Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation...Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation effect. Thus,this kind of thread-embedding materials which can be buried into acupuncture points to produce a long-time stimulation is popular in the acupuncture and moxibustion therapies. The variation tendencies of diameter,weight, hydrophilicity, and flexibility of the samples under the change of chitosan coating concentration,coating time and coating times were studied respectively. The results showed that the hydrophilicity,weight,and rigidity after coating rose in a certain range with the increase of coating time,coating times and coating concentration. The coating time had little influence on the diameter of fiber.展开更多
Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and ...Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+western medicine group (allied-therapy group), 30 cases in each one. In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with flixonase sprayer was applied once per day, continuously for 30 days in treatment. In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups ( P>0.05 ). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the groups with single therapy applied (P<0.05). Conclusion: Quite good recent therapeutic effect of either acupoint-thread embedding or western medicine (certirizine+flixonase) was achieved on perennial allergic rhinitis. The remote therapeutic effect of allied therapy was more advantageous than that of single application of either thread embedding or western medicine.展开更多
Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should...Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should have excellent properties of good biocompatibility,biodegradability and moderate rigidity.Polyactic acid(PLA) as the thread-embedding material had some shortcomings such as poor hydrophilicity and slowly biodegradable speed.In this paper,PLA thread-embedding material was modified by chitosan coating which could improve rigidity,hydrophilicity and moisture absorption and thus produce better stimulation effect.The variation tendency of diameter,mass,hydrophilicity,and initial modulus of the sample under the change of chitosan coating concentration,coating time and coating times were studied respectively.The results showed that the hydrophilicity,mass,and initial modulus after coating rose in a certain range when the coating time,coating times and coating concentration increased,while the changing of coating had little impact on fiber diameter.展开更多
Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cyto...Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.展开更多
The J55 tubing thread fastener in an electric pump well experienced corrosion failure.The causes of the failure were investigated through physical and chemical property tests,corrosion product analysis,and microbial a...The J55 tubing thread fastener in an electric pump well experienced corrosion failure.The causes of the failure were investigated through physical and chemical property tests,corrosion product analysis,and microbial analysis.The results show that the metallographic structure and composition of the J55 tubing were normal.CO 2 corrosion was not the main cause of the thread fastener failure.The actual cause of the corrosion failure was microbiological corrosion,such as sulfate-reducing bacteria,thiosulfate-reducing bacteria,and iron-oxidizing bacteria.展开更多
With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Further...With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate.展开更多
In recent years,ransomware attacks have become one of the most common and destructive types of cyberattacks.Their impact is significant on the operations,finances and reputation of affected companies.Despite the effor...In recent years,ransomware attacks have become one of the most common and destructive types of cyberattacks.Their impact is significant on the operations,finances and reputation of affected companies.Despite the efforts of researchers and security experts to protect information systems from these attacks,the threat persists and the proposed solutions are not able to significantly stop the spread of ransomware attacks.The latest remarkable achievements of large language models(LLMs)in NLP tasks have caught the attention of cybersecurity researchers to integrate thesemodels into security threat detection.Thesemodels offer high embedding capabilities,able to extract rich semantic representations and paving theway formore accurate and adaptive solutions.In this context,we propose a new approach for ransomware detection based on an ensemblemethod that leverages three distinctLLMembeddingmodels.This ensemble strategy takes advantage of the variety of embedding methods and the strengths of each model.In the proposed solution,each embedding model is associated with an independently trainedMLP classifier.The predictions obtained are then merged using a weighted voting technique,assigning each model an influence proportional to its performance.This approach makes it possible to exploit the complementarity of representations,improve detection accuracy and robustness,and offer a more reliable solution in the face of the growing diversity and complexity of modern ransomware.展开更多
