Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S....Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),have developed immune escape mechanisms that hinder phagolysosomal killing.By shielding themselves from humoral immune factors and limiting exposure to antibiotics,these pathogens can establish long-term reservoirs and sustain recurrent infections.展开更多
文摘Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),have developed immune escape mechanisms that hinder phagolysosomal killing.By shielding themselves from humoral immune factors and limiting exposure to antibiotics,these pathogens can establish long-term reservoirs and sustain recurrent infections.
