Spray cooling has proved its superior heat transfer performance in removing high heat flux for ground applications. However, the dissipation of vapor liquid mixture from the heat sur- face and the closed-loop circulat...Spray cooling has proved its superior heat transfer performance in removing high heat flux for ground applications. However, the dissipation of vapor liquid mixture from the heat sur- face and the closed-loop circulation of the coolant are two challenges in reduced or zero gravity space enviromnents. In this paper, an ejected spray cooling system for space closed-loop application was proposed and the negative pressure in the ejected condenser chamber was applied to sucking the two-phase mixture from the spray chamber. Its ground experimental setup was built and exper- imental investigations on the smooth circle heat surface with a diameter of 5 mm were conducted with distilled water as the coolant spraying from a nozzle of 0.51 mm orifice diameter at the inlet temperatures of 69.2 ℃ and 78.2 ℃ under the conditions of heat flux ranging from 69.76 W/cm2 to 311.45 W/cm2, volume flow through the spray nozzle varying from 11,22 L：h to 15.76 L·h. Work performance of the spray nozzle and heat transfer performance of the spray cooling system were analyzed; results show that this ejected spray cooling system has a good heat transfer performance and provides valid foundation for space closed-loop application in the near future.展开更多
As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to pr...As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.展开更多
In this paper,we perform a follow-up investigation of the solar eruption originating from active region 13575 on 2024 February 9.The primary eruption of a hot channel generates an X3.4 class flare,a full-halo coronal ...In this paper,we perform a follow-up investigation of the solar eruption originating from active region 13575 on 2024 February 9.The primary eruption of a hot channel generates an X3.4 class flare,a full-halo coronal mass ejection(CME),and an extreme-ultraviolet(EUV)wave.Interaction between the wave and a quiescent prominence(QP)leads to a large-amplitude,transverse oscillation of QP.After the transverse oscillation,QP loses equilibrium and rises up.The ascending motion of the prominence is coherently detected and tracked up to∼1.68 R_(⊙)by the Solar UltraViolet Imager onboard the GOES-16 spacecraft and up to∼2.2 R_(⊙)by the Solar Corona Imager(SCI_UV)of the LyαSolar Telescope onboard the ASO-S spacecraft.The velocity increases linearly from 12.3 to 68.5 km s^(−1)at 18:30 UT.The sympathetic eruption of QP drives the second CME with a typical three-part structure.The bright core comes from the eruptive prominence,which could be further observed up to∼3.3 R_(⊙) by the Large Angle Spectroscopic Coronagraph onboard the Solar and Heliospheric Observatory mission.The leading edge of the second CME accelerates continuously from∼120 to∼277 km s^(−1).The EUV wave plays an important role in linking the primary eruption with the sympathetic eruption.展开更多
Objective:In addition to dyspnea and edema,gastrointestinal discomfort is common among patients with heart failure(HF).Reduced cardiac output can lead to inadequate perfusion of the intestinal mucosa and subsequent im...Objective:In addition to dyspnea and edema,gastrointestinal discomfort is common among patients with heart failure(HF).Reduced cardiac output can lead to inadequate perfusion of the intestinal mucosa and subsequent impairment of the intestinal barrier.Levosimendan,a novel inotropic agent,binds to cardiac troponin C to enhance calcium sensitivity,activates ATP-dependent potassium channels in cardiomyocytes and vascular smooth muscle cells,exerts positive inotropic and vasodilatory effects,and reduces free radical generation,thereby improving systemic hemodynamics including intestinal circulation.However,clinical evidence regarding its protective effects on the intestinal barrier in HF patients remains limited,and the underlying mechanisms require further clarification.This study aims to investigate whether levosimendan confers protective effects on the intestinal barrier in HF patients and to explore its potential mechanisms.Methods:Network pharmacology was first used to analyze potential mechanisms of levosimendan in treating intestinal barrier dysfunction among HF patients.A total of 62 hospitalized patients with acute exacerbation of HF with reduced ejection fraction(HFrEF)were enrolled based on echocardiographic left ventricular ejection fraction.According to clinical medication regimens,patients were assigned to a conventional treatment group(n=31)or a levosimendan treatment group(n=31).The conventional treatment group received standard anti-HF therapy,while the levosimendan treatment group received levosimendan in addition to standard therapy.Enzyme-linked immunosorbent assays were used to measure plasma levels and changes in the intestinal-barrier proteins zonulin,intestinal fatty acid binding protein(I-FABP),proinflammatory cytokines[interleukin(IL)-17,IL-6,and tumor necrosis factor(TNF)-α],anti-inflammatory cytokine IL-10,and N-terminal probrain natriuretic peptide(NT-proBNP).Improvements in cardiac function and gastrointestinal symptoms were evaluated using the Kansas City Cardiomyopathy Questionnaire(KCCQ)and the Gastrointestinal Symptom Rating Scale(GSRS).Results:Network pharmacology indicated that the effects of levosimendan on intestinal barrier dysfunction in HF patients may involve inflammation-related pathways such as IL-17 and TNF.Clinically,after treatment,zonulin decreased by 32.94 ng/mL in the levosimendan treatment group versus 15.05 ng/mL in the conventional treatment group(P<0.05).I-FABP decreased by 6.97 pg/mL in the levosimendan treatment group but increased by 35.16 pg/mL in the conventional treatment group(P<0.05).IL-6,IL-17,and TNF-αdecreased by 1.11 pg/mL,1.21 pg/mL,and 2.83 pg/mL,respectively,in the levosimendan treatment group,whereas they increased by 7.68 pg/mL,0.67 pg/mL,and 2.38 pg/mL in the conventional treatment group(all P<0.05).IL-10 decreased by 24.48 pg/mL in the conventional treatment group but increased by 24.98 pg/mL in the levosimendan treatment group(P<0.05).NT-proBNP increased by 7.35 pg/mL in the conventional treatment group but decreased by 4.73 pg/mL in the levosimendan treatment group(P<0.05).KCCQ scores increased by 0.36 in the conventional treatment group and 1.86 in the levosimendan treatment group,GSRS scores decreased by 1.00 in the conventional treatment group and 2.40 in the levosimendan treatment group,respectively,but the differences were not statistically significant(both P>0.05).Conclusion:Levosimendan not only improves HF and gastrointestinal symptoms in hospitalized patients with acute exacerbation of HFrEF but also reduces plasma intestinal barrier factor levels.These effects may be associated with decreased plasma proinflammatory cytokines and increased anti-inflammatory cytokines after treatment,potentially involving IL-17 and TNF signaling pathways.展开更多
Clinical guidelines typically classify heart failure(HF)into three categories based on left ventricular ejection fraction(LVEF):reduced(HFr EF),mildly reduced(HFmr EF),and preserved(HFp EF).[1]Sodium-glucose co-transp...Clinical guidelines typically classify heart failure(HF)into three categories based on left ventricular ejection fraction(LVEF):reduced(HFr EF),mildly reduced(HFmr EF),and preserved(HFp EF).[1]Sodium-glucose co-transporter 2(SGLT2)inhibitors have been demonstrated to lower cardiovascular mortality and HF events.The EMPEROR trials indicated similar efficacy and safety for SGLT2 inhibitors compared to placebo in outpatients with HFrEF as well as HFmrEF and HFpEF.展开更多
In this study,it is aimed to develop a generic model which calculates the trajectory of the ejection seat from the jet aircraft,by taking into account the parameters that will affect the seat movement such as the seat...In this study,it is aimed to develop a generic model which calculates the trajectory of the ejection seat from the jet aircraft,by taking into account the parameters that will affect the seat movement such as the seat’s launch speed,ejection direction,ejection angle,altitude of the aircraft,distance/height from the aircraft rudder and canopy,pilot and ejection seat weight.With the model algorithm proposed,the ejection seat trajectory model was developed on MATLAB.The ejection seat trajectory model is based on point mass trajectory mathematical model.In this study,an analytical study of the problem has been made for modeling the flight trajectory of the ejection seat after it has been ejected.Past studies were used as a basis for validation and simulation.By writing a generic MATLAB code,a user interface was developed and presented to the user as a module.This generic code that has been developed could be used for simulations by users in the future by revising it in accordance with their own job descriptions.展开更多
