To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced...To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced by cecal ligation and puncture (CLP). ET1 receptor was assayed by using [125I]- ET1 binding. Marker enzyme activities, protein yield, and dry- to- wet weight ratio of cardiac membranes were measured. Results. Septic rat heart exhibited two distinct phases: an initial hyperdynamic phase( 9h after CLP; early stage of sepsis) followed by a hypodynamic (18h after CLP, late stage of sepsis) phase. [125I]- ET1 binding study showed that during early stage of sepsis, the Bmax of ET1 receptors was increased by 30％ in sarcolemma but decreased by 19％ in light vesicles, while during late stage of sepsis, the Bmax was decreased by 24％ in sarcolemma but increased by 38％ in light vesicles.The total binding of sarcolemma and light vesicles was increased by 25％ during early stage of sepsis but decreased by 17％ during late stage of sepsis. Conclusions. These data indicated that ET1 receptors in the rat heart were externalized from light vesicles to sarcolemmal membranes during early hyperdynamic phase while internalized from surface membranes to intracellular compartment during late hypodynamic phase of sepsis.展开更多
Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention(PCI) for coronary chronic total occlusion(CTO), retrograde wire externalization still remains challenging and ti...Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention(PCI) for coronary chronic total occlusion(CTO), retrograde wire externalization still remains challenging and time-consuming in some cases. Cases utilizing ‘‘Active Greeting Technique(AGT)", a mother-and-child catheter based technique to facilitate retrograde wire externalization, were extracted from Chronic Total Occlusion Club, China(CTOCC) database. AGT was performed by deep intubation a mother-and-child catheter(GuidezillaTMextension, 4 or 5 Fr inner catheter, and etc.) in combination with either reverse controlled antegrade or retrograde subintimal tracking(CART) technique or retrograde wire crossing technique. A total of 111 patients with 112 CTO lesions treated with this technique were retrospectively analyzed. Reverse CART technique and retrograde wire crossing technique were performed in 90.2% and 9.8% of all procedures. The utilization of GuidezillaTMextension, 4 Fr, and 5 Fr inner catheter accounted for 94.6%, 3.6%, and 1.8%, respectively. Externalization of retrograde wire was successful in all cases. No procedural complications were adjudicated to AGT. Complications independent of AGT included two target vessel perforations and two collateral perforations. No in-hospital major adverse cardiac events were found. AGT is a feasible and safe technique that facilitates retrograde wire externalization.展开更多
Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other...Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.展开更多
Bcakground: Pancreatic pseudocyst (PPC) is a common complication arising from acute or chronic pancreatitis, trauma, or pancreatic duct obstruction. When acute fluid collection persists for 4 - 6 weeks and is encapsul...Bcakground: Pancreatic pseudocyst (PPC) is a common complication arising from acute or chronic pancreatitis, trauma, or pancreatic duct obstruction. When acute fluid collection persists for 4 - 6 weeks and is encapsulated by a fibrous wall, it is classified as a pancreatic pseudocyst. While PPC is generally asymptomatic in many patients, it can manifest with persistent abdominal pain, dyspepsia, intra-cystic infection, and potentially lead to gastrointestinal obstruction in some cases. Although smaller PPCs may resolve spontaneously, larger PPCs tend to be refractory to absorption and often necessitate surgical intervention to prevent complications such as intracystic hemorrhage. Objective: To explore the efficacy of percutaneous catheterization with negative pressure in the treatment of large pancreatic pseudocysts. Methods: The cases of large pancreatic pseudocysts treated in our hospital from 2004 to 2022 were retrospectively collected, and the general condition, operation time, drainage time, feeding time, postoperative complications, hospital stay, cost and follow-up of the patients were analyzed. Results: A total of 132 patients with large pancreatic pseudocysts were collected. The average operation time was 32.4 ± 2.1 min;The retention time of the drainage tube was 30 ± 1.8 days in the percutaneous negative pressure drainage group;The postoperative feeding time was no fasting after local anesthesia drainage;Postoperative complications (bleeding, infection, pancreatic leakage, recurrence, anastomotic leakage, etc.): Two of the 132 patients had recurrent cysts, which were cured by re-puncture and negative pressure drainage. The length of hospital stay was 6 ± 1.1 days;The cost was 11,200 ± 1300 yuan;Follow-up: The follow-up time ranged from 1 to 3 years, and the patients had no discomfort. Conclusion: Percutaneous catheterization and negative pressure drainage can effectively treat large pancreatic pseudocysts. Compared with other treatment methods, it is simple and effective, the postoperative recovery of patients is faster, the physical damage is less, the hospital stay is shorter, and the cost is lower.展开更多
High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile industry.Mg can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress aro...High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile industry.Mg can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated die-castings.Herein,the development of non-heat treatment Al alloys is becoming the hot topic.In addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of castings.To achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and Ce.Their influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic simulation.Our results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased porosity.Meanwhile,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical properties.Subsequent introduction of Ce resulted in the poisoning effect and reduced mechanical properties.展开更多
The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an ...The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 versa.The results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack time.In addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate erosion.The damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC pastes.Furthermore,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.展开更多
BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core muscles.In both static and dynamic movements,the Sahrmann core stability test provides an assessment of cor...BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core muscles.In both static and dynamic movements,the Sahrmann core stability test provides an assessment of core muscle activation and a person's ability to stabilize the lumbopelvic complex.Preparatory cues and images can be used to increase the activation of these muscles.To attain optimal movement patterns,it will be necessary to determine what cueing will give the most effective results for core stability.AIM To investigate the effects of external and internal cues on core muscle activation during the Sahrmann five-level core stability test.METHODS Total 68 participants(21.83±3.47 years)were randomly allocated to an external(n=35)or internal cue group(n=33).Participants performed the Sahrmann fivelevel core stability test without a cue as baseline and the five-level stability exercises with an internal or external cue.External cue group received a pressure biofeedback unit(PBU),and the internal cue group received an audio cue.A Delsys Trigno^(TM)surface electromyography unit was used for muscle activation from the rectus abdominis,external oblique,and transverse abdominis/internal oblique muscles.RESULTS Linear mixed effects model analysis showed that cueing had a significant effect on core muscle activation(P=0.001);however,there was no significant difference between cue types(internal or external)(P=0.130).CONCLUSION Both external and internal cueing have significant effects on core muscle activation during the Sahrmann five-level core stability test and the PBU does not create higher muscle activation than internal cueing.展开更多
3D audio effects can provide immersive auditory experience, but we often face the so-called in-head localization （IHL） problem in headphone sound reproduction. To ad- dress this problem, we propose an effective soun...3D audio effects can provide immersive auditory experience, but we often face the so-called in-head localization （IHL） problem in headphone sound reproduction. To ad- dress this problem, we propose an effective sound image externalization approach. Specifically, we consider several important factors related to sound propagation, which include image-source model based early reflections with distance decay, wall absorption and air absorption, late reverberation and other dynamic factors like head movement. We apply our sound image externalization approach to a headphone based real-time 3D audio system. Subjective listening tests show that the sound image externalization performance is significantly improved and the sound source direction is preserved as well. A/B preference test further shows that, as compared with a recent popular approach, the proposed approach is mostly preferred by the listeners.展开更多
Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was sched...Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was scheduled for suspected urothelial carcinoma of the distal ureter in a 60-year-old woman.The patient involved in the present research signed a dedicated form to consent to the publication of images and/or information about her.Past medical history included Brugada syndrome diagnosed in 2015,and hypercholesterolemia.Past surgical history included one cesarean section only.Family history included ovarian cancer(sister),colorectal cancer(mother),and kidney cancer(father).展开更多
This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in t...This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in the Hunan Province(China)in 2022 and searched for data in the published literature from January2000 to December 2023 in China.On the basis of these data,we analyzed the coefficients of variation and acceptable biases of different quality control materials for basic semen analysis through robust statistics.We compared these findings with quality specifications based on biological variation from optimal,desirable,and minimum levels of bias to seek a unified and more suitable semen EQAbias evaluation standard for China's national conditions.Different sources of semen quality control material exhibited considerable variation in acceptable biases among laboratories,ranging from 8.2%to 56.9%.A total of 50.0% of the laboratories met the minimum quality specifications for progressive motility(PR),whereas 100.0%and 75.0%of laboratories met only the minimum quality specifications for sperm concentration and total motility(nonprogressive[NP]+PR),respectively.The Z value for sperm concentration and PR+NP was equivalent to the desirable performance specification,whereas the Z value for PR was equivalent only to the minimum performance specification.This study highlights the feasibility of operating external quality assessment schemes for basic semen analysis using quality specifications based on biological variation.These specifications should be unified among external quality control(EQC)centers based on biological variation.展开更多
Basic life support for cardiac arrest associates cardiopulmonary resuscitation(CPR)and defibrillation.CPR relies on chest compressions(CC)and ventilation.Current guidelines on CPR recommend a depth of 5-6 cm at a rhyt...Basic life support for cardiac arrest associates cardiopulmonary resuscitation(CPR)and defibrillation.CPR relies on chest compressions(CC)and ventilation.Current guidelines on CPR recommend a depth of 5-6 cm at a rhythm of 100-120 times/min for CC.[1,2]Interruptions of the CC must be as short as possible and are related to ventilation,defibrillation and turnover of the rescuers.Most of the automated external defibrillators(AEDs)require interruptions of the CC to perform rhythm analysis.Among the numerous marketed models of AEDs,some provide real-time feedback about the quality of the CC.展开更多
The metamaterial based on external meshing gears(MEG)is designed based on the principle of external meshing gear transmission.Based on the meshing transmission principle of external meshing gears and planetary gear tr...The metamaterial based on external meshing gears(MEG)is designed based on the principle of external meshing gear transmission.Based on the meshing transmission principle of external meshing gears and planetary gear trains,the internal and external gear rings are designed.Based on the internal and external gear rings,the metamaterial based on inner and outer planetary gear trains(MIP)is designed to study the shear modulus,Young's modulus,and amplitude-frequency characteristics of the metamaterial based on gears at different angles.The effects of the number of planetary gears on the physical characteristics of the MIP are studied.The results show that the MEG can be continuously adjusted by adjusting the shear modulus and Young's modulus due to its meshing characteristics.With the same number of gears,the adjustment range of the MIP is larger than the adjustment range of the MEG.When the number of planetary gears increases,the adjustment range of the MIP decreases.Moreover,when the metamaterial based on gears rotates,the harmonic response changes with the change of the angle.展开更多
