Long non-coding RNAs （lncRNAs） have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert functio...Long non-coding RNAs （lncRNAs） have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs （eRNAs）. The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.展开更多
Dear editor,In 2016,several landmark government initiatives were launched in an effort to build a more healthy China.In March,the National People’s Congress of China adopted the 13th FiveYear Plan,which sets out new ...Dear editor,In 2016,several landmark government initiatives were launched in an effort to build a more healthy China.In March,the National People’s Congress of China adopted the 13th FiveYear Plan,which sets out new objectives,principles,and targets for 2016–2020,1including action plans for enhancing environmental protection and green growth,promoting individual展开更多
Direct N2O decomposition has been investigated over bare NiO and a series of its alkali-promoted catalysts. These catalysts were characterized by X-ray diffractometry, X-ray photoelectron spectroscopy （XPS） and fiel...Direct N2O decomposition has been investigated over bare NiO and a series of its alkali-promoted catalysts. These catalysts were characterized by X-ray diffractometry, X-ray photoelectron spectroscopy （XPS） and field emission scanning electron microscopy. XPS analysis revealed that surface nickel is present in three forms： metal particles, NiO and Ni（OH）2. It is suggested that nickel（0） valent atoms are essential for the interaction with N2O molecules at the catalyst surfaces. Bare NiO exhibited a very low N2O decomposition reactivity. However, the alkali-containing catalysts exhibited a marked activity enhancement.展开更多
Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/C...Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.展开更多
Ag3PO4 microcrystals with highly enhanced visible light photocatalytic activity are prepared by a facile and simple solid state reaction at room temperature. The composition, morphology and optical properties of the a...Ag3PO4 microcrystals with highly enhanced visible light photocatalytic activity are prepared by a facile and simple solid state reaction at room temperature. The composition, morphology and optical properties of the asprepared Ag3PO4 microcrystMs are characterized by x-ray diffraction, scanning electron microscopy and UV-vis diffuse reflectance spectra. The photocatalytie properties of Ag3PO4 are investigated by the degradation of both methylene blue and methyl orange dyes under visible light irradiation. The as-prepared Ag3PO4 microcrystals possess high photocatalytic oxygen production with the rate of 673μmolh-1g-1. Moreover, the as-prepared Ag3PO4 microcrystals show an enhanced photoelectrochemistry performance under irradiation of visible light.展开更多
Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode mater...Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode material for its electrically-induced antimicrobialproperties. However, LIG surfaces exhibit antimicrobial properties exclusively in the presenceof electricity. In this work, copper-doped LIG (Cu-LIG) composite electrodes and filterswere developed with enhanced antimicrobial properties in single-step laser scribing. Thework emphasizes the optimization of copper doping with LIG for both electrical and nonelectrical-based disinfection. The copper doping was optimized to a minimal concentration(∼1%) just to enhance the electrochemical properties of LIG. Furthermore, the excess additionof copper was helpful towards non-electricity-based treatment without significantleaching. The prepared surfaces were tested in both electrodes and filter configuration andshowed excellent antibacterial and antiviral activity against mixed bacterial culture and amodel enteric virus, MS2 bacteriophage. On the application of 2.5 V with Cu-LIG electrodes,6-log removal of bacteria and virus was achieved. Furthermore, the membrane-based electroconductivefilters were tested in a flow-through configuration and demonstrated 6-logremoval at 2.5 V with a flux of ∼ 500 (L·m^(2))/h with both bacteria and viruses at minimumenergy expense. Additionally, reactive oxygen species scavenging and hydrogen peroxidegeneration experiments have confirmed the role of electrical effects and indirect oxidationon the inactivation mechanism. The prepared Cu-LIG composite surfaces showed potentialfor environmental remediation applications.展开更多
Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive imm...Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive immunosorbent approach was elaborately developed based on high-affinity immunoglobulin G(IgG)coupled CuO-anchored Fe_(3)O_(4)nanozymes for precise and ultrasensitive detection of AFB_(1)in food crops including peanut,corn and wheat.The high-affinity nanozymes were fabricated by the assembly of inner core Fe_(3)O_(4)nanoparticles and mesoporous silica capping layer,Cu O further situated within large aperture of the coating layer via in-situ growth,and then conjugated with ligand rabbit anti-mouse Ig G,which can specifically bind with AFB_(1).The results showed the hybrid high-affinity nanozymes displayed enhanced peroxidasemimic activities and catalytic performances,achieving a linear range of 0.06-61.93(lg(ng/mL))and a detection limit of 0.0037 ng/mL,30 times better than that of the conventional enzyme-linked immunosorbent assay.The constructed nanozymes were successfully applied to the detection of AFB_(1)in food products with an average spiked recovery of 96.53%and relative standard deviations less than 2.8%.Therefore,the accurate hybrid nanozymes may serve for AFB_(1)detection in various foods in future.展开更多