BACKGROUND There is no available data about the trajectory of heart failure(HF)with improved ejection fraction(EF)and patient clinical outcomes in Qatar.AIM To explore the difference in characteristics and outcomes be...BACKGROUND There is no available data about the trajectory of heart failure(HF)with improved ejection fraction(EF)and patient clinical outcomes in Qatar.AIM To explore the difference in characteristics and outcomes between patients with transient and sustained improvement in left ventricular ejection fraction(LVEF)and to determine the independent predictors for sustained improvement in LVEF.METHODS This is a retrospective cohort study that was conducted at the advanced HF clinic of a tertiary care hospital in Qatar between January 2017 and December 2018.This were divided into two groups:HF with transient improvement in EF(HFtimpEF)and HF with sustained improvement in EF(HFsimpEF).RESULTS A total of 175 patients with HF and improved EF were included.Among them 136(77.7%)patients showed sustained improvement in LVEF.The remaining patients with HFtimpEF were predominantly males[37(94.9%)vs 101(74.3%),P=0.005]with a higher incidence of ischemic cardiomyopathy[32(82.1%)vs 68(50.4%),P=0.002],dyslipidemia[24(61.5%)vs 54(39.7%),P=0.03],and hypertension[34(87.2%)vs 93(68.4%),P=0.03]than those with HFsimpEF.The latter experienced significantly lower rates of hospitalization[39(28.7%)vs 20(51.3%),P=0.01]and diagnosis of new cardiovascular conditions during the follow-up(e.g.,acute coronary syndrome,stroke,decompensated HF,and atrial fibrillation)[14(10.3%)vs 10(25.6%),P=0.03]without a difference in emergency department visits or in-hospital death.Sustained improvement in LVEF was positively associated with being female[adjusted odds ratio(aOR)=6.8,95%confidence interval(CI):1.4-32.3,P=0.02],having non-ischemic etiology of HF(aOR=3.1,95%CI:1.03-9.3,P=0.04),and using a mineralocorticoid receptor antagonist(aOR=7.0,95%CI:1.50-31.8,P=0.01).CONCLUSION Patients with HFsimpEF experienced significantly lower rates of hospitalization and diagnosis of new cardiova-scular conditions than patients with HFtimpEF.Sustained improvement in LVEF was positively associated with being a female,having non-ischemic etiology of HF,and using a mineralocorticoid receptor antagonist.展开更多
We present an analysis of the magnetic mechanism of an X6.4-class confined flare in NOAA Active Region(AR)13590 on 2024 February 22.Despite a pre-existing magnetic flux rope(MFR)embedded within a null-point topology,t...We present an analysis of the magnetic mechanism of an X6.4-class confined flare in NOAA Active Region(AR)13590 on 2024 February 22.Despite a pre-existing magnetic flux rope(MFR)embedded within a null-point topology,the flare produced only a localized jet without an associated coronal mass ejection.Using data from the Solar Dynamics Observatory and nonlinear force-free field extrapolations,we traced the formation and evolution of the MFR,which developed under photospheric shearing motions but remained weakly twisted(with twist number being lower than 1.3)and below the thresholds for kink instability.Meanwhile,the MFR is located at heights where the decay index(n≤1.0)of the overlying field was insufficient to trigger torus instability.Furthermore,we calculated two important parameters measuring the non-potentiality of the AR,one is the ratio of the free energy to the potential-field energy,and the other is the ratio of the non-potential helicity to the square of the magnetic flux.Both the two parameters were significantly lower than critical values for eruptive flares.These factors,combined with the stabilizing influence of the strong overlying field,confined the MFR and limited the eruption to a jet.Our findings highlight the importance of both local magnetic properties and global energy constraints in determining the eruptive potential of solar flares.展开更多
The high-pressure mercury intrusion (HPMI) experiment is widely used to assess the pore architecture oftight sandstone reservoirs. However, the conventional analysis of the high- pressure mercury intrusionhas always f...The high-pressure mercury intrusion (HPMI) experiment is widely used to assess the pore architecture oftight sandstone reservoirs. However, the conventional analysis of the high- pressure mercury intrusionhas always focused on the mercury injection curves themselves, neglecting the important geologicalinformation conveyed by the mercury ejection curves. This paper quantitatively describes the fractalcharacteristics of ejection curves by using four fractal models, i.e.,. Menger model, Thermodynamicmodel, Sierpinski model, and multi- fractal model. In comparison with mercury injection curves, weexplore the fractal significance of mercury ejection curves and define the applicability of different fractalmodels in characterizing pore architectures. Investigated tight sandstone samples can be divided intofour types (Types A, B, C and D) based on porosity, permeability, and mercury removal efficiency. Type Dsamples are unique in that they have higher permeability (>0.6 mD) but lower mercury removal effi-ciency (<35%). Fractal studies of the mercury injection curve show that it mainly reflects the pore throatcharacteristics, while the mercury ejection curve serves to reveal the pore features, and porosity andpermeability correlate well with the fractal dimension of the injection curve, while mercury removalefficiency correlates only with the Ds' value of the ejection curve. The studies on the mercury ejectioncurves also reveal that the small pores and micropores of the Type C and Type D samples are moredeveloped, with varying pore architecture. The fractal dimension Ds' value of Type D samples is greaterthan that of Type C samples, and the dissolution of Type D samples is more intense than that of Type Csamples, which further indicates that the Type D samples are smaller in pore size, rougher in surface, andwith greater difficulty for the hydrocarbon to enter, resulting in their reservoir capacity probably lessthan that of Type C samples. In this regard, the important information characterized by the mercuryejection curve should be considered in evaluating the tight sandstone reservoirs. Finally, the Menger andThermodynamic models prove to be more suitable for describing the total pore architecture, while theSierpinski model is better for characterizing the variability of the interconnected pores.展开更多
Heart failure(HF)with preserved ejection fraction(HFpEF)has exceeded HF with reduced ejection fraction(HFrEF),becoming the most common type of HF.Unlike HFrEF,HFpEF is primarily a chronic low-grade inflammatory proces...Heart failure(HF)with preserved ejection fraction(HFpEF)has exceeded HF with reduced ejection fraction(HFrEF),becoming the most common type of HF.Unlike HFrEF,HFpEF is primarily a chronic low-grade inflammatory process closely associated with metabolic disorders.The coexistence of HFpEF and metabolic dysfunction-associated steatotic liver disease(MASLD)presents significant clinical challenges due to shared metabolic pathophysiology and complex inter-play.Management strategies for HFpEF and MASLD remain challenging.Sodium-glucose cotransporter 2 inhibitors have shown benefits in managing both conditions.Additionally,glucagon-like peptide-1 receptor agonists are being actively investigated for their potential benefits,particularly in MASLD.A comprehensive,patient-centered approach that combines metabolic and cardiova-scular care is essential for improving outcomes in patients with HFpEF and MASLD,addressing the global metabolic health challenges.展开更多
Knowing the optimal operating parameters of Stirling engines is important for efficient combustion through adaptability to changed pressures and oxygen atmospheres. In this study, the optimum operating conditions for ...Knowing the optimal operating parameters of Stirling engines is important for efficient combustion through adaptability to changed pressures and oxygen atmospheres. In this study, the optimum operating conditions for efficient combustion in a singular Stirling engine combustor at different oxygen atmospheres were investigated and determined. Numerical simulations were performed to investigate the effects of ejection ratio and pressure on combustion performance. In an oxygen/carbon dioxide atmosphere, the results show that increasing the ejection ratio substantially alters the flame distribution in the Stirling engine combustor, increasing heat transfer and external combustion efficiency. In contrast, increasing the ejection ratio reduces the average and maximum temperatures of the Stirling engine combustor. Increased pressure affects the flame distribution in the Stirling engine combustor and impedes the flow and convective heat transfer in the combustor, reducing the overall external combustion efficiency at pressures above 6.5 MPa. In an air/carbon dioxide atmosphere, an increased ejection ratio reduces the average and maximum temperatures in the Stirling engine combustor. However, the overall flame distribution does not change substantially. The external combustion efficiency tends to increase and then decrease because of two opposing factors: the increase in the convective heat transfer coefficient and the decrease in the temperature difference. Increasing pressure inhibits forced convection heat transfer in the Stirling engine combustor, reducing external combustion efficiency, which drops from 78% to 65% when pressure increases from 0.2 MPa to 0.5 MPa.展开更多
Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a nov...Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a novel form of regulated cell deaths,marked by cellular energy depletion and metabolic dysregulation stemming from excessive ATP accumulation,identifying its uniqueness compared to other cell death processes modalities such as programmed cell death and necrosis.Growing evidence suggests that ATP-induced cell death(AICD)is predominantly governed by various biological pathways,including energy meta-bolism,redox homeostasis and intracellular calcium equilibrium.Recent research has shown that AICD is crucial in HF induced by pathological conditions like myocardial infarction,ischemia-reperfusion injury,and chemotherapy.Thus,it is essential to investigate the function of AICD in the pathogenesis of HF,as this may provide a foundation for the development of targeted therapies and novel treatment strategies.This review synthesizes current advancements in under-standing the link between AICD and HF,while further elucidating its invol-vement in cardiac remodeling and HF progression.展开更多
BACKGROUND Heart failure with preserved ejection fraction(HFpEF)accounts for approximately half of heart failure cases and is associated with high morbidity and mortality.Beta-blockers(BB)and calcium channel blockers(...BACKGROUND Heart failure with preserved ejection fraction(HFpEF)accounts for approximately half of heart failure cases and is associated with high morbidity and mortality.Beta-blockers(BB)and calcium channel blockers(CCB)are commonly used for symptom control and comorbidity management,but their comparative effectiveness and safety remain unclear.AIM To compare the effectiveness and safety of BB vs CCB in patients with HFpEF using simulated real-world data and propensity score-matched analyses.METHODS Simulated data for 4000 HFpEF patients(2000 BB,2000 CCB)were generated based on distributions extracted from electronic medical records spanning 2014-2023.Inclusion criteria included adults with left ventricular ejection fraction≥50%and initiation of BB or CCB.Effectiveness outcomes encompassed mortality,heart failure hospitalizations,and changes in clinical parameters.Safety outcomes included bradycardia,hypotension,and drug discontinuation.Statistical analyses used t-tests,χ2 tests,Cox proportional hazards models for hazard ratios(HR),and incidence rate ratios(IRR)in R software.Propensity score matching(PSM)was performed to balance baseline characteristics,with outcomes reassessed in the matched cohort.RESULTS Baseline characteristics were largely balanced,with minor differences in sex,chronic kidney disease,systolic blood pressure,and left atrial volume index.BB demonstrated lower all-cause mortality(crude HR 0.78,95%CI:0.70-0.87,P=0.003),heart failure hospitalization(crude HR 0.86,95%CI:0.77-0.96,P=0.031),and composite endpoint(crude HR 0.85,95%CI:0.79-0.91,P<0.001)rates compared to CCB.IRR for heart failure hospitalizations and emergency visits favored BB.Safety profiles showed higher symptomatic bradycardia(9.2%vs 4.9%,P<0.001)and drug discontinuation(11.3%vs 9.3%,P=0.043)with BB,and higher hypotension(7.2%vs 11.5%,P<0.001)with CCB.Matched analyses showed all-cause mortality rates of 0.0622 per person-year for BB vs 0.0649 for CCB(HR 0.96,95%CI:0.85-1.08),heart failure hospitalization rates of 0.0751 vs 0.0888(HR 0.84,95%CI:0.75-0.94),and IRR for number of heart failure hospitalizations of 1.65 for CCB vs BB(95%CI:1.51-1.80,P<0.001).CONCLUSION BB may offer potential advantages in reducing mortality and hospitalizations in HFpEF compared to CCB,with distinct safety considerations.PSM confirmed these trends with reduced confounding.Personalized therapy is recommended,warranting prospective trials for validation.展开更多
Major solar plasma disturbances are subjected to Lomb-Scargle periodogram and wavelet analysis to determine the occurrence frequency.These disruptions include interplanetary coronal mass ejection,sudden storm commence...Major solar plasma disturbances are subjected to Lomb-Scargle periodogram and wavelet analysis to determine the occurrence frequency.These disruptions include interplanetary coronal mass ejection,sudden storm commencement,high-speed streams,corotating interaction regions,interplanetary shocks and Forbush decreases.We included information on all of the aforementioned solar disturbances for the last six solar cycles,from 1965 to 2023,for this study.Our findings reveal some intriguing and noteworthy results that clearly distinguish between even and odd-numbered solar cycles.The study suggests that the Sun behaves differently in odd and even-numbered solar cycles as it comes from the massive solar eruptions.During even-numbered solar cycles,variations with a period of∼44 days are prominently observed in addition to solar rotation(∼27 days)and extended solar(∼36 days)rotation.However,in addition to solar rotation,prolonged solar rotation,and periods of around 44 days,we also detect a number of intermittent changes with nearly comparable amplitude during the oddnumbered solar cycles.The findings also demonstrate that,in contrast to odd-numbered solar cycles,the emissions rate of these disruptions is more distinct and predictable during even-numbered solar cycles.展开更多
Background Elderly patients(age≥60 years)with ST-segment elevation myocardial infarction(STEMI)are at an elevated risk of mortality.This study aimed to investigate the association of the creatinine to ejection fracti...Background Elderly patients(age≥60 years)with ST-segment elevation myocardial infarction(STEMI)are at an elevated risk of mortality.This study aimed to investigate the association of the creatinine to ejection fraction ratio(CER)with in-hospital and 1-year death in elderly patients with STEMI.Methods A total of 753 consecutive elderly patients(age≥60 years)with STEMI undergoing percutaneous coronary intervention(PCI)were enrolled and divided into three groups according to the tertiles of CER at admission:<1.5(n=250),1.5-2.2(n=249)and>2.2(n=254).Multivariate analyses were performed to evaluate the prognostic value of CRE for short-term death in this population.Results The in-hospital and 1-year mortality reached 6.0%and 13.3%,respectively.Patients with higher CER exhibited a higher in-hospital mortality(0.8%vs.2.8%vs.14.2%,P<0.001).An optimal cut-off value of 2.5 for CER was identified for predicting in-hospital death by receiver operating characteristic curve analysis,yielding a sensitivity of 77.8%and a specificity of 76.1%[area under curve(AUC):0.791,95%confidence interval(CI):0.734-0.847,P<0.001].Multivariate regression analyses revealed that CER>2.5 was an independent risk factor for both in-hospital[adjusted odds ratio(OR):9.006,95%CI:2.707-29.967,P<0.001]and 1-year mortality[adjusted hazard ratio(HR):5.082,95%CI:2.462-10.490,P<0.001].Conclusions Elevated CER is associated with adverse short-term mortality in elderly STEMI patients undergone PCI,offering valuable insights for the early identification and management of high-risk individuals in clinical practice.展开更多
BACKGROUND Early diagnosis of left ventricular diastolic dysfunction(LVDD)is essential for preventing heart failure.B-type natriuretic peptide(BNP)is a viable marker for predicting LVDD,as elevated BNP levels have bee...BACKGROUND Early diagnosis of left ventricular diastolic dysfunction(LVDD)is essential for preventing heart failure.B-type natriuretic peptide(BNP)is a viable marker for predicting LVDD,as elevated BNP levels have been associated with worsening LVDD in patients with diabetes over time.However,the utility of BNP as a diagnostic marker in diabetes is controversial,as BNP levels are often low in overweight individuals.AIM To examine the effectiveness of BNP levels and fragmented QRS(fQRS)on electrocardiography for diagnosing LVDD in patients with type 2 diabetes.METHODS This retrospective cohort study included 303 patients with type 2 diabetes(67.4±12.3 years old)with preserved ejection fraction(EF)≥50%admitted to Toyama University Hospital for glycemic management and comorbidity evaluation between November 2017 and April 2021.All participants underwent plasma BNP measurement,electrocardiography,and echocardiography.Cardiologists who were blinded to the BNP results assessed the electrocardiograms and echocardiograms.Subgroup analyses were conducted for overweight individuals.RESULTS Receiver operating characteristic(ROC)curve analysis determined optimal BNP cut-off values of 34.8 pg/mL and 7.2 pg/mL for diagnosing LVDD in non-overweight[area under the ROC curve(AUC):0.70]and overweight(AUC:0.55)groups,respectively(P=0.040).In the overweight subgroup,fQRS showed greater diagnostic accuracy for LVDD(AUC:0.67),indicating moderate diagnostic utility compared with the low performance of the BNP cutoff of 35 pg/mL(AUC:0.52)(P=0.010).Multivariate analyses confirmed that fQRS was superior to BNP for LVDD diagnosis regardless of the patient’s weight.CONCLUSION A BNP level≥35 pg/mL in non-overweight individuals may be a reliable LVDD marker.Additionally,fQRS was more effective than BNP in diagnosing LVDD irrespective of the patient’s weight.fQRS can complement BNP in the early detection of LVDD,especially in overweight patients,potentially improving early detection and mitigating progression to heart failure with preserved EF in patients with type 2 diabetes.展开更多