Direct numerical simulations of a uniform flow past a fixed spherical droplet are performed to investigate the parameter range within which the axisymmetric flow becomes unstable due to an external flow bifurcation.Th...Direct numerical simulations of a uniform flow past a fixed spherical droplet are performed to investigate the parameter range within which the axisymmetric flow becomes unstable due to an external flow bifurcation.The hydrodynamics is governed by three dimensionless parameters:the viscosity ratioμ*,the external Reynolds numbers Re^(e),and internal Reynolds numbers Re^(i),respectively.The drop-to-fluid density ratio is related to these parameters asρ*=μ*Re^(i)/Re^(e).This study focuses on highly viscous droplets withμ*≥5,where wake instability is driven by the vorticity flux transferred from the droplet surface into the surrounding fluid.By analysing the wake structure,we confirm that the onset of the external bifurcation is linked to the tilting of the azimuthal vorticityωϕ,in the wake and that the bifurcation occurs once the isocontours ofωϕalign nearly perpendicular to the symmetry axis.We propose an empirical criterion for predicting the onset of the external bifurcation,formulated in terms of the maximum vorticity on the external side of the droplet surface.This criterion is applicable for sufficiently high Re^(i) and holds over a wide range ofμ*and Re^(e).Additionally,we examine the bifurcation sequence for two specific external Reynolds numbers,Re^(e)=300 and Re^(e)=500,and show that,beyond a critical viscosity ratio,the axisymmetric wake first transitions to a steady planar-symmetric state before undergoing a secondary Hopf bifurcation.Finally,we highlight the influence of Re^(i) on external bifurcation and show that,at moderate Re^(i),wake instability may set in at a lower vorticity threshold than predicted by our criterion.These findings provide new insights into the external flow bifurcation of viscous droplets.展开更多
[Objectives]To observe the clinical efficacy of external application of Scorzonera Herpes Ointment combined with Methylprednisolone Sodium Succinate for Injection in the treatment of herpes zoster oticus(HZO).[Methods...[Objectives]To observe the clinical efficacy of external application of Scorzonera Herpes Ointment combined with Methylprednisolone Sodium Succinate for Injection in the treatment of herpes zoster oticus(HZO).[Methods]A total of 100 HZO patients admitted to the 988 th Hospital of the Joint Logistics Support Force and Henan Provincial People's Hospital from June 2021 to June 2023 were selected.They were divided into a treatment group and a control group using a random number table method,with 50 cases in each group.Both groups received Methylprednisolone Sodium Succinate for Injection.Additionally,the treatment group was treated with external application of Scorzonera Herpes Ointment,while the control group received acyclovir ointment.Both groups were treated for 10 d.The comparisons included clinical efficacy,total symptom and sign scores,pain level[Visual Analogue Scale(VAS)],time for erythema reduction,cessation of blister formation,scab formation,and scab shedding,incidence of post-herpetic neuralgia(PHN),air conduction hearing threshold,and air-bone gap.[Results]After 10 d of treatment,the total effective rate was 98.00%(49/50)in the treatment group and 84.00%(42/50)in the control group,with a statistically significant difference between the two groups(P<0.05).After 10 d of treatment,the total symptom and sign scores and VAS scores of both groups decreased compared to those before treatment.The treatment group had significantly lower scores than the control group(P<0.05).The treatment group showed significantly shorter time for erythema reduction,cessation of blister formation,scab formation,and scab shedding compared to the control group(P<0.05).During the 1-month follow-up after treatment,no PHN cases occurred in the treatment group,while the incidence of PHN in the control group was 24.00%(12/50),showing a statistically significant difference(P<0.05).After 10 d of treatment,both groups showed reduced air conduction hearing thresholds,and the treatment group exhibited significantly lower air conduction thresholds and air-bone gaps compared to the control group(P<0.05).No statistically significant difference was observed in the air-bone gap before and after treatment in the control group(P>0.05).[Conclusions]The combination of external application of Scorzonera Herpes Ointment and Methylprednisolone Sodium Succinate for Injection can alleviate pain and other discomforts,reduce PHN incidence,shorten disease duration,and improve hearing in HZO patients.展开更多
Objective To study the redistribution of ET1 receptors in two subcellular organelles, the sarcolemmal membrane and the light vesicle, of rat heart during the progress of septic shock Methods Male Sprague Dawley ...Objective To study the redistribution of ET1 receptors in two subcellular organelles, the sarcolemmal membrane and the light vesicle, of rat heart during the progress of septic shock Methods Male Sprague Dawley rats weighing from 270 to 320?g were randomly divided into three groups: control, early sepsis, and late sepsis Each group included six rats Sepsis was induced by cecal ligation and puncture (CLP) Control rats were sham operated After operation for 9 hours or 18 hours, animals of the three groups were anesthetized with sodium pentobarbital (60?mg/kg IP) and the hearts were removed for preparation of sarcolemma and light vesicle Hemodynamic parameters were determined with polygraph via femoral artery and intraventricular cannula ET1 receptor was assayed by [ 125 I] ET1 binding Results Heart rate, cardiac output and left ventricular +dp/dt max undergo biphasic changes: an increase in early phase of sepsis (9?h after CLP) followed by a decrease in late phase of sepsis (18?h after CLP) Mean arterial blood pressure and left ventricular dp/dt max remained relatively unaltered during early phase of sepsis but was decreased during late phase of sepsis Although septic rat heart exhibited biphasic cardiodynamic changes, myocardial function showed signs of progressive deterioration during the development of sepsis, as indicated by a progressive elevation of LVEDP [ 125 I] ET1 bindings to cardiac membranes exhibited a saturable process with a single component binding characteristic for all three experimental groups In sarcolemmal membrane fraction, the maximum binding capacity (B max ) calculated from scatchard plot was increased 30% ( P <0 01) during early phase of sepsis but decreased 24% ( P <0 01) during late phase of sepsis The affinity [the reciprocal of the dissociation contant (Kd)] for [ 125 I] ET1 binding in sarcolemmal membranes remained unaffected during early and late phases of sepsis In light vesicle fraction, the B max for [ 125 I] ET1 binding was decreased by 19% ( P <0 05) during early phase of sepsis but increased by 38% ( P <0 01) during late phase of sepsis The affinity for [ 125 I] ET1 binding in light vesicles was unaltered in early and late phases of sepsis It should be mentioned that the sum of Bmax of sarcolemmal and light vesicle fractions was increased by 25% ( P <0 01) during early phase of sepsis but was decreased by 17% ( P <0 01) during late phase of sepsis Conclusions These data indicated that a biphasic intracellular redistribution of ET1 receptor in the heart might contribute to the development of the initial hyperdynamic and subsequent hypodynamic state during sepsis展开更多