Spam emails remain one of the most persistent threats to digital communication,necessitating effective detection solutions that safeguard both individuals and organisations.We propose a spam email classification frame...Spam emails remain one of the most persistent threats to digital communication,necessitating effective detection solutions that safeguard both individuals and organisations.We propose a spam email classification frame-work that uses Bidirectional Encoder Representations from Transformers(BERT)for contextual feature extraction and a multiple-window Convolutional Neural Network(CNN)for classification.To identify semantic nuances in email content,BERT embeddings are used,and CNN filters extract discriminative n-gram patterns at various levels of detail,enabling accurate spam identification.The proposed model outperformed Word2Vec-based baselines on a sample of 5728 labelled emails,achieving an accuracy of 98.69%,AUC of 0.9981,F1 Score of 0.9724,and MCC of 0.9639.With a medium kernel size of(6,9)and compact multi-window CNN architectures,it improves performance.Cross-validation illustrates stability and generalization across folds.By balancing high recall with minimal false positives,our method provides a reliable and scalable solution for current spam detection in advanced deep learning.By combining contextual embedding and a neural architecture,this study develops a security analysis method.展开更多
Message structure reconstruction is a critical task in protocol reverse engineering,aiming to recover protocol field structures without access to source code.It enables important applications in network security,inclu...Message structure reconstruction is a critical task in protocol reverse engineering,aiming to recover protocol field structures without access to source code.It enables important applications in network security,including malware analysis and protocol fuzzing.However,existing methods suffer from inaccurate field boundary delineation and lack hierarchical relationship recovery,resulting in imprecise and incomplete reconstructions.In this paper,we propose ProRE,a novel method for reconstructing protocol field structures based on program execution slice embedding.ProRE extracts code slices from protocol parsing at runtime,converts them into embedding vectors using a data flow-sensitive assembly language model,and performs hierarchical clustering to recover complete protocol field structures.Evaluation on two datasets containing 12 protocols shows that ProRE achieves an average F1 score of 0.85 and a cophenetic correlation coefficient of 0.189,improving by 19%and 0.126%respectively over state-of-the-art methods(including BinPRE,Tupni,Netlifter,and QwQ-32B-preview),demonstrating significant superiority in both accuracy and completeness of field structure recovery.Case studies further validate the effectiveness of ProRE in practical malware analysis scenarios.展开更多
E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing ...E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.展开更多
Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,transl...Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,translation-based embedding models constitute a prominent approach in TKGC research.However,existing translation-based methods typically incorporate timestamps into entities or relations,rather than utilizing them independently.This practice fails to fully exploit the rich semantics inherent in temporal information,thereby weakening the expressive capability of models.To address this limitation,we propose embedding timestamps,like entities and relations,in one or more dedicated semantic spaces.After projecting all embeddings into a shared space,we use the relation-timestamp pair instead of the conventional relation embedding as the translation vector between head and tail entities.Our method elevates timestamps to the same representational significance as entities and relations.Based on this strategy,we introduce two novel translation-based embedding models:TE-TransR and TE-TransT.With the independent representation of timestamps,our method not only enhances capabilities in link prediction but also facilitates a relatively underexplored task,namely time prediction.To further bolster the precision and reliability of time prediction,we introduce a granular,time unit-based timestamp setting and a relation-specific evaluation protocol.Extensive experiments demonstrate that our models achieve strong performance on link prediction benchmarks,with TE-TransR outperforming existing baselines in the time prediction task.展开更多
The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild r...The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild reaction conditions.Using Cu as a model,the resulting Cu-aPN(copper‐embedded all‐inorganic phosphazene network)retains the intrinsic N_(3)P_(3)backbone and exhibits an amorphous structure where Cu species are uniformly anchored at dense P/N coordination sites of the network.Time of flight secondary ion mass spectrometry(TOF‐SIMS)and X‐ray diffraction(XRD)reveal a gradual CuCl‐to‐CuO phase conversion during ammonia treatment,which effectively ensures the structural stability of the phosphazene framework.In 1 M KOH,Cu-aPN delivers an overpotential of 280 mV at 10 mA cm^(−2)and a Tafel slope of 48 mV dec^(−1),markedly outperforming Ga-aPN.In situ Raman and density functional theory(DFT)analyses indicate stronger Cu-P/N coordination coupling that lowers the*OH formation barrier(0.39 vs.0.88 eV for Ga).This MR-DC route furnishes a general and versatile pathway for constructing metal‐embedded all‐inorganic phosphazene frameworks with tunable coordination environments for advanced electrocatalytic applications.展开更多
Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional con...Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional constipation of intestinal excess heat were randomly divided into a thread-embedding group(40 cases,2 cases dropped out)and a Chinese patent medication group(40 cases,1 case dropped out).Based on the theory of combined lower he-sea and front-mu points for diseases of fu organs,Zhongwan(CV12),Guanyuan(CV4)and bilateral Zusanli(ST36),Shangjuxu(ST37),Tianshu(ST25),Xiajuxu(ST39)were selected and threadembedding therapy was delivered in the thread-embedding group,once a week.Maren Runchang pll was given orally in the Chinese patent medication group,6-12 g each time,twice a day.Both groups were treated for 4 weeks.Before and after treatment,the scores of constipation assessment scale(CAS),Bristol stool form scale(BSFS),patient-assessment of constipation quality of life(PAC-QOL)and TCM syndrome were observed,and the clinical efficacy was evaluated after treatment in the two groups.Results After treatment,the CAS scores and the TCM syndrome scores were decreased compared with those before treatment(P<0.05),while the BSFS scores were increased compared with those before treatment(P<0.05)in the two groups;the total scores,as well as the physical discomfort and psychosocial discomfort scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the two groups,the worry and anxiety,and the satisfaction scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the thread-embedding group.After treatment,the CAS score,the total score and item-scores of PAC-QOL,as well as the TCM syndrome score in the thread-embedding groupwere lower than those in the Chinese patent medication group(P<0.05).The total effective rate was 78.9%(30/38)in the thread-embedding group,which was higher than 56.4%(22/39)in the Chinese patent medication group(P<0.05).Conclusion Thread-embedding at the combined lower he-sea and front-mu points can effectively treat functional constipation with intestinal excess heat and improve quality of life.展开更多
Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional(3D)imaging.A newly published transparent embedding system,TESOS(Transparent Embedding Solvent ...Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional(3D)imaging.A newly published transparent embedding system,TESOS(Transparent Embedding Solvent System),ensures consistent submicron resolution imaging throughout the entire sample,and can be compatible with different microscopy systems.This method shows great potential in connectome mapping,and might be an optimal option for future 3D multiplex immunofluorescence and RNA in situ hybridization imaging.Additional efforts would be needed to innovate labeling,imaging,and data processing strategies to fully utilize the potential of transparent embedding systems in highresolution imaging of large-scale samples.展开更多
BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different tre...BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.AIM To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation(RPH).METHODS A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group(n=50)and the treatment group(n=50)by rolling the dice.The procedure for prolapse and hemorrhoids(PPH)was adopted in the control group,while polidocanol foam injection+RPH was adopted in the treatment group.The therapeutic effects,operation time,wound healing time,hospital stay,pain situation(24 hours post-operative pain score,first defecation pain score),quality of life(QOL),incidence of complications(post-operative hemorrhage,edema,infection),incidence of anal stenosis 3 months post-operatively and recurrence rate 1 year post-operatively of the two groups were compared.RESULTS Compared with the control group,the total effective rate of treatment group was higher,and the difference was significant(P<0.05).The operation time/wound healing time/hospital stay in the treatment group were shorter than those in the control group(P<0.05).The pain scores at 24 hours after operation/first defecation pain score of the treatment group was significantly lower than those in the control group(P<0.05).After surgery,the QOL scores of the two groups decreased,with the treatment group having higher scores than that of the control group(P<0.05).Compared with the control group,the incidence of postoperative complications in the treatment group was lower,and the difference was significant(P<0.05);However,there was no significant difference in the incidence of postoperative bleeding between the two groups(P>0.05);There was no significant difference in the incidence of anal stenosis 3 months after operation and the recurrence rate 1 year after operation between the two groups(P>0.05).CONCLUSION For patients with mixed hemorrhoids,the therapeutic effect achieved by using polidocanol injection combined with RPH was better.The wounds of the patients healed faster,the postoperative pain was milder,QOL improved,and the incidence of complications was lower,and the short-term and long-term prognosis was good.展开更多
