Changes in lake levels, as an indicator of climate change, are crucial for understanding water resources.Satellite altimetry has proven to be an effective technique for monitoring water level changes in inland lakes. ...Changes in lake levels, as an indicator of climate change, are crucial for understanding water resources.Satellite altimetry has proven to be an effective technique for monitoring water level changes in inland lakes. However, high-altitude and high-latitude lakes undergo seasonal freezing and melting, affecting satellite altimetry accuracy. This paper evaluates the accuracy of lake level height observations by the CryoSat-2, which uses synthetic aperture radar(SAR) across seasons. First, we used lake boundary based on optical remote sensing data to extract the footprints of CryoSat-2 that fall on Namco and Zhari Namco.After elevation conversion and anomaly identification, we obtained the time series of lake levels. These data were compared and verified against lake levels from in-situ measurements to assess the accuracy of CryoSat-2. The results show that CryoSat-2 can monitor lake level height with an accuracy of about 10-13 cm. The correlation coefficient between CryoSat-2 observations and in-situ measurements over Namco is 0.80(p < 0.01), with a Root Mean Square Error(RMSE) of 13 cm. For Zhari Namco, the correlation coefficient is 0.91, with an RMSE of 10 cm, indicating a better match. At the seasonal scale, the seasonal correlation coefficients between CryoSat-2 and in-situ measurement in Namco are 0.47(spring),0.79(summer), and 0.91(fall) with no observations available for winter. The lower correlation in spring may be due to incomplete ice melting. For Zhari Namco, the seasonal correlation coefficients are 0.89(spring), 0.93(summer), 0.89(fall), and 0.87(winter). The results show that CryoSat-2 accuracy is higher in summer and fall, while slightly lower in spring and winter, indicating that ice formation affects accuracy. Even during winter, the altimetry results do not significantly exceed the in-situ lake water level observations.展开更多
BACKGROUND Diabetic kidney disease(DKD)has become the leading cause of end-stage renal disease.The disease characteristics,morbidity,and renal function progression rate of patients with DKD are all related to sex.This...BACKGROUND Diabetic kidney disease(DKD)has become the leading cause of end-stage renal disease.The disease characteristics,morbidity,and renal function progression rate of patients with DKD are all related to sex.This suggests that sex hormones may play an important role in changing renal function in patients with diabetes.There have been only a few studies on the correlation between sex hormones and DKD,which have contradictory conclusions.AIM To investigate the relationship between circulating sex hormone levels and DKD in men and postmenopausal women with type 2 diabetes mellitus(T2DM).METHODS This retrospective cross-sectional study included 356 patients with T2DM.Pearson or Spearman rank correlation analyses assessed the relationships between sex hormone levels and renal function indices.By adjusting for age,body mass index,systolic blood pressure,diastolic blood pressure,duration of diabetes,use of sodium-glucose cotrasporter-2 inhibitor,use of glucagon-like peptide-1 receptor agonist,hypertension,use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor,diabetic retinopathy,diabetic peripheral vascular disease,triglyceride,uric acid,and hemoglobin A1c,multiple linear regression and logistic regression analyses were conducted to identify factors influencing the urinary albumin/creatinine ratio(UACR)and DKD.RESULTS In men,dehydroepiandrosterone sulfate levels were inversely associated with log-transformed UACR after adjustment for covariate factors[regression coefficient(β)=-0.691,95%confidence interval(CI):-1.241 to-0.141 for quartile 4 vs quartile 1;P=0.006 for trend].Elevated levels of estradiol were positively associated with DKD[odds ratio(OR)=3.097,95%CI:1.083-8.856 for quartile 4 vs quartile 1;P=0.041 for trend],and higher luteinizing hormone(LH)levels were similarly associated with DKD(OR=4.164,95%CI:1.30-13.330 for quartile 4 vs quartile 1;P=0.048 for trend).In postmenopausal women,LH levels were positively correlated with log-transformed UACR and DKD(β=1.039,95%CI:0.284-1.794 for quartile 4 vs quartile 1;P=0.006 for trend and OR=15.117,95%CI:2.191-104.326 for quartile 4 vs quartile 1;P=0.004 for trend).Follicle-stimulating hormone(FSH)levels were also positively associated with DKD(OR=9.588,95%CI:1.680-54.709 for quartile 4 vs quartile 1;P=0.014 for trend).CONCLUSION In men with T2DM,elevated levels of estradiol and LH levels were positively associated with increased risk of DKD.In postmenopausal women with T2DM,high FSH and LH levels were positively associated with increased risk of DKD.展开更多
Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJ...Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJTCs(heated junction thermocouples)are widely used for this purpose due to their ability to withstand extreme temperatures and radiation conditions.This article explores the role of HJTCs in reactor water level measurement and compares the performance of 2-wire and 3-wire connections.While the 2-wire connection is simple and cost-effective,it can introduce measurement inaccuracies due to wire resistance.In contrast,the 3-wire connection compensates for lead resistance,offering more precise and reliable measurements,particularly in long-distance applications.This paper discusses the operational considerations of these wiring configurations in the context of nuclear reactors and highlights the importance of choosing the appropriate connection type to optimize safety and measurement accuracy in PWR and BWR reactors.展开更多
目的探讨大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果以及对患者血管内皮功能等指标的影响。方法研究总计纳入2型糖尿病患者114例(2022年1月—2023年6月收治),以随机数字表法将患者分为单药组与联合中药组,各组57例,单药组患者采...目的探讨大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果以及对患者血管内皮功能等指标的影响。方法研究总计纳入2型糖尿病患者114例(2022年1月—2023年6月收治),以随机数字表法将患者分为单药组与联合中药组,各组57例,单药组患者采取吡格列酮治疗,联合中药组患者采取吡格列酮结合大柴胡汤加味治疗,研究过程中单药组脱落2例,联合中药组脱落1例,比较各组患者数据:疗效、治疗前后糖化血红蛋白(glycosylated hemoglobin,HbAlc)、空腹血糖(fasting blood glucose,FPG)与餐后2 h血糖(2 hours postprandial blood glucose,2 h PG)等血糖指标变化及中医证候积分变化、丙二醛(malonaldehyde,MDA)及超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)等氧化应激指标与舒张早期反向血流峰值速度(PRV)、收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、动脉搏动指数(PI)等血流动力学指标变化、不良反应。结果联合中药组治疗效果优于单药组,P<0.05;治疗前各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标比较,P>0.05,治疗后各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均改善,而联合中药组治疗后HbAlc、FPG、2 h PG、中医症候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均优于单药组,P<0.05;联合中药组与单药组不良反应率均较低,P>0.05。结论大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果显著,可较好降低患者血糖水平,改善患者临床症状、血流动力学情况,且治疗不良反应少,较为安全。展开更多
基金financial supported by National Natural Science Foundation of China (42104010, 42174097, 41974093, and 41774088)the Fundamental Research Funds for the Central Universities
文摘Changes in lake levels, as an indicator of climate change, are crucial for understanding water resources.Satellite altimetry has proven to be an effective technique for monitoring water level changes in inland lakes. However, high-altitude and high-latitude lakes undergo seasonal freezing and melting, affecting satellite altimetry accuracy. This paper evaluates the accuracy of lake level height observations by the CryoSat-2, which uses synthetic aperture radar(SAR) across seasons. First, we used lake boundary based on optical remote sensing data to extract the footprints of CryoSat-2 that fall on Namco and Zhari Namco.After elevation conversion and anomaly identification, we obtained the time series of lake levels. These data were compared and verified against lake levels from in-situ measurements to assess the accuracy of CryoSat-2. The results show that CryoSat-2 can monitor lake level height with an accuracy of about 10-13 cm. The correlation coefficient between CryoSat-2 observations and in-situ measurements over Namco is 0.80(p < 0.01), with a Root Mean Square Error(RMSE) of 13 cm. For Zhari Namco, the correlation coefficient is 0.91, with an RMSE of 10 cm, indicating a better match. At the seasonal scale, the seasonal correlation coefficients between CryoSat-2 and in-situ measurement in Namco are 0.47(spring),0.79(summer), and 0.91(fall) with no observations available for winter. The lower correlation in spring may be due to incomplete ice melting. For Zhari Namco, the seasonal correlation coefficients are 0.89(spring), 0.93(summer), 0.89(fall), and 0.87(winter). The results show that CryoSat-2 accuracy is higher in summer and fall, while slightly lower in spring and winter, indicating that ice formation affects accuracy. Even during winter, the altimetry results do not significantly exceed the in-situ lake water level observations.
基金Supported by the National Natural Science Foundation of China,No.82270942.
