Objective To observe the clinical efficacy of excitement transfer therapy for insomnia. Methods According to the inclusion criteria, 32 patients, selected from Guoyitang, affiliated Zhongshan Hospital Yanwu Branch of ...Objective To observe the clinical efficacy of excitement transfer therapy for insomnia. Methods According to the inclusion criteria, 32 patients, selected from Guoyitang, affiliated Zhongshan Hospital Yanwu Branch of Xiamen University from May to October, 2016, were diagnosed with insomnia and included in this study. All the patients were treated by adopting the excitement transfer therapy, i.e. cluster needling was carried out at the acupoints of wrist and ankle in the manner of penetration needling, and combined with sliding- cupping at governor vessel and bladder meridian on the back. All the subjects were treated for 3 times per week, and treatment for 6 times was considered as I course of treatment. The curative effect was observed after treatment for 2 courses, and follow-up visit was performed for two months after treatment. Efficacy evaluation criteria were established by reference to Guidelines of Clinical Research on Chinese New Herbal Medicine （Trial） Results Cured： 11 cases （34%4 markedly effective： 16 cases （50%）, effective： 4 cases （13%4 ineffective： 1 case. The total effective rate was up to 97%. There was no relapse during two months after the treatment. Conclusion The efficacy of excitement transfer therapy for insomnia was significant, which was worthy of clinical promotion and application.展开更多
after a successful launch of the year-long event at the State Theater in capital Pretoda. At the inaugural ceremony, artists from China and South Africa provided a large appreciative audience the opportunity to engage...after a successful launch of the year-long event at the State Theater in capital Pretoda. At the inaugural ceremony, artists from China and South Africa provided a large appreciative audience the opportunity to engage in an eclectic mix of entertainment. Ancient Chinese folk songs sung by African singers and South African mining songs sung by Chinese tenors all created a rapport that lies at the heart of the Sino-South African relationship.展开更多
One of the pleasantest of Toms dreams had been realized.He had often longed to go off on some adventure with a band of outlaws,and here was his opportunity.The day was perfect,the river was smooth,and the woods along ...One of the pleasantest of Toms dreams had been realized.He had often longed to go off on some adventure with a band of outlaws,and here was his opportunity.The day was perfect,the river was smooth,and the woods along the shore were full of the music of birds.Tom and Joe Harper had planned their escape carefully.They had gathered their provisions and hidden them in a secret place.Now,with their hearts full of excitement,they set off down the river in a small raft they had built.展开更多
The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700nm) has attracted considerable attention in the past decade. In contrast to conventional NIR-I window excitation (808nm/980nm), FLI ...The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700nm) has attracted considerable attention in the past decade. In contrast to conventional NIR-I window excitation (808nm/980nm), FLI with NIR-II window excitation (1064nm/other wavelength beyond 1000nm) can afford deeper tissue penetration depth with high clarity due to the merits of suppressed photon scattering and diminished autofluorescence. In this review, we have summarized NIR-II window excitable/emissive organic/polymeric fluorophores recently developed. The characteristics of these fluorophores such as chemical structures and photophysical properties have also been critically discussed. Furthermore, the latest development of noninvasive in vivo FLI with NIR-II excitation was highlighted. The ideal imaging results emphasized the importance of NIR-II excitation of these fluorophores in enabling deep tissue penetration and high-resolution imaging. Finally, a perspective on the challenges and prospects of NIR-II excitable/emissive organic/polymeric fluorophores was also discussed. We expected this review will be served as a source of inspiration for researchers, stimulating the creation of novel NIR-II excitable fluorophores and fostering the development of bioimaging applications.展开更多
The dissolved organic matter(DOM)with high mobility and reactivity plays a crucial role in soil.In this study,the characteristics and phytotoxicity ofDOMreleased fromthe hydrochars prepared from different feedstocks(c...The dissolved organic matter(DOM)with high mobility and reactivity plays a crucial role in soil.In this study,the characteristics and phytotoxicity ofDOMreleased fromthe hydrochars prepared from different feedstocks(cowmanure,corn stalk and Myriophyllum aquaticum)under three hydrothermal carbonization(HTC)temperatures(180,200 and 220°C)were evaluated.The results showed that the hydrochars had high dissolved organic carbon content(20.15 to 37.65 mg/g)and its content showed a gradual reduction as HTC temperature increased.Three fluorescent components including mixed substance of fulvic acid-like and humic acid-like substances(C1,30.92%-58.32%),UVA humic acid-like substance(C2,25.27%-29.94%)and protein-like substance(C3,11.74%-41.92%)were identified in hydrochar DOM by excitation emission matrix spectra coupled with parallel factor analysis.High HTC temperature increased the relative proportion of aromatic substances(C1+C2)and humification degree of hydrochar DOM from cow manure,while it presented adverse effects on the hydrochar DOM from corn stalk and Myriophyllum.aquaticum.The principal component analysis suggested that feedstock type and HTC temperature posed significant effects on the characteristics of hydrochar DOM.Additionally,seed germination test of all hydrochar DOM demonstrated that the root length was reduced by 8.88%-26.43%in contrast with control,and the germination index values were 73.57%-91.12%.These findings provided new insights into the potential environmental effects for hydrochar application in soil.展开更多
