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The Timing of the Palaeoproterozoic Great Oxidation Event using Dykes,Sills and Bolcanics of the Ongeluk Large Igneous Province,Kaapvaal Craton
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作者 Ashley P.GUMSLEY Kevin R.CHAMBERLAIN +5 位作者 Wouter BLEEKER Ulf SODERLUND Michiel O.DE KOCK Tobias C.KAMPMANN Emilie R.LARSSON Andrey BEKKER 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第S1期67-68,共2页
The Neoarchaean to Palaeoproterozoic Transvaal Supergroup of the Kaapvaal Craton,southern Africa,is one of the best-preserved and most complete stratigraphic records across a critical in juncture in the Earth’s history.
关键词 Sills and Bolcanics of the Ongeluk Large Igneous Province The timing of the Palaeoproterozoic Great Oxidation event using Dykes GOE
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Intrusion Detection System for PS-Poll DoS Attack in 802.11 Networks Using Real Time Discrete Event System 被引量:5
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作者 Mayank Agarwal Sanketh Purwar +1 位作者 Santosh Biswas Sukumar Nandi 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2017年第4期792-808,共17页
Wi-Fi devices have limited battery life because of which conserving battery life is imperative. The 802.11 Wi-Fi standard provides power management feature that allows stations(STAs) to enter into sleep state to prese... Wi-Fi devices have limited battery life because of which conserving battery life is imperative. The 802.11 Wi-Fi standard provides power management feature that allows stations(STAs) to enter into sleep state to preserve energy without any frame losses. After the STA wakes up, it sends a null data or PS-Poll frame to retrieve frame(s) buffered by the access point(AP), if any during its sleep period. An attacker can launch a power save denial of service(PS-DoS) attack on the sleeping STA(s) by transmitting a spoofed null data or PS-Poll frame(s) to retrieve the buffered frame(s) of the sleeping STA(s) from the AP causing frame losses for the targeted STA(s). Current approaches to prevent or detect the PS-DoS attack require encryption,change in protocol or installation of proprietary hardware. These solutions suffer from expensive setup, maintenance, scalability and deployment issues. The PS-DoS attack does not differ in semantics or statistics under normal and attack circumstances.So signature and anomaly based intrusion detection system(IDS) are unfit to detect the PS-DoS attack. In this paper we propose a timed IDS based on real time discrete event system(RTDES) for detecting PS-DoS attack. The proposed DES based IDS overcomes the drawbacks of existing systems and detects the PS-DoS attack with high accuracy and detection rate. The correctness of the RTDES based IDS is proved by experimenting all possible attack scenarios. 展开更多
关键词 Fault detection and diagnosis intrusion detection system(IDS) null data frame power save attack PS-Poll frame real time discrete event system(DES)
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Key Dolerite Dyke Swarms of Amazonia:U-Pb Constraints on Supercontinent Cycles and Geodynamic Connections with Global LIP Events Through Time
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作者 Wilson TEIXEIRA Mike A.HAMILTON +1 位作者 Vicente A.V.GIRARDI Frederico M.FALEIROS 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第S1期84-85,共2页
High-resolution U–Pb(ID-TIMS,baddeleyite)ages are presented for mafic dykes from selected swarms in two important Amazonian regions:the Carajás Province in the east,and the Rio Apa block in the southwest–areas
关键词 Pb U-Pb Constraints on Supercontinent Cycles and Geodynamic Connections with Global LIP events Through Time Key Dolerite Dyke Swarms of Amazonia LIP
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Adaptive Conditional Hazard Regression Modeling of Multiple Event Times
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作者 George J. Knafl 《Open Journal of Statistics》 2023年第4期492-513,共22页
Recurrent event time data and more general multiple event time data are commonly analyzed using extensions of Cox regression, or proportional hazards regression, as used with single event time data. These methods trea... Recurrent event time data and more general multiple event time data are commonly analyzed using extensions of Cox regression, or proportional hazards regression, as used with single event time data. These methods treat covariates, either time-invariant or time-varying, as having multiplicative effects while general dependence on time is left un-estimated. An adaptive approach is formulated for analyzing multiple event time data. Conditional hazard rates are modeled in terms of dependence on both time and covariates using fractional polynomials restricted so that the conditional hazard rates are positive-valued and so that excess time probability functions (generalizing survival functions for single event times) are decreasing. Maximum likelihood is used to estimate parameters adjusting for right censored event times. Likelihood cross-validation (LCV) scores are used to compare models. Adaptive searches through alternate conditional hazard rate models are controlled by LCV scores combined with tolerance