Hierarchical microspheres of a graphene oxide（GO） coupled to N‐doped（BiO）2CO3 composite（N‐BOC‐GO） was synthesized by a simple hydrothermal approach. The N‐BOC‐GO composite gave enhancement in photocatalytic...Hierarchical microspheres of a graphene oxide（GO） coupled to N‐doped（BiO）2CO3 composite（N‐BOC‐GO） was synthesized by a simple hydrothermal approach. The N‐BOC‐GO composite gave enhancement in photocatalytic activity compared to the pure BOC and N‐BOC samples. With 1.0wt% GO, 62% NO removal was obtained with N‐BOC‐GO. The factors enhancing the photocatalytic performance were the high electron‐withdrawing ability and high conductivity of GO and improved visible light‐harvesting ability of N‐BOC‐GO with a 3D hierarchical architecture due to the surface scattering and reflecting（SSR） effect. An effective charge transfer from N‐BOC to GO was demonstrated by the much weakened photoluminescene intensity of the N‐BOC‐GO composite. This work highlights the potential application of GO‐based photocatalysts in air purification.展开更多
NiFe catalysts show compelling oxygen evolution reaction (OER) activity in alkaline solution but their hydrogen evolution reaction (HER) activity is limited.In this work Rh was incorporated in Fe-doped Ni_(2)S_(3) nan...NiFe catalysts show compelling oxygen evolution reaction (OER) activity in alkaline solution but their hydrogen evolution reaction (HER) activity is limited.In this work Rh was incorporated in Fe-doped Ni_(2)S_(3) nanosheets with the assistance of hydrogen plasma to significantly enhance the HER/OER catalytic activity.The resultant catalyst,p-Rh/Fe-Ni_(2)S_(3)/NF,was composed of Rh/Rh_(2)S_(3) heterostructured clusters embedded in Fe-Ni_(2)S_(3) nanosheets;it needs overpotentials of only 108 and 237 mV to achieve HER and OER currents of 100 mA cm^(-2),respectively,and drives overall water splitting at 1.79 V with a current of 100 mA cm^(-2) as a bifunctional catalyst.Post-characterization and density functional theory (DFT) calculation reveal its operando evolution behavior and a unique Janus catalytic mechanism for the HER and OER.For the HER,a Rh/Rh_(2)S_(3) heterointerface with strong H_(2)O adsorption energy and optimal H adsorption energy is the active site;in the OER,it experiences surface transformation under operando conditions;an in situ formed Rh/Fe-doped NiOOH layer with strengthened binding of ^(*)O facilitates the rate determining step of ^(*)O formation to accelerate the OER process.Hydrogen plasma treatment not only helps partially reduce Rh to form HER-active Rh/Rh_(2)S_(3) heterostructures but also induces rich defects/vacancies to facilitate surface reconstruction/phase transformation to form an active co-doped NiOOH phase under OER conditions.This work may shed light on the promotive role of noble metals on NiFe-based catalysts for water splitting.展开更多
Due to the low cost,abundant reserves and redox-active features,electrocatalysts based on 3d transition metals have been thoroughly evaluated and are considered promising candidates to the current commercial noble met...Due to the low cost,abundant reserves and redox-active features,electrocatalysts based on 3d transition metals have been thoroughly evaluated and are considered promising candidates to the current commercial noble metal-based materials.Designing elaborate structures and favorable phase composition is regarded as effective to improve the activity in electrocatalysis.展开更多
15 compounds,including two new ones crepidatuols A(1)and B(2)were isolated from the stems of Dendrobium crepidatum.The planar structures of these compounds were elucidated by spectroscopic methods(NMR,MS,UV,and IR)and...15 compounds,including two new ones crepidatuols A(1)and B(2)were isolated from the stems of Dendrobium crepidatum.The planar structures of these compounds were elucidated by spectroscopic methods(NMR,MS,UV,and IR)and comparison with those from literatures.10 compounds were send for enhancing activities on nerve growth factor(NGF)medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A(1),confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0μM.展开更多
Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address ...Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin regeneration.However,the use of stem cells in skin regeneration presents several challenges.Recently,stem cells and biomaterials have been identified as crucial components of the wound-healing process.Combination therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable attention.Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the ECM.These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing.This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine functions.Additionally,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.展开更多