Let G be a group.The family of all sets which are closed in every Hausdorf group topology of G form the family of closed sets of a T_(1) topology M_(G) on G called the Markov topology.Similarly,the family of all algeb...Let G be a group.The family of all sets which are closed in every Hausdorf group topology of G form the family of closed sets of a T_(1) topology M_(G) on G called the Markov topology.Similarly,the family of all algebraic subsets of G forms a family of closed sets for another T_(1)topology Z_(G) on G called the Zarski topology.A subgroup H of G is said to be Markov(resp.Zarski)embedded if the equality M_(G|H)=M_(H)(resp.Z_(G|H)=Z_(H))holds.I's proved that an abirary subgroup of a free group is both Zariski and Markov embedded in it.展开更多
BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fl...BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their promotion.AIM To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.METHODS From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this study.All patients underwent 3D-LAST in precise resection of liver tumors.RESULTS All patients(8/8,100%)underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.CONCLUSION In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to promote.Core Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.Eight patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.In conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to promote.INTRODUCTION Hepatectomy is widely used for the treatment of liver tumors.In recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise resection.Necessary assistive technologies have enabled these advances.Intraoperative ultrasound(IOUS)localization and indocyanine green(ICG)fluorescence imaging guidance are two frequently-used approaches for laparoscopic hepatectomy[1,2].IOUS is an invaluable auxiliary means widely accepted in surgery for real-time diagnostic information to determine resection range and navigate the surgical path[3].However,the major limitation of IOUS is the time cost during the procedure for paging the sono-graphers and the difficulty of deciphering two dimensional images[4].ICG is a non-toxic water-soluble fluorophore that reveals fluorescence under the near-infrared spectrum[5].Since liver tissue penetration is limited to 5 to 10 mm,that restricted the visualization of deeper tumors by ICG excitation,thereby interfering with its application in laparoscopic hepatectomy[6].IOUS and ICG navigation require specific technical equipment,making implementation difficult in many centers.And these techniques will significantly increase the operation time.Three-dimensional(3D)visualization involves extracting features and producing volumetric images based on computed tomography(CT)through a computer postprocessing technique.This tool offers a reasonable approach to the clinical decision for the potential to display the complex internal anatomy in an intuitive and stereoscopic manner[7].In the past few decades,applying 3D simulation software for liver volume calculation,virtual simulation surgery,portal hypertension monitor,and surgical navigation has proven to be safe and effective[8].Therefore,we propose a new method to find obvious anatomical markers and calculate the resection range according to 3D positioning before operation.During the operation,the scope of resection was delineated with silk thread,and resection was performed.This is a new practical approach,which we named as 3D location approach with silk thread(3D-LAST).RESULTS During the study period from September 2020 to January 2022,5 patients with hepatocellular carcinoma,1 patient with intrahepatic cholangiocarcinoma,1 patient with hilar cholangiocarcinoma,and 1 patient with gastric cancer liver metastasis were assessed for liver resection.There were 5 males and 3 females.The mean age of these patients was 54.3±10.2 years(34-66 years).Preoperative 3D positioning was conducted and the scope of resection was delineated with a surgical suture successfully performed in all 8 patients without complications.The treatment results of these 8 patients are shown in Table 1.The 90-day operative mortality was zero.Complications worse than Dindo-Clavien IIIa was not observed at a mean follow-up time of 8.7 months(4-16 months),there was no evidence of tumor recurrence or extrahepatic metastasis.At the time of reporting,the patients are all alive and lead normal lives.We take one patient as an example,58-year-old male,who found a liver lesion 10 months after gastric cancer surgery.Enhanced CT showed that the lesion was located in the liver S5,about 1.5 cm in diameter,and considered metastatic lesions.We performed 3D-LAST guided hepatectomy on this patient(Figure 1).Other representative 3D-LAST surgical procedures are shown in Figure 2.展开更多
基金Biomedical Textile Materials Science and Technology(111 Project),China(No.B07024)
文摘Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation effect. Thus,this kind of thread-embedding materials which can be buried into acupuncture points to produce a long-time stimulation is popular in the acupuncture and moxibustion therapies. The variation tendencies of diameter,weight, hydrophilicity, and flexibility of the samples under the change of chitosan coating concentration,coating time and coating times were studied respectively. The results showed that the hydrophilicity,weight,and rigidity after coating rose in a certain range with the increase of coating time,coating times and coating concentration. The coating time had little influence on the diameter of fiber.