parameters. These searches identify effective models for the underlying multiple event time data. Conditional hazard regression is demonstrated using data on times between tumor recurrence for bladder cancer patients. Analyses of theory-based models for these data using extensions of Cox regression provide conflicting results on effects to treatment group and the initial number of tumors. On the other hand, fractional polynomial analyses of these theory-based models provide consistent results identifying significant effects to treatment group and initial number of tumors using both model-based and robust empirical tests. Adaptive analyses further identify distinct moderation by group of the effect of tumor order and an additive effect to group after controlling for nonlinear effects to initial number of tumors and tumor order. Results of example analyses indicate that adaptive conditional hazard rate modeling can generate useful insights into multiple event time data. 展开更多
关键词 Adaptive Regression Fractional Polynomials Hazard Rate Multiple event Times Recurrent events
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Adaptive Conditional Hazard Regression Modeling of Multiple Event Times
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作者 George J. Knafl 《Open Journal of Endocrine and Metabolic Diseases》 2023年第4期492-513,共22页
Recurrent event time data and more general multiple event time data are commonly analyzed using extensions of Cox regression, or proportional hazards regression, as used with single event time data. These methods trea... Recurrent event time data and more general multiple event time data are commonly analyzed using extensions of Cox regression, or proportional hazards regression, as used with single event time data. These methods treat covariates, either time-invariant or time-varying, as having multiplicative effects while general dependence on time is left un-estimated. An adaptive approach is formulated for analyzing multiple event time data. Conditional hazard rates are modeled in terms of dependence on both time and covariates using fractional polynomials restricted so that the conditional hazard rates are positive-valued and so that excess time probability functions (generalizing survival functions for single event times) are decreasing. Maximum likelihood is used to estimate parameters adjusting for right censored event times. Likelihood cross-validation (LCV) scores are used to compare models. Adaptive searches through alternate conditional hazard rate models are controlled by LCV scores combined with tolerance parameters. These searches identify effective models for the underlying multiple event time data. Conditional hazard regression is demonstrated using data on times between tumor recurrence for bladder cancer patients. Analyses of theory-based models for these data using extensions of Cox regression provide conflicting results on effects to treatment group and the initial number of tumors. On the other hand, fractional polynomial analyses of these theory-based models provide consistent results identifying significant effects to treatment group and initial number of tumors using both model-based and robust empirical tests. Adaptive analyses further identify distinct moderation by group of the effect of tumor order and an additive effect to group after controlling for nonlinear effects to initial number of tumors and tumor order. Results of example analyses indicate that adaptive conditional hazard rate modeling can generate useful insights into multiple event time data. 展开更多
关键词 Adaptive Regression Fractional Polynomials Hazard Rate Multiple event Times Recurrent events
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Neural and Spinal Modules in Implementation of a Simple Ballistic Movement
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作者 Hooshang Hemami Behzad Dariush 《Journal of Software Engineering and Applications》 2016年第7期326-345,共21页
A simple ballistic movement and two of its attributes (namely, reversal in time and synchronization with external events) are formulated. A three-dimensional, three-link musculoskeletal arm is subjected to a fast ball... A simple ballistic movement and two of its attributes (namely, reversal in time and synchronization with external events) are formulated. A three-dimensional, three-link musculoskeletal arm is subjected to a fast ballistic type movement. The central components of the movement from hippocampal, cerebellar, basal ganglia and reticular formation structures that may be involved in timing are identified. The role of agonist muscles and spinal reflexes in the execution of ballistic movements (namely, in fast starts and fast stops) is discussed. The needed three time intervals are constructed in real time and can be coordinated with external events. Delaying or advancing in time, synchronization, time scaling and inverting events in time relative to the movement is formulated. Digital computer simulations are presented to test the behavior of the formulated neural and spinal processing and demonstrate the behavior of the arm under such control. 展开更多
关键词 Arm Model Ballistic Movement event timing Neural Modules and Spinal Reflex
