According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are r...According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect.展开更多
Accurate pedestrian trajectory predictions are critical in self-driving systems,as they are fundamental to the response-and decision-making of ego vehicles.In this study,we focus on the problem of predicting the futur...Accurate pedestrian trajectory predictions are critical in self-driving systems,as they are fundamental to the response-and decision-making of ego vehicles.In this study,we focus on the problem of predicting the future trajectory of pedestrians from a first-person perspective.Most existing trajectory prediction methods from the first-person view copy the bird’s-eye view,neglecting the differences between the two.To this end,we clarify the differences between the two views and highlight the importance of action-aware trajectory prediction in the first-person view.We propose a new action-aware network based on an encoder-decoder framework with an action prediction and a goal estimation branch at the end of the encoder.In the decoder part,bidirectional long short-term memory(Bi-LSTM)blocks are adopted to generate the ultimate prediction of pedestrians’future trajectories.Our method was evaluated on a public dataset and achieved a competitive performance,compared with other approaches.An ablation study demonstrates the effectiveness of the action prediction branch.展开更多
Noise reduction analysis of signals is essential for modern underwater acoustic detection systems.The traditional noise reduction techniques gradually lose efficacy because the target signal is masked by biological an...Noise reduction analysis of signals is essential for modern underwater acoustic detection systems.The traditional noise reduction techniques gradually lose efficacy because the target signal is masked by biological and natural noise in the marine environ-ment.The feature extraction method combining time-frequency spectrograms and deep learning can effectively achieve the separation of noise and target signals.A fully convolutional encoder-decoder neural network(FCEDN)is proposed to address the issue of noise reduc-tion in underwater acoustic signals.The time-domain waveform map of underwater acoustic signals is converted into a wavelet low-frequency analysis recording spectrogram during the denoising process to preserve as many underwater acoustic signal characteristics as possible.The FCEDN is built to learn the spectrogram mapping between noise and target signals that can be learned at each time level.The transposed convolution transforms are introduced,which can transform the spectrogram features of the signals into listenable audio files.After evaluating the systems on the ShipsEar Dataset,the proposed method can increase SNR and SI-SNR by 10.02 and 9.5dB,re-spectively.展开更多
Finger-vein recognition is widely applied on access control system due to the high user acceptance and convince. Improving the integrity of finger-vein is helpful for increasing the finger-vein recognition accuracy. D...Finger-vein recognition is widely applied on access control system due to the high user acceptance and convince. Improving the integrity of finger-vein is helpful for increasing the finger-vein recognition accuracy. During the process of finger-vein imaging, foreign objects may be attached on fingers, which directly affects the integrity of finger-vein images. In order to effectively extract finger-vein networks, the integrity of venous networks is still not ideal after preprocessing of finger vein images. In this paper, we propose a novel deep learning based image restoration method to improve the integrity of finger-vein networks. First, a region detecting method based on adaptive threshold is presented to locate the incomplete region. Next, an encoder-decoder model is used to restore the venous networks of the finger-vein images. Then we analyze the restoration results using several different methods. Experimental results show that the proposed method is effective to restore the venous networks of the finger-vein images.展开更多
Current spatio-temporal action detection methods lack sufficient capabilities in extracting and comprehending spatio-temporal information. This paper introduces an end-to-end Adaptive Cross-Scale Fusion Encoder-Decode...Current spatio-temporal action detection methods lack sufficient capabilities in extracting and comprehending spatio-temporal information. This paper introduces an end-to-end Adaptive Cross-Scale Fusion Encoder-Decoder (ACSF-ED) network to predict the action and locate the object efficiently. In the Adaptive Cross-Scale Fusion Spatio-Temporal Encoder (ACSF ST-Encoder), the Asymptotic Cross-scale Feature-fusion Module (ACCFM) is designed to address the issue of information degradation caused by the propagation of high-level semantic information, thereby extracting high-quality multi-scale features to provide superior features for subsequent spatio-temporal information modeling. Within the Shared-Head Decoder structure, a shared classification and regression detection head is constructed. A multi-constraint loss function composed of one-to-one, one-to-many, and contrastive denoising losses is designed to address the problem of insufficient constraint force in predicting results with traditional methods. This loss function enhances the accuracy of model classification predictions and improves the proximity of regression position predictions to ground truth objects. The proposed method model is evaluated on the popular dataset UCF101-24 and JHMDB-21. Experimental results demonstrate that the proposed method achieves an accuracy of 81.52% on the Frame-mAP metric, surpassing current existing methods.展开更多