Rationally,engineering a favorable physicochemical microenvironment for enzymes has recently emerged as an effective strategy to improve their catalytic performance.In this review,we discuss four microenvironmental ef...Rationally,engineering a favorable physicochemical microenvironment for enzymes has recently emerged as an effective strategy to improve their catalytic performance.In this review,we discuss four microenvironmental effects according to the mechanism of action:localizing and excluding reactants and regulators,regulating microenvironmental pH,creating a water-like microenvironment,and increasing the local temperature.These mechanisms are enzyme-independent and can in principle be used in combination to tailor enzyme behaviors,offering new approaches to enabling,enhancing,and regulating enzyme catalysis in diverse applications without the need for genetic engineering.展开更多
Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water separation.However,it is still a challenge to fabrica...Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water separation.However,it is still a challenge to fabricate multifunctional and environmentally friendly materials,which can be stably applied to purify the actual complicated wastewater.Here,a Ag/Ag/α-Fe_(2)O_(3) heterostructure anchored copper mesh was intentionally synthesized using a facile two-step hydrothermal method.The resultant mesh with superhydrophilicity and underwater superoleophobicity was capable of separating various oil/water mixtures with superior separation efficiency and high permeationflux driven by gravity.Benefiting from the joint effects of the smaller band gap of Ag/α-Fe_(2)O_(3) heterojunction,inherent antibacterial capacity of Ag/α-Fe_(2)O_(3) and Ag nanoparticles,favorable conductive substrate,as well as the hierarchical structure with superwettability,such mesh presented remarkably enhanced degradation capability toward organic dyes under visible light irradiation and antibacterial activity against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)compared with the pure Ag/α-Fe_(2)O_(3) coated mesh.Impressively,the mesh exhibited bifunctional water purification performance,in which organic dyes were eliminated simultaneously from water during oil/water separation in onefiltration process.More importantly,this mesh behaved exceptional chemical resistance,mechanical stability and long-term reusability.Therefore,this material with multifunctional integration may hold promising potential for steady water purification in practice.展开更多
A system combining granular activated carbon and powdered activated carbon technologies along with shortcut biological nitrogen removal （GAC-PACT-SBNR） was developed to enhance total nitrogen （TN） removal for anae...A system combining granular activated carbon and powdered activated carbon technologies along with shortcut biological nitrogen removal （GAC-PACT-SBNR） was developed to enhance total nitrogen （TN） removal for anaerobically treated coal gasification wastewater with less need for external carbon resources. The TN removal efficiency in SBNR was significantly improved by introducing the effluent from the GAC process into SBNR during the anoxic stage, with removal percentage increasing from 43.8%49.6% to 68.8%-75.8%. However, the TN removal rate decreased with the progressive deterioration of GAC adsorption. After adding activated sludge to the GAG compartment, the granular carbon had a longer service-life and the demand for external carbon resources became lower. Eventually, the TN removal rate in SBNR was almost constant at approx. 43.3%, as compared to approx. 20.0% before seeding with sludge. In addition, the production of some alkalinity during the denitrification resulted in a net savings in alkalinity requirements for the nitrification reaction and refractory chemical oxygen demand （COD） degradation by autotrophic bacteria in SBNR under oxic conditions. PACT showed excellent resilience to increasing organic loadings. The microbial community analysis revealed that the PACT had a greater variety of bacterial taxons and the dominant species associated with the three compartments were in good agreement with the removal of typical pollutants. The study demonstrated that pre-adsorption by the GAC-sludge process could be a technically and economically feasible method to enhance TN removal in coal gasification wastewater （CGW）.展开更多
We previously found that oxygen-glucose-serum deprivation/restoration(OGSD/R)induces apoptosis of spinal cord astrocytes,possibly via caspase-12 and the integrated stress response,which involves protein kinase R-like ...We previously found that oxygen-glucose-serum deprivation/restoration(OGSD/R)induces apoptosis of spinal cord astrocytes,possibly via caspase-12 and the integrated stress response,which involves protein kinase R-like endoplasmic reticulum kinase(PERK),eukaryotic initiation factor 2-alpha(eIF2α)and activating transcription factor 4(ATF4).We hypothesized that edaravone,a low molecular weight,lipophilic free radical scavenger,would reduce OGSD/R-induced apoptosis of spinal cord astrocytes.To test this,we established primary cultures of rat astrocytes,and exposed them to 8 hours/6 hours of OGSD/R with or without edaravone(0.1,1,10,100μM)treatment.We found that 100μM of edaravone significantly suppressed astrocyte apoptosis and inhibited the release of reactive oxygen species.It also inhibited the activation of caspase-12 and caspase-3,and reduced the expression of homologous CCAAT/enhancer binding protein,phosphorylated(p)-PERK,p-eIF2α,and ATF4.These results point to a new use of an established drug in the prevention of OGSD/R-mediated spinal cord astrocyte apoptosis via the integrated stress response.展开更多