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Acoustic emission monitoring of rockbursts during TBM-excavated headrace tunneling at Jinping Ⅱ hydropower station 被引量:7
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作者 Wuwei Cheng Wenyou Wang +1 位作者 Shiqiang Huang Peng Ma 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2013年第6期486-494,共9页
To better understand the mechanical properties of marble at Jinping II hydropower station, this paper examines the changes of brittle rocks in excavation damaged zones(EDZs) before and after excavation of tunnel with ... To better understand the mechanical properties of marble at Jinping II hydropower station, this paper examines the changes of brittle rocks in excavation damaged zones(EDZs) before and after excavation of tunnel with the tunnel boring machine(TBM). The paper attempts to employ the acoustic emission(AE) to study the AE characteristics and distribution of rockburst before and after TBM-excavated tunnel. It is known that the headrace tunnel #2, excavated by the drill-and-blast(D&B) method, is ahead of the headrace tunnel #3 that is excavated by TBM method. The experimental sub-tunnel #2–1, about 2000 m in depth and 13 m in diameter, between the two tunnels is scheduled. In the experimental sub-tunnel #2–1, a large number of experimental boreholes are arranged, and AE sensors are installed within 10 m apart from the wall of the headrace tunnel #3. By tracking the microseismic signals in rocks, the location, frequency, quantity, scope and intensity of the microseismic signals are basically identifed. It is observed that the AE signals mainly occur within 5 m around the rock wall, basically lasting for one day before tunnel excavation and a week after excavation. Monitoring results indicate that the rockburst signals are closely related to rock stress adjustment. The rock structure has a rapid self-adjustment capacity before and after a certain period of time during tunneling. The variations of rock stresses would last for a long time before reaching a fnal steady state. Based on this, the site-specifc support parameters for the deep tunnels can be accordingly optimized. 展开更多
关键词 Acoustic emission(AE) monitoring Tunnel construction Microseismic event Relaxation time Rockbursts
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Digitalization of mine operations:Scenarios to benefit in real-time truck dispatching 被引量:6
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作者 Patarawan Chaowasakoo Heikki Seppala +1 位作者 Heikki Koivo Quan Zhou 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第2期229-236,共8页
One of the key factors in a profitable open-pit mine is the efficiency of the waste disposal system. Using GPS-technology, the truck-dispatching decisions can be made in real-time but the chosen strategy has a crucial... One of the key factors in a profitable open-pit mine is the efficiency of the waste disposal system. Using GPS-technology, the truck-dispatching decisions can be made in real-time but the chosen strategy has a crucial role. Therefore, finding the optimal dispatching strategy for truck-shovel operations is extremely important. Dispatching strategies have been reported in the literature, but the comparison of these strategies is still missing. This paper illustrates the differences between the strategies by conducting a stochastic simulation study based on the data gathered from an actual mine. The findings underline the importance of the global vision in dispatching decisions. 展开更多
关键词 Discrete event simulation GPS Truck dispatching Cycle time Fleet management
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Understanding Dependent Competing Risks: A Simulation Study to Illustrate the Relationship Between Cause-Specific Hazard and Marginal Hazard
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作者 Zihang Lu Jenna Sykes Melania Pintilie 《Journal of Statistical Science and Application》 2016年第2期96-107,共12页
In the analysis of competing risk data, the observed effect of a covariate can be obtained via a Fine and Gray sub-distribution hazard ratio. Sometimes, it is also desirable to obtain the virtual effect of a covariate... In the analysis of competing risk data, the observed effect of a covariate can be obtained via a Fine and Gray sub-distribution hazard ratio. Sometimes, it is also desirable to obtain the virtual effect of a covariate as if the competing risks were non-existent. Under the latent failure time scenario, when the event of interest and the competing risk event are independent, the cause-specific hazard ratio obtained from the Cox model where the competing events are censored represents the ratio of the marginal hazards and can be interpreted as the virtual effect of the covariate. However, when the two events are not independent, the cause-specific hazard ratio is not the ratio of the marginal hazards as the ratio depends not only on the marginal hazards but also on the correlation between the competing risk and the event of interest. Using simulation, we investigated the degree to which the cause-specific hazard ratio changes relative to the marginal hazard with this correlation. It was found that the discrepancy between the cause-specific hazard ratio and the theoretical marginal hazard ratio increased as the proportion of competing risk events and the correlation between the events increased (〉0.2). Depending on the direction of the correlation, the cause-specific hazard ratio can over- or under-estimate the marginal hazard ratio. Using real-life datasets, we show how these results can be used to make inferences on the virtual effects. 展开更多