Decameter-hectometric(DH)Type Ⅱ bursts,arising from coronal mass ejection(CME)-driven shock waves,are crucial for understanding solar-terrestrial interactions and space weather forecasting.This study provides a compr...Decameter-hectometric(DH)Type Ⅱ bursts,arising from coronal mass ejection(CME)-driven shock waves,are crucial for understanding solar-terrestrial interactions and space weather forecasting.This study provides a comprehensive statistical analysis of CMEs associated with DH type Ⅱ solar radio bursts during Solar Cycle 24(2009–2019),utilizing data from the Wind/WAVES,Solar TErrestrial RElations Observatory/SWAVES,and Solar and Heliospheric Observatory/LASCO catalogs.Analyzing 180 events,we report key spectral and kinematic properties,including a mean CME speed of(1058±531)km s^(−1) and a mean width of(288.39±99.3),with 62%classified as halo CMEs.About 12%of the total CMEs are accelerated,58%of them are decelerated,and 30%of them are constant.Similarly,CMEs having a speed≤800 km s^(−1) are constant,and those with speed≥800 km s^(−1) are decelerated.DH type Ⅱ bursts displayed a mean starting frequency of(12,169.72±4939)kHz,ending frequency of(2152.69±3022.07)kHz,bandwidth of(10,017±5353)kHz,and an average duration of(345.62±453)minutes.A power-law relationship was established between the drift rate(df/dt)and burst duration(D),characterized by df/dt=2749.07·D^(−0.88),highlighting the inverse dependence of drift rate on burst longevity.This suggests a dynamic interplay between shock parameters and the ambient solar corona.The findings underscore the persistent and robust spectral coverage of CME-driven shocks,offering new insights into their evolution and impact on the heliospheric environment.展开更多
We investigate the relationship between the magnitudes of Forbush decreases(FDs)and solar-geomagnetic characteristics using daily-averaged galactic cosmic ray(GCR)data from Inuvick(INVK)and Magadan(MGDN)neutron monito...We investigate the relationship between the magnitudes of Forbush decreases(FDs)and solar-geomagnetic characteristics using daily-averaged galactic cosmic ray(GCR)data from Inuvick(INVK)and Magadan(MGDN)neutron monitor(NM)stations to aid in counting the case of GCR flux intensity modulation.The FDs,obtained with an automated new computer software algorithm from daily-averaged GCR data from the IZMIRAN common website:http://cr0.izmiran.ru/common,at INVK(224)and MGDN(229)NM stations,from 1998 to 2002,were used in the present work.The associated solar-geomagnetic parameters of the same time range were obtained from the OMNI website.A statistical analytical method was employed to test the link between FD amplitudes and solargeomagnetic variables.We observed negative trends in FD-IMF,FD-SWS,FD-Kp,FD-SSN and FD-SI,while a positive relation was indicated in FD-Dst at both stations.All are statistically significant at a 95%confidence level.The results obtained here imply that solar emission characteristics impact the GCR flux intensity modulation.展开更多
BACKGROUND Myocardial infarction(MI)is a significant global cause of chronic heart failure.In post-ischemic cardiac hypertrophy,multiple molecular targets and signals within the cardiac tissue are evident.Mesenchymal ...BACKGROUND Myocardial infarction(MI)is a significant global cause of chronic heart failure.In post-ischemic cardiac hypertrophy,multiple molecular targets and signals within the cardiac tissue are evident.Mesenchymal stem cell-derived exosomes(MSC-EXO)and exercise(EXE)showed promise in enhancing post-ischemic cardiac repair.AIM To investigate how the exosomes released by stem cells and/or EXE can promote cardiac repair and improve isoproterenol(ISO)-induced post-ischemic hypertrophy.METHODS The enrolled animals were divided into 8 control rats and 32 experimental rats.Induction of MI was performed using ISO.Then,the experimental rats were divided into 4 groups:Rats subjected to 4 weeks of swimming EXE,rats treated with exosomes,and the combined treatment.Additionally,functional and interactional exploration of targeted proteins was conducted using Gene Ontology,Kyoto Encyclopedia of Genes and Genomes analysis,and STRING database,along with histological examination.RESULTS Both MSC-EXO or EXE significantly improved ISO induced elevation of cardiac enzymes,oxidative stress,and inflammatory markers,as well as the degenerative changes of the cardiac muscles,fibrosis,and apoptosis.Meanwhile,the combined treatment of EXE and MSC-EXO resulted in a significant improvement in cardiac function and structure as compared to all groups that synchronized with dual inhibition of extracellular signal-regulated kinase and protein kinase B/mammalian target of rapamycin(P<0.01)signaling and modulation of matrix metalloproteinase 9 and sarcoplasmic endoplasmic reticulum calcium ATPase type 2a,with significant improved angiogenesis.CONCLUSION Functional and structural cardiac improvements are accompanied by reduced inflammation,oxidative stress,and apoptosis.Both MSC-EXO and EXE exert cardio-protection by upregulating sarcoplasmic endoplasmic reticulum calcium ATPase,the critical pump for normal calcium handling.展开更多
Partitioning the solar cycle into ascending and descending phases,we examine the solar cycle distribution of the north-south(N-S)asymmetry in the source locations of super geomagnetic storms(SGSs;Dst≤-250 nT)during 1...Partitioning the solar cycle into ascending and descending phases,we examine the solar cycle distribution of the north-south(N-S)asymmetry in the source locations of super geomagnetic storms(SGSs;Dst≤-250 nT)during 1932-2018.We found that during the ascending phases,SGS source locations were predominantly in the northern hemisphere(NH),exhibiting significant N-S asymmetry.For the SGSs in the descending phases,source locations of the SGSs dominated in the NH and N-S asymmetry was only significant in the western hemisphere.For the period from 1932 to 2018,the source locations of SGSs were predominantly in the NH,and the N-S asymmetry was significant.The cumulative numbers of SGSs originating from the two hemispheres were strongly anticorrelated during the ascending phases,descending phases,and the entire period from 1932 to 2018.For the source locations of SGSs with different intensities,significant N-S asymmetries were observed in the source location distribution.Specifically,for all SGSs,SGSs with-400 nT<Dst≤-300 nT,and SGSs with Dst≤-300 nT,the NH exhibited a higher number of events compared to the southern hemisphere(SH),indicating a dominance of SGSs in the NH.From the perspective of the evolution of N-S asymmetry with the solar cycle,the source locations of the SGSs always dominated in the NH during the ascending phases.However,during solar cycles 17-19 and 21,the source locations of the SGSs dominated in the NH,while during solar cycles 20,22,and 23 the source locations of the SGSs dominated in the SH.From the perspective of N-S asymmetry for Solar Cycles 17-23,solar activity across the two hemispheres is largely balanced.However,the solar activities manifested by CMEs that can trigger SGSs during Solar Cycles 17-23 were predominantly in the NH.Therefore,factors beyond solar activity,such as the propagation of the CMEs from the Sun to the Earth,likely contribute to the observed N-S asymmetric distribution of the source locations of SGSs.展开更多
基金supported by the National Natural Science Foundation of China(No.50506003)
文摘Spray cooling has proved its superior heat transfer performance in removing high heat flux for ground applications. However, the dissipation of vapor liquid mixture from the heat sur- face and the closed-loop circulation of the coolant are two challenges in reduced or zero gravity space enviromnents. In this paper, an ejected spray cooling system for space closed-loop application was proposed and the negative pressure in the ejected condenser chamber was applied to sucking the two-phase mixture from the spray chamber. Its ground experimental setup was built and exper- imental investigations on the smooth circle heat surface with a diameter of 5 mm were conducted with distilled water as the coolant spraying from a nozzle of 0.51 mm orifice diameter at the inlet temperatures of 69.2 ℃ and 78.2 ℃ under the conditions of heat flux ranging from 69.76 W/cm2 to 311.45 W/cm2, volume flow through the spray nozzle varying from 11,22 L：h to 15.76 L·h. Work performance of the spray nozzle and heat transfer performance of the spray cooling system were analyzed; results show that this ejected spray cooling system has a good heat transfer performance and provides valid foundation for space closed-loop application in the near future.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82430018 to Q.C.,82270361 and 82570402 to H.Z.)the Nanjing Medical University Undergraduate Innovation and Entrepreneurship Training Program Fund(Grant No.202410312138Y to C.Z.)the Basic Sciences of Jiangsu Higher Education Institutions(Grant No.22KJA310002 to H.Z.)。
文摘As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.