As a common and high-risk type of disease,heart disease seriously threatens people’s health.At the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical...As a common and high-risk type of disease,heart disease seriously threatens people’s health.At the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical workers and patients because of its ability to assist in the diagnosis of diseases.Therefore,the research of real-time diagnosis and classification algorithms for arrhythmia can help to improve the diagnostic efficiency of diseases.In this paper,we design an automatic arrhythmia classification algorithm model based on Convolutional Neural Network(CNN)and Encoder-Decoder model.The model uses Long Short-Term Memory(LSTM)to consider the influence of time series features on classification results.Simultaneously,it is trained and tested by the MIT-BIH arrhythmia database.Besides,Generative Adversarial Networks(GAN)is adopted as a method of data equalization for solving data imbalance problem.The simulation results show that for the inter-patient arrhythmia classification,the hybrid model combining CNN and Encoder-Decoder model has the best classification accuracy,of which the accuracy can reach 94.05%.Especially,it has a better advantage for the classification effect of supraventricular ectopic beats(class S)and fusion beats(class F).展开更多
Cardiomyopathy is one of the most serious public health threats.The precise structural and functional cardiac measurement is an essential step for clinical diagnosis and follow-up treatment planning.Cardiologists are ...Cardiomyopathy is one of the most serious public health threats.The precise structural and functional cardiac measurement is an essential step for clinical diagnosis and follow-up treatment planning.Cardiologists are often required to draw endocardial and epicardial contours of the left ventricle(LV)manually in routine clinical diagnosis or treatment planning period.This task is time-consuming and error-prone.Therefore,it is necessary to develop a fully automated end-to-end semantic segmentation method on cardiac magnetic resonance(CMR)imaging datasets.However,due to the low image quality and the deformation caused by heartbeat,there is no effective tool for fully automated end-to-end cardiac segmentation task.In this work,we propose a multi-scale segmentation network(MSSN)for left ventricle segmentation.It can effectively learn myocardium and blood pool structure representations from 2D short-axis CMR image slices in a multi-scale way.Specifically,our method employs both parallel and serial of dilated convolution layers with different dilation rates to capture multi-scale semantic features.Moreover,we design graduated up-sampling layers with subpixel layers as the decoder to reconstruct lost spatial information and produce accurate segmentation masks.We validated our method using 164 T1 Mapping CMR images and showed that it outperforms the advanced convolutional neural network(CNN)models.In validation metrics,we archived the Dice Similarity Coefficient(DSC)metric of 78.96%.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based methods.In the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature ma...Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based methods.In the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding phase.However,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature information.To address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CBL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding stage.Furthermore,we incorporate a Multiplexed Dilation Convolution(MDC)module to expand the network's receptive field.Also,although we have removed the decoding stage,we still need to recover the feature map resolution.Therefore,we introduced the Global Feature Recovery(GFR)module.It uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature information.We conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDB and MoNuSeg datasets.Experimental results show that our proposed network outperforms state-of-the-art methods in medical image segmentation.In addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.展开更多
As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low ...As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low contrast and discontinuity of cracks bring great challenges to existing crack detection methods based on deep learning.Therefore,an end-to-end deep convolutional neural network(AttentionCrack)is proposed for automatic crack detection to overcome the inaccuracy of boundary location between crack and non-crack pixels.The AttentionCrack network is built on U-Net based encoder-decoder architecture,and an attention mechanism is incorporated into the multi-scale convolutional feature to enhance the recognition of crack region.Additionally,a dilated convolution module is introduced in the encoder-decoder architecture to reduce the loss of crack detail due to the pooling operation in the encoder network.Furthermore,since up-sampling will lead to the loss of crack boundary information in the decoder network,a depthwise separable residual module is proposed to capture the boundary information of pavement crack.The AttentionCrack net on public pavement crack image datasets named CrackSegNet and Crack500 is trained and tested,the results demonstrate that the AttentionCrack achieves F1 score over 0.70 on the CrackSegNet and 0.71 on the Crack500 in average and outperforms the current state-of-the-art methods.展开更多
基金National Natural Science Foundation of China(Nos.61673017,61403398)and Natural Science Foundation of Shaanxi Province(Nos.2017JM6077,2018ZDXM-GY-039)。
文摘According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect.