关键词 competing risk correlated event times cause-specific hazard ratio marginal hazard ratio
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The Additive-multiplicative Hazards Model for Multiple Type of Recurrent Gap Times
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作者 Zhang Qi-xian Liu Ji-cai +1 位作者 Guan Qiang Wang De-hui 《Communications in Mathematical Research》 CSCD 2015年第2期97-107,共11页
Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, ther... Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, there exist two types of hazards models: the multiplicative hazards model and the additive hazards model. In the paper, we propose a more flexible additive-multiplicative hazards model for multiple type of recurrent gap times data, wherein some covariates are assumed to be additive while others are multiplicative. An estimating equation approach is presented to estimate the regression parameters. We establish asymptotic properties of the proposed estimators. 展开更多
关键词 additive-multiplicative hazards model estimating equation gap time multiple recurrent event data semi-parametric regression model
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Observation evidence for the entropy switch model of substorm onset
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作者 YunXiang Song ChuXin Chen 《Earth and Planetary Physics》 EI CSCD 2022年第2期161-176,共16页
The cause of substorm onset is not yet understood. Chen CX(2016) proposed an entropy switch model, in which substorm onset results from the development of interchange instability. In this study, we sought observationa... The cause of substorm onset is not yet understood. Chen CX(2016) proposed an entropy switch model, in which substorm onset results from the development of interchange instability. In this study, we sought observational evidence for this model by using Time History of Events and Macroscale Interactions during Substorms(THEMIS) data. We examined two events, one with and the other without a streamer before substorm onset. In contrast to the stable magnetosphere, where the total magnetic field strength is a decreasing function and entropy is an increasing function of the downtail distance, in both events the total magnetic field strength and entropy were reversed before substorm onset. After onset, the total magnetic field strength, entropy, and other plasma quantities fluctuated. In addition, a statistical study was performed. By confining the events with THEMIS satellites located in the downtail region between ~8 and ~12 Earth radii, and 3 hours before and after midnight, we found the occurrence rate of the total magnetic field strength reversal to be 69% and the occurrence rate of entropy reversal to be 77% of the total 205 events. 展开更多
关键词 substorm onset entropy switch model interchange or ballooning instability Time History of events and Macroscale Interactions during Substorms(THEMIS)data
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The design of HEPS global timing system 被引量:1
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作者 Fang Liu Ge Lei +11 位作者 Zhe Duan Cai Meng Chenyan Lu Yanhua Shao Xinpeng Ma Nan Gan Yuemei Peng Jianshe Cao Chungming Chu Yanfeng Sui Jingyi Li IHEP 《Radiation Detection Technology and Methods》 CSCD 2021年第3期379-388,共10页
Purpose The high energy photon source(HEPS)is a 4th generation synchrotron light source under construction by the institute of high energy physics.The accelerator complex consists of a 500-MeV Linac,a full-energy sync... Purpose The high energy photon source(HEPS)is a 4th generation synchrotron light source under construction by the institute of high energy physics.The accelerator complex consists of a 500-MeV Linac,a full-energy synchrotron booster,a 6-GeV synchrotron storage ring(SR),and three e-beam transport lines for injection and extraction among accelerators.A global timing system(GTS)covers the timing needs for all accelerator,beamline,and experiment systems.The GTS is designed to coordinate the injection processes and various measurements and protections.Most systems require that the RMS jitter of the GTS signal is less than 30 ps,while the trigger jitters for the electron gun and SR injection and extraction kickers are less than 10 ps.Method The HEPS GTS is an event-based timing system based on MicroTCA.4 hardware architecture.The MicroTCA.4300 series products from the micro-research Finland Oy are implemented in the HEPS GTS system.Results and conclusions The RMS jitter,integrated from 1 Hz to 10 MHz,of the 166.6 MHz event clock is 5.489 ps.The RMS jitter of TTL outputs is less than 30 ps.This paper reports the design of the HEPS GTS,which satisfies all of the HEPS physics requirements for timing with preliminary test results shown. 展开更多
关键词 HEPS Global timing system event timing system MacroTCA.4
