Zinc-ion batteries(ZIBs)have significant potential for advancements in energy storage systems owing to their high level of safety and theoretical capacity.However,ZIBs face several challenges,such as cathode capacity ...Zinc-ion batteries(ZIBs)have significant potential for advancements in energy storage systems owing to their high level of safety and theoretical capacity.However,ZIBs face several challenges,such as cathode capacity degradation and short cycle life.Ordinary metal–organic frameworks(MOFs)are characterized by high specific surface areas,large pore channels,and controllable structures and functions,making them suitable for use in ZIB cathodes with good performance.However,the insulating properties of MOFs hinder their further development.In contrast,electronic conductive MOFs(EC-MOFs)show high electronic conductivity,which facilitates rapid electron transport and ameliorates the charging and discharging efficiency of ZIBs.This paper introduces the unique conduction mechanism of EC-MOFs and elaborates various strategies for constructing EC-MOFs with high conductivity and stability.Additionally,the synthesis methods of EC-MOF-based cathode materials and their properties in ZIBs are elucidated.Finally,this paper presents a summary and outlook on the advancements of EC-MOFs for ZIB cathodes.This review provides guidance for designing and applying EC-MOFs in ZIBs and other energy storage devices.展开更多
目的:研究当前国内电子递交制度在药品注册全生命周期管理中的应用现状,分析面临的挑战,提出完善我国电子递交制度的建议。方法:采用文献研究和比较研究等方法,回顾并对比分析国内电子递交制度的发展历程及实施现状,结合我国实际情况,...目的:研究当前国内电子递交制度在药品注册全生命周期管理中的应用现状,分析面临的挑战,提出完善我国电子递交制度的建议。方法:采用文献研究和比较研究等方法,回顾并对比分析国内电子递交制度的发展历程及实施现状,结合我国实际情况,提出针对性的改进建议。结果与结论:我国的电子递交存在电子通用技术文档(electronic common technical document,eCTD)递交与非eCTD递交2种形式,目前处于两者并行的过渡阶段。但在实施过程中仍面临申请事项递交格式标准不统一、省级药品监管机构接收和审阅eCTD能力不足等问题。针对这些问题,本文提出了以下具体措施:①深化eCTD改革的进程,扩大实施范围。②强化药品从上市前到上市后管理的有效衔接。③加速药品全生命周期文件递交的标准化。通过这些措施的实施,以期加速推进我国药品注册申报全面电子化的进程,从而提升审评审批的效率与质量。展开更多
基金financially supported by the National Natural Science Foundation of China (No. 62464010)the Spring City Plan-Special Program for Young Talents (K202005007)+3 种基金the Yunnan Talents Support Plan for Young Talents (XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects (202101BA070001-138)Key Laboratory of Artificial Microstructures in Yunnan Higher EducationFrontier Research Team of Kunming University 2023
文摘Zinc-ion batteries(ZIBs)have significant potential for advancements in energy storage systems owing to their high level of safety and theoretical capacity.However,ZIBs face several challenges,such as cathode capacity degradation and short cycle life.Ordinary metal–organic frameworks(MOFs)are characterized by high specific surface areas,large pore channels,and controllable structures and functions,making them suitable for use in ZIB cathodes with good performance.However,the insulating properties of MOFs hinder their further development.In contrast,electronic conductive MOFs(EC-MOFs)show high electronic conductivity,which facilitates rapid electron transport and ameliorates the charging and discharging efficiency of ZIBs.This paper introduces the unique conduction mechanism of EC-MOFs and elaborates various strategies for constructing EC-MOFs with high conductivity and stability.Additionally,the synthesis methods of EC-MOF-based cathode materials and their properties in ZIBs are elucidated.Finally,this paper presents a summary and outlook on the advancements of EC-MOFs for ZIB cathodes.This review provides guidance for designing and applying EC-MOFs in ZIBs and other energy storage devices.
文摘目的:研究当前国内电子递交制度在药品注册全生命周期管理中的应用现状,分析面临的挑战,提出完善我国电子递交制度的建议。方法:采用文献研究和比较研究等方法,回顾并对比分析国内电子递交制度的发展历程及实施现状,结合我国实际情况,提出针对性的改进建议。结果与结论:我国的电子递交存在电子通用技术文档(electronic common technical document,eCTD)递交与非eCTD递交2种形式,目前处于两者并行的过渡阶段。但在实施过程中仍面临申请事项递交格式标准不统一、省级药品监管机构接收和审阅eCTD能力不足等问题。针对这些问题,本文提出了以下具体措施:①深化eCTD改革的进程,扩大实施范围。②强化药品从上市前到上市后管理的有效衔接。③加速药品全生命周期文件递交的标准化。通过这些措施的实施,以期加速推进我国药品注册申报全面电子化的进程,从而提升审评审批的效率与质量。