The ultrafast excitation dynamics of atoms and molecules exposed to circularly polarized two-color(CPTC)laser fields constitute a fascinating topic in attosecond science. Although extensive research has established th...The ultrafast excitation dynamics of atoms and molecules exposed to circularly polarized two-color(CPTC)laser fields constitute a fascinating topic in attosecond science. Although extensive research has established the relationship between the Rydberg state excitation(RSE) yields and the CPTC field parameters, such as field amplitude ratios and helicity of two components, the role of the relative phase(φ) in modulating RSE efficiency remains unclear. In this work, we theoretically investigate the φ dependence of RSE and ionization yields in the co-rotating and counter-rotating circularly polarized two-color(CPTC) few-cycle laser fields by a semiclassical model. We find that, in co-rotating CPTC fields, both RSE and ionization yields display pronounced oscillations as a function of φ and these oscillations are significantly suppressed in the counter-rotating configuration, particularly for ionization yields. Moreover, the ratio of RSE to ionization yields exhibits an out-of-phase oscillatory pattern between low-and high-intensity regimes. These results can be comprehended by the unique feature of φ dependence of CPTC few-cycle fields, based on our semiclassical analysis. Our results demonstrate that phase-controlled CPTC fields offer a versatile tool for steering ultrafast ionization and RSE dynamics of atoms and molecules.展开更多
Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and...Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and safety of acupuncture on corticospinal excitability(CSE),and the credibility of the evidence has yet to be quantified.Objective:This study was designed to assess the efficacy and safety of electroacupuncture(EA)and manual acupuncture(MA)in enhancing brain excitability,specifically focusing on CSE as measured by transcranial magnetic stimulation(TMS).Search strategy:This study followed a systematic approach,searching 9 databases up to August 2024 and examining grey literature,in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Inclusion criteria:Studies were included if they compared the clinical efficacy of EA or MA with sham acupuncture,no treatment or usual training.Data extraction and analysis:Three investigators independently conducted literature screening,data extraction,and risk of bias assessment.The primary outcome focused on motor-evoked potentials as measured by TMS,with treatment effects quantified using mean differences or standardized mean differences between pre-and post-treatment.Subgroup analyses were conducted using mixed-effects models,while random-effects or fixed-effects models were used to estimate average treatment differences across studies.Results:Based on 34 studies involving 1031 adults,acupuncture techniques significantly enhanced CSE.EA had a greater impact than MA,with effect sizes of 0.53 mV vs 0.43 mV(95%confidence interval[CI]:[0.30,0.76],P<0.00001 vs 95%CI:[0.28,0.59],P<0.00001).The 5 most frequently used acupoints were LI4(Hegu,32 times),ST36(Zusanli,10 times),LI11(Quchi,7 times),TE5(Waiguan,6 times),and GB34(Yanglingquan,5 times).Conclusion:This systematic review indicates that both EA and MA could effectively and safely enhance CSE,bringing the corticospinal pathway closer to the threshold for firing,which may ultimately improve motor function.LI4,ST36,LI11,TE5 and GB34 are the most commonly used acupoints.展开更多
This article presents the optical evaluation of the vibrational behavior of a steel bar,by a non-conventional optoacoustic procedure,the LPD(laser photo deflection)method.On this occasion the bar is located horizontal...This article presents the optical evaluation of the vibrational behavior of a steel bar,by a non-conventional optoacoustic procedure,the LPD(laser photo deflection)method.On this occasion the bar is located horizontal and fixed at both ends.Through our procedure we experimentally find the first 9 Eigen frequencies(21 Hz,60 Hz,116 Hz...)and correlate them using the cantilever theory.展开更多
Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically active molecules.An appealing approach for synthesizing these molecules is the amination of enamines,but few examples have been exp...Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically active molecules.An appealing approach for synthesizing these molecules is the amination of enamines,but few examples have been explored.With the utilization of nitrogen-centered radicals(NCRs),here we present the development of a dual bio-/photo-catalytic system for achieving enantioselective hydroamination of enamides,which can give easy access to diverse enantioenriched vicinal diamines.These reactions progress efficiently under green light excitation and exhibit excellent enantioselectivities(up to>99%enantiomeric excess).Mechanistic studies uncovered the synergistic effect of the enzyme and the externally added organophotoredox catalyst Rhodamine B(RhB).This work demonstrates the effectiveness of photobiocatalysis to generate and control high-energy radical intermediates,addressing a long-standing challenge in chemical synthesis.展开更多
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.展开更多
On the basis of the model tests,this paper explores the coupled hydrodynamic performance of the moonpool and the hull.This study aims to compare and analyze the variation in the hull heave response between the piston ...On the basis of the model tests,this paper explores the coupled hydrodynamic performance of the moonpool and the hull.This study aims to compare and analyze the variation in the hull heave response between the piston resonance state of the moonpool under wave excitation and the non-resonance state of the moonpool under wave-current excitation.A novel damping device specifically designed and fabricated for stepped moonpools has been developed.Before and after the installation of the damping device,the free surface response characteristics of the moonpool and heave motion response characteristics of the hull are compared.The findings show a clear correlation between the current speed and heave response characteristics of the hull.During the seakeeping design phase of the drilling vessel,the current speed is an additional critical factor that cannot be disregarded,alongside the moonpool effect.A correlation exists between the fluid dynamics occurring within the moonpool and the heave motion of the vessel hull.A reduction in the amplitude of the motion of the moonpool water results in a decrease in the heave motion of the hull.This study provides a reference for alleviating the seakeeping of a drill ship’s heave response and enhancing the safety and efficiency of the operation.展开更多
