With the continuous development of the times,local university libraries in Yunnan are also undergoing a new development process in the context of integration into the national strategy.This important cultural position...With the continuous development of the times,local university libraries in Yunnan are also undergoing a new development process in the context of integration into the national strategy.This important cultural position of the school should actively seek a path consistent with educational development,deeply integrate the important educational direction of ideological and political education for college students,and build itself into an important platform for cultivating well-rounded socialist builders and successors.Therefore,university libraries should constantly optimize their resource structure and service model in response to the needs of students’ideological and political education.Through various forms of innovation and adjustment,they should constantly meet the diverse and individualized learning needs that arise in the process of students’development,with the aim of maximizing the utilization of resources.Starting from the advantages of university libraries in integrating ideological and political education for college students,this paper deeply analyzes the effective paths for university libraries to integrate ideological and political education for college students,hoping to provide new ideas and methods for local university libraries to better play their educational functions in the context of Yunnan’s integration into the national strategy,and promote the in-depth development of ideological and political education for college students.展开更多
Previous animal experiments have implied that organophosphate esters（OPEs） have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, ...Previous animal experiments have implied that organophosphate esters（OPEs） have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, the activities of four OPEs have been characterized against the thyroid hormone（TH） nuclear receptor（TR） using two in vitro models, with the aim of evaluating their toxicity mechanisms towards the TR. The results of a TH-dependent cell proliferation assay showed that tris（2-chloro-1-（chloromethyl）ethyl）phosphate（TDCPP） could induce cell growth, while the other three OPEs had no effect. The results of a luciferase reporter gene assay revealed that all four of the OPEs tested in the current study showed agonistic activity towards TRβ, with TDCPP being the most potent one. Moreover, molecular docking revealed that all the tested OPEs could fit into the ligand binding pocket of TRβ, with TDCPP binding more effectively than the other three OPEs. Taken together, these data suggest that OPEs might disrupt the thyroid endocrine system via a mechanism involving the activation of TR.展开更多
Objective To study the effect of glucagon-like peptide-1 agonist(exendin-4)on insulin signaling pathway in skeletal muscle of mice with insulin resistance(IR).Methods Thirty male KM mice were divided into normal contr...Objective To study the effect of glucagon-like peptide-1 agonist(exendin-4)on insulin signaling pathway in skeletal muscle of mice with insulin resistance(IR).Methods Thirty male KM mice were divided into normal control group(NC group,n=10)and IR group(n=20).The mice in NC group and IR group were fed展开更多
基金This paper is one of the research results of the Scientific Research Foundation project of Yunnan Provincial Department of Education,“Research on the Role of Local University Libraries in the Context of Yunnan’s Integration into the National Strategy”(202130745).
文摘With the continuous development of the times,local university libraries in Yunnan are also undergoing a new development process in the context of integration into the national strategy.This important cultural position of the school should actively seek a path consistent with educational development,deeply integrate the important educational direction of ideological and political education for college students,and build itself into an important platform for cultivating well-rounded socialist builders and successors.Therefore,university libraries should constantly optimize their resource structure and service model in response to the needs of students’ideological and political education.Through various forms of innovation and adjustment,they should constantly meet the diverse and individualized learning needs that arise in the process of students’development,with the aim of maximizing the utilization of resources.Starting from the advantages of university libraries in integrating ideological and political education for college students,this paper deeply analyzes the effective paths for university libraries to integrate ideological and political education for college students,hoping to provide new ideas and methods for local university libraries to better play their educational functions in the context of Yunnan’s integration into the national strategy,and promote the in-depth development of ideological and political education for college students.
基金supported by the National Natural Science Foundation of China (Nos. 21407168, 21377142 and 21477146)the Young Scientists Fund of RCEES (No. RCEES-QN-20130004F)Chinese Academy of Sciences (Nos. XDB14040100 and YSW2013A01)
文摘Previous animal experiments have implied that organophosphate esters（OPEs） have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, the activities of four OPEs have been characterized against the thyroid hormone（TH） nuclear receptor（TR） using two in vitro models, with the aim of evaluating their toxicity mechanisms towards the TR. The results of a TH-dependent cell proliferation assay showed that tris（2-chloro-1-（chloromethyl）ethyl）phosphate（TDCPP） could induce cell growth, while the other three OPEs had no effect. The results of a luciferase reporter gene assay revealed that all four of the OPEs tested in the current study showed agonistic activity towards TRβ, with TDCPP being the most potent one. Moreover, molecular docking revealed that all the tested OPEs could fit into the ligand binding pocket of TRβ, with TDCPP binding more effectively than the other three OPEs. Taken together, these data suggest that OPEs might disrupt the thyroid endocrine system via a mechanism involving the activation of TR.
文摘Objective To study the effect of glucagon-like peptide-1 agonist(exendin-4)on insulin signaling pathway in skeletal muscle of mice with insulin resistance(IR).Methods Thirty male KM mice were divided into normal control group(NC group,n=10)and IR group(n=20).The mice in NC group and IR group were fed