文摘Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+western medicine group (allied-therapy group), 30 cases in each one. In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with flixonase sprayer was applied once per day, continuously for 30 days in treatment. In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups ( P>0.05 ). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the groups with single therapy applied (P<0.05). Conclusion: Quite good recent therapeutic effect of either acupoint-thread embedding or western medicine (certirizine+flixonase) was achieved on perennial allergic rhinitis. The remote therapeutic effect of allied therapy was more advantageous than that of single application of either thread embedding or western medicine.
文摘Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should have excellent properties of good biocompatibility,biodegradability and moderate rigidity.Polyactic acid(PLA) as the thread-embedding material had some shortcomings such as poor hydrophilicity and slowly biodegradable speed.In this paper,PLA thread-embedding material was modified by chitosan coating which could improve rigidity,hydrophilicity and moisture absorption and thus produce better stimulation effect.The variation tendency of diameter,mass,hydrophilicity,and initial modulus of the sample under the change of chitosan coating concentration,coating time and coating times were studied respectively.The results showed that the hydrophilicity,mass,and initial modulus after coating rose in a certain range when the coating time,coating times and coating concentration increased,while the changing of coating had little impact on fiber diameter.
基金2020 Hebei provincial research project of Chinese medicine(No.2020374)
文摘Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.
文摘The J55 tubing thread fastener in an electric pump well experienced corrosion failure.The causes of the failure were investigated through physical and chemical property tests,corrosion product analysis,and microbial analysis.The results show that the metallographic structure and composition of the J55 tubing were normal.CO 2 corrosion was not the main cause of the thread fastener failure.The actual cause of the corrosion failure was microbiological corrosion,such as sulfate-reducing bacteria,thiosulfate-reducing bacteria,and iron-oxidizing bacteria.
基金supported by the National Natural Science Foundation of China under Grant 62471493supported by the Natural Science Foundation of Shandong Province under Grant ZR2023LZH017,ZR2024MF066。
文摘With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate.
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2024-02-01176).
文摘In recent years,ransomware attacks have become one of the most common and destructive types of cyberattacks.Their impact is significant on the operations,finances and reputation of affected companies.Despite the efforts of researchers and security experts to protect information systems from these attacks,the threat persists and the proposed solutions are not able to significantly stop the spread of ransomware attacks.The latest remarkable achievements of large language models(LLMs)in NLP tasks have caught the attention of cybersecurity researchers to integrate thesemodels into security threat detection.Thesemodels offer high embedding capabilities,able to extract rich semantic representations and paving theway formore accurate and adaptive solutions.In this context,we propose a new approach for ransomware detection based on an ensemblemethod that leverages three distinctLLMembeddingmodels.This ensemble strategy takes advantage of the variety of embedding methods and the strengths of each model.In the proposed solution,each embedding model is associated with an independently trainedMLP classifier.The predictions obtained are then merged using a weighted voting technique,assigning each model an influence proportional to its performance.This approach makes it possible to exploit the complementarity of representations,improve detection accuracy and robustness,and offer a more reliable solution in the face of the growing diversity and complexity of modern ransomware.
