To editor:Neural tube defects(NTDs)are congenital anomalies that can be classified as open or closed.Open NTDs include acrania,exencephaly,anencephaly,spina bifida,craniorachischisis,encephalocele,and iniencephaly.The...To editor:Neural tube defects(NTDs)are congenital anomalies that can be classified as open or closed.Open NTDs include acrania,exencephaly,anencephaly,spina bifida,craniorachischisis,encephalocele,and iniencephaly.The acrania-exencephaly-anencephaly sequence represents a spectrum of central nervous system(CNS)malformations characterized by gross deformities of brain tissue and the absence of the cranial vault.Craniorachischisis results from congenital fissuring of the skull and vertebral column,occurring due to the failure of normal neural tube closure during primary neurulation in early CNS development.1 Failure of cranial pore closure leads to anencephaly,while failure along the spinal axis results in spinal rachischisis totalis.展开更多
文摘To editor:Neural tube defects(NTDs)are congenital anomalies that can be classified as open or closed.Open NTDs include acrania,exencephaly,anencephaly,spina bifida,craniorachischisis,encephalocele,and iniencephaly.The acrania-exencephaly-anencephaly sequence represents a spectrum of central nervous system(CNS)malformations characterized by gross deformities of brain tissue and the absence of the cranial vault.Craniorachischisis results from congenital fissuring of the skull and vertebral column,occurring due to the failure of normal neural tube closure during primary neurulation in early CNS development.1 Failure of cranial pore closure leads to anencephaly,while failure along the spinal axis results in spinal rachischisis totalis.
