Objective:To explore the key points of early identification and comprehensive nursing intervention strategy for necrotizing fasciitis patients,to improve the efficiency of clinical diagnosis and treatment and the qual...Objective:To explore the key points of early identification and comprehensive nursing intervention strategy for necrotizing fasciitis patients,to improve the efficiency of clinical diagnosis and treatment and the quality of prognosis.Methods:The clinical data of a 70-year-old female patient with right-hand trauma complicated by infection progressing to necrotizing fasciitis were reviewed and analyzed.Laboratory,imaging,and surgical findings were integrated to summarize the early identification features and key nursing considerations.Results:The patient retained the affected limb,albeit with some functional limitations,following early identification,timely surgical debridement,broad-spectrum anti-infective therapy,and comprehensive nursing care.Conclusion:The early clinical manifestations of necrotizing fasciitis are often subtle,and the disease progresses rapidly.This necessitates heightened vigilance among medical staff in all healthcare settings.Implementing multidisciplinary collaboration and systematic nursing interventions can improve patient prognosis while reducing amputation rates and mortality.展开更多
Due to an increasing incidence of necrotizing enterocolitis (NEC), as well as its associated mortality and long-term complications seen in surviving patients, the main focus of research in NEC has shifted to the preve...Due to an increasing incidence of necrotizing enterocolitis (NEC), as well as its associated mortality and long-term complications seen in surviving patients, the main focus of research in NEC has shifted to the prevention and treatment of the disease. The hypothesis of this work is that the strain Lactobacillus salivarius LPLM-O1 can decrease the intestinal injuries in a model of induced NEC. 26 newborn Sprague-Dawley pups were used in this study and randomized in three groups: control group (n = 6), which were fed with infant formula (Similac NeosureTM, Abbott);probiotic group (n = 10), which were fed with the same infant formula but fortified with 109 colony-forming units (CFU) of Lactobacillus salivarius LPLM-O1, and the NEC-induced group (n = 10). Each group was fed with 100 μl of food formula every three hours, using a modified syringe. The probiotic and NEC groups were exposed to asphyxia- and cold-induced stress to develop experimental NEC. At the end of the experiment (96 hrs), animals were sacrificed, and their small intestines were carefully removed and evaluated for typical signs of NEC, microbiological count and histological analyses. The histological analysis of the NEC-induced group showed transmural necrosis (grade 4);in the probiotic group, the grade was comparatively lower (grade 2). Survival ratewas higher in the probiotic group (83%) than in the NEC-induced group (46%);however, the difference in not statistically significant (p = 0.14). Lactic acid bacteria counts were higher in the probiotic group than in the NEC-induced group (8.4 × 108 and 6.1 × 107 CFU/intestine tissue gram, respectively). According to these results, the model of artificial induction of NEC was effectively establishedin all pups, and the probiotic strain slightly decreases the injuries’ grade in newborn pups.展开更多
文摘Objective:To explore the key points of early identification and comprehensive nursing intervention strategy for necrotizing fasciitis patients,to improve the efficiency of clinical diagnosis and treatment and the quality of prognosis.Methods:The clinical data of a 70-year-old female patient with right-hand trauma complicated by infection progressing to necrotizing fasciitis were reviewed and analyzed.Laboratory,imaging,and surgical findings were integrated to summarize the early identification features and key nursing considerations.Results:The patient retained the affected limb,albeit with some functional limitations,following early identification,timely surgical debridement,broad-spectrum anti-infective therapy,and comprehensive nursing care.Conclusion:The early clinical manifestations of necrotizing fasciitis are often subtle,and the disease progresses rapidly.This necessitates heightened vigilance among medical staff in all healthcare settings.Implementing multidisciplinary collaboration and systematic nursing interventions can improve patient prognosis while reducing amputation rates and mortality.
文摘Due to an increasing incidence of necrotizing enterocolitis (NEC), as well as its associated mortality and long-term complications seen in surviving patients, the main focus of research in NEC has shifted to the prevention and treatment of the disease. The hypothesis of this work is that the strain Lactobacillus salivarius LPLM-O1 can decrease the intestinal injuries in a model of induced NEC. 26 newborn Sprague-Dawley pups were used in this study and randomized in three groups: control group (n = 6), which were fed with infant formula (Similac NeosureTM, Abbott);probiotic group (n = 10), which were fed with the same infant formula but fortified with 109 colony-forming units (CFU) of Lactobacillus salivarius LPLM-O1, and the NEC-induced group (n = 10). Each group was fed with 100 μl of food formula every three hours, using a modified syringe. The probiotic and NEC groups were exposed to asphyxia- and cold-induced stress to develop experimental NEC. At the end of the experiment (96 hrs), animals were sacrificed, and their small intestines were carefully removed and evaluated for typical signs of NEC, microbiological count and histological analyses. The histological analysis of the NEC-induced group showed transmural necrosis (grade 4);in the probiotic group, the grade was comparatively lower (grade 2). Survival ratewas higher in the probiotic group (83%) than in the NEC-induced group (46%);however, the difference in not statistically significant (p = 0.14). Lactic acid bacteria counts were higher in the probiotic group than in the NEC-induced group (8.4 × 108 and 6.1 × 107 CFU/intestine tissue gram, respectively). According to these results, the model of artificial induction of NEC was effectively establishedin all pups, and the probiotic strain slightly decreases the injuries’ grade in newborn pups.