The sluggish kinetics of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have always restricted the development of lithium oxygen batteries(LOBs).Herein,hollow carbon spheres loaded with Pd/Pd_(4)S het...The sluggish kinetics of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have always restricted the development of lithium oxygen batteries(LOBs).Herein,hollow carbon spheres loaded with Pd/Pd_(4)S heterostructure(Pd/Pd_(4)S@HCS)were successfully prepared via the in-situ deposition to improve the electrocatalytic activities for both ORR and OER in LOBs.With the welldispersed Pd/Pd_(4)S nanoparticles,the hierarchical composite with large specific surface area offers favorable transport channels for ions,electron and oxygen.Especially,the Pd/Pd_(4)S nanoparticles could exhibit excellent electrochemical performance for ORR and OER due to their intrinsic catalytic property and interfacial effect from the heterostructure.Therefore,the LOBs with Pd/Pd_(4)S@HCS as cathode catalyst show improved specific capacities,good rate ability and stable cycling performance.展开更多
Promoting Health Enhancing Physical Activity (HEPA) behavior is an important undertaking in Germany as well as in China. In order to create successful interventions in different nations, knowledge about the relevant p...Promoting Health Enhancing Physical Activity (HEPA) behavior is an important undertaking in Germany as well as in China. In order to create successful interventions in different nations, knowledge about the relevant psychosocial correlates that may encourage successful progression through the behavior change process is necessary. Therefore, the relationships of selected psychosocial correlates of physical activity with stages of change were examined in a German-Chinese sample. In total, 2071 adults (865 Germans, 1206 Chinese) completed a questionnaire. The theoretical framework used was the FIT-model, which consists of the following stages of change: not considering, considering, preparing, exploring, fluctuating and maintaining. All data were analyzed with a two-way ANOVA. Significant main effects for the stages of change on all psychosocial correlates were found. Significant interactions between stages and nations emerged for all correlates except for social support, although these results revealed small effect sizes. To progress within the stages of inactivity, interventions should focus on outcome expectations, barriers, social support and affective attitudes. The successful initiation of physical activity depends on considerations of barriers, maintenance self-efficacy, intrinsic motivation and affective attitudes. These same correlates plus social support are relevant for long-term adherence to physical activity. In Germany, perceived barriers and emotional aspects of physical activity appear to be important for initiating and maintaining regular physical activity. Furthermore, for long-term adherence to physical activity, Germans—in contrast to Chinese adults—may not necessarily benefit from social support;however they could benefit from learning how to strengthen their physical activity outcome expectations.展开更多
Sigma-1 receptors are unique receptors that are postulated to act as intracellular amplifiers for signal transduction within cells of the nervous system.The present paper studied the effect and mechanism of sigma-1 re...Sigma-1 receptors are unique receptors that are postulated to act as intracellular amplifiers for signal transduction within cells of the nervous system.The present paper studied the effect and mechanism of sigma-1 receptor agonists on intracellular Ca2+concentration at presynaptic sites using synaptosomes from the medial prefrontal cortex by fluorometric and biochemical methods combined with a pharmacological approach.The results showed that sigma-1 receptor agonist PRE-084 and SKF10047 could increase intrasynaptosomal Ca2+concentration in a dose-dependent manner.展开更多
After publication of the research article "Constructing inter diffusive PtCuNi/WOg interface to enhance the catalytic activity and stability in oxygen reduction"(https://doi.org/10.1007/s42864-023-00226-0).T...After publication of the research article "Constructing inter diffusive PtCuNi/WOg interface to enhance the catalytic activity and stability in oxygen reduction"(https://doi.org/10.1007/s42864-023-00226-0).The authors discovered that the"Acknowledgement"is missing from the published online version,due to the unintentional mistake when preparing the manuscript.This could be unfair to the entities/scholars providing meaningful help to this work,as well as the funding agency that provided the financial support to this work.Therefore,an erratum is requested by the authors to acknowledge the following parties.展开更多
基金supported by the National Key Research and Development Project(Grant No.2017YFA0504300)the National Basic Research Program of China(973 Program+3 种基金Grant No.2011CB504203)the National Natural Science Foundation of China(Grant Nos.81490752,31671347,31000579,31371325,and 30971634)the Doctoral Programs Foundation of the Ministry of Education,China(Grant No.20130181130010)the Research Foundation of Sichuan University for Excellent Youth Scholars(Grant No.2015SCU04A23)
文摘Long non-coding RNAs （lncRNAs） have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs （eRNAs）. The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.