基金funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2026R234)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Spam emails remain one of the most persistent threats to digital communication,necessitating effective detection solutions that safeguard both individuals and organisations.We propose a spam email classification frame-work that uses Bidirectional Encoder Representations from Transformers(BERT)for contextual feature extraction and a multiple-window Convolutional Neural Network(CNN)for classification.To identify semantic nuances in email content,BERT embeddings are used,and CNN filters extract discriminative n-gram patterns at various levels of detail,enabling accurate spam identification.The proposed model outperformed Word2Vec-based baselines on a sample of 5728 labelled emails,achieving an accuracy of 98.69%,AUC of 0.9981,F1 Score of 0.9724,and MCC of 0.9639.With a medium kernel size of(6,9)and compact multi-window CNN architectures,it improves performance.Cross-validation illustrates stability and generalization across folds.By balancing high recall with minimal false positives,our method provides a reliable and scalable solution for current spam detection in advanced deep learning.By combining contextual embedding and a neural architecture,this study develops a security analysis method.
文摘Message structure reconstruction is a critical task in protocol reverse engineering,aiming to recover protocol field structures without access to source code.It enables important applications in network security,including malware analysis and protocol fuzzing.However,existing methods suffer from inaccurate field boundary delineation and lack hierarchical relationship recovery,resulting in imprecise and incomplete reconstructions.In this paper,we propose ProRE,a novel method for reconstructing protocol field structures based on program execution slice embedding.ProRE extracts code slices from protocol parsing at runtime,converts them into embedding vectors using a data flow-sensitive assembly language model,and performs hierarchical clustering to recover complete protocol field structures.Evaluation on two datasets containing 12 protocols shows that ProRE achieves an average F1 score of 0.85 and a cophenetic correlation coefficient of 0.189,improving by 19%and 0.126%respectively over state-of-the-art methods(including BinPRE,Tupni,Netlifter,and QwQ-32B-preview),demonstrating significant superiority in both accuracy and completeness of field structure recovery.Case studies further validate the effectiveness of ProRE in practical malware analysis scenarios.
文摘E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.
基金supported by the National Natural Science Foundation of China under Grant No.72293575.
文摘Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,translation-based embedding models constitute a prominent approach in TKGC research.However,existing translation-based methods typically incorporate timestamps into entities or relations,rather than utilizing them independently.This practice fails to fully exploit the rich semantics inherent in temporal information,thereby weakening the expressive capability of models.To address this limitation,we propose embedding timestamps,like entities and relations,in one or more dedicated semantic spaces.After projecting all embeddings into a shared space,we use the relation-timestamp pair instead of the conventional relation embedding as the translation vector between head and tail entities.Our method elevates timestamps to the same representational significance as entities and relations.Based on this strategy,we introduce two novel translation-based embedding models:TE-TransR and TE-TransT.With the independent representation of timestamps,our method not only enhances capabilities in link prediction but also facilitates a relatively underexplored task,namely time prediction.To further bolster the precision and reliability of time prediction,we introduce a granular,time unit-based timestamp setting and a relation-specific evaluation protocol.Extensive experiments demonstrate that our models achieve strong performance on link prediction benchmarks,with TE-TransR outperforming existing baselines in the time prediction task.
基金financially supported by the National Natural Science Foundation of China(Grant 22205173)the Innovation Capability Support Program of Shaanxi(Grant 2024CX‐GXPT‐12)。
文摘The metal‐reduction‐induced dechlorination coupling(MR-DC)strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network(aPN)from hexachlorocyclotriphosphazene(HCCP)under mild reaction conditions.Using Cu as a model,the resulting Cu-aPN(copper‐embedded all‐inorganic phosphazene network)retains the intrinsic N_(3)P_(3)backbone and exhibits an amorphous structure where Cu species are uniformly anchored at dense P/N coordination sites of the network.Time of flight secondary ion mass spectrometry(TOF‐SIMS)and X‐ray diffraction(XRD)reveal a gradual CuCl‐to‐CuO phase conversion during ammonia treatment,which effectively ensures the structural stability of the phosphazene framework.In 1 M KOH,Cu-aPN delivers an overpotential of 280 mV at 10 mA cm^(−2)and a Tafel slope of 48 mV dec^(−1),markedly outperforming Ga-aPN.In situ Raman and density functional theory(DFT)analyses indicate stronger Cu-P/N coordination coupling that lowers the*OH formation barrier(0.39 vs.0.88 eV for Ga).This MR-DC route furnishes a general and versatile pathway for constructing metal‐embedded all‐inorganic phosphazene frameworks with tunable coordination environments for advanced electrocatalytic applications.