The kagome lattice has garnered significant attention due to its ability to host quantum spin Fermi liquid states.Recently,the combination of unique lattice geometry,electron–electron correlations,and adjustable magn...The kagome lattice has garnered significant attention due to its ability to host quantum spin Fermi liquid states.Recently,the combination of unique lattice geometry,electron–electron correlations,and adjustable magnetism in solid kagome materials has led to the discovery of numerous fascinating quantum properties.These include unconventional superconductivity,charge and spin density waves(CDW/SDW),pair density waves(PDW),and Chern insulator phases.These emergent states are closely associated with the distinctive characteristics of the kagome lattice's electronic structure,such as van Hove singularities,Dirac fermions,and flat bands,which can exhibit exotic quasi-particle excitations under different symmetries and magnetic conditions.Recently,various quantum kagome materials have been developed,typically consisting of kagome layers stacked along the z-axis with atoms either filling the geometric centers of the kagome lattice or embedded between the layers.In this topical review,we begin by introducing the fundamental properties of several kagome materials.To gain an in-depth understanding of the relationship between topology and correlation,we then discuss the complex phenomena observed in these systems.These include the simplest kagome metal T_(3)X,kagome intercalation metal T X,and the ternary compounds AT_(6)X_(6)and RT_(3)X_(5)(A=Li,Mg,Ca,or rare earth;T=V,Cr,Mn,Fe,Co,Ni;X=Sn,Ge;R=K,Rb,Cs).Finally,we provide a perspective on future experimental work in this field.展开更多
"You worked hard.You're almost done,"says Philip as he looks around.He's at his friend Brett's house。"Almost.Packing all these boxes was a lot of work.I'm excited to move into my new ap..."You worked hard.You're almost done,"says Philip as he looks around.He's at his friend Brett's house。"Almost.Packing all these boxes was a lot of work.I'm excited to move into my new apartment,"Brett says.展开更多
We studied the dynamic correlations of non-integrable systems with quantum many-body scar(QMBS)states generated by a ladder operator.The ladder operator's spectral function has an exact δ-function peak induced by...We studied the dynamic correlations of non-integrable systems with quantum many-body scar(QMBS)states generated by a ladder operator.The ladder operator's spectral function has an exact δ-function peak induced by the QMBS states.As a concrete example,we show that in the one-dimensional(1D)spin-1 Affleck-Kennedy-Lieb-Tasaki model,the spectral function of two-magnon excitations exhibits a characteristic bowtie shape composed of aδ-function resonance peak at momentum k=π and a continuum spectrum elsewhere.The two-magnon excitations can be observed via resonant inelastic X-ray scattering spectroscopy on quasi-1D nickelates and other spin-1 antiferromagnetic materials.Therefore,the findings of this study pave the way for detecting(approximate)QMBS states in realistic materials.展开更多
Fluorophores emitting in the second near-infrared window (NIR-II, 900–1700nm) allow for high-resolution deep-tissue bioimaging owing to minimal tissue scattering. Although J-aggregation offers a promising approach to...Fluorophores emitting in the second near-infrared window (NIR-II, 900–1700nm) allow for high-resolution deep-tissue bioimaging owing to minimal tissue scattering. Although J-aggregation offers a promising approach to developing long-wavelength emitters, the scarcity of J-type backbones and reliable design principles limits their application in biological imaging. Here, we introduce a strategy for engineering high-brightness NIR-II J-aggregated fluorophores by incorporating electron-withdrawing substituents into a fused-ring backbone. These substituents modulate the electrostatic potential (ESP) distribution across the conjugated backbone, reducing both electrostatic repulsion and intermolecular distance, which promotes ordered J-aggregation. As a result, Y8 aggregate (Y8 nanoparticles) exhibits an outstanding fluorescence quantum yield of up to 12.9% and strong near-infrared absorption in aqueous solution for high-performance NIR-II fluorescence imaging in vivo. This work not only presents a novel J-type backbone but also advances the understanding of the structure–property relationship critical to designing NIR-II J-aggregates.展开更多
Hydro-pneumatic near-zero frequency(NZF)vibration isolators have better performance at isolating vibration with low frequencies and heavy loadings when the nonlinear fluidic damping is introduced and the pressurized g...Hydro-pneumatic near-zero frequency(NZF)vibration isolators have better performance at isolating vibration with low frequencies and heavy loadings when the nonlinear fluidic damping is introduced and the pressurized gas pressure is properly adjusted.The nonlinear characteristics of such devices make their corresponding dynamic research involve chaotic dynamics.Chaos may bring negative influence and disorder to the structure and low-frequency working efficiency of isolators,which makes it necessary to clarify and control the threshold ranges for chaos generation in advance.In this work,the chaotic characteristics for a class of hydro-pneumatic NZF vibration isolators under dry friction,harmonic,and environmental noise excitations are analyzed by the analytical and numerical methods.The parameter ranges for the generation of chaos are obtained by the classical and random Melnikov methods.The chaotic characteristics and thresholds of the parameters in the systems with or without noise excitation are discussed and described.The analytical solutions and the influence of noise and harmonic excitation about chaos are tested and further analyzed through many numerical simulations.The results show that chaos in the system can be induced or inhibited with the adjustment of the magnitudes of harmonic excitation and noise intensity.展开更多