文摘BACKGROUND Diabetic kidney disease(DKD)has become the leading cause of end-stage renal disease.The disease characteristics,morbidity,and renal function progression rate of patients with DKD are all related to sex.This suggests that sex hormones may play an important role in changing renal function in patients with diabetes.There have been only a few studies on the correlation between sex hormones and DKD,which have contradictory conclusions.AIM To investigate the relationship between circulating sex hormone levels and DKD in men and postmenopausal women with type 2 diabetes mellitus(T2DM).METHODS This retrospective cross-sectional study included 356 patients with T2DM.Pearson or Spearman rank correlation analyses assessed the relationships between sex hormone levels and renal function indices.By adjusting for age,body mass index,systolic blood pressure,diastolic blood pressure,duration of diabetes,use of sodium-glucose cotrasporter-2 inhibitor,use of glucagon-like peptide-1 receptor agonist,hypertension,use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor,diabetic retinopathy,diabetic peripheral vascular disease,triglyceride,uric acid,and hemoglobin A1c,multiple linear regression and logistic regression analyses were conducted to identify factors influencing the urinary albumin/creatinine ratio(UACR)and DKD.RESULTS In men,dehydroepiandrosterone sulfate levels were inversely associated with log-transformed UACR after adjustment for covariate factors[regression coefficient(β)=-0.691,95%confidence interval(CI):-1.241 to-0.141 for quartile 4 vs quartile 1;P=0.006 for trend].Elevated levels of estradiol were positively associated with DKD[odds ratio(OR)=3.097,95%CI:1.083-8.856 for quartile 4 vs quartile 1;P=0.041 for trend],and higher luteinizing hormone(LH)levels were similarly associated with DKD(OR=4.164,95%CI:1.30-13.330 for quartile 4 vs quartile 1;P=0.048 for trend).In postmenopausal women,LH levels were positively correlated with log-transformed UACR and DKD(β=1.039,95%CI:0.284-1.794 for quartile 4 vs quartile 1;P=0.006 for trend and OR=15.117,95%CI:2.191-104.326 for quartile 4 vs quartile 1;P=0.004 for trend).Follicle-stimulating hormone(FSH)levels were also positively associated with DKD(OR=9.588,95%CI:1.680-54.709 for quartile 4 vs quartile 1;P=0.014 for trend).CONCLUSION In men with T2DM,elevated levels of estradiol and LH levels were positively associated with increased risk of DKD.In postmenopausal women with T2DM,high FSH and LH levels were positively associated with increased risk of DKD.
文摘Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJTCs(heated junction thermocouples)are widely used for this purpose due to their ability to withstand extreme temperatures and radiation conditions.This article explores the role of HJTCs in reactor water level measurement and compares the performance of 2-wire and 3-wire connections.While the 2-wire connection is simple and cost-effective,it can introduce measurement inaccuracies due to wire resistance.In contrast,the 3-wire connection compensates for lead resistance,offering more precise and reliable measurements,particularly in long-distance applications.This paper discusses the operational considerations of these wiring configurations in the context of nuclear reactors and highlights the importance of choosing the appropriate connection type to optimize safety and measurement accuracy in PWR and BWR reactors.
文摘目的探讨大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果以及对患者血管内皮功能等指标的影响。方法研究总计纳入2型糖尿病患者114例(2022年1月—2023年6月收治),以随机数字表法将患者分为单药组与联合中药组,各组57例,单药组患者采取吡格列酮治疗,联合中药组患者采取吡格列酮结合大柴胡汤加味治疗,研究过程中单药组脱落2例,联合中药组脱落1例,比较各组患者数据:疗效、治疗前后糖化血红蛋白(glycosylated hemoglobin,HbAlc)、空腹血糖(fasting blood glucose,FPG)与餐后2 h血糖(2 hours postprandial blood glucose,2 h PG)等血糖指标变化及中医证候积分变化、丙二醛(malonaldehyde,MDA)及超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)等氧化应激指标与舒张早期反向血流峰值速度(PRV)、收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、动脉搏动指数(PI)等血流动力学指标变化、不良反应。结果联合中药组治疗效果优于单药组,P<0.05;治疗前各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标比较,P>0.05,治疗后各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均改善,而联合中药组治疗后HbAlc、FPG、2 h PG、中医症候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均优于单药组,P<0.05;联合中药组与单药组不良反应率均较低,P>0.05。结论大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果显著,可较好降低患者血糖水平,改善患者临床症状、血流动力学情况,且治疗不良反应少,较为安全。