文摘Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional constipation of intestinal excess heat were randomly divided into a thread-embedding group(40 cases,2 cases dropped out)and a Chinese patent medication group(40 cases,1 case dropped out).Based on the theory of combined lower he-sea and front-mu points for diseases of fu organs,Zhongwan(CV12),Guanyuan(CV4)and bilateral Zusanli(ST36),Shangjuxu(ST37),Tianshu(ST25),Xiajuxu(ST39)were selected and threadembedding therapy was delivered in the thread-embedding group,once a week.Maren Runchang pll was given orally in the Chinese patent medication group,6-12 g each time,twice a day.Both groups were treated for 4 weeks.Before and after treatment,the scores of constipation assessment scale(CAS),Bristol stool form scale(BSFS),patient-assessment of constipation quality of life(PAC-QOL)and TCM syndrome were observed,and the clinical efficacy was evaluated after treatment in the two groups.Results After treatment,the CAS scores and the TCM syndrome scores were decreased compared with those before treatment(P<0.05),while the BSFS scores were increased compared with those before treatment(P<0.05)in the two groups;the total scores,as well as the physical discomfort and psychosocial discomfort scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the two groups,the worry and anxiety,and the satisfaction scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the thread-embedding group.After treatment,the CAS score,the total score and item-scores of PAC-QOL,as well as the TCM syndrome score in the thread-embedding groupwere lower than those in the Chinese patent medication group(P<0.05).The total effective rate was 78.9%(30/38)in the thread-embedding group,which was higher than 56.4%(22/39)in the Chinese patent medication group(P<0.05).Conclusion Thread-embedding at the combined lower he-sea and front-mu points can effectively treat functional constipation with intestinal excess heat and improve quality of life.
基金supported by a startup fund from the Chinese Institute for Brain Research,National Natural Science Foundation of China(82101059)research funding from West China School/Hospital of Stomatology Sichuan University(RCDWJS2022-11).
文摘Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional(3D)imaging.A newly published transparent embedding system,TESOS(Transparent Embedding Solvent System),ensures consistent submicron resolution imaging throughout the entire sample,and can be compatible with different microscopy systems.This method shows great potential in connectome mapping,and might be an optimal option for future 3D multiplex immunofluorescence and RNA in situ hybridization imaging.Additional efforts would be needed to innovate labeling,imaging,and data processing strategies to fully utilize the potential of transparent embedding systems in highresolution imaging of large-scale samples.
文摘BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.AIM To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation(RPH).METHODS A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group(n=50)and the treatment group(n=50)by rolling the dice.The procedure for prolapse and hemorrhoids(PPH)was adopted in the control group,while polidocanol foam injection+RPH was adopted in the treatment group.The therapeutic effects,operation time,wound healing time,hospital stay,pain situation(24 hours post-operative pain score,first defecation pain score),quality of life(QOL),incidence of complications(post-operative hemorrhage,edema,infection),incidence of anal stenosis 3 months post-operatively and recurrence rate 1 year post-operatively of the two groups were compared.RESULTS Compared with the control group,the total effective rate of treatment group was higher,and the difference was significant(P<0.05).The operation time/wound healing time/hospital stay in the treatment group were shorter than those in the control group(P<0.05).The pain scores at 24 hours after operation/first defecation pain score of the treatment group was significantly lower than those in the control group(P<0.05).After surgery,the QOL scores of the two groups decreased,with the treatment group having higher scores than that of the control group(P<0.05).Compared with the control group,the incidence of postoperative complications in the treatment group was lower,and the difference was significant(P<0.05);However,there was no significant difference in the incidence of postoperative bleeding between the two groups(P>0.05);There was no significant difference in the incidence of anal stenosis 3 months after operation and the recurrence rate 1 year after operation between the two groups(P>0.05).CONCLUSION For patients with mixed hemorrhoids,the therapeutic effect achieved by using polidocanol injection combined with RPH was better.The wounds of the patients healed faster,the postoperative pain was milder,QOL improved,and the incidence of complications was lower,and the short-term and long-term prognosis was good.