This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent ...This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent damping balance has been validated,which ensures computational accuracy while reducing response calculation time to only 1%of the traditional transient response method.At resonance speed,unsteady pressure disturbances on the rotor blade surface mainly arise from two sources:IGV wakes and blade vibrations.The unsteady pressure caused by the IGV wakes provides excitation for the system,while the unsteady pressure caused by rotor blade vibrations provides damping.By studying the characteristics of unsteady pressure caused by IGV wakes and vibrations at resonance speed,a method for separating unsteady pressure caused by stator wakes and vibrations has been presented,accurately obtaining aerodynamic damping under multi-row resonance conditions.Compared to the aerodynamic damping obtained from multi-row scenarios without separating unsteady pressures caused by stator wakes and vibrations,and the traditional isolated blade row scheme,the aerodynamic damping considering the effects of multi-row and IGV wakes at resonance speed is smaller.Based on the separated unsteady pressures caused by IGV wakes and vibrations,and combined with the equivalent damping balance method for predicting forced response,a forced response analysis method considering both flow field disturbance excitation and damping effects has been established.展开更多
Soil nailing is an effective method used for stabilizing excavations and natural ground slopes.In situations with space constraints due to rapid urbanization,the available space near the soil-nailed vertical cuts can ...Soil nailing is an effective method used for stabilizing excavations and natural ground slopes.In situations with space constraints due to rapid urbanization,the available space near the soil-nailed vertical cuts can be utilized to construct multi-storied buildings.However,the presence of a building in proximity to the retained soil mass may alter the seismic response of a nailed structure.The building can be either constructed at a distance,connected or attached to the soil-nailed structure depending on the space availability.This study evaluates the behavior of such an integrated soil-nailed,wall-building system under seismic excitations by employing finite element analysis.The seismic response of a nailed wall supporting a vertical cut of a height of 6m under different connectivity conditions with an adjacent multi-story RC building is analyzed.Parametric studies are conducted with various heights of a building and under different frequency content of seismic excitations.The performance of the integrated system is evaluated regarding displacement and the acceleration response of the soil-nailed wall,as well as tensile force mobilized in nails.The innovative concept of integration between the two structures yields better seismic stability of the nailed structure,as well as for optimum use of land in space-constrained grounds with vertical cuts.展开更多
Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parval...Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parvalbumin(PV) interneurons are pivotal contributors to cognitive processes and have been implicated in various central nervous system dysfunctions, including SAE. Oxytocin, known for its ability to augment the firing rate of gamma-aminobutyric acid(GABA)-ergic interneurons and directly stimulate inhibitory interneurons to enhance the tonic inhibition of pyramidal neurons, has prompted an investigation into its potential therapeutic effects on cognitive dysfunction in SAE. In the current study, we administered intranasal oxytocin to SAE mice induced by lipopolysaccharide. Behavioral assessments, including open field, Y-maze, and fear conditioning, were used to evaluate cognitive performance. Golgi staining revealed hippocampal synaptic deterioration, local field potential recordings showed weakened gamma oscillations, and immunofluorescence staining demonstrated decreased PV expression in the cornu ammonis 1(CA1) region of the hippocampus following lipopolysaccharide treatment, all of which were alleviated by oxytocin administration. Furthermore, immunofluorescence staining of PV co-localization with vesicular glutamate transporter 1 or vesicular GABA transporter indicated a balanced excitation/inhibition effect of neurotransmitters on PV interneurons after oxytocin administration in the SAE mice, leading to an improved cognitive function. In conclusion, oxytocin treatment improved cognitive function by increasing the number of PV^(+) neurons in the hippocampal CA1 region, restoring the balance of excitatory/inhibitory synaptic transmission on PV interneurons, and enhancing hippocampal CA1 local field potential gamma oscillations. These findings suggest a potential mechanism underlying the beneficial effects of oxytocin in SAE.展开更多
We theoretically investigate the elliptical high-order harmonic generation from H_(2)^(+)in two-color cross-linearlypolarized laser fields by numerically solving the two-dimensional time-dependent Schr¨odinger eq...We theoretically investigate the elliptical high-order harmonic generation from H_(2)^(+)in two-color cross-linearlypolarized laser fields by numerically solving the two-dimensional time-dependent Schr¨odinger equation.Numerical simulations show that the crossing-angle-dependent harmonic ellipticity exhibits a prominent antisymmetric structure,which tends to disappear as the internuclear distance increases.Furthermore,ground-state electrons experience resonant transitions to the first excited state at larger internuclear distances,where the disruption of symmetric electron motion suppresses the antisymmetric structure.Additionally,a near-circularly-polarized attosecond pulse can be obtained by modulating the crossing angle.展开更多
文摘Objective To observe the clinical efficacy of excitement transfer therapy for insomnia. Methods According to the inclusion criteria, 32 patients, selected from Guoyitang, affiliated Zhongshan Hospital Yanwu Branch of Xiamen University from May to October, 2016, were diagnosed with insomnia and included in this study. All the patients were treated by adopting the excitement transfer therapy, i.e. cluster needling was carried out at the acupoints of wrist and ankle in the manner of penetration needling, and combined with sliding- cupping at governor vessel and bladder meridian on the back. All the subjects were treated for 3 times per week, and treatment for 6 times was considered as I course of treatment. The curative effect was observed after treatment for 2 courses, and follow-up visit was performed for two months after treatment. Efficacy evaluation criteria were established by reference to Guidelines of Clinical Research on Chinese New Herbal Medicine （Trial） Results Cured： 11 cases （34%4 markedly effective： 16 cases （50%）, effective： 4 cases （13%4 ineffective： 1 case. The total effective rate was up to 97%. There was no relapse during two months after the treatment. Conclusion The efficacy of excitement transfer therapy for insomnia was significant, which was worthy of clinical promotion and application.