文摘Accurate pedestrian trajectory predictions are critical in self-driving systems,as they are fundamental to the response-and decision-making of ego vehicles.In this study,we focus on the problem of predicting the future trajectory of pedestrians from a first-person perspective.Most existing trajectory prediction methods from the first-person view copy the bird’s-eye view,neglecting the differences between the two.To this end,we clarify the differences between the two views and highlight the importance of action-aware trajectory prediction in the first-person view.We propose a new action-aware network based on an encoder-decoder framework with an action prediction and a goal estimation branch at the end of the encoder.In the decoder part,bidirectional long short-term memory(Bi-LSTM)blocks are adopted to generate the ultimate prediction of pedestrians’future trajectories.Our method was evaluated on a public dataset and achieved a competitive performance,compared with other approaches.An ablation study demonstrates the effectiveness of the action prediction branch.
基金supported by the National Natural Science Foundation of China(No.41906169)the PLA Academy of Military Sciences.
文摘Noise reduction analysis of signals is essential for modern underwater acoustic detection systems.The traditional noise reduction techniques gradually lose efficacy because the target signal is masked by biological and natural noise in the marine environ-ment.The feature extraction method combining time-frequency spectrograms and deep learning can effectively achieve the separation of noise and target signals.A fully convolutional encoder-decoder neural network(FCEDN)is proposed to address the issue of noise reduc-tion in underwater acoustic signals.The time-domain waveform map of underwater acoustic signals is converted into a wavelet low-frequency analysis recording spectrogram during the denoising process to preserve as many underwater acoustic signal characteristics as possible.The FCEDN is built to learn the spectrogram mapping between noise and target signals that can be learned at each time level.The transposed convolution transforms are introduced,which can transform the spectrogram features of the signals into listenable audio files.After evaluating the systems on the ShipsEar Dataset,the proposed method can increase SNR and SI-SNR by 10.02 and 9.5dB,re-spectively.
基金supported by the National Natural Science Foundation of China(No.61806208)
文摘Finger-vein recognition is widely applied on access control system due to the high user acceptance and convince. Improving the integrity of finger-vein is helpful for increasing the finger-vein recognition accuracy. During the process of finger-vein imaging, foreign objects may be attached on fingers, which directly affects the integrity of finger-vein images. In order to effectively extract finger-vein networks, the integrity of venous networks is still not ideal after preprocessing of finger vein images. In this paper, we propose a novel deep learning based image restoration method to improve the integrity of finger-vein networks. First, a region detecting method based on adaptive threshold is presented to locate the incomplete region. Next, an encoder-decoder model is used to restore the venous networks of the finger-vein images. Then we analyze the restoration results using several different methods. Experimental results show that the proposed method is effective to restore the venous networks of the finger-vein images.
基金support for this work was supported by Key Lab of Intelligent and Green Flexographic Printing under Grant ZBKT202301.
文摘Current spatio-temporal action detection methods lack sufficient capabilities in extracting and comprehending spatio-temporal information. This paper introduces an end-to-end Adaptive Cross-Scale Fusion Encoder-Decoder (ACSF-ED) network to predict the action and locate the object efficiently. In the Adaptive Cross-Scale Fusion Spatio-Temporal Encoder (ACSF ST-Encoder), the Asymptotic Cross-scale Feature-fusion Module (ACCFM) is designed to address the issue of information degradation caused by the propagation of high-level semantic information, thereby extracting high-quality multi-scale features to provide superior features for subsequent spatio-temporal information modeling. Within the Shared-Head Decoder structure, a shared classification and regression detection head is constructed. A multi-constraint loss function composed of one-to-one, one-to-many, and contrastive denoising losses is designed to address the problem of insufficient constraint force in predicting results with traditional methods. This loss function enhances the accuracy of model classification predictions and improves the proximity of regression position predictions to ground truth objects. The proposed method model is evaluated on the popular dataset UCF101-24 and JHMDB-21. Experimental results demonstrate that the proposed method achieves an accuracy of 81.52% on the Frame-mAP metric, surpassing current existing methods.
基金Fundamental Research Funds for the Central Universities(Grant No.FRF-TP-19-006A3).
