The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis.These compounds have antiproliferative activity against fungal pathogensand mammalian cancer ...The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis.These compounds have antiproliferative activity against fungal pathogensand mammalian cancer cell lines.Analysis of E.gracilis extracts revealed that the algae produce not only the euglenatides,but also a corresponding family of analogs that have the same molecular weights as the euglenatides,but are lacking the characteristic triene chromophore.In comparison to the euglenatides,the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay,indicating that the triene is critical to the biological activity of the euglenatides.展开更多
基金supported by a grant from the National Institutes of Health(R35 GM144076 to R.A.B.).
文摘The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis.These compounds have antiproliferative activity against fungal pathogensand mammalian cancer cell lines.Analysis of E.gracilis extracts revealed that the algae produce not only the euglenatides,but also a corresponding family of analogs that have the same molecular weights as the euglenatides,but are lacking the characteristic triene chromophore.In comparison to the euglenatides,the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay,indicating that the triene is critical to the biological activity of the euglenatides.