文摘after a successful launch of the year-long event at the State Theater in capital Pretoda. At the inaugural ceremony, artists from China and South Africa provided a large appreciative audience the opportunity to engage in an eclectic mix of entertainment. Ancient Chinese folk songs sung by African singers and South African mining songs sung by Chinese tenors all created a rapport that lies at the heart of the Sino-South African relationship.
文摘One of the pleasantest of Toms dreams had been realized.He had often longed to go off on some adventure with a band of outlaws,and here was his opportunity.The day was perfect,the river was smooth,and the woods along the shore were full of the music of birds.Tom and Joe Harper had planned their escape carefully.They had gathered their provisions and hidden them in a secret place.Now,with their hearts full of excitement,they set off down the river in a small raft they had built.
基金supported by the National Nature Science Foundation of China(Nos.62075079,62305127,61975200)the Natural Science Foundation of Jilin Province(20230508135RC)the Science and Technology Development Foundation of Changchun City(23GZZ15).
文摘The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700nm) has attracted considerable attention in the past decade. In contrast to conventional NIR-I window excitation (808nm/980nm), FLI with NIR-II window excitation (1064nm/other wavelength beyond 1000nm) can afford deeper tissue penetration depth with high clarity due to the merits of suppressed photon scattering and diminished autofluorescence. In this review, we have summarized NIR-II window excitable/emissive organic/polymeric fluorophores recently developed. The characteristics of these fluorophores such as chemical structures and photophysical properties have also been critically discussed. Furthermore, the latest development of noninvasive in vivo FLI with NIR-II excitation was highlighted. The ideal imaging results emphasized the importance of NIR-II excitation of these fluorophores in enabling deep tissue penetration and high-resolution imaging. Finally, a perspective on the challenges and prospects of NIR-II excitable/emissive organic/polymeric fluorophores was also discussed. We expected this review will be served as a source of inspiration for researchers, stimulating the creation of novel NIR-II excitable fluorophores and fostering the development of bioimaging applications.
基金supported by the Director Fund Project provided by the Institute of Plant Nutrition,Resources and Environment,Beijing Academy of Agriculture and Forestry Sciences(No.YZS202101)the Youth Fund Project provided by Beijing Academy of Agriculture and Forestry Sciences(No.QNJJ202125)China Agriculture Research System of MOF and MARA.
文摘The dissolved organic matter(DOM)with high mobility and reactivity plays a crucial role in soil.In this study,the characteristics and phytotoxicity ofDOMreleased fromthe hydrochars prepared from different feedstocks(cowmanure,corn stalk and Myriophyllum aquaticum)under three hydrothermal carbonization(HTC)temperatures(180,200 and 220°C)were evaluated.The results showed that the hydrochars had high dissolved organic carbon content(20.15 to 37.65 mg/g)and its content showed a gradual reduction as HTC temperature increased.Three fluorescent components including mixed substance of fulvic acid-like and humic acid-like substances(C1,30.92%-58.32%),UVA humic acid-like substance(C2,25.27%-29.94%)and protein-like substance(C3,11.74%-41.92%)were identified in hydrochar DOM by excitation emission matrix spectra coupled with parallel factor analysis.High HTC temperature increased the relative proportion of aromatic substances(C1+C2)and humification degree of hydrochar DOM from cow manure,while it presented adverse effects on the hydrochar DOM from corn stalk and Myriophyllum.aquaticum.The principal component analysis suggested that feedstock type and HTC temperature posed significant effects on the characteristics of hydrochar DOM.Additionally,seed germination test of all hydrochar DOM demonstrated that the root length was reduced by 8.88%-26.43%in contrast with control,and the germination index values were 73.57%-91.12%.These findings provided new insights into the potential environmental effects for hydrochar application in soil.