文摘As a common and high-risk type of disease,heart disease seriously threatens people’s health.At the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical workers and patients because of its ability to assist in the diagnosis of diseases.Therefore,the research of real-time diagnosis and classification algorithms for arrhythmia can help to improve the diagnostic efficiency of diseases.In this paper,we design an automatic arrhythmia classification algorithm model based on Convolutional Neural Network(CNN)and Encoder-Decoder model.The model uses Long Short-Term Memory(LSTM)to consider the influence of time series features on classification results.Simultaneously,it is trained and tested by the MIT-BIH arrhythmia database.Besides,Generative Adversarial Networks(GAN)is adopted as a method of data equalization for solving data imbalance problem.The simulation results show that for the inter-patient arrhythmia classification,the hybrid model combining CNN and Encoder-Decoder model has the best classification accuracy,of which the accuracy can reach 94.05%.Especially,it has a better advantage for the classification effect of supraventricular ectopic beats(class S)and fusion beats(class F).
基金This work was supported by the Project of Sichuan Outstanding Young Scientific and Technological Talents(19JCQN0003)the major Project of Education Department in Sichuan(17ZA0063 and 2017JQ0030)+1 种基金in part by the Natural Science Foundation for Young Scientists of CUIT(J201704)the Sichuan Science and Technology Program(2019JDRC0077).
文摘Cardiomyopathy is one of the most serious public health threats.The precise structural and functional cardiac measurement is an essential step for clinical diagnosis and follow-up treatment planning.Cardiologists are often required to draw endocardial and epicardial contours of the left ventricle(LV)manually in routine clinical diagnosis or treatment planning period.This task is time-consuming and error-prone.Therefore,it is necessary to develop a fully automated end-to-end semantic segmentation method on cardiac magnetic resonance(CMR)imaging datasets.However,due to the low image quality and the deformation caused by heartbeat,there is no effective tool for fully automated end-to-end cardiac segmentation task.In this work,we propose a multi-scale segmentation network(MSSN)for left ventricle segmentation.It can effectively learn myocardium and blood pool structure representations from 2D short-axis CMR image slices in a multi-scale way.Specifically,our method employs both parallel and serial of dilated convolution layers with different dilation rates to capture multi-scale semantic features.Moreover,we design graduated up-sampling layers with subpixel layers as the decoder to reconstruct lost spatial information and produce accurate segmentation masks.We validated our method using 164 T1 Mapping CMR images and showed that it outperforms the advanced convolutional neural network(CNN)models.In validation metrics,we archived the Dice Similarity Coefficient(DSC)metric of 78.96%.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金funded by the National Key Research and Development Program of China(Grant 2020YFB1708900)the Fundamental Research Funds for the Central Universities(Grant No.B220201044).
文摘Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based methods.In the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding phase.However,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature information.To address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CBL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding stage.Furthermore,we incorporate a Multiplexed Dilation Convolution(MDC)module to expand the network's receptive field.Also,although we have removed the decoding stage,we still need to recover the feature map resolution.Therefore,we introduced the Global Feature Recovery(GFR)module.It uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature information.We conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDB and MoNuSeg datasets.Experimental results show that our proposed network outperforms state-of-the-art methods in medical image segmentation.In addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.
基金supported by the National Natural Science Foundation of China under Grant No.62001004the Key Provincial Natural Science Research Projects of Colleges and Universities in Anhui Province under Grant No.KJ2019A0768+2 种基金the Key Research and Development Program of Anhui Province under Grant No.202104A07020017the Research Project Reserve of Anhui Jianzhu University under Grant No.2020XMK04the Natural Science Foundation of the Anhui Higher Education Institutions of China,No.KJ2019A0789.
文摘As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low contrast and discontinuity of cracks bring great challenges to existing crack detection methods based on deep learning.Therefore,an end-to-end deep convolutional neural network(AttentionCrack)is proposed for automatic crack detection to overcome the inaccuracy of boundary location between crack and non-crack pixels.The AttentionCrack network is built on U-Net based encoder-decoder architecture,and an attention mechanism is incorporated into the multi-scale convolutional feature to enhance the recognition of crack region.Additionally,a dilated convolution module is introduced in the encoder-decoder architecture to reduce the loss of crack detail due to the pooling operation in the encoder network.Furthermore,since up-sampling will lead to the loss of crack boundary information in the decoder network,a depthwise separable residual module is proposed to capture the boundary information of pavement crack.The AttentionCrack net on public pavement crack image datasets named CrackSegNet and Crack500 is trained and tested,the results demonstrate that the AttentionCrack achieves F1 score over 0.70 on the CrackSegNet and 0.71 on the Crack500 in average and outperforms the current state-of-the-art methods.