Management of post-traumatic long-bone defects remains relevant and cha-llenging despite the rapid development of approaches to their treatment.Do-minant positions are occupied by the Ilizarov method,bone autogenous g...Management of post-traumatic long-bone defects remains relevant and cha-llenging despite the rapid development of approaches to their treatment.Do-minant positions are occupied by the Ilizarov method,bone autogenous grafting and the Masquelet induced membrane technique(IMT).The IMT is aimed at reducing extensive defect treatment duration and for this reason has gained great popularity.However,the assessment of its effectiveness is difficult due to a limited number of clinical series.The varying clinical manifestations of bone defect severity do not allow a comprehensive evaluation of IMT effectiveness.One of them is infection in the defect area.The purpose of our literature review is an analysis of studies on IMT application in infected vs non-infected long-bone defects of the lower extremities published over the last 10 years.It focuses on the investigation of similarities and fundamental differences in the need for antibiotics,timing of spacer fixation,methods of collecting donor bone and fixators used for consolidation.The studies show that the IMT has been globally used in aseptic and osteomyelitic defects due to its clinical effectiveness.Authors’variations and improvements in its practical implementation indicate the ongoing development and the interest of researchers in this technique.展开更多
As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced brid...As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced bridges.Numerical examples show that compared with the natural frequencies of first-order modes,the natural frequencies of higher-order modes are more sensitive and can reflect the damage situation and external cable reinforcement effect of T-beam bridges.For damaged bridges,as the damage to the T-beam increases,the natural frequency value of the bridge gradually decreases.When the degree of local damage to the beam reaches 60%,the amplitude of natural frequency change exceeds 10%for the first time.The natural frequencies of the firstorder vibration mode and higher-order vibration mode can be selected as indexes for different degrees of the damaged T-beam bridges.For damaged bridges reinforced with external cables,the traditional natural frequency of the first-order vibration mode cannot be used as the index,which is insensitive to changes in prestress of the external cable.Some natural frequencies of higher-order vibration modes can be selected as indexes,which can reflect the reinforcement effect of externally prestressed damaged T-beam bridges,and its numerical value increases with the increase of external prestressed cable force.展开更多
Since the mid-20th century,the Mongolian Plateau(MP)has experienced decadal droughts coupled with extreme heatwaves,severely affecting regional ecology and social development.However,the mechanisms behind these decada...Since the mid-20th century,the Mongolian Plateau(MP)has experienced decadal droughts coupled with extreme heatwaves,severely affecting regional ecology and social development.However,the mechanisms behind these decadalscale compound heatwavedrought events remain debated.Here,using reconstructions and simulations from the Community Earth System Model Last Millennium Ensemble,we demonstrate that,over the last millennium,decadal droughts on the MP occurred under both warm and cold conditions,differing from recent compound heatwavedrought events.We found that by examining temperature changes during these drought periods,the distinct influences of external forcings and internal variability can be simply and effectively distinguished.Specifically,colddry events were primarily driven by volcanic eruptions that weakened the East Asian summer monsoon and midlatitude westerlies,reducing moisture transport to the MP.In contrast,warmdry events were predominantly induced by internal variability,notably the negative phase of the Atlantic Multidecadal Oscillation and the expansion of the Barents Sea ice extent.The recent extreme compound event was probably influenced by the combined effects of anthropogenic forcings and internal variability.These findings deepen our understanding of how external forcings and internal variability affect decadal drought events on the MP and highlight that recent compound events are unprecedented in the context of the last millennium.展开更多
The estimated annual incidence of out-of-hospital cardiac arrest(OHCA)is approximately 120 cases per 100000 inhabitants in western countries.Although the rates of bystander cardiopulmonary resuscitation(CPR)and use of...The estimated annual incidence of out-of-hospital cardiac arrest(OHCA)is approximately 120 cases per 100000 inhabitants in western countries.Although the rates of bystander cardiopulmonary resuscitation(CPR)and use of automated external defibrillator are increasing,the likelihood of survival to hospital discharge is no more than 8%.To date,various devices and methods have been utilized in the initial CPR approach targeting to improve survival and neurological outcomes in OHCA patients.The aim of this review is to discuss strategies that facilitate resuscitation,increase the chance to achieve return to spontaneous circulation and improve survival to hospital discharge and neurological outcomes in the prehospital setting.展开更多
Methane,the primary constituent of natural gas,shale gas,and flammable ice,serves as a crucial carbon-based energy source and chemical feedstock.Traditional gas reserves are universally acknowledged as limited and non...Methane,the primary constituent of natural gas,shale gas,and flammable ice,serves as a crucial carbon-based energy source and chemical feedstock.Traditional gas reserves are universally acknowledged as limited and non-renewable resources over an extended timespan stretching from decades to millennia.Biomethane,with its unique renewable properties,showcases remarkable development potential and presents a compelling supplement and even alternative for fossil fuel.Although catalytic hydrothermal processes appear as promising valorization routes to transfer biomass to sustainable methane,the safety and supply source of high-pressure hydrogen remain key factors restricting the widespread application.Herein,a catalytic approach without an external hydrogen source was developed to transform waste biomass resources into CH_(4)under the Ni-Mo catalyst.The total carbon yield of gas products reached up to 92.2%,of which the yield of methane and C2–C4 hydrocarbons were 44.9%and 3.0%,respectively.And it’s calculated that approximately 343.6 liters of CH_(4)could potentially be generated from 1 kilogram of raw biomass.Ni-based catalysts exhibited the robust activity in cleaving C–C and C–O bonds.And the introduction of an appropriate amount of molybdenum significantly enhanced catalytic performance of reforming and subsequent methanation reaction,likely due to the high adsorption capacity of highly dispersed Ni-Mo catalysts for carbon monoxide and hydrogen molecules,facilitating the methanation reaction.The pathway of catalytic methane production might be inferred that CO,H_(2)and a large number of oxygen-containing intermediates were formed via decarbonylation,dehydrogenation,and retro-aldol condensation reaction under hydrothermal condition.These intermediates then underwent the reforming reaction to generate H_(2)and CO_(2),ultimately forming CH_(4)through the methanation reaction.展开更多
基金This study was supported by the National Nature Scientific Fund (No.39730220).