基金supported by China Institute of Sport Science(No.16-16,16-53)
文摘Dear editor,In 2016,several landmark government initiatives were launched in an effort to build a more healthy China.In March,the National People’s Congress of China adopted the 13th FiveYear Plan,which sets out new objectives,principles,and targets for 2016–2020,1including action plans for enhancing environmental protection and green growth,promoting individual
文摘Direct N2O decomposition has been investigated over bare NiO and a series of its alkali-promoted catalysts. These catalysts were characterized by X-ray diffractometry, X-ray photoelectron spectroscopy （XPS） and field emission scanning electron microscopy. XPS analysis revealed that surface nickel is present in three forms： metal particles, NiO and Ni（OH）2. It is suggested that nickel（0） valent atoms are essential for the interaction with N2O molecules at the catalyst surfaces. Bare NiO exhibited a very low N2O decomposition reactivity. However, the alkali-containing catalysts exhibited a marked activity enhancement.
基金financially supported by the National Natural Science Foundation of China(Nos.52174283 and 52274308)。
文摘Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.
基金Supported by the Beijing Higher Education Young Elite Teacher Project under Grant No YETP1297the Fundamental Research Funds for the Central Universities under Grant No 2014MDLXYZY05+1 种基金the Undergraduate Innovative Test Program of China under Grant Nos GCCX2015110009 and BEIJ2015110024the National Natural Science Foundation of China under Grant Nos11074312 and 11374377
文摘Ag3PO4 microcrystals with highly enhanced visible light photocatalytic activity are prepared by a facile and simple solid state reaction at room temperature. The composition, morphology and optical properties of the asprepared Ag3PO4 microcrystMs are characterized by x-ray diffraction, scanning electron microscopy and UV-vis diffuse reflectance spectra. The photocatalytie properties of Ag3PO4 are investigated by the degradation of both methylene blue and methyl orange dyes under visible light irradiation. The as-prepared Ag3PO4 microcrystals possess high photocatalytic oxygen production with the rate of 673μmolh-1g-1. Moreover, the as-prepared Ag3PO4 microcrystals show an enhanced photoelectrochemistry performance under irradiation of visible light.
基金supported by the DST(DST-WTIDST/TMD/EWO/WTI/DM/2021/283,DST-SYST,and DSTinspire faculty award)and Science and Engineering Research Board(SERB+1 种基金No.CRG/2019/005280)the Indian Institute of Technology Bombay(IITB)for their funding support for this work.ND and AMN acknowledge the Ministry of Education,India,for their doctoral fellowship support.We thank Prof.Suparna Mukherjee at IIT Bombay for kindly providing us with the host E.coli C3000(No.ATCC 15597).
文摘Waterborne pathogens pose a lifelong threat, necessitating advanced disinfection systemswith state-of-the-art materials. Laser-Induced Graphene (LIG), a 3-dimensional form ofgraphene, is a widely known electrode material for its electrically-induced antimicrobialproperties. However, LIG surfaces exhibit antimicrobial properties exclusively in the presenceof electricity. In this work, copper-doped LIG (Cu-LIG) composite electrodes and filterswere developed with enhanced antimicrobial properties in single-step laser scribing. Thework emphasizes the optimization of copper doping with LIG for both electrical and nonelectrical-based disinfection. The copper doping was optimized to a minimal concentration(∼1%) just to enhance the electrochemical properties of LIG. Furthermore, the excess additionof copper was helpful towards non-electricity-based treatment without significantleaching. The prepared surfaces were tested in both electrodes and filter configuration andshowed excellent antibacterial and antiviral activity against mixed bacterial culture and amodel enteric virus, MS2 bacteriophage. On the application of 2.5 V with Cu-LIG electrodes,6-log removal of bacteria and virus was achieved. Furthermore, the membrane-based electroconductivefilters were tested in a flow-through configuration and demonstrated 6-logremoval at 2.5 V with a flux of ∼ 500 (L·m^(2))/h with both bacteria and viruses at minimumenergy expense. Additionally, reactive oxygen species scavenging and hydrogen peroxidegeneration experiments have confirmed the role of electrical effects and indirect oxidationon the inactivation mechanism. The prepared Cu-LIG composite surfaces showed potentialfor environmental remediation applications.
