In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere Si02 is reported. First, the silica nanoparticles were modified with triethoxysilylp...In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere Si02 is reported. First, the silica nanoparticles were modified with triethoxysilylpropyl chloride and then 2-aminopyridine was attached to the support via covalent linkages. This new heterogenized catalyst was used for efficient microwave-assisted synthesis of azlactone derivatives with Ac20 as a condensing agent under solvent-free conditions. The present method offers advantages including high yields, short reaction times and simple work-up. Also, the catalyst can be easily recycled and reused several times, which makes this method attractive, economic and environmentally-benign.展开更多
Pyle’s disease is a rare genetic skeletal disorder also known as Metaphyseal dysplasia. A case of 36 yrs old female with fracture supracondylar femur in Pyle’s disease is presented. She had mild facial dysmorphism, ...Pyle’s disease is a rare genetic skeletal disorder also known as Metaphyseal dysplasia. A case of 36 yrs old female with fracture supracondylar femur in Pyle’s disease is presented. She had mild facial dysmorphism, dental malformation & mild genu valgum. Skeletal radiology revealed the characteristic Erlenmeyer flask sign at distal femoral and proximal tibial metaphysis. The fracture supracondylar femur was treated with interlocking nail. The fracture was united in sixteen weeks period. The patient is followed up for two years. The aim of the case report is the rarity of the condition with fracture supracondylar femur in adult female successfully treated with interlocking nail.展开更多
基金financial support from the Research Council of Arak University
文摘In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere Si02 is reported. First, the silica nanoparticles were modified with triethoxysilylpropyl chloride and then 2-aminopyridine was attached to the support via covalent linkages. This new heterogenized catalyst was used for efficient microwave-assisted synthesis of azlactone derivatives with Ac20 as a condensing agent under solvent-free conditions. The present method offers advantages including high yields, short reaction times and simple work-up. Also, the catalyst can be easily recycled and reused several times, which makes this method attractive, economic and environmentally-benign.
文摘Pyle’s disease is a rare genetic skeletal disorder also known as Metaphyseal dysplasia. A case of 36 yrs old female with fracture supracondylar femur in Pyle’s disease is presented. She had mild facial dysmorphism, dental malformation & mild genu valgum. Skeletal radiology revealed the characteristic Erlenmeyer flask sign at distal femoral and proximal tibial metaphysis. The fracture supracondylar femur was treated with interlocking nail. The fracture was united in sixteen weeks period. The patient is followed up for two years. The aim of the case report is the rarity of the condition with fracture supracondylar femur in adult female successfully treated with interlocking nail.