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Precise dating of East-Asian-Monsoon D/O events during 95―56 ka BP:Based on stalagmite data from Shanbao Cave at Shennongjia,China 被引量:4
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作者 XIA ZhiFeng KONG XingGong +1 位作者 JIANG XiuYang CHENG Hai 《Science China Earth Sciences》 SCIE EI CAS 2007年第2期228-235,共8页
Based on 23 U/Th analyses and 532 oxygen isotopic data, an averaged 80-a stalagmite oxygen isotopic composition series was established through 95 to 56 thousand years before present (ka BP) from two speleothems in Sha... Based on 23 U/Th analyses and 532 oxygen isotopic data, an averaged 80-a stalagmite oxygen isotopic composition series was established through 95 to 56 thousand years before present (ka BP) from two speleothems in Shanbao Cave, Shennongjia, central China. Shanbao Cave record (referred to as SB record) replicates well with Hulu Cave record, extending the characteristics of millennial oscillations in East-Asian-Summer-Monsoon (EASM) to the past 95 ka. The trend of the SB record generally follows mid-July solar insolation at 65°N, suggesting that mid-high northern latitude insolation, in the first or- der, controls changes of EASM intensity. Millennial oscillations of EASM recorded in the stalagmites are well related to the Greenland interstadials referred to as Dansgaard/Oeschger (D/O) events from 1 to 22, indicating that rapid ocean-atmosphere reorganization in North Atlantic has a remote effect in EASM. The well-dated D/O events by stalagmites probably provide an absolute calibration for chro- nologies of Greenland ice cores. The timings of D/O events in the SB record are different variously from those in Greenland ice cores. For D/O 19 and 20, the age offsets between the stalagmites' and the Greenland ice cores' record are significant, larger than the uncertainties of uranium-series dating. The two events in the SB record are younger than those in North GRIP time scale by 1―2 ka, and older than the counterparts in GISP2 by approximately 3―4 ka. A comparison between the SB and Brazil stalag- mite record shows an anti-phase relation in millennial-scale monsoon precipitation between the two localities. This supports a mode for the coupled ocean-atmosphere "See-saw". 展开更多
关键词 the last glacial Shennongjia STALAGMITE Greenland ice cores timing of D/O event
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Determination of event start time at BESⅢ
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作者 马想 毛泽普 +53 位作者 边渐鸣 曹国富 曹学香 陈申见 邓子艳 傅成栋 高原宁 何康林 何苗 花春飞 黄彬 黄性涛 季晓斌 李海波 李卫东 梁羽铁 刘春秀 刘怀民 刘秋光 刘锁 刘英杰 马秋梅 冒亚军 莫晓虎 潘明华 庞彩莹 平荣刚 秦刚 秦亚红 邱进发 孙胜森 孙永昭 王纪科 王亮亮 文硕频 伍灵慧 谢宇广 徐敏 严亮 尤郑昀 俞国威 苑长征 袁野 臧石磊 张炳云 张长春 张建勇 张学尧 张瑶 郑阳恒 朱科军 朱永生 朱志丽 邹佳恒 《Chinese Physics C》 SCIE CAS CSCD 北大核心 2008年第9期744-749,共6页
The principle of the method for the BESⅢ event start time determination and the code construction are described. The investigation of influence of the noise, the method of rejecting noise and the performance checking... The principle of the method for the BESⅢ event start time determination and the code construction are described. The investigation of influence of the noise, the method of rejecting noise and the performance checking by the Monte Carlo physics data sample are also presented. The preliminary results got from the Monte Carlo simulation are presented, the reconstruction efficiency of J/ψ → anything events at noise level 0 - 60% can achieve above 99%, and the error rate is below 1%. 展开更多
关键词 event start time TIME-OF-FLIGHT drift-chamber track reconstruction
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Study of the efficiency of event start time determination at BESⅢ
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作者 管颖慧 吕晓睿 +1 位作者 郑阳恒 王贻芳 《Chinese Physics C》 SCIE CAS CSCD 2014年第1期61-64,共4页
A method to estimate the efficiency of event start time determination at BESIII is developed. This method estimates the efficiency at the event level by combining the efficiencies of various tracks (e, μ, π, K, p, ... A method to estimate the efficiency of event start time determination at BESIII is developed. This method estimates the efficiency at the event level by combining the efficiencies of various tracks (e, μ, π, K, p, y) in a Bayesian way. Efficiencies results and the difference between data and MC at the track level are presented in this paper. For a given physics channel, event start time efficiency and systematic error can be estimated following this method. 展开更多
关键词 event start time MDC BESⅢ
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OBSERVABILITY OF EXTENDED TIMED EVENT GRAPH
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作者 ZHUOZhibing CHENWende 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2004年第3期306-309,共4页
In this paper, we study some results of extended timed event graph (ETEG)by using graph theory's methods in the dioid framework. A necessary and sufficient con-dition for the observability of ETEG is obtained and ... In this paper, we study some results of extended timed event graph (ETEG)by using graph theory's methods in the dioid framework. A necessary and sufficient con-dition for the observability of ETEG is obtained and ETEG's standard structure is alsoestablished. 展开更多