基金supported by the Strategic Priority Research Program on Space Science,Chinese Academy of Sciencessupported by the National Key R&D Program of China 2022YFF0503003(2022YFF0503000),2021YFA1600500 (2021YFA1600502)+3 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences,grant No.XDB0560000the National Natural Science Foundation of China (NSFC,grant Nos.12373065,12203102,12403064,and 12403068)Natural Science Foundation of Jiangsu Province (BK20231510,BK20241707)Supported by the Specialized Research Fund for State Key Laboratories,and Yunnan Key Laboratory of Solar Physics and Space Science under the grant No.YNSPCC202206
文摘In this paper,we perform a follow-up investigation of the solar eruption originating from active region 13575 on 2024 February 9.The primary eruption of a hot channel generates an X3.4 class flare,a full-halo coronal mass ejection(CME),and an extreme-ultraviolet(EUV)wave.Interaction between the wave and a quiescent prominence(QP)leads to a large-amplitude,transverse oscillation of QP.After the transverse oscillation,QP loses equilibrium and rises up.The ascending motion of the prominence is coherently detected and tracked up to∼1.68 R_(⊙)by the Solar UltraViolet Imager onboard the GOES-16 spacecraft and up to∼2.2 R_(⊙)by the Solar Corona Imager(SCI_UV)of the LyαSolar Telescope onboard the ASO-S spacecraft.The velocity increases linearly from 12.3 to 68.5 km s^(−1)at 18:30 UT.The sympathetic eruption of QP drives the second CME with a typical three-part structure.The bright core comes from the eruptive prominence,which could be further observed up to∼3.3 R_(⊙) by the Large Angle Spectroscopic Coronagraph onboard the Solar and Heliospheric Observatory mission.The leading edge of the second CME accelerates continuously from∼120 to∼277 km s^(−1).The EUV wave plays an important role in linking the primary eruption with the sympathetic eruption.
基金supported by the Hunan Provincial Science and Technology Major Special Fund(2021SK1020)the Natural Science Foundation of Hunan Province(2023JJ30948)+1 种基金the Health Commission of Hunan Province(202203014687)the International Medical Exchange Cardiovascular Multidisciplinary Integrated Thinking Research Foundation(Z-2016-23-2101-20),China.
文摘Objective:In addition to dyspnea and edema,gastrointestinal discomfort is common among patients with heart failure(HF).Reduced cardiac output can lead to inadequate perfusion of the intestinal mucosa and subsequent impairment of the intestinal barrier.Levosimendan,a novel inotropic agent,binds to cardiac troponin C to enhance calcium sensitivity,activates ATP-dependent potassium channels in cardiomyocytes and vascular smooth muscle cells,exerts positive inotropic and vasodilatory effects,and reduces free radical generation,thereby improving systemic hemodynamics including intestinal circulation.However,clinical evidence regarding its protective effects on the intestinal barrier in HF patients remains limited,and the underlying mechanisms require further clarification.This study aims to investigate whether levosimendan confers protective effects on the intestinal barrier in HF patients and to explore its potential mechanisms.Methods:Network pharmacology was first used to analyze potential mechanisms of levosimendan in treating intestinal barrier dysfunction among HF patients.A total of 62 hospitalized patients with acute exacerbation of HF with reduced ejection fraction(HFrEF)were enrolled based on echocardiographic left ventricular ejection fraction.According to clinical medication regimens,patients were assigned to a conventional treatment group(n=31)or a levosimendan treatment group(n=31).The conventional treatment group received standard anti-HF therapy,while the levosimendan treatment group received levosimendan in addition to standard therapy.Enzyme-linked immunosorbent assays were used to measure plasma levels and changes in the intestinal-barrier proteins zonulin,intestinal fatty acid binding protein(I-FABP),proinflammatory cytokines[interleukin(IL)-17,IL-6,and tumor necrosis factor(TNF)-α],anti-inflammatory cytokine IL-10,and N-terminal probrain natriuretic peptide(NT-proBNP).Improvements in cardiac function and gastrointestinal symptoms were evaluated using the Kansas City Cardiomyopathy Questionnaire(KCCQ)and the Gastrointestinal Symptom Rating Scale(GSRS).Results:Network pharmacology indicated that the effects of levosimendan on intestinal barrier dysfunction in HF patients may involve inflammation-related pathways such as IL-17 and TNF.Clinically,after treatment,zonulin decreased by 32.94 ng/mL in the levosimendan treatment group versus 15.05 ng/mL in the conventional treatment group(P<0.05).I-FABP decreased by 6.97 pg/mL in the levosimendan treatment group but increased by 35.16 pg/mL in the conventional treatment group(P<0.05).IL-6,IL-17,and TNF-αdecreased by 1.11 pg/mL,1.21 pg/mL,and 2.83 pg/mL,respectively,in the levosimendan treatment group,whereas they increased by 7.68 pg/mL,0.67 pg/mL,and 2.38 pg/mL in the conventional treatment group(all P<0.05).IL-10 decreased by 24.48 pg/mL in the conventional treatment group but increased by 24.98 pg/mL in the levosimendan treatment group(P<0.05).NT-proBNP increased by 7.35 pg/mL in the conventional treatment group but decreased by 4.73 pg/mL in the levosimendan treatment group(P<0.05).KCCQ scores increased by 0.36 in the conventional treatment group and 1.86 in the levosimendan treatment group,GSRS scores decreased by 1.00 in the conventional treatment group and 2.40 in the levosimendan treatment group,respectively,but the differences were not statistically significant(both P>0.05).Conclusion:Levosimendan not only improves HF and gastrointestinal symptoms in hospitalized patients with acute exacerbation of HFrEF but also reduces plasma intestinal barrier factor levels.These effects may be associated with decreased plasma proinflammatory cytokines and increased anti-inflammatory cytokines after treatment,potentially involving IL-17 and TNF signaling pathways.
基金the National Natural Science Foundation of China(81800250)China Postdoctoral Science Foundation(2022M711417)+3 种基金Jiangsu Province Traditional Chinese Medicine Project(MS2023-137)Yangzhou Science and Technology Plan Social Development Project(YZ2023096)Clinical Trials from the Northern Jiangsu People’s Hospital(SBLC23002)Health Project of Yangzhou Basic Research Program(2024-2-12)。
文摘Clinical guidelines typically classify heart failure(HF)into three categories based on left ventricular ejection fraction(LVEF):reduced(HFr EF),mildly reduced(HFmr EF),and preserved(HFp EF).[1]Sodium-glucose co-transporter 2(SGLT2)inhibitors have been demonstrated to lower cardiovascular mortality and HF events.The EMPEROR trials indicated similar efficacy and safety for SGLT2 inhibitors compared to placebo in outpatients with HFrEF as well as HFmrEF and HFpEF.
