Electroshocking treatment(EST),an efficient and rapid material treatment method,promotes microstructure evolution and improves mechanical properties.This study incorporates EST into the conventional cold rolling-quenc...Electroshocking treatment(EST),an efficient and rapid material treatment method,promotes microstructure evolution and improves mechanical properties.This study incorporates EST into the conventional cold rolling-quenching tempering process of M50 steel and investigates the influence and mechanism of applying EST at different stages of the process on the microstructure and mechanical properties.Scanning electron microscope(SEM),transmission electron microscope(TEM),and X-ray diffraction(XRD)were used to characterize the effect of EST on microstructure.The results show that EST can refine the grains of M50(average reduction of 10.1%in grain size),homogenize the grain size distribution,reduce the dislocation density(20.9%in average),promote the dissolution of carbides in the matrix and distribute them more uniformly along the grain boundaries,resulting in the improvement of mechanical properties.The mechanical properties of the specimen with the process flow of rolling-quenching-tempering-electroshocking showed excellent performance,with an increase in hardness of 1.4%,tensile strength of 17.7%,and elongation at break of 24.3%as compared to the specimen without EST.The tensile properties of the specimen with the process flow of rolling electroshocking-quenching-tempering showed the best performance,with an increase in tensile strength of 30.0%and elongation at break of 30.7%as compared to the specimen without EST.展开更多
In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,t...In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 MPa.The effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and TiB.Before EST,TiB fracture introduced cracks that extended into the matrix,resulting in material failure.After EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC strength.Moreover,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix first.With an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of pores.Analyzing the propagation path of the main crack after EST showed that the deflection angle of the main crack increased.The micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was brittle.After EST,the size and area of the dimples increased,confirming the increase in plasticity.The results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after EST.Hence,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.展开更多
In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical prope...In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical properties of LMD Ti-6.5Al-3.5Mo-1.5Zr-0.3Si were investigated.The results showed that the width of the heat affected band decreased and disappeared under the thermal and athermal effects of EST,resulting in the uniform microstructure.In the microstructure,theαlaths became coarser gradually,and the quantity ofα/βinterface was reduced.The reduction of the quantity ofα/βinterface leads to make less resistant to dislocation,resulting in the reduction in hardness and strength.The discontinuous grain boundaryαphase and nucleationαcolony near grain boundary inhibited the crack propagation and improved the ductility.Summary,EST can manipulate the microstructure and improve the mechanical properties of LMD titanium alloys.展开更多
BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properti...BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic effects.AIM To evaluate the anticonvulsant effects of rosuvastatin in animal models of epilepsy.METHODS Ninety-six albino mice were divided into 16 groups.In the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a combination.Outcomes measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and mortality.In the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and mortality.RESULTS In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of mice.Rosuvastatin shortens the duration of THLE in a dose-dependent manner.However,none of these were statistically significant com-pared to the control group.The combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/kg.In the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or mortality.However,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/kg.CONCLUSION Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and valproate.Further studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.展开更多
Forced normalization(FN)is a unique phenomenon that is often seen in the treatment of epilepsy.FN is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly impro...Forced normalization(FN)is a unique phenomenon that is often seen in the treatment of epilepsy.FN is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control;the occurrence of FN seriously affects patients’quality of life.The causes of FN include antiseizure medications(ASMs),epilepsy surgery and vagus nerve stimulation,with ASMs being the most common cause.However,with the timely reduction or discontinuation of ASMs and the use of antipsychotic drugs,the overall prognosis is good.Here,we perform an extensive review of the literature pertaining to FN,including its epidemiology,possible mechanisms,clinical features,treatment and prognosis.展开更多
Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the elec...Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the electrophysiological variation among three developmental stages in young mice(no more than 5 weeks old).The induced electroshock seizure(ES)behavior of early post natal mice(1-2-weeks old)differed from that during weaning(3 weeks old)and early puberty(4-5-weeks old).Thus,we further explored their respective characteristic responses to the ES parameters.When the stimulation current(SC)was limited to 4.0 mA,only the 1-2-week-old mice were induced to exhibit ES behavior at voltages of 30 V and 40 V,indicating they were more sensitive to maximal electroshock seizure(MES)(response to lower voltage).展开更多