基金Supported by the Grant-in-Aid for Scientific Research(C)by the Japan Society for the Promotion of Science(20K03615)。
文摘Let G be a group.The family of all sets which are closed in every Hausdorf group topology of G form the family of closed sets of a T_(1) topology M_(G) on G called the Markov topology.Similarly,the family of all algebraic subsets of G forms a family of closed sets for another T_(1)topology Z_(G) on G called the Zarski topology.A subgroup H of G is said to be Markov(resp.Zarski)embedded if the equality M_(G|H)=M_(H)(resp.Z_(G|H)=Z_(H))holds.I's proved that an abirary subgroup of a free group is both Zariski and Markov embedded in it.
文摘BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their promotion.AIM To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.METHODS From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this study.All patients underwent 3D-LAST in precise resection of liver tumors.RESULTS All patients(8/8,100%)underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.CONCLUSION In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to promote.Core Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.Eight patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.In conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to promote.INTRODUCTION Hepatectomy is widely used for the treatment of liver tumors.In recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise resection.Necessary assistive technologies have enabled these advances.Intraoperative ultrasound(IOUS)localization and indocyanine green(ICG)fluorescence imaging guidance are two frequently-used approaches for laparoscopic hepatectomy[1,2].IOUS is an invaluable auxiliary means widely accepted in surgery for real-time diagnostic information to determine resection range and navigate the surgical path[3].However,the major limitation of IOUS is the time cost during the procedure for paging the sono-graphers and the difficulty of deciphering two dimensional images[4].ICG is a non-toxic water-soluble fluorophore that reveals fluorescence under the near-infrared spectrum[5].Since liver tissue penetration is limited to 5 to 10 mm,that restricted the visualization of deeper tumors by ICG excitation,thereby interfering with its application in laparoscopic hepatectomy[6].IOUS and ICG navigation require specific technical equipment,making implementation difficult in many centers.And these techniques will significantly increase the operation time.Three-dimensional(3D)visualization involves extracting features and producing volumetric images based on computed tomography(CT)through a computer postprocessing technique.This tool offers a reasonable approach to the clinical decision for the potential to display the complex internal anatomy in an intuitive and stereoscopic manner[7].In the past few decades,applying 3D simulation software for liver volume calculation,virtual simulation surgery,portal hypertension monitor,and surgical navigation has proven to be safe and effective[8].Therefore,we propose a new method to find obvious anatomical markers and calculate the resection range according to 3D positioning before operation.During the operation,the scope of resection was delineated with silk thread,and resection was performed.This is a new practical approach,which we named as 3D location approach with silk thread(3D-LAST).RESULTS During the study period from September 2020 to January 2022,5 patients with hepatocellular carcinoma,1 patient with intrahepatic cholangiocarcinoma,1 patient with hilar cholangiocarcinoma,and 1 patient with gastric cancer liver metastasis were assessed for liver resection.There were 5 males and 3 females.The mean age of these patients was 54.3±10.2 years(34-66 years).Preoperative 3D positioning was conducted and the scope of resection was delineated with a surgical suture successfully performed in all 8 patients without complications.The treatment results of these 8 patients are shown in Table 1.The 90-day operative mortality was zero.Complications worse than Dindo-Clavien IIIa was not observed at a mean follow-up time of 8.7 months(4-16 months),there was no evidence of tumor recurrence or extrahepatic metastasis.At the time of reporting,the patients are all alive and lead normal lives.We take one patient as an example,58-year-old male,who found a liver lesion 10 months after gastric cancer surgery.Enhanced CT showed that the lesion was located in the liver S5,about 1.5 cm in diameter,and considered metastatic lesions.We performed 3D-LAST guided hepatectomy on this patient(Figure 1).Other representative 3D-LAST surgical procedures are shown in Figure 2.