文摘To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced by cecal ligation and puncture (CLP). ET1 receptor was assayed by using [125I]- ET1 binding. Marker enzyme activities, protein yield, and dry- to- wet weight ratio of cardiac membranes were measured. Results. Septic rat heart exhibited two distinct phases: an initial hyperdynamic phase( 9h after CLP; early stage of sepsis) followed by a hypodynamic (18h after CLP, late stage of sepsis) phase. [125I]- ET1 binding study showed that during early stage of sepsis, the Bmax of ET1 receptors was increased by 30％ in sarcolemma but decreased by 19％ in light vesicles, while during late stage of sepsis, the Bmax was decreased by 24％ in sarcolemma but increased by 38％ in light vesicles.The total binding of sarcolemma and light vesicles was increased by 25％ during early stage of sepsis but decreased by 17％ during late stage of sepsis. Conclusions. These data indicated that ET1 receptors in the rat heart were externalized from light vesicles to sarcolemmal membranes during early hyperdynamic phase while internalized from surface membranes to intracellular compartment during late hypodynamic phase of sepsis.
基金funded by National Key R&D Program of China (2016YFC1301200)
文摘Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention(PCI) for coronary chronic total occlusion(CTO), retrograde wire externalization still remains challenging and time-consuming in some cases. Cases utilizing ‘‘Active Greeting Technique(AGT)", a mother-and-child catheter based technique to facilitate retrograde wire externalization, were extracted from Chronic Total Occlusion Club, China(CTOCC) database. AGT was performed by deep intubation a mother-and-child catheter(GuidezillaTMextension, 4 or 5 Fr inner catheter, and etc.) in combination with either reverse controlled antegrade or retrograde subintimal tracking(CART) technique or retrograde wire crossing technique. A total of 111 patients with 112 CTO lesions treated with this technique were retrospectively analyzed. Reverse CART technique and retrograde wire crossing technique were performed in 90.2% and 9.8% of all procedures. The utilization of GuidezillaTMextension, 4 Fr, and 5 Fr inner catheter accounted for 94.6%, 3.6%, and 1.8%, respectively. Externalization of retrograde wire was successful in all cases. No procedural complications were adjudicated to AGT. Complications independent of AGT included two target vessel perforations and two collateral perforations. No in-hospital major adverse cardiac events were found. AGT is a feasible and safe technique that facilitates retrograde wire externalization.
基金financially supported by the Key Research and Development Program of Ningbo(Grant No.2023Z098)Natural Science Foundation of Inner Mongolia(Grant No.2023MS05040)+1 种基金Shenyang Collaborative Innovation Center Project for Multiple Energy Fields Composite Processing of Special Materials(Grant No.JG210027)Shenyang Key Technology Special Project of The Open Competition Mechanism to Select the Best Solution(Grant Nos.2022210101000827,2022-0-43-048).
文摘Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.
文摘Bcakground: Pancreatic pseudocyst (PPC) is a common complication arising from acute or chronic pancreatitis, trauma, or pancreatic duct obstruction. When acute fluid collection persists for 4 - 6 weeks and is encapsulated by a fibrous wall, it is classified as a pancreatic pseudocyst. While PPC is generally asymptomatic in many patients, it can manifest with persistent abdominal pain, dyspepsia, intra-cystic infection, and potentially lead to gastrointestinal obstruction in some cases. Although smaller PPCs may resolve spontaneously, larger PPCs tend to be refractory to absorption and often necessitate surgical intervention to prevent complications such as intracystic hemorrhage. Objective: To explore the efficacy of percutaneous catheterization with negative pressure in the treatment of large pancreatic pseudocysts. Methods: The cases of large pancreatic pseudocysts treated in our hospital from 2004 to 2022 were retrospectively collected, and the general condition, operation time, drainage time, feeding time, postoperative complications, hospital stay, cost and follow-up of the patients were analyzed. Results: A total of 132 patients with large pancreatic pseudocysts were collected. The average operation time was 32.4 ± 2.1 min;The retention time of the drainage tube was 30 ± 1.8 days in the percutaneous negative pressure drainage group;The postoperative feeding time was no fasting after local anesthesia drainage;Postoperative complications (bleeding, infection, pancreatic leakage, recurrence, anastomotic leakage, etc.): Two of the 132 patients had recurrent cysts, which were cured by re-puncture and negative pressure drainage. The length of hospital stay was 6 ± 1.1 days;The cost was 11,200 ± 1300 yuan;Follow-up: The follow-up time ranged from 1 to 3 years, and the patients had no discomfort. Conclusion: Percutaneous catheterization and negative pressure drainage can effectively treat large pancreatic pseudocysts. Compared with other treatment methods, it is simple and effective, the postoperative recovery of patients is faster, the physical damage is less, the hospital stay is shorter, and the cost is lower.
基金financially supported by the National Natural Science Foundation of China(Nos.52175284 and 52474396)the National Key Research and Development Program of China(No.2022YFB3404201)。
文摘High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile industry.Mg can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated die-castings.Herein,the development of non-heat treatment Al alloys is becoming the hot topic.In addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of castings.To achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and Ce.Their influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic simulation.Our results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased porosity.Meanwhile,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical properties.Subsequent introduction of Ce resulted in the poisoning effect and reduced mechanical properties.
基金Funded by Chinese National Natural Science Foundation of China(No.U2006224)。
文摘The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 versa.The results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack time.In addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate erosion.The damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC pastes.Furthermore,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.