Objective: to explore the nursing effect of patients with schizophrenia receiving electroshock intervention. Methods: a comparative study was conducted among 100 schizophrenic patients who received medical interventio...Objective: to explore the nursing effect of patients with schizophrenia receiving electroshock intervention. Methods: a comparative study was conducted among 100 schizophrenic patients who received medical intervention in our hospital from April 2020 to May 2021. Based on different nursing interventions, the patients were divided into two groups. All patients received relevant treatment after admission. The routine group was given routine treatment, which was mainly based on nursing measures such as medicine and life. The experimental group applied the nursing measures related to electroshock. The emotional state of patients before and after the intervention was compared with the incidence of related adverse reactions. Results: the effective rate of intervention in the experimental group was significantly higher than that in the conventional group (p < 0.05). After the intervention, the emotional state of the experimental group was significantly better than that of the conventional group (P < 0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the conventional group (p < 0.05). Conclusion: the electroshock intervention can significantly improve the early prognosis of patients with schizophrenia, especially for the improvement of patients' emotional state, mental state and physiological state. It is worthy of promotion.展开更多
基金Project(G202403)supported by the Open Foundation of The State Key Laboratory of Refractories and Metallurgy,ChinaProject(2022CFB378)supported by the Natural Science Foundation of Hubei Province,China+2 种基金Project(B 17034)supported by 111 Project,ChinaProject(IRT_17R83)supported by the Innovative Research Team Development Program of Ministry of Education of ChinaProject(P2024-026)supported by the Open Foundation of The State Key Laboratory of Materials Processing and Die&Mould Technology,China。
文摘Electroshocking treatment(EST),an efficient and rapid material treatment method,promotes microstructure evolution and improves mechanical properties.This study incorporates EST into the conventional cold rolling-quenching tempering process of M50 steel and investigates the influence and mechanism of applying EST at different stages of the process on the microstructure and mechanical properties.Scanning electron microscope(SEM),transmission electron microscope(TEM),and X-ray diffraction(XRD)were used to characterize the effect of EST on microstructure.The results show that EST can refine the grains of M50(average reduction of 10.1%in grain size),homogenize the grain size distribution,reduce the dislocation density(20.9%in average),promote the dissolution of carbides in the matrix and distribute them more uniformly along the grain boundaries,resulting in the improvement of mechanical properties.The mechanical properties of the specimen with the process flow of rolling-quenching-tempering-electroshocking showed excellent performance,with an increase in hardness of 1.4%,tensile strength of 17.7%,and elongation at break of 24.3%as compared to the specimen without EST.The tensile properties of the specimen with the process flow of rolling electroshocking-quenching-tempering showed the best performance,with an increase in tensile strength of 30.0%and elongation at break of 30.7%as compared to the specimen without EST.
基金financially supported by the National Natural Science Foundation of China(No.52271135)the Major Research Plan of the National Natural Science Foundation of China(No.92266102)+5 种基金the Natural Science Foundation of Hubei Province(No.2022CFB492)the Knowledge Innovation Program of Wuhan-Basic Research(No.2022010801010174)the Application Foundation Frontier Project of Wuhan(No.2020010601012171)"Chu Tian Scholar"Project of Hubei Province(No.CTXZ2017-05)the Overseas Expertise Introduction Project for Discipline Innovation(No.B17034)the Innovative Research Team Development Program of Ministry of Education of China(No.IRT_17R83)。
文摘In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 MPa.The effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and TiB.Before EST,TiB fracture introduced cracks that extended into the matrix,resulting in material failure.After EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC strength.Moreover,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix first.With an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of pores.Analyzing the propagation path of the main crack after EST showed that the deflection angle of the main crack increased.The micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was brittle.After EST,the size and area of the dimples increased,confirming the increase in plasticity.The results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after EST.Hence,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.51975441 and 52271135)the Innovation Funding Project of National Engineering and Research Center for Commercial Aircraft Manufacturing(No.COMAC-SFGS-2022-1871)+6 种基金the Major Research Plan of the National Natural Science Foundation of China(Grant No.92266102)the Natural Science Foundation of Hubei Province(Grant No.2022CFB492)the Knowledge Innovation Program of Wuhan-Basic Research(No.2022010801010174)the Application Foundation Frontier Project of Wuhan(No.2020010601012171)the“Chu Tian Scholar”project of Hubei Province(No.CTXZ2017-05)the Overseas Expertise Introduction Project for Discipline Innovation(No.B17034)Innovative Research Team Development Program of Ministry of Education of China(No.IRT_17R83).