基金supported by the Scientific and Technological Project of Henan Province(232102321117)National Natural Science Foundation of China(82202198)+2 种基金the National Engineering Research Center of Wheat and Corn Further Processing of Henan University of Technology(NL2022010)Project of Basic Research Fund of Henan Provincial Institute of Medical and Pharmacological Sciences(2023BP0106)the Innovative Funds Plan of Henan University of Technology(2020ZKCJ23)。
文摘Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive immunosorbent approach was elaborately developed based on high-affinity immunoglobulin G(IgG)coupled CuO-anchored Fe_(3)O_(4)nanozymes for precise and ultrasensitive detection of AFB_(1)in food crops including peanut,corn and wheat.The high-affinity nanozymes were fabricated by the assembly of inner core Fe_(3)O_(4)nanoparticles and mesoporous silica capping layer,Cu O further situated within large aperture of the coating layer via in-situ growth,and then conjugated with ligand rabbit anti-mouse Ig G,which can specifically bind with AFB_(1).The results showed the hybrid high-affinity nanozymes displayed enhanced peroxidasemimic activities and catalytic performances,achieving a linear range of 0.06-61.93(lg(ng/mL))and a detection limit of 0.0037 ng/mL,30 times better than that of the conventional enzyme-linked immunosorbent assay.The constructed nanozymes were successfully applied to the detection of AFB_(1)in food products with an average spiked recovery of 96.53%and relative standard deviations less than 2.8%.Therefore,the accurate hybrid nanozymes may serve for AFB_(1)detection in various foods in future.
基金supported by the National Natural Science Foundation of China(21277097)the Key Projects in the National Science&Technology Pillar Program during the 12th Five-Year Plan Period(2012BAJ21B01)~~
文摘Hierarchical microspheres of a graphene oxide（GO） coupled to N‐doped（BiO）2CO3 composite（N‐BOC‐GO） was synthesized by a simple hydrothermal approach. The N‐BOC‐GO composite gave enhancement in photocatalytic activity compared to the pure BOC and N‐BOC samples. With 1.0wt% GO, 62% NO removal was obtained with N‐BOC‐GO. The factors enhancing the photocatalytic performance were the high electron‐withdrawing ability and high conductivity of GO and improved visible light‐harvesting ability of N‐BOC‐GO with a 3D hierarchical architecture due to the surface scattering and reflecting（SSR） effect. An effective charge transfer from N‐BOC to GO was demonstrated by the much weakened photoluminescene intensity of the N‐BOC‐GO composite. This work highlights the potential application of GO‐based photocatalysts in air purification.
基金The financial support from the National Natural Science Foundation of China(No.22074125)the Natural Science Foundation Project of CQ CSTC(cstc2021jcyj-msxmX1165)The Innovation Platform for Academicians of Hainan Province is gratefully acknowledged.
文摘NiFe catalysts show compelling oxygen evolution reaction (OER) activity in alkaline solution but their hydrogen evolution reaction (HER) activity is limited.In this work Rh was incorporated in Fe-doped Ni_(2)S_(3) nanosheets with the assistance of hydrogen plasma to significantly enhance the HER/OER catalytic activity.The resultant catalyst,p-Rh/Fe-Ni_(2)S_(3)/NF,was composed of Rh/Rh_(2)S_(3) heterostructured clusters embedded in Fe-Ni_(2)S_(3) nanosheets;it needs overpotentials of only 108 and 237 mV to achieve HER and OER currents of 100 mA cm^(-2),respectively,and drives overall water splitting at 1.79 V with a current of 100 mA cm^(-2) as a bifunctional catalyst.Post-characterization and density functional theory (DFT) calculation reveal its operando evolution behavior and a unique Janus catalytic mechanism for the HER and OER.For the HER,a Rh/Rh_(2)S_(3) heterointerface with strong H_(2)O adsorption energy and optimal H adsorption energy is the active site;in the OER,it experiences surface transformation under operando conditions;an in situ formed Rh/Fe-doped NiOOH layer with strengthened binding of ^(*)O facilitates the rate determining step of ^(*)O formation to accelerate the OER process.Hydrogen plasma treatment not only helps partially reduce Rh to form HER-active Rh/Rh_(2)S_(3) heterostructures but also induces rich defects/vacancies to facilitate surface reconstruction/phase transformation to form an active co-doped NiOOH phase under OER conditions.This work may shed light on the promotive role of noble metals on NiFe-based catalysts for water splitting.
基金support by National Natural Science Foundation of China(51874357,51872333)Hunan Provincial Natural Science Foundation of China(2019JJ10006)X.L.acknowledges support from Shenghua Scholar Program of Central South University.R.M.acknowledges support from JSPS KAKENNHI(18H03869).
文摘Due to the low cost,abundant reserves and redox-active features,electrocatalysts based on 3d transition metals have been thoroughly evaluated and are considered promising candidates to the current commercial noble metal-based materials.Designing elaborate structures and favorable phase composition is regarded as effective to improve the activity in electrocatalysis.
基金National Natural and Science Foundations of China(No.30800090)"Xi-Bu-Zhi-Guang"project(2009-2012)from Chinese Academy of Science and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ012).