文摘BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core muscles.In both static and dynamic movements,the Sahrmann core stability test provides an assessment of core muscle activation and a person's ability to stabilize the lumbopelvic complex.Preparatory cues and images can be used to increase the activation of these muscles.To attain optimal movement patterns,it will be necessary to determine what cueing will give the most effective results for core stability.AIM To investigate the effects of external and internal cues on core muscle activation during the Sahrmann five-level core stability test.METHODS Total 68 participants(21.83±3.47 years)were randomly allocated to an external(n=35)or internal cue group(n=33).Participants performed the Sahrmann fivelevel core stability test without a cue as baseline and the five-level stability exercises with an internal or external cue.External cue group received a pressure biofeedback unit(PBU),and the internal cue group received an audio cue.A Delsys Trigno^(TM)surface electromyography unit was used for muscle activation from the rectus abdominis,external oblique,and transverse abdominis/internal oblique muscles.RESULTS Linear mixed effects model analysis showed that cueing had a significant effect on core muscle activation(P=0.001);however,there was no significant difference between cue types(internal or external)(P=0.130).CONCLUSION Both external and internal cueing have significant effects on core muscle activation during the Sahrmann five-level core stability test and the PBU does not create higher muscle activation than internal cueing.
文摘3D audio effects can provide immersive auditory experience, but we often face the so-called in-head localization （IHL） problem in headphone sound reproduction. To ad- dress this problem, we propose an effective sound image externalization approach. Specifically, we consider several important factors related to sound propagation, which include image-source model based early reflections with distance decay, wall absorption and air absorption, late reverberation and other dynamic factors like head movement. We apply our sound image externalization approach to a headphone based real-time 3D audio system. Subjective listening tests show that the sound image externalization performance is significantly improved and the sound source direction is preserved as well. A/B preference test further shows that, as compared with a recent popular approach, the proposed approach is mostly preferred by the listeners.
文摘Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was scheduled for suspected urothelial carcinoma of the distal ureter in a 60-year-old woman.The patient involved in the present research signed a dedicated form to consent to the publication of images and/or information about her.Past medical history included Brugada syndrome diagnosed in 2015,and hypercholesterolemia.Past surgical history included one cesarean section only.Family history included ovarian cancer(sister),colorectal cancer(mother),and kidney cancer(father).
基金supported by the Hunan Province Municipal Natural Science Foundation(2022JJ30018)the Hunan Province Health Commission Science Foundation(B202301037899)to WNL。
文摘This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in the Hunan Province(China)in 2022 and searched for data in the published literature from January2000 to December 2023 in China.On the basis of these data,we analyzed the coefficients of variation and acceptable biases of different quality control materials for basic semen analysis through robust statistics.We compared these findings with quality specifications based on biological variation from optimal,desirable,and minimum levels of bias to seek a unified and more suitable semen EQAbias evaluation standard for China's national conditions.Different sources of semen quality control material exhibited considerable variation in acceptable biases among laboratories,ranging from 8.2%to 56.9%.A total of 50.0% of the laboratories met the minimum quality specifications for progressive motility(PR),whereas 100.0%and 75.0%of laboratories met only the minimum quality specifications for sperm concentration and total motility(nonprogressive[NP]+PR),respectively.The Z value for sperm concentration and PR+NP was equivalent to the desirable performance specification,whereas the Z value for PR was equivalent only to the minimum performance specification.This study highlights the feasibility of operating external quality assessment schemes for basic semen analysis using quality specifications based on biological variation.These specifications should be unified among external quality control(EQC)centers based on biological variation.
文摘Basic life support for cardiac arrest associates cardiopulmonary resuscitation(CPR)and defibrillation.CPR relies on chest compressions(CC)and ventilation.Current guidelines on CPR recommend a depth of 5-6 cm at a rhythm of 100-120 times/min for CC.[1,2]Interruptions of the CC must be as short as possible and are related to ventilation,defibrillation and turnover of the rescuers.Most of the automated external defibrillators(AEDs)require interruptions of the CC to perform rhythm analysis.Among the numerous marketed models of AEDs,some provide real-time feedback about the quality of the CC.
基金supported by the Guangxi Science and Technology Major Program of China(Nos.AA23073019 and AA24263074)the National Natural Science Foundation of China(No.52265004)+7 种基金the Guangxi Natural Science Fund for Distinguished Young Scholars of China(No.2024JJG160014)the Innovation Project of Guangxi Graduate Education of China(No.YCSW2024119)the Open Fund of State Key Laboratory of Intelligent Manufacturing Equipment and Technology of China(No.IMETKF2025021)the Open Research Fund of State Key Laboratory of Precision Manufacturing for Extreme Service Performance-Central South University of China(No.Kfkt2023-06)the Open Fund of High-end Basic Component Innovation Station of China(No.KY01080030124001)the Open Fund for Academician Mao Ming's Workstation of China(No.XSJSFW-QNKXJ-202404-007)the Technology Innovation Platform Project of China Aviation Engine Group Corporation(No.CXPT-2023-044)the Open Fund for Innovation Workstation in the National Defense Science and Technology Innovation Special Zone(Xi'an Jiaotong University).
文摘The metamaterial based on external meshing gears(MEG)is designed based on the principle of external meshing gear transmission.Based on the meshing transmission principle of external meshing gears and planetary gear trains,the internal and external gear rings are designed.Based on the internal and external gear rings,the metamaterial based on inner and outer planetary gear trains(MIP)is designed to study the shear modulus,Young's modulus,and amplitude-frequency characteristics of the metamaterial based on gears at different angles.The effects of the number of planetary gears on the physical characteristics of the MIP are studied.The results show that the MEG can be continuously adjusted by adjusting the shear modulus and Young's modulus due to its meshing characteristics.With the same number of gears,the adjustment range of the MIP is larger than the adjustment range of the MEG.When the number of planetary gears increases,the adjustment range of the MIP decreases.Moreover,when the metamaterial based on gears rotates,the harmonic response changes with the change of the angle.
