 几何精确梁模型
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面向天河新一代超算系统的大规模精确对角化方法
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作者 李彪 刘杰 王庆林 《计算机研究与发展》 北大核心 2025年第6期1347-1362,共16页
精确对角化(exact diagonalization)方法是一种在量子物理、凝聚态物理等领域广泛应用的数值计算方法,是最直接求得量子系统基态的数值方法.仅从哈密顿矩阵的对称性出发,利用无矩阵(matrix-free)方法、分层通信模型以及适配于MT-3000的... 精确对角化(exact diagonalization)方法是一种在量子物理、凝聚态物理等领域广泛应用的数值计算方法,是最直接求得量子系统基态的数值方法.仅从哈密顿矩阵的对称性出发,利用无矩阵(matrix-free)方法、分层通信模型以及适配于MT-3000的数据级并行算法,提出了面向天河新一代超算系统上的超大稀疏哈密顿矩阵向量乘异构并行算法,可以实现基于一维Hubbard模型的大规模精确对角化.提出的并行算法在天河新一代超算系统上进行了测试,其中在1400亿维度矩阵规模上,8192进程相比256进程强扩展效率为55.27%,而弱扩展到7300亿维度矩阵规模上,13740个进程相比64进程的弱扩展效率保持在51.25%以上. 展开更多
关键词 精确对角化 HUBBARD模型 异构并行计算 MT-3000处理器 量子多体系统
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二部分随机块模型的精确恢复判别
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作者 赵涛 冯群强 《应用概率统计》 北大核心 2025年第1期136-151,共16页
社区检测是网络数据统计分析的核心问题之一.本文研究了在非对称稀疏二部分随机块模型中社区结构能否达成精确恢复的条件,主要表现为在极大似然方法下给出了一个仅与相对稠密社区内部连边概率和两社区间的连边概率有关的阈值.此外,我们... 社区检测是网络数据统计分析的核心问题之一.本文研究了在非对称稀疏二部分随机块模型中社区结构能否达成精确恢复的条件,主要表现为在极大似然方法下给出了一个仅与相对稠密社区内部连边概率和两社区间的连边概率有关的阈值.此外,我们通过谱聚类方法进行了一系列数据模拟试验,模拟结果很好地验证了本文的结论. 展开更多
关键词 统计网络模型 社区结构 社区检测 精确恢复
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改良检测血浆中3种双酯型乌头碱含量的UPLC/Q Exactive MS方法学研究 被引量:1
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作者 苗鑫 张晓菲 +2 位作者 邢海燕 赵璐璐 李刚 《中华中医药杂志》 CAS CSCD 北大核心 2020年第7期3614-3618,共5页
目的:改良UPLC/Q Exactive MS用于同时测定大鼠血浆中乌头碱、次乌头碱和新乌头碱含量的方法学。方法:采用Dionex UltiMate 3000快速超高效液相色谱仪和Q Exactive四极杆-静电场轨道阱高分辨质谱系统检测。采用HypersilGOLD色谱柱分离,... 目的:改良UPLC/Q Exactive MS用于同时测定大鼠血浆中乌头碱、次乌头碱和新乌头碱含量的方法学。方法:采用Dionex UltiMate 3000快速超高效液相色谱仪和Q Exactive四极杆-静电场轨道阱高分辨质谱系统检测。采用HypersilGOLD色谱柱分离,流动相A(0.1%甲酸-水):流动相B(乙腈)=35∶65,通过全扫描/选择离子监测(FullMS/SIM)模式进行定性筛查和定量检测。结果:此检测方法专属性高,绝对基质效应在99.22%~100.79%;线性相关系数r≥0.9995,次乌头碱、乌头碱和新乌头碱在1~64ng/mL范围内线性关系良好,定量下限(S/N=10),次乌头碱为0.2ng/mL,乌头碱和新乌头碱为0.5ng/mL;准确度RE%在-2.3800%~2.131%,精密度RSD%在0.0971%~8.8111%,符合生物样本定量分析要求;稳定性考察结果表明室温放置8h、-20℃冻存2周的条件下稳定,-20℃冻融3次后将不再适合生物样本测定。结论:改良后的方法更适合同时测定大鼠血浆中3种双酯型乌头碱的含量。 展开更多
关键词 草乌 乌头碱 次乌头碱 新乌头碱 UPLC/Q exactive MS技术 毒物代谢动力学与毒物效应动力学模型
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