文摘15 compounds,including two new ones crepidatuols A(1)and B(2)were isolated from the stems of Dendrobium crepidatum.The planar structures of these compounds were elucidated by spectroscopic methods(NMR,MS,UV,and IR)and comparison with those from literatures.10 compounds were send for enhancing activities on nerve growth factor(NGF)medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A(1),confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0μM.
基金Supported by CAMS Innovation Fund for Medical Sciences,No.2020-I2M-C&T-A-004National High Level Hospital Clinical Research Funding,No.2022-PUMCH-A-210,No.2022-PUMCH-B-041,and No.2022-PUMCH-C-025and National Key R&D Program of China,No.2020YFE0201600.
文摘Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin regeneration.However,the use of stem cells in skin regeneration presents several challenges.Recently,stem cells and biomaterials have been identified as crucial components of the wound-healing process.Combination therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable attention.Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the ECM.These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing.This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine functions.Additionally,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.
基金supported by the National Science Foundation of USA under Award Number NSF-ENG 1844149。
文摘Rationally,engineering a favorable physicochemical microenvironment for enzymes has recently emerged as an effective strategy to improve their catalytic performance.In this review,we discuss four microenvironmental effects according to the mechanism of action:localizing and excluding reactants and regulators,regulating microenvironmental pH,creating a water-like microenvironment,and increasing the local temperature.These mechanisms are enzyme-independent and can in principle be used in combination to tailor enzyme behaviors,offering new approaches to enabling,enhancing,and regulating enzyme catalysis in diverse applications without the need for genetic engineering.
基金This work was financially supported by the Shandong Provincial Natural Science Foundation(ZR2020QB116)the Excellent Young Talents Foundation in Universities of Anhui Province(gxyq2021223)the Key Research Project of Natural Science in Universities of Anhui Province.(KJ2020A0749).
文摘Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water separation.However,it is still a challenge to fabricate multifunctional and environmentally friendly materials,which can be stably applied to purify the actual complicated wastewater.Here,a Ag/Ag/α-Fe_(2)O_(3) heterostructure anchored copper mesh was intentionally synthesized using a facile two-step hydrothermal method.The resultant mesh with superhydrophilicity and underwater superoleophobicity was capable of separating various oil/water mixtures with superior separation efficiency and high permeationflux driven by gravity.Benefiting from the joint effects of the smaller band gap of Ag/α-Fe_(2)O_(3) heterojunction,inherent antibacterial capacity of Ag/α-Fe_(2)O_(3) and Ag nanoparticles,favorable conductive substrate,as well as the hierarchical structure with superwettability,such mesh presented remarkably enhanced degradation capability toward organic dyes under visible light irradiation and antibacterial activity against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)compared with the pure Ag/α-Fe_(2)O_(3) coated mesh.Impressively,the mesh exhibited bifunctional water purification performance,in which organic dyes were eliminated simultaneously from water during oil/water separation in onefiltration process.More importantly,this mesh behaved exceptional chemical resistance,mechanical stability and long-term reusability.Therefore,this material with multifunctional integration may hold promising potential for steady water purification in practice.
基金supported by Sino-Dutch Research Program (SDRP2011-2015)the independent subject sponsored by State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (No. 2013DX10)
文摘A system combining granular activated carbon and powdered activated carbon technologies along with shortcut biological nitrogen removal （GAC-PACT-SBNR） was developed to enhance total nitrogen （TN） removal for anaerobically treated coal gasification wastewater with less need for external carbon resources. The TN removal efficiency in SBNR was significantly improved by introducing the effluent from the GAC process into SBNR during the anoxic stage, with removal percentage increasing from 43.8%49.6% to 68.8%-75.8%. However, the TN removal rate decreased with the progressive deterioration of GAC adsorption. After adding activated sludge to the GAG compartment, the granular carbon had a longer service-life and the demand for external carbon resources became lower. Eventually, the TN removal rate in SBNR was almost constant at approx. 43.3%, as compared to approx. 20.0% before seeding with sludge. In addition, the production of some alkalinity during the denitrification resulted in a net savings in alkalinity requirements for the nitrification reaction and refractory chemical oxygen demand （COD） degradation by autotrophic bacteria in SBNR under oxic conditions. PACT showed excellent resilience to increasing organic loadings. The microbial community analysis revealed that the PACT had a greater variety of bacterial taxons and the dominant species associated with the three compartments were in good agreement with the removal of typical pollutants. The study demonstrated that pre-adsorption by the GAC-sludge process could be a technically and economically feasible method to enhance TN removal in coal gasification wastewater （CGW）.