基金supported by the Deutsche Forschungsgemeinschaft(DFG)(Grant No.501298479)。
文摘Direct numerical simulations of a uniform flow past a fixed spherical droplet are performed to investigate the parameter range within which the axisymmetric flow becomes unstable due to an external flow bifurcation.The hydrodynamics is governed by three dimensionless parameters:the viscosity ratioμ*,the external Reynolds numbers Re^(e),and internal Reynolds numbers Re^(i),respectively.The drop-to-fluid density ratio is related to these parameters asρ*=μ*Re^(i)/Re^(e).This study focuses on highly viscous droplets withμ*≥5,where wake instability is driven by the vorticity flux transferred from the droplet surface into the surrounding fluid.By analysing the wake structure,we confirm that the onset of the external bifurcation is linked to the tilting of the azimuthal vorticityωϕ,in the wake and that the bifurcation occurs once the isocontours ofωϕalign nearly perpendicular to the symmetry axis.We propose an empirical criterion for predicting the onset of the external bifurcation,formulated in terms of the maximum vorticity on the external side of the droplet surface.This criterion is applicable for sufficiently high Re^(i) and holds over a wide range ofμ*and Re^(e).Additionally,we examine the bifurcation sequence for two specific external Reynolds numbers,Re^(e)=300 and Re^(e)=500,and show that,beyond a critical viscosity ratio,the axisymmetric wake first transitions to a steady planar-symmetric state before undergoing a secondary Hopf bifurcation.Finally,we highlight the influence of Re^(i) on external bifurcation and show that,at moderate Re^(i),wake instability may set in at a lower vorticity threshold than predicted by our criterion.These findings provide new insights into the external flow bifurcation of viscous droplets.
基金Supported by the Joint Construction Project of Medical Science and Technology Research Plan in Henan Province(LHGJ20190879).
文摘[Objectives]To observe the clinical efficacy of external application of Scorzonera Herpes Ointment combined with Methylprednisolone Sodium Succinate for Injection in the treatment of herpes zoster oticus(HZO).[Methods]A total of 100 HZO patients admitted to the 988 th Hospital of the Joint Logistics Support Force and Henan Provincial People's Hospital from June 2021 to June 2023 were selected.They were divided into a treatment group and a control group using a random number table method,with 50 cases in each group.Both groups received Methylprednisolone Sodium Succinate for Injection.Additionally,the treatment group was treated with external application of Scorzonera Herpes Ointment,while the control group received acyclovir ointment.Both groups were treated for 10 d.The comparisons included clinical efficacy,total symptom and sign scores,pain level[Visual Analogue Scale(VAS)],time for erythema reduction,cessation of blister formation,scab formation,and scab shedding,incidence of post-herpetic neuralgia(PHN),air conduction hearing threshold,and air-bone gap.[Results]After 10 d of treatment,the total effective rate was 98.00%(49/50)in the treatment group and 84.00%(42/50)in the control group,with a statistically significant difference between the two groups(P<0.05).After 10 d of treatment,the total symptom and sign scores and VAS scores of both groups decreased compared to those before treatment.The treatment group had significantly lower scores than the control group(P<0.05).The treatment group showed significantly shorter time for erythema reduction,cessation of blister formation,scab formation,and scab shedding compared to the control group(P<0.05).During the 1-month follow-up after treatment,no PHN cases occurred in the treatment group,while the incidence of PHN in the control group was 24.00%(12/50),showing a statistically significant difference(P<0.05).After 10 d of treatment,both groups showed reduced air conduction hearing thresholds,and the treatment group exhibited significantly lower air conduction thresholds and air-bone gaps compared to the control group(P<0.05).No statistically significant difference was observed in the air-bone gap before and after treatment in the control group(P>0.05).[Conclusions]The combination of external application of Scorzonera Herpes Ointment and Methylprednisolone Sodium Succinate for Injection can alleviate pain and other discomforts,reduce PHN incidence,shorten disease duration,and improve hearing in HZO patients.
文摘Objective To study the redistribution of ET1 receptors in two subcellular organelles, the sarcolemmal membrane and the light vesicle, of rat heart during the progress of septic shock Methods Male Sprague Dawley rats weighing from 270 to 320?g were randomly divided into three groups: control, early sepsis, and late sepsis Each group included six rats Sepsis was induced by cecal ligation and puncture (CLP) Control rats were sham operated After operation for 9 hours or 18 hours, animals of the three groups were anesthetized with sodium pentobarbital (60?mg/kg IP) and the hearts were removed for preparation of sarcolemma and light vesicle Hemodynamic parameters were determined with polygraph via femoral artery and intraventricular cannula ET1 receptor was assayed by [ 125 I] ET1 binding Results Heart rate, cardiac output and left ventricular +dp/dt max undergo biphasic changes: an increase in early phase of sepsis (9?h after CLP) followed by a decrease in late phase of sepsis (18?h after CLP) Mean arterial blood pressure and left ventricular dp/dt max remained relatively unaltered during early phase of sepsis but was decreased during late phase of sepsis Although septic rat heart exhibited biphasic cardiodynamic changes, myocardial function showed signs of progressive deterioration during the development of sepsis, as indicated by a progressive elevation of LVEDP [ 125 I] ET1 bindings to cardiac membranes exhibited a saturable process with a single component binding characteristic for all three experimental groups In sarcolemmal membrane fraction, the maximum binding capacity (B max ) calculated from scatchard plot was increased 30% ( P <0 01) during early phase of sepsis but decreased 24% ( P <0 01) during late phase of sepsis The affinity [the reciprocal of the dissociation contant (Kd)] for [ 125 I] ET1 binding in sarcolemmal membranes remained unaffected during early and late phases of sepsis In light vesicle fraction, the B max for [ 125 I] ET1 binding was decreased by 19% ( P <0 05) during early phase of sepsis but increased by 38% ( P <0 01) during late phase of sepsis The affinity for [ 125 I] ET1 binding in light vesicles was unaltered in early and late phases of sepsis It should be mentioned that the sum of Bmax of sarcolemmal and light vesicle fractions was increased by 25% ( P <0 01) during early phase of sepsis but was decreased by 17% ( P <0 01) during late phase of sepsis Conclusions These data indicated that a biphasic intracellular redistribution of ET1 receptor in the heart might contribute to the development of the initial hyperdynamic and subsequent hypodynamic state during sepsis
文摘Management of post-traumatic long-bone defects remains relevant and cha-llenging despite the rapid development of approaches to their treatment.Do-minant positions are occupied by the Ilizarov method,bone autogenous grafting and the Masquelet induced membrane technique(IMT).The IMT is aimed at reducing extensive defect treatment duration and for this reason has gained great popularity.However,the assessment of its effectiveness is difficult due to a limited number of clinical series.The varying clinical manifestations of bone defect severity do not allow a comprehensive evaluation of IMT effectiveness.One of them is infection in the defect area.The purpose of our literature review is an analysis of studies on IMT application in infected vs non-infected long-bone defects of the lower extremities published over the last 10 years.It focuses on the investigation of similarities and fundamental differences in the need for antibiotics,timing of spacer fixation,methods of collecting donor bone and fixators used for consolidation.The studies show that the IMT has been globally used in aseptic and osteomyelitic defects due to its clinical effectiveness.Authors’variations and improvements in its practical implementation indicate the ongoing development and the interest of researchers in this technique.
