大量研究表明,以Ets1(erythroblastosis-twenty six 1)基因为代表的Ets信号依赖转录调控因子家族,在消化道肿瘤的发生、浸润转移、血管生成等方面均起到重要作用。有关转录因子Ets1介导肿瘤细胞的发育分化、增殖凋亡、血管发生及组织重...大量研究表明,以Ets1(erythroblastosis-twenty six 1)基因为代表的Ets信号依赖转录调控因子家族,在消化道肿瘤的发生、浸润转移、血管生成等方面均起到重要作用。有关转录因子Ets1介导肿瘤细胞的发育分化、增殖凋亡、血管发生及组织重建等方面的研究,使得Ets1有望成为消化道肿瘤靶向治疗的潜在分子靶点。作者就近年来转录因子Ets1在消化道肿瘤中的研究进展作一综述。展开更多
AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expressi...AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expression and patients'' clinicopathological factors in gastric carcinoma. METHODS: Immunohistochemical analysis was performed for gastric tumor paraffin-embedded sections, followed by image analysis. RESULTS: Ets1 was not expressed in the normal gastric epithelium and its surrounding cells. The percentage of Ets1 expressing cells detected increased significantly in both epithelial tumor and stromal cells from high T classification, lymph node metastasis positive, clinical advanced-stage groups (P<0.05). The level of Etsl staining in epithelial tumor cells also reflected the degree of cell differentiation. The percentage of epithelial and stromal cells expressing Ets1 was significantly correlated with the presence of lymph node metastasis (P=0.014 and P=0.O01 respectively). Ets1 expression was not observed in tissue samples from patients with benign gastric ulcers.CONCLUSION: Ets1 protein expression in epithelial tumor cells reflects the degree of differentiation, and the percentage of Etsl positive tumor and stromal cells correlates with lymph node metastasis. Thus Etsl is a valuable marker of malignant potential in terms of invasiveness and metastasis of gastric carcinoma. It is also possible that inhibition of Etsl is a potential avenue for therapy in gastric cancer.展开更多
文摘大量研究表明,以Ets1(erythroblastosis-twenty six 1)基因为代表的Ets信号依赖转录调控因子家族,在消化道肿瘤的发生、浸润转移、血管生成等方面均起到重要作用。有关转录因子Ets1介导肿瘤细胞的发育分化、增殖凋亡、血管发生及组织重建等方面的研究,使得Ets1有望成为消化道肿瘤靶向治疗的潜在分子靶点。作者就近年来转录因子Ets1在消化道肿瘤中的研究进展作一综述。
文摘AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expression and patients'' clinicopathological factors in gastric carcinoma. METHODS: Immunohistochemical analysis was performed for gastric tumor paraffin-embedded sections, followed by image analysis. RESULTS: Ets1 was not expressed in the normal gastric epithelium and its surrounding cells. The percentage of Ets1 expressing cells detected increased significantly in both epithelial tumor and stromal cells from high T classification, lymph node metastasis positive, clinical advanced-stage groups (P<0.05). The level of Etsl staining in epithelial tumor cells also reflected the degree of cell differentiation. The percentage of epithelial and stromal cells expressing Ets1 was significantly correlated with the presence of lymph node metastasis (P=0.014 and P=0.O01 respectively). Ets1 expression was not observed in tissue samples from patients with benign gastric ulcers.CONCLUSION: Ets1 protein expression in epithelial tumor cells reflects the degree of differentiation, and the percentage of Etsl positive tumor and stromal cells correlates with lymph node metastasis. Thus Etsl is a valuable marker of malignant potential in terms of invasiveness and metastasis of gastric carcinoma. It is also possible that inhibition of Etsl is a potential avenue for therapy in gastric cancer.