文摘In this study,it is aimed to develop a generic model which calculates the trajectory of the ejection seat from the jet aircraft,by taking into account the parameters that will affect the seat movement such as the seat’s launch speed,ejection direction,ejection angle,altitude of the aircraft,distance/height from the aircraft rudder and canopy,pilot and ejection seat weight.With the model algorithm proposed,the ejection seat trajectory model was developed on MATLAB.The ejection seat trajectory model is based on point mass trajectory mathematical model.In this study,an analytical study of the problem has been made for modeling the flight trajectory of the ejection seat after it has been ejected.Past studies were used as a basis for validation and simulation.By writing a generic MATLAB code,a user interface was developed and presented to the user as a module.This generic code that has been developed could be used for simulations by users in the future by revising it in accordance with their own job descriptions.
文摘BACKGROUND There is no available data about the trajectory of heart failure(HF)with improved ejection fraction(EF)and patient clinical outcomes in Qatar.AIM To explore the difference in characteristics and outcomes between patients with transient and sustained improvement in left ventricular ejection fraction(LVEF)and to determine the independent predictors for sustained improvement in LVEF.METHODS This is a retrospective cohort study that was conducted at the advanced HF clinic of a tertiary care hospital in Qatar between January 2017 and December 2018.This were divided into two groups:HF with transient improvement in EF(HFtimpEF)and HF with sustained improvement in EF(HFsimpEF).RESULTS A total of 175 patients with HF and improved EF were included.Among them 136(77.7%)patients showed sustained improvement in LVEF.The remaining patients with HFtimpEF were predominantly males[37(94.9%)vs 101(74.3%),P=0.005]with a higher incidence of ischemic cardiomyopathy[32(82.1%)vs 68(50.4%),P=0.002],dyslipidemia[24(61.5%)vs 54(39.7%),P=0.03],and hypertension[34(87.2%)vs 93(68.4%),P=0.03]than those with HFsimpEF.The latter experienced significantly lower rates of hospitalization[39(28.7%)vs 20(51.3%),P=0.01]and diagnosis of new cardiovascular conditions during the follow-up(e.g.,acute coronary syndrome,stroke,decompensated HF,and atrial fibrillation)[14(10.3%)vs 10(25.6%),P=0.03]without a difference in emergency department visits or in-hospital death.Sustained improvement in LVEF was positively associated with being female[adjusted odds ratio(aOR)=6.8,95%confidence interval(CI):1.4-32.3,P=0.02],having non-ischemic etiology of HF(aOR=3.1,95%CI:1.03-9.3,P=0.04),and using a mineralocorticoid receptor antagonist(aOR=7.0,95%CI:1.50-31.8,P=0.01).CONCLUSION Patients with HFsimpEF experienced significantly lower rates of hospitalization and diagnosis of new cardiova-scular conditions than patients with HFtimpEF.Sustained improvement in LVEF was positively associated with being a female,having non-ischemic etiology of HF,and using a mineralocorticoid receptor antagonist.
基金supported by Guangdong Basic and Applied Basic Research Foundation(2025A1515011353)the Specialized Research Fund for State Key Laboratory of Solar Activity and Space Weather.
文摘We present an analysis of the magnetic mechanism of an X6.4-class confined flare in NOAA Active Region(AR)13590 on 2024 February 22.Despite a pre-existing magnetic flux rope(MFR)embedded within a null-point topology,the flare produced only a localized jet without an associated coronal mass ejection.Using data from the Solar Dynamics Observatory and nonlinear force-free field extrapolations,we traced the formation and evolution of the MFR,which developed under photospheric shearing motions but remained weakly twisted(with twist number being lower than 1.3)and below the thresholds for kink instability.Meanwhile,the MFR is located at heights where the decay index(n≤1.0)of the overlying field was insufficient to trigger torus instability.Furthermore,we calculated two important parameters measuring the non-potentiality of the AR,one is the ratio of the free energy to the potential-field energy,and the other is the ratio of the non-potential helicity to the square of the magnetic flux.Both the two parameters were significantly lower than critical values for eruptive flares.These factors,combined with the stabilizing influence of the strong overlying field,confined the MFR and limited the eruption to a jet.Our findings highlight the importance of both local magnetic properties and global energy constraints in determining the eruptive potential of solar flares.
基金The research project was co-funded by the National Natural Science Foundation of China(No.42072172,No.41772120)Shandong Province Natural Science Fund for Distinguished Young Scholars(No.JQ201311)the Graduate Scientific and Technological Innovation Project Financially Supported by Shandong University of Science and Technology(No.SDKDYC190313).
文摘The high-pressure mercury intrusion (HPMI) experiment is widely used to assess the pore architecture oftight sandstone reservoirs. However, the conventional analysis of the high- pressure mercury intrusionhas always focused on the mercury injection curves themselves, neglecting the important geologicalinformation conveyed by the mercury ejection curves. This paper quantitatively describes the fractalcharacteristics of ejection curves by using four fractal models, i.e.,. Menger model, Thermodynamicmodel, Sierpinski model, and multi- fractal model. In comparison with mercury injection curves, weexplore the fractal significance of mercury ejection curves and define the applicability of different fractalmodels in characterizing pore architectures. Investigated tight sandstone samples can be divided intofour types (Types A, B, C and D) based on porosity, permeability, and mercury removal efficiency. Type Dsamples are unique in that they have higher permeability (>0.6 mD) but lower mercury removal effi-ciency (<35%). Fractal studies of the mercury injection curve show that it mainly reflects the pore throatcharacteristics, while the mercury ejection curve serves to reveal the pore features, and porosity andpermeability correlate well with the fractal dimension of the injection curve, while mercury removalefficiency correlates only with the Ds' value of the ejection curve. The studies on the mercury ejectioncurves also reveal that the small pores and micropores of the Type C and Type D samples are moredeveloped, with varying pore architecture. The fractal dimension Ds' value of Type D samples is greaterthan that of Type C samples, and the dissolution of Type D samples is more intense than that of Type Csamples, which further indicates that the Type D samples are smaller in pore size, rougher in surface, andwith greater difficulty for the hydrocarbon to enter, resulting in their reservoir capacity probably lessthan that of Type C samples. In this regard, the important information characterized by the mercuryejection curve should be considered in evaluating the tight sandstone reservoirs. Finally, the Menger andThermodynamic models prove to be more suitable for describing the total pore architecture, while theSierpinski model is better for characterizing the variability of the interconnected pores.
基金Supported by Wenzhou Science Technology Bureau Foundation,No.2022Y0726.
文摘Heart failure(HF)with preserved ejection fraction(HFpEF)has exceeded HF with reduced ejection fraction(HFrEF),becoming the most common type of HF.Unlike HFrEF,HFpEF is primarily a chronic low-grade inflammatory process closely associated with metabolic disorders.The coexistence of HFpEF and metabolic dysfunction-associated steatotic liver disease(MASLD)presents significant clinical challenges due to shared metabolic pathophysiology and complex inter-play.Management strategies for HFpEF and MASLD remain challenging.Sodium-glucose cotransporter 2 inhibitors have shown benefits in managing both conditions.Additionally,glucagon-like peptide-1 receptor agonists are being actively investigated for their potential benefits,particularly in MASLD.A comprehensive,patient-centered approach that combines metabolic and cardiova-scular care is essential for improving outcomes in patients with HFpEF and MASLD,addressing the global metabolic health challenges.