文摘In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical properties of LMD Ti-6.5Al-3.5Mo-1.5Zr-0.3Si were investigated.The results showed that the width of the heat affected band decreased and disappeared under the thermal and athermal effects of EST,resulting in the uniform microstructure.In the microstructure,theαlaths became coarser gradually,and the quantity ofα/βinterface was reduced.The reduction of the quantity ofα/βinterface leads to make less resistant to dislocation,resulting in the reduction in hardness and strength.The discontinuous grain boundaryαphase and nucleationαcolony near grain boundary inhibited the crack propagation and improved the ductility.Summary,EST can manipulate the microstructure and improve the mechanical properties of LMD titanium alloys.
文摘BACKGROUND Epilepsy impacts millions of people,with many not responding to existing treatments.Some evidence links neuroinflammatory processes to epilepsy.Statins exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic effects.AIM To evaluate the anticonvulsant effects of rosuvastatin in animal models of epilepsy.METHODS Ninety-six albino mice were divided into 16 groups.In the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a combination.Outcomes measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and mortality.In the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and mortality.RESULTS In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of mice.Rosuvastatin shortens the duration of THLE in a dose-dependent manner.However,none of these were statistically significant com-pared to the control group.The combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/kg.In the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or mortality.However,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/kg.CONCLUSION Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and valproate.Further studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.
文摘Forced normalization(FN)is a unique phenomenon that is often seen in the treatment of epilepsy.FN is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control;the occurrence of FN seriously affects patients’quality of life.The causes of FN include antiseizure medications(ASMs),epilepsy surgery and vagus nerve stimulation,with ASMs being the most common cause.However,with the timely reduction or discontinuation of ASMs and the use of antipsychotic drugs,the overall prognosis is good.Here,we perform an extensive review of the literature pertaining to FN,including its epidemiology,possible mechanisms,clinical features,treatment and prognosis.
基金supported by the National Natural Science Foundation of China(81403191)Yunnan Provincial Natural Science Foundation(2018FB118,2015FA004,and KKSY201626001)
文摘Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the electrophysiological variation among three developmental stages in young mice(no more than 5 weeks old).The induced electroshock seizure(ES)behavior of early post natal mice(1-2-weeks old)differed from that during weaning(3 weeks old)and early puberty(4-5-weeks old).Thus,we further explored their respective characteristic responses to the ES parameters.When the stimulation current(SC)was limited to 4.0 mA,only the 1-2-week-old mice were induced to exhibit ES behavior at voltages of 30 V and 40 V,indicating they were more sensitive to maximal electroshock seizure(MES)(response to lower voltage).
文摘Objective: to explore the nursing effect of patients with schizophrenia receiving electroshock intervention. Methods: a comparative study was conducted among 100 schizophrenic patients who received medical intervention in our hospital from April 2020 to May 2021. Based on different nursing interventions, the patients were divided into two groups. All patients received relevant treatment after admission. The routine group was given routine treatment, which was mainly based on nursing measures such as medicine and life. The experimental group applied the nursing measures related to electroshock. The emotional state of patients before and after the intervention was compared with the incidence of related adverse reactions. Results: the effective rate of intervention in the experimental group was significantly higher than that in the conventional group (p < 0.05). After the intervention, the emotional state of the experimental group was significantly better than that of the conventional group (P < 0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the conventional group (p < 0.05). Conclusion: the electroshock intervention can significantly improve the early prognosis of patients with schizophrenia, especially for the improvement of patients' emotional state, mental state and physiological state. It is worthy of promotion.
