Fourteen compounds of azastene and epostane derivatives (from YG101 to YG114) have been studied. Results showed that only YG102 and YG103 wore found to be positive in interceptivo activities, although they were less p...Fourteen compounds of azastene and epostane derivatives (from YG101 to YG114) have been studied. Results showed that only YG102 and YG103 wore found to be positive in interceptivo activities, although they were less potent than their parent compound──azastene. Levels ofprogesterone in plasma were decreased significantly after administrstion or YG102, 103 and 106. Only YG107 possessed an interceptive activity approximately as potent as that of its paront compound──epostane. Epostane is a mixture of its enol and keto forms and the percentage of both forms defends on various condions. Since YG107 exists only in one form, we believe this derivative of epostane might be useful in the future work.展开更多
文摘Fourteen compounds of azastene and epostane derivatives (from YG101 to YG114) have been studied. Results showed that only YG102 and YG103 wore found to be positive in interceptivo activities, although they were less potent than their parent compound──azastene. Levels ofprogesterone in plasma were decreased significantly after administrstion or YG102, 103 and 106. Only YG107 possessed an interceptive activity approximately as potent as that of its paront compound──epostane. Epostane is a mixture of its enol and keto forms and the percentage of both forms defends on various condions. Since YG107 exists only in one form, we believe this derivative of epostane might be useful in the future work.