基金supported by a grant from the Science&Technology Bureau of Changzhou City of China,No.CJ20130029
文摘We previously found that oxygen-glucose-serum deprivation/restoration(OGSD/R)induces apoptosis of spinal cord astrocytes,possibly via caspase-12 and the integrated stress response,which involves protein kinase R-like endoplasmic reticulum kinase(PERK),eukaryotic initiation factor 2-alpha(eIF2α)and activating transcription factor 4(ATF4).We hypothesized that edaravone,a low molecular weight,lipophilic free radical scavenger,would reduce OGSD/R-induced apoptosis of spinal cord astrocytes.To test this,we established primary cultures of rat astrocytes,and exposed them to 8 hours/6 hours of OGSD/R with or without edaravone(0.1,1,10,100μM)treatment.We found that 100μM of edaravone significantly suppressed astrocyte apoptosis and inhibited the release of reactive oxygen species.It also inhibited the activation of caspase-12 and caspase-3,and reduced the expression of homologous CCAAT/enhancer binding protein,phosphorylated(p)-PERK,p-eIF2α,and ATF4.These results point to a new use of an established drug in the prevention of OGSD/R-mediated spinal cord astrocyte apoptosis via the integrated stress response.
基金supported by the Taishan Scholars Programme of Shandong Province(No.tsqn20161004)Project for Scientific Research Innovation Team of Young Scholar in Colleges and Universities of Shandong Province(No.2019KJC025)+1 种基金Young Scholars Program of Shandong University(No.2019WLJH21)China Postdoctoral Science Foundation(No.2020M672054)。
文摘The sluggish kinetics of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have always restricted the development of lithium oxygen batteries(LOBs).Herein,hollow carbon spheres loaded with Pd/Pd_(4)S heterostructure(Pd/Pd_(4)S@HCS)were successfully prepared via the in-situ deposition to improve the electrocatalytic activities for both ORR and OER in LOBs.With the welldispersed Pd/Pd_(4)S nanoparticles,the hierarchical composite with large specific surface area offers favorable transport channels for ions,electron and oxygen.Especially,the Pd/Pd_(4)S nanoparticles could exhibit excellent electrochemical performance for ORR and OER due to their intrinsic catalytic property and interfacial effect from the heterostructure.Therefore,the LOBs with Pd/Pd_(4)S@HCS as cathode catalyst show improved specific capacities,good rate ability and stable cycling performance.
文摘Promoting Health Enhancing Physical Activity (HEPA) behavior is an important undertaking in Germany as well as in China. In order to create successful interventions in different nations, knowledge about the relevant psychosocial correlates that may encourage successful progression through the behavior change process is necessary. Therefore, the relationships of selected psychosocial correlates of physical activity with stages of change were examined in a German-Chinese sample. In total, 2071 adults (865 Germans, 1206 Chinese) completed a questionnaire. The theoretical framework used was the FIT-model, which consists of the following stages of change: not considering, considering, preparing, exploring, fluctuating and maintaining. All data were analyzed with a two-way ANOVA. Significant main effects for the stages of change on all psychosocial correlates were found. Significant interactions between stages and nations emerged for all correlates except for social support, although these results revealed small effect sizes. To progress within the stages of inactivity, interventions should focus on outcome expectations, barriers, social support and affective attitudes. The successful initiation of physical activity depends on considerations of barriers, maintenance self-efficacy, intrinsic motivation and affective attitudes. These same correlates plus social support are relevant for long-term adherence to physical activity. In Germany, perceived barriers and emotional aspects of physical activity appear to be important for initiating and maintaining regular physical activity. Furthermore, for long-term adherence to physical activity, Germans—in contrast to Chinese adults—may not necessarily benefit from social support;however they could benefit from learning how to strengthen their physical activity outcome expectations.
文摘Sigma-1 receptors are unique receptors that are postulated to act as intracellular amplifiers for signal transduction within cells of the nervous system.The present paper studied the effect and mechanism of sigma-1 receptor agonists on intracellular Ca2+concentration at presynaptic sites using synaptosomes from the medial prefrontal cortex by fluorometric and biochemical methods combined with a pharmacological approach.The results showed that sigma-1 receptor agonist PRE-084 and SKF10047 could increase intrasynaptosomal Ca2+concentration in a dose-dependent manner.
文摘After publication of the research article "Constructing inter diffusive PtCuNi/WOg interface to enhance the catalytic activity and stability in oxygen reduction"(https://doi.org/10.1007/s42864-023-00226-0).The authors discovered that the"Acknowledgement"is missing from the published online version,due to the unintentional mistake when preparing the manuscript.This could be unfair to the entities/scholars providing meaningful help to this work,as well as the funding agency that provided the financial support to this work.Therefore,an erratum is requested by the authors to acknowledge the following parties.