基金Supported by the Shanghai Rising Star Program (Grant No. 21QB1403900)the Shanghai Municipal Commission of Science and Technology (Grant No. 22170712600)。
文摘Knowing the optimal operating parameters of Stirling engines is important for efficient combustion through adaptability to changed pressures and oxygen atmospheres. In this study, the optimum operating conditions for efficient combustion in a singular Stirling engine combustor at different oxygen atmospheres were investigated and determined. Numerical simulations were performed to investigate the effects of ejection ratio and pressure on combustion performance. In an oxygen/carbon dioxide atmosphere, the results show that increasing the ejection ratio substantially alters the flame distribution in the Stirling engine combustor, increasing heat transfer and external combustion efficiency. In contrast, increasing the ejection ratio reduces the average and maximum temperatures of the Stirling engine combustor. Increased pressure affects the flame distribution in the Stirling engine combustor and impedes the flow and convective heat transfer in the combustor, reducing the overall external combustion efficiency at pressures above 6.5 MPa. In an air/carbon dioxide atmosphere, an increased ejection ratio reduces the average and maximum temperatures in the Stirling engine combustor. However, the overall flame distribution does not change substantially. The external combustion efficiency tends to increase and then decrease because of two opposing factors: the increase in the convective heat transfer coefficient and the decrease in the temperature difference. Increasing pressure inhibits forced convection heat transfer in the Stirling engine combustor, reducing external combustion efficiency, which drops from 78% to 65% when pressure increases from 0.2 MPa to 0.5 MPa.
基金Supported by Science and Technology Department of Yunnan Province-Kunming Medical University,Kunming Medical Joint Special Project-Surface Project,No.202401AY070001-164Yunnan Provincial Clinical Research Center Cardiovascular Diseases-New Technology Research for Development Project for Diagnosis and Treatment Cardiovascular Diseases,No.202102AA310002the Key Technology Research and Device Development Project for Innovative Diagnosis and Treatment of Structural Heart Disease in the Southwest Plateau Region,No.202302AA310045.
文摘Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a novel form of regulated cell deaths,marked by cellular energy depletion and metabolic dysregulation stemming from excessive ATP accumulation,identifying its uniqueness compared to other cell death processes modalities such as programmed cell death and necrosis.Growing evidence suggests that ATP-induced cell death(AICD)is predominantly governed by various biological pathways,including energy meta-bolism,redox homeostasis and intracellular calcium equilibrium.Recent research has shown that AICD is crucial in HF induced by pathological conditions like myocardial infarction,ischemia-reperfusion injury,and chemotherapy.Thus,it is essential to investigate the function of AICD in the pathogenesis of HF,as this may provide a foundation for the development of targeted therapies and novel treatment strategies.This review synthesizes current advancements in under-standing the link between AICD and HF,while further elucidating its invol-vement in cardiac remodeling and HF progression.
文摘BACKGROUND Heart failure with preserved ejection fraction(HFpEF)accounts for approximately half of heart failure cases and is associated with high morbidity and mortality.Beta-blockers(BB)and calcium channel blockers(CCB)are commonly used for symptom control and comorbidity management,but their comparative effectiveness and safety remain unclear.AIM To compare the effectiveness and safety of BB vs CCB in patients with HFpEF using simulated real-world data and propensity score-matched analyses.METHODS Simulated data for 4000 HFpEF patients(2000 BB,2000 CCB)were generated based on distributions extracted from electronic medical records spanning 2014-2023.Inclusion criteria included adults with left ventricular ejection fraction≥50%and initiation of BB or CCB.Effectiveness outcomes encompassed mortality,heart failure hospitalizations,and changes in clinical parameters.Safety outcomes included bradycardia,hypotension,and drug discontinuation.Statistical analyses used t-tests,χ2 tests,Cox proportional hazards models for hazard ratios(HR),and incidence rate ratios(IRR)in R software.Propensity score matching(PSM)was performed to balance baseline characteristics,with outcomes reassessed in the matched cohort.RESULTS Baseline characteristics were largely balanced,with minor differences in sex,chronic kidney disease,systolic blood pressure,and left atrial volume index.BB demonstrated lower all-cause mortality(crude HR 0.78,95%CI:0.70-0.87,P=0.003),heart failure hospitalization(crude HR 0.86,95%CI:0.77-0.96,P=0.031),and composite endpoint(crude HR 0.85,95%CI:0.79-0.91,P<0.001)rates compared to CCB.IRR for heart failure hospitalizations and emergency visits favored BB.Safety profiles showed higher symptomatic bradycardia(9.2%vs 4.9%,P<0.001)and drug discontinuation(11.3%vs 9.3%,P=0.043)with BB,and higher hypotension(7.2%vs 11.5%,P<0.001)with CCB.Matched analyses showed all-cause mortality rates of 0.0622 per person-year for BB vs 0.0649 for CCB(HR 0.96,95%CI:0.85-1.08),heart failure hospitalization rates of 0.0751 vs 0.0888(HR 0.84,95%CI:0.75-0.94),and IRR for number of heart failure hospitalizations of 1.65 for CCB vs BB(95%CI:1.51-1.80,P<0.001).CONCLUSION BB may offer potential advantages in reducing mortality and hospitalizations in HFpEF compared to CCB,with distinct safety considerations.PSM confirmed these trends with reduced confounding.Personalized therapy is recommended,warranting prospective trials for validation.
文摘Major solar plasma disturbances are subjected to Lomb-Scargle periodogram and wavelet analysis to determine the occurrence frequency.These disruptions include interplanetary coronal mass ejection,sudden storm commencement,high-speed streams,corotating interaction regions,interplanetary shocks and Forbush decreases.We included information on all of the aforementioned solar disturbances for the last six solar cycles,from 1965 to 2023,for this study.Our findings reveal some intriguing and noteworthy results that clearly distinguish between even and odd-numbered solar cycles.The study suggests that the Sun behaves differently in odd and even-numbered solar cycles as it comes from the massive solar eruptions.During even-numbered solar cycles,variations with a period of∼44 days are prominently observed in addition to solar rotation(∼27 days)and extended solar(∼36 days)rotation.However,in addition to solar rotation,prolonged solar rotation,and periods of around 44 days,we also detect a number of intermittent changes with nearly comparable amplitude during the oddnumbered solar cycles.The findings also demonstrate that,in contrast to odd-numbered solar cycles,the emissions rate of these disruptions is more distinct and predictable during even-numbered solar cycles.
文摘Background Elderly patients(age≥60 years)with ST-segment elevation myocardial infarction(STEMI)are at an elevated risk of mortality.This study aimed to investigate the association of the creatinine to ejection fraction ratio(CER)with in-hospital and 1-year death in elderly patients with STEMI.Methods A total of 753 consecutive elderly patients(age≥60 years)with STEMI undergoing percutaneous coronary intervention(PCI)were enrolled and divided into three groups according to the tertiles of CER at admission:<1.5(n=250),1.5-2.2(n=249)and>2.2(n=254).Multivariate analyses were performed to evaluate the prognostic value of CRE for short-term death in this population.Results The in-hospital and 1-year mortality reached 6.0%and 13.3%,respectively.Patients with higher CER exhibited a higher in-hospital mortality(0.8%vs.2.8%vs.14.2%,P<0.001).An optimal cut-off value of 2.5 for CER was identified for predicting in-hospital death by receiver operating characteristic curve analysis,yielding a sensitivity of 77.8%and a specificity of 76.1%[area under curve(AUC):0.791,95%confidence interval(CI):0.734-0.847,P<0.001].Multivariate regression analyses revealed that CER>2.5 was an independent risk factor for both in-hospital[adjusted odds ratio(OR):9.006,95%CI:2.707-29.967,P<0.001]and 1-year mortality[adjusted hazard ratio(HR):5.082,95%CI:2.462-10.490,P<0.001].Conclusions Elevated CER is associated with adverse short-term mortality in elderly STEMI patients undergone PCI,offering valuable insights for the early identification and management of high-risk individuals in clinical practice.
基金Supported by the JSPS KAKENHI,No.JP21K10300 and No.JP24K02714.