关键词 extended timed event graph(ETEG) OBSERVABILITY dioid REACHABILITY discrete event dynamic system(DEDS)
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Supervisory Control of Extended Timed Event Graphs
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作者 Zhi-bing Zhuo, Wen-de ChenInstitute of Systems Science, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2003年第2期281-288,共8页
Abstract This paper describes the dynamic behavior of extended timed event graphs related to place delay in the dioid framework. By Cofer and Garg's supervisory control theory^|3|, we address control problems of e... Abstract This paper describes the dynamic behavior of extended timed event graphs related to place delay in the dioid framework. By Cofer and Garg's supervisory control theory^|3|, we address control problems of extended timed events graphs. Supervisory control of extended timed event graphs (a class of discrete event dynamic systems) is studied in the dioid framework, a necessary and sufficient condition for the ideals of the set of firing time sequences of transitions to be controllable is presented. We prove all the strongly controllable subsets can form a complete lattice. 展开更多
关键词 Keywords Supervisory control extended timed event graph (ETEG) dioid strong controllability discrete event dynamic system (DEDS)
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Technique research of embedded event receiver for BEPC-II
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作者 Zhao Zhang Zhi Liu +5 位作者 Sinong Cheng Ge Lei Yuliang Zhang Peng Zhu Guanglei Xu Lin Wang 《Radiation Detection Technology and Methods》 CSCD 2023年第1期124-133,共10页
Purpose The event receiver is an important component of the BEPC-II timing system.It receives event codes from the event generator and then generates triggers and interrupts.The currently applied event receiver is imp... Purpose The event receiver is an important component of the BEPC-II timing system.It receives event codes from the event generator and then generates triggers and interrupts.The currently applied event receiver is implemented in a single FPGA board,which has to work in conjunction with a single-board computer and an external bus chassis.With the rapid development of System-on-Chip(SoC)technology,combining them in one SoC is more efficient,more integrated,and cheaper.Thereby,an embedded event receiver based on ZYNQ SoC is proposed.Methods and Results In this paper,some key techniques of embedded event receiver have been researched.These techniques have been implemented in an embedded event receiver prototype named ER-Z.And the function test results show that ER-Z has the ability to receive event codes and handle them through interrupts while attaching timestamps with event clock precision.The performance test results show that the average interrupt latency is less than 30μs and the average AXI-Lite read latency is less than 170 ns. 展开更多
关键词 timing system event receiver Embedded system ZYNQ SoC
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Time-varying latent model for longitudinal data with informative observation and terminal event times
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作者 PEI YanBo DU Ting SUN LiuQuan 《Science China Mathematics》 SCIE CSCD 2016年第12期2393-2410,共18页
Longitudinal data often occur in follow-up studies, and in many situations, there may exist informative observation times and a dependent terminal event such as death that stops the follow-up. We propose a semiparamet... Longitudinal data often occur in follow-up studies, and in many situations, there may exist informative observation times and a dependent terminal event such as death that stops the follow-up. We propose a semiparametric mixed effect model with time-varying latent effects in the analysis of longitudinal data with informative observation times and a dependent terminal event. Estimating equation approaches are developed for parameter estimation, and asymptotic properties of the resulting estimators are established. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a bladder cancer study is provided. 展开更多
关键词 estimating equations informative observation times joint modeling longitudinal data terminal event time-varying effect
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The Proportional Hazards Model for Multiple Type Recurrent Gap Times 被引量:1
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作者 Ji-cai LIU Huan-bin LIU Ri-quan ZHANG 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2016年第1期221-230,共10页
Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consi... Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consider a proportional hazards model for multiple type recurrent gap times data to assess the effect of covaxiates on the censored event processes of interest.An estimating equation approach is used to obtain the estimators of regression coefficients and baseline cumulative hazard functions.We examine asymptotic properties of the proposed estimators.Finite sample properties of these estimators are demonstrated by simulations. 展开更多
关键词 proportional hazards model estimating equation multiple type recurrent events gap times semiparametric inference
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