基金supported by the National Natural Science Foundation of China (Nos. 12121004, 12274273, and 12450402)the Science and Technology Department of Hubei Province (No. 2020CFA029)+1 种基金CAS Project for Young Scientists in Basic Research (No. YSBR-091)the Youth Innovation Promotion Association CAS (No. 2021328)。
文摘The ultrafast excitation dynamics of atoms and molecules exposed to circularly polarized two-color(CPTC)laser fields constitute a fascinating topic in attosecond science. Although extensive research has established the relationship between the Rydberg state excitation(RSE) yields and the CPTC field parameters, such as field amplitude ratios and helicity of two components, the role of the relative phase(φ) in modulating RSE efficiency remains unclear. In this work, we theoretically investigate the φ dependence of RSE and ionization yields in the co-rotating and counter-rotating circularly polarized two-color(CPTC) few-cycle laser fields by a semiclassical model. We find that, in co-rotating CPTC fields, both RSE and ionization yields display pronounced oscillations as a function of φ and these oscillations are significantly suppressed in the counter-rotating configuration, particularly for ionization yields. Moreover, the ratio of RSE to ionization yields exhibits an out-of-phase oscillatory pattern between low-and high-intensity regimes. These results can be comprehended by the unique feature of φ dependence of CPTC few-cycle fields, based on our semiclassical analysis. Our results demonstrate that phase-controlled CPTC fields offer a versatile tool for steering ultrafast ionization and RSE dynamics of atoms and molecules.
文摘Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and safety of acupuncture on corticospinal excitability(CSE),and the credibility of the evidence has yet to be quantified.Objective:This study was designed to assess the efficacy and safety of electroacupuncture(EA)and manual acupuncture(MA)in enhancing brain excitability,specifically focusing on CSE as measured by transcranial magnetic stimulation(TMS).Search strategy:This study followed a systematic approach,searching 9 databases up to August 2024 and examining grey literature,in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Inclusion criteria:Studies were included if they compared the clinical efficacy of EA or MA with sham acupuncture,no treatment or usual training.Data extraction and analysis:Three investigators independently conducted literature screening,data extraction,and risk of bias assessment.The primary outcome focused on motor-evoked potentials as measured by TMS,with treatment effects quantified using mean differences or standardized mean differences between pre-and post-treatment.Subgroup analyses were conducted using mixed-effects models,while random-effects or fixed-effects models were used to estimate average treatment differences across studies.Results:Based on 34 studies involving 1031 adults,acupuncture techniques significantly enhanced CSE.EA had a greater impact than MA,with effect sizes of 0.53 mV vs 0.43 mV(95%confidence interval[CI]:[0.30,0.76],P<0.00001 vs 95%CI:[0.28,0.59],P<0.00001).The 5 most frequently used acupoints were LI4(Hegu,32 times),ST36(Zusanli,10 times),LI11(Quchi,7 times),TE5(Waiguan,6 times),and GB34(Yanglingquan,5 times).Conclusion:This systematic review indicates that both EA and MA could effectively and safely enhance CSE,bringing the corticospinal pathway closer to the threshold for firing,which may ultimately improve motor function.LI4,ST36,LI11,TE5 and GB34 are the most commonly used acupoints.
文摘This article presents the optical evaluation of the vibrational behavior of a steel bar,by a non-conventional optoacoustic procedure,the LPD(laser photo deflection)method.On this occasion the bar is located horizontal and fixed at both ends.Through our procedure we experimentally find the first 9 Eigen frequencies(21 Hz,60 Hz,116 Hz...)and correlate them using the cantilever theory.
文摘Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically active molecules.An appealing approach for synthesizing these molecules is the amination of enamines,but few examples have been explored.With the utilization of nitrogen-centered radicals(NCRs),here we present the development of a dual bio-/photo-catalytic system for achieving enantioselective hydroamination of enamides,which can give easy access to diverse enantioenriched vicinal diamines.These reactions progress efficiently under green light excitation and exhibit excellent enantioselectivities(up to>99%enantiomeric excess).Mechanistic studies uncovered the synergistic effect of the enzyme and the externally added organophotoredox catalyst Rhodamine B(RhB).This work demonstrates the effectiveness of photobiocatalysis to generate and control high-energy radical intermediates,addressing a long-standing challenge in chemical synthesis.
基金supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW)the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW)+3 种基金the Shanghai Rising-Star Program,No. 23QA1407700 (to CW)the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW)the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL)the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
文摘Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.
基金supported by the National Natural Science Foundation of Jiangsu Province,China(Grant No.BK20231255).
文摘On the basis of the model tests,this paper explores the coupled hydrodynamic performance of the moonpool and the hull.This study aims to compare and analyze the variation in the hull heave response between the piston resonance state of the moonpool under wave excitation and the non-resonance state of the moonpool under wave-current excitation.A novel damping device specifically designed and fabricated for stepped moonpools has been developed.Before and after the installation of the damping device,the free surface response characteristics of the moonpool and heave motion response characteristics of the hull are compared.The findings show a clear correlation between the current speed and heave response characteristics of the hull.During the seakeeping design phase of the drilling vessel,the current speed is an additional critical factor that cannot be disregarded,alongside the moonpool effect.A correlation exists between the fluid dynamics occurring within the moonpool and the heave motion of the vessel hull.A reduction in the amplitude of the motion of the moonpool water results in a decrease in the heave motion of the hull.This study provides a reference for alleviating the seakeeping of a drill ship’s heave response and enhancing the safety and efficiency of the operation.
