Rationale Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke(AIS).Preclinical research indicates that tocilizumab,an interleukin-6 receptor antagonist,can atten...Rationale Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke(AIS).Preclinical research indicates that tocilizumab,an interleukin-6 receptor antagonist,can attenuate ischaemia-reperfusion damage by exerting anti-inflammatory and neuroprotective effects.Aim To determine tocilizumab’s efficacy and safety when combined with endovascular thrombectomy(EVT)in patients with acute anterior circulation large vessel occlusion(LVO).Sample size estimates To determine a 30%decrease in average infarct core volume comparing the intervention and historical control groups(mean increase of 18.7 mL(SD=9.7 mL)post-thrombectomy)via a two-sided test(alpha=0.05,power=80%),accounting for a 10%drop-out rate,we plan to recruit 108 participants.Methods and design This trial is designed as a randomised,multicentre,double-blind,placebo-controlled trial.Patients will be randomly and evenly allocated to the tocilizumab or placebo groups.Study outcomes The primary endpoint is the change in infarct core volume between baseline and 72 hours post-treatment.Secondary outcomes include the 90-day modified Rankin scale score(0–2,indicating functional independence).The key safety endpoints include 90-day mortality and symptomatic intracerebral haemorrhage within 72 hours after EVT.Discussion Administering tocilizumab within 24 hours of stroke as an adjunct to EVT may effectively reduce the infarct core volume for patients experiencing AIS with anterior circulation LVO,potentially improving functional outcomes in these patients.展开更多
数字化变电站通信网络CNDS(Communication Network of Digital Substation)与传统变电站自动化系统中的通信网络在结构、功能、性能和重要性等方面存在较大差异。在IEC 61850标准对变电站自动化系统功能分层的要求和明确数字化变电站通...数字化变电站通信网络CNDS(Communication Network of Digital Substation)与传统变电站自动化系统中的通信网络在结构、功能、性能和重要性等方面存在较大差异。在IEC 61850标准对变电站自动化系统功能分层的要求和明确数字化变电站通信网络效能目标的基础上,提出了过程层点对点/多点、过程层总线和站内统一网络3种数字化变电站通信网络组网方式;指出前2种组网方式目前较易实现,而站内统一网络将凭借信息高度共享等优势成为数字化变电站通信网络的最终形态。在分析以太网介质访问控制方法的基础上,针对标准以太网存在延时不确定的问题,提出了改进以太网实时性能的若干措施,并从中选择出适用于数字化变电站通信网络的方法。研究了数字化变电站通信网络广播域的划分方法。展开更多
基金Beijing Physician Scientist Training Project(BJPSTP-2024-04)National Natural Science Foundation of China(8207146882271507)Beijing Science Foundation for Distinguished Young Scholars(JQ24041)。
文摘Rationale Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke(AIS).Preclinical research indicates that tocilizumab,an interleukin-6 receptor antagonist,can attenuate ischaemia-reperfusion damage by exerting anti-inflammatory and neuroprotective effects.Aim To determine tocilizumab’s efficacy and safety when combined with endovascular thrombectomy(EVT)in patients with acute anterior circulation large vessel occlusion(LVO).Sample size estimates To determine a 30%decrease in average infarct core volume comparing the intervention and historical control groups(mean increase of 18.7 mL(SD=9.7 mL)post-thrombectomy)via a two-sided test(alpha=0.05,power=80%),accounting for a 10%drop-out rate,we plan to recruit 108 participants.Methods and design This trial is designed as a randomised,multicentre,double-blind,placebo-controlled trial.Patients will be randomly and evenly allocated to the tocilizumab or placebo groups.Study outcomes The primary endpoint is the change in infarct core volume between baseline and 72 hours post-treatment.Secondary outcomes include the 90-day modified Rankin scale score(0–2,indicating functional independence).The key safety endpoints include 90-day mortality and symptomatic intracerebral haemorrhage within 72 hours after EVT.Discussion Administering tocilizumab within 24 hours of stroke as an adjunct to EVT may effectively reduce the infarct core volume for patients experiencing AIS with anterior circulation LVO,potentially improving functional outcomes in these patients.
文摘数字化变电站通信网络CNDS(Communication Network of Digital Substation)与传统变电站自动化系统中的通信网络在结构、功能、性能和重要性等方面存在较大差异。在IEC 61850标准对变电站自动化系统功能分层的要求和明确数字化变电站通信网络效能目标的基础上,提出了过程层点对点/多点、过程层总线和站内统一网络3种数字化变电站通信网络组网方式;指出前2种组网方式目前较易实现,而站内统一网络将凭借信息高度共享等优势成为数字化变电站通信网络的最终形态。在分析以太网介质访问控制方法的基础上,针对标准以太网存在延时不确定的问题,提出了改进以太网实时性能的若干措施,并从中选择出适用于数字化变电站通信网络的方法。研究了数字化变电站通信网络广播域的划分方法。