基金supported by Henan Province Science and Technology Research Funding Project(No.222102320129)the Key Research Project of Henan Higher Education Institutions(Grant Nos.22A560004,22A56005).
文摘As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced bridges.Numerical examples show that compared with the natural frequencies of first-order modes,the natural frequencies of higher-order modes are more sensitive and can reflect the damage situation and external cable reinforcement effect of T-beam bridges.For damaged bridges,as the damage to the T-beam increases,the natural frequency value of the bridge gradually decreases.When the degree of local damage to the beam reaches 60%,the amplitude of natural frequency change exceeds 10%for the first time.The natural frequencies of the firstorder vibration mode and higher-order vibration mode can be selected as indexes for different degrees of the damaged T-beam bridges.For damaged bridges reinforced with external cables,the traditional natural frequency of the first-order vibration mode cannot be used as the index,which is insensitive to changes in prestress of the external cable.Some natural frequencies of higher-order vibration modes can be selected as indexes,which can reflect the reinforcement effect of externally prestressed damaged T-beam bridges,and its numerical value increases with the increase of external prestressed cable force.
基金supported by the National Natural Science Foundation of China(Grant Nos.42130604)the National Key Research and Development Program of China(Grant No.2023YFF0804704)+2 种基金the National Natural Science Foundation of China(Grant Nos.42105044)Swedish STINT(Grant No.CH2019-8377)the Priority Academic Program Development of Jiangsu Higher Education Institutions(Grant No.164320H116)。
文摘Since the mid-20th century,the Mongolian Plateau(MP)has experienced decadal droughts coupled with extreme heatwaves,severely affecting regional ecology and social development.However,the mechanisms behind these decadalscale compound heatwavedrought events remain debated.Here,using reconstructions and simulations from the Community Earth System Model Last Millennium Ensemble,we demonstrate that,over the last millennium,decadal droughts on the MP occurred under both warm and cold conditions,differing from recent compound heatwavedrought events.We found that by examining temperature changes during these drought periods,the distinct influences of external forcings and internal variability can be simply and effectively distinguished.Specifically,colddry events were primarily driven by volcanic eruptions that weakened the East Asian summer monsoon and midlatitude westerlies,reducing moisture transport to the MP.In contrast,warmdry events were predominantly induced by internal variability,notably the negative phase of the Atlantic Multidecadal Oscillation and the expansion of the Barents Sea ice extent.The recent extreme compound event was probably influenced by the combined effects of anthropogenic forcings and internal variability.These findings deepen our understanding of how external forcings and internal variability affect decadal drought events on the MP and highlight that recent compound events are unprecedented in the context of the last millennium.
文摘The estimated annual incidence of out-of-hospital cardiac arrest(OHCA)is approximately 120 cases per 100000 inhabitants in western countries.Although the rates of bystander cardiopulmonary resuscitation(CPR)and use of automated external defibrillator are increasing,the likelihood of survival to hospital discharge is no more than 8%.To date,various devices and methods have been utilized in the initial CPR approach targeting to improve survival and neurological outcomes in OHCA patients.The aim of this review is to discuss strategies that facilitate resuscitation,increase the chance to achieve return to spontaneous circulation and improve survival to hospital discharge and neurological outcomes in the prehospital setting.
文摘Methane,the primary constituent of natural gas,shale gas,and flammable ice,serves as a crucial carbon-based energy source and chemical feedstock.Traditional gas reserves are universally acknowledged as limited and non-renewable resources over an extended timespan stretching from decades to millennia.Biomethane,with its unique renewable properties,showcases remarkable development potential and presents a compelling supplement and even alternative for fossil fuel.Although catalytic hydrothermal processes appear as promising valorization routes to transfer biomass to sustainable methane,the safety and supply source of high-pressure hydrogen remain key factors restricting the widespread application.Herein,a catalytic approach without an external hydrogen source was developed to transform waste biomass resources into CH_(4)under the Ni-Mo catalyst.The total carbon yield of gas products reached up to 92.2%,of which the yield of methane and C2–C4 hydrocarbons were 44.9%and 3.0%,respectively.And it’s calculated that approximately 343.6 liters of CH_(4)could potentially be generated from 1 kilogram of raw biomass.Ni-based catalysts exhibited the robust activity in cleaving C–C and C–O bonds.And the introduction of an appropriate amount of molybdenum significantly enhanced catalytic performance of reforming and subsequent methanation reaction,likely due to the high adsorption capacity of highly dispersed Ni-Mo catalysts for carbon monoxide and hydrogen molecules,facilitating the methanation reaction.The pathway of catalytic methane production might be inferred that CO,H_(2)and a large number of oxygen-containing intermediates were formed via decarbonylation,dehydrogenation,and retro-aldol condensation reaction under hydrothermal condition.These intermediates then underwent the reforming reaction to generate H_(2)and CO_(2),ultimately forming CH_(4)through the methanation reaction.