基金Project supported by the National Natural Science Foundation of China(Grant No.12204536)the Fundamental Research Funds for the Central Universitiesthe Research Funds of People’s Public Security University of China(PPSUC)(Grant No.2023JKF02ZK09)。
文摘The kagome lattice has garnered significant attention due to its ability to host quantum spin Fermi liquid states.Recently,the combination of unique lattice geometry,electron–electron correlations,and adjustable magnetism in solid kagome materials has led to the discovery of numerous fascinating quantum properties.These include unconventional superconductivity,charge and spin density waves(CDW/SDW),pair density waves(PDW),and Chern insulator phases.These emergent states are closely associated with the distinctive characteristics of the kagome lattice's electronic structure,such as van Hove singularities,Dirac fermions,and flat bands,which can exhibit exotic quasi-particle excitations under different symmetries and magnetic conditions.Recently,various quantum kagome materials have been developed,typically consisting of kagome layers stacked along the z-axis with atoms either filling the geometric centers of the kagome lattice or embedded between the layers.In this topical review,we begin by introducing the fundamental properties of several kagome materials.To gain an in-depth understanding of the relationship between topology and correlation,we then discuss the complex phenomena observed in these systems.These include the simplest kagome metal T_(3)X,kagome intercalation metal T X,and the ternary compounds AT_(6)X_(6)and RT_(3)X_(5)(A=Li,Mg,Ca,or rare earth;T=V,Cr,Mn,Fe,Co,Ni;X=Sn,Ge;R=K,Rb,Cs).Finally,we provide a perspective on future experimental work in this field.
文摘"You worked hard.You're almost done,"says Philip as he looks around.He's at his friend Brett's house。"Almost.Packing all these boxes was a lot of work.I'm excited to move into my new apartment,"Brett says.
基金supported by the National Natural Science Foundation of China(Grant No.12174387)the Chinese Academy of Sciences(Grant Nos.YSBR-057 and JZHKYPT-2021-08)the Innovative Program for Quantum Science and Technology(Grant No.2021ZD0302600)。
文摘We studied the dynamic correlations of non-integrable systems with quantum many-body scar(QMBS)states generated by a ladder operator.The ladder operator's spectral function has an exact δ-function peak induced by the QMBS states.As a concrete example,we show that in the one-dimensional(1D)spin-1 Affleck-Kennedy-Lieb-Tasaki model,the spectral function of two-magnon excitations exhibits a characteristic bowtie shape composed of aδ-function resonance peak at momentum k=π and a continuum spectrum elsewhere.The two-magnon excitations can be observed via resonant inelastic X-ray scattering spectroscopy on quasi-1D nickelates and other spin-1 antiferromagnetic materials.Therefore,the findings of this study pave the way for detecting(approximate)QMBS states in realistic materials.
基金support from the National Natural Science Foundation of China (Nos. 62175201 and 52373142)the Natural Science Foundation of Jiangsu Province of China (No. BK20220404)+1 种基金the Fundamental Research Funds for the Central Universitiesthe open research fund of State Key Laboratory of Organic Electronics and Information Displays.
文摘Fluorophores emitting in the second near-infrared window (NIR-II, 900–1700nm) allow for high-resolution deep-tissue bioimaging owing to minimal tissue scattering. Although J-aggregation offers a promising approach to developing long-wavelength emitters, the scarcity of J-type backbones and reliable design principles limits their application in biological imaging. Here, we introduce a strategy for engineering high-brightness NIR-II J-aggregated fluorophores by incorporating electron-withdrawing substituents into a fused-ring backbone. These substituents modulate the electrostatic potential (ESP) distribution across the conjugated backbone, reducing both electrostatic repulsion and intermolecular distance, which promotes ordered J-aggregation. As a result, Y8 aggregate (Y8 nanoparticles) exhibits an outstanding fluorescence quantum yield of up to 12.9% and strong near-infrared absorption in aqueous solution for high-performance NIR-II fluorescence imaging in vivo. This work not only presents a novel J-type backbone but also advances the understanding of the structure–property relationship critical to designing NIR-II J-aggregates.
基金Project supported by the National Natural Science Foundation of China(Nos.12172340 and12411530068)the Shenzhen Science and Technology Program(No.JCYJ20240813114012016)+2 种基金the High-Level Talent Introduction Plan of Guangzhou Citythe Fundamental Research Funds for the Central Universities-China University of Geosciences(Wuhan)(No.G1323524005)the Young Top-Notch Talent Cultivation Program of Hubei Province。
文摘Hydro-pneumatic near-zero frequency(NZF)vibration isolators have better performance at isolating vibration with low frequencies and heavy loadings when the nonlinear fluidic damping is introduced and the pressurized gas pressure is properly adjusted.The nonlinear characteristics of such devices make their corresponding dynamic research involve chaotic dynamics.Chaos may bring negative influence and disorder to the structure and low-frequency working efficiency of isolators,which makes it necessary to clarify and control the threshold ranges for chaos generation in advance.In this work,the chaotic characteristics for a class of hydro-pneumatic NZF vibration isolators under dry friction,harmonic,and environmental noise excitations are analyzed by the analytical and numerical methods.The parameter ranges for the generation of chaos are obtained by the classical and random Melnikov methods.The chaotic characteristics and thresholds of the parameters in the systems with or without noise excitation are discussed and described.The analytical solutions and the influence of noise and harmonic excitation about chaos are tested and further analyzed through many numerical simulations.The results show that chaos in the system can be induced or inhibited with the adjustment of the magnitudes of harmonic excitation and noise intensity.