文摘BACKGROUND Early diagnosis of left ventricular diastolic dysfunction(LVDD)is essential for preventing heart failure.B-type natriuretic peptide(BNP)is a viable marker for predicting LVDD,as elevated BNP levels have been associated with worsening LVDD in patients with diabetes over time.However,the utility of BNP as a diagnostic marker in diabetes is controversial,as BNP levels are often low in overweight individuals.AIM To examine the effectiveness of BNP levels and fragmented QRS(fQRS)on electrocardiography for diagnosing LVDD in patients with type 2 diabetes.METHODS This retrospective cohort study included 303 patients with type 2 diabetes(67.4±12.3 years old)with preserved ejection fraction(EF)≥50%admitted to Toyama University Hospital for glycemic management and comorbidity evaluation between November 2017 and April 2021.All participants underwent plasma BNP measurement,electrocardiography,and echocardiography.Cardiologists who were blinded to the BNP results assessed the electrocardiograms and echocardiograms.Subgroup analyses were conducted for overweight individuals.RESULTS Receiver operating characteristic(ROC)curve analysis determined optimal BNP cut-off values of 34.8 pg/mL and 7.2 pg/mL for diagnosing LVDD in non-overweight[area under the ROC curve(AUC):0.70]and overweight(AUC:0.55)groups,respectively(P=0.040).In the overweight subgroup,fQRS showed greater diagnostic accuracy for LVDD(AUC:0.67),indicating moderate diagnostic utility compared with the low performance of the BNP cutoff of 35 pg/mL(AUC:0.52)(P=0.010).Multivariate analyses confirmed that fQRS was superior to BNP for LVDD diagnosis regardless of the patient’s weight.CONCLUSION A BNP level≥35 pg/mL in non-overweight individuals may be a reliable LVDD marker.Additionally,fQRS was more effective than BNP in diagnosing LVDD irrespective of the patient’s weight.fQRS can complement BNP in the early detection of LVDD,especially in overweight patients,potentially improving early detection and mitigating progression to heart failure with preserved EF in patients with type 2 diabetes.
基金supported by the National Key R&D Program of China(2021YFA1600500 and 2021YFA1600503)sponsored by the CAS-TWAS President Fellowship Programpartially supported by the Tianchi Talent Program of the Xinjiang Uygur Autonomous Region of China.
文摘Decameter-hectometric(DH)Type Ⅱ bursts,arising from coronal mass ejection(CME)-driven shock waves,are crucial for understanding solar-terrestrial interactions and space weather forecasting.This study provides a comprehensive statistical analysis of CMEs associated with DH type Ⅱ solar radio bursts during Solar Cycle 24(2009–2019),utilizing data from the Wind/WAVES,Solar TErrestrial RElations Observatory/SWAVES,and Solar and Heliospheric Observatory/LASCO catalogs.Analyzing 180 events,we report key spectral and kinematic properties,including a mean CME speed of(1058±531)km s^(−1) and a mean width of(288.39±99.3),with 62%classified as halo CMEs.About 12%of the total CMEs are accelerated,58%of them are decelerated,and 30%of them are constant.Similarly,CMEs having a speed≤800 km s^(−1) are constant,and those with speed≥800 km s^(−1) are decelerated.DH type Ⅱ bursts displayed a mean starting frequency of(12,169.72±4939)kHz,ending frequency of(2152.69±3022.07)kHz,bandwidth of(10,017±5353)kHz,and an average duration of(345.62±453)minutes.A power-law relationship was established between the drift rate(df/dt)and burst duration(D),characterized by df/dt=2749.07·D^(−0.88),highlighting the inverse dependence of drift rate on burst longevity.This suggests a dynamic interplay between shock parameters and the ambient solar corona.The findings underscore the persistent and robust spectral coverage of CME-driven shocks,offering new insights into their evolution and impact on the heliospheric environment.
文摘We investigate the relationship between the magnitudes of Forbush decreases(FDs)and solar-geomagnetic characteristics using daily-averaged galactic cosmic ray(GCR)data from Inuvick(INVK)and Magadan(MGDN)neutron monitor(NM)stations to aid in counting the case of GCR flux intensity modulation.The FDs,obtained with an automated new computer software algorithm from daily-averaged GCR data from the IZMIRAN common website:http://cr0.izmiran.ru/common,at INVK(224)and MGDN(229)NM stations,from 1998 to 2002,were used in the present work.The associated solar-geomagnetic parameters of the same time range were obtained from the OMNI website.A statistical analytical method was employed to test the link between FD amplitudes and solargeomagnetic variables.We observed negative trends in FD-IMF,FD-SWS,FD-Kp,FD-SSN and FD-SI,while a positive relation was indicated in FD-Dst at both stations.All are statistically significant at a 95%confidence level.The results obtained here imply that solar emission characteristics impact the GCR flux intensity modulation.
文摘BACKGROUND Myocardial infarction(MI)is a significant global cause of chronic heart failure.In post-ischemic cardiac hypertrophy,multiple molecular targets and signals within the cardiac tissue are evident.Mesenchymal stem cell-derived exosomes(MSC-EXO)and exercise(EXE)showed promise in enhancing post-ischemic cardiac repair.AIM To investigate how the exosomes released by stem cells and/or EXE can promote cardiac repair and improve isoproterenol(ISO)-induced post-ischemic hypertrophy.METHODS The enrolled animals were divided into 8 control rats and 32 experimental rats.Induction of MI was performed using ISO.Then,the experimental rats were divided into 4 groups:Rats subjected to 4 weeks of swimming EXE,rats treated with exosomes,and the combined treatment.Additionally,functional and interactional exploration of targeted proteins was conducted using Gene Ontology,Kyoto Encyclopedia of Genes and Genomes analysis,and STRING database,along with histological examination.RESULTS Both MSC-EXO or EXE significantly improved ISO induced elevation of cardiac enzymes,oxidative stress,and inflammatory markers,as well as the degenerative changes of the cardiac muscles,fibrosis,and apoptosis.Meanwhile,the combined treatment of EXE and MSC-EXO resulted in a significant improvement in cardiac function and structure as compared to all groups that synchronized with dual inhibition of extracellular signal-regulated kinase and protein kinase B/mammalian target of rapamycin(P<0.01)signaling and modulation of matrix metalloproteinase 9 and sarcoplasmic endoplasmic reticulum calcium ATPase type 2a,with significant improved angiogenesis.CONCLUSION Functional and structural cardiac improvements are accompanied by reduced inflammation,oxidative stress,and apoptosis.Both MSC-EXO and EXE exert cardio-protection by upregulating sarcoplasmic endoplasmic reticulum calcium ATPase,the critical pump for normal calcium handling.
基金supported by the National Natural Science Foundation of China(NSFC,grant Nos.41774085,41074132,41274193 and 41674166)the Special Fund of the Institute of Geophysics,China Earthquake Administration(grant Nos.DQJB22X12 and DQJB24X25)。
文摘Partitioning the solar cycle into ascending and descending phases,we examine the solar cycle distribution of the north-south(N-S)asymmetry in the source locations of super geomagnetic storms(SGSs;Dst≤-250 nT)during 1932-2018.We found that during the ascending phases,SGS source locations were predominantly in the northern hemisphere(NH),exhibiting significant N-S asymmetry.For the SGSs in the descending phases,source locations of the SGSs dominated in the NH and N-S asymmetry was only significant in the western hemisphere.For the period from 1932 to 2018,the source locations of SGSs were predominantly in the NH,and the N-S asymmetry was significant.The cumulative numbers of SGSs originating from the two hemispheres were strongly anticorrelated during the ascending phases,descending phases,and the entire period from 1932 to 2018.For the source locations of SGSs with different intensities,significant N-S asymmetries were observed in the source location distribution.Specifically,for all SGSs,SGSs with-400 nT<Dst≤-300 nT,and SGSs with Dst≤-300 nT,the NH exhibited a higher number of events compared to the southern hemisphere(SH),indicating a dominance of SGSs in the NH.From the perspective of the evolution of N-S asymmetry with the solar cycle,the source locations of the SGSs always dominated in the NH during the ascending phases.However,during solar cycles 17-19 and 21,the source locations of the SGSs dominated in the NH,while during solar cycles 20,22,and 23 the source locations of the SGSs dominated in the SH.From the perspective of N-S asymmetry for Solar Cycles 17-23,solar activity across the two hemispheres is largely balanced.However,the solar activities manifested by CMEs that can trigger SGSs during Solar Cycles 17-23 were predominantly in the NH.Therefore,factors beyond solar activity,such as the propagation of the CMEs from the Sun to the Earth,likely contribute to the observed N-S asymmetric distribution of the source locations of SGSs.
