Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, ...Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.展开更多
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven...Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.展开更多
Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. I...Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. It is in this context that the present study was carried out to evaluate the measles epidemiological surveillance system in the Kangaba health district. Method: This was a descriptive cross-sectional study with retrospective data collection for the period from 1 January to 31 December 2022 in the Kangaba health district with 18 epidemiological surveillance officers. Data were collected using an observation grid and documentary analysis. Results: We found a simplicity of 97%, a representativeness of 95% and a reactivity of 53%. Not all notified cases were sampled (64%). Of the 17 CSCom, 8 were positive. A total of 34 confirmed cases of measles were recorded, with one death. Conclusion: Overall, the system is functional and well