基金co-supported by the National Natural Science Foundation of China(No.52306034)the National Science and Technology Major Project,China(No.J2022-IV-00100024)+1 种基金the Fundamental Research Funds for the Central Universities,Chinathe National Science and Technology Major Project,China(No.J2017-IV-0002-0039)。
文摘This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent damping balance has been validated,which ensures computational accuracy while reducing response calculation time to only 1%of the traditional transient response method.At resonance speed,unsteady pressure disturbances on the rotor blade surface mainly arise from two sources:IGV wakes and blade vibrations.The unsteady pressure caused by the IGV wakes provides excitation for the system,while the unsteady pressure caused by rotor blade vibrations provides damping.By studying the characteristics of unsteady pressure caused by IGV wakes and vibrations at resonance speed,a method for separating unsteady pressure caused by stator wakes and vibrations has been presented,accurately obtaining aerodynamic damping under multi-row resonance conditions.Compared to the aerodynamic damping obtained from multi-row scenarios without separating unsteady pressures caused by stator wakes and vibrations,and the traditional isolated blade row scheme,the aerodynamic damping considering the effects of multi-row and IGV wakes at resonance speed is smaller.Based on the separated unsteady pressures caused by IGV wakes and vibrations,and combined with the equivalent damping balance method for predicting forced response,a forced response analysis method considering both flow field disturbance excitation and damping effects has been established.
文摘Soil nailing is an effective method used for stabilizing excavations and natural ground slopes.In situations with space constraints due to rapid urbanization,the available space near the soil-nailed vertical cuts can be utilized to construct multi-storied buildings.However,the presence of a building in proximity to the retained soil mass may alter the seismic response of a nailed structure.The building can be either constructed at a distance,connected or attached to the soil-nailed structure depending on the space availability.This study evaluates the behavior of such an integrated soil-nailed,wall-building system under seismic excitations by employing finite element analysis.The seismic response of a nailed wall supporting a vertical cut of a height of 6m under different connectivity conditions with an adjacent multi-story RC building is analyzed.Parametric studies are conducted with various heights of a building and under different frequency content of seismic excitations.The performance of the integrated system is evaluated regarding displacement and the acceleration response of the soil-nailed wall,as well as tensile force mobilized in nails.The innovative concept of integration between the two structures yields better seismic stability of the nailed structure,as well as for optimum use of land in space-constrained grounds with vertical cuts.
基金supported by grants from the general project of Nanjing Medical University Science and Technology Development Foundation (Grant No.NMUB20210112)。
文摘Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parvalbumin(PV) interneurons are pivotal contributors to cognitive processes and have been implicated in various central nervous system dysfunctions, including SAE. Oxytocin, known for its ability to augment the firing rate of gamma-aminobutyric acid(GABA)-ergic interneurons and directly stimulate inhibitory interneurons to enhance the tonic inhibition of pyramidal neurons, has prompted an investigation into its potential therapeutic effects on cognitive dysfunction in SAE. In the current study, we administered intranasal oxytocin to SAE mice induced by lipopolysaccharide. Behavioral assessments, including open field, Y-maze, and fear conditioning, were used to evaluate cognitive performance. Golgi staining revealed hippocampal synaptic deterioration, local field potential recordings showed weakened gamma oscillations, and immunofluorescence staining demonstrated decreased PV expression in the cornu ammonis 1(CA1) region of the hippocampus following lipopolysaccharide treatment, all of which were alleviated by oxytocin administration. Furthermore, immunofluorescence staining of PV co-localization with vesicular glutamate transporter 1 or vesicular GABA transporter indicated a balanced excitation/inhibition effect of neurotransmitters on PV interneurons after oxytocin administration in the SAE mice, leading to an improved cognitive function. In conclusion, oxytocin treatment improved cognitive function by increasing the number of PV^(+) neurons in the hippocampal CA1 region, restoring the balance of excitatory/inhibitory synaptic transmission on PV interneurons, and enhancing hippocampal CA1 local field potential gamma oscillations. These findings suggest a potential mechanism underlying the beneficial effects of oxytocin in SAE.
基金supported by the National Natural Science Foundation of China(Grant Nos.11974229,12204291,and 11404204)the Fund from Graduate Students of Shanxi Normal University,China(Grant No.2023XSY044).
文摘We theoretically investigate the elliptical high-order harmonic generation from H_(2)^(+)in two-color cross-linearlypolarized laser fields by numerically solving the two-dimensional time-dependent Schr¨odinger equation.Numerical simulations show that the crossing-angle-dependent harmonic ellipticity exhibits a prominent antisymmetric structure,which tends to disappear as the internuclear distance increases.Furthermore,ground-state electrons experience resonant transitions to the first excited state at larger internuclear distances,where the disruption of symmetric electron motion suppresses the antisymmetric structure.Additionally,a near-circularly-polarized attosecond pulse can be obtained by modulating the crossing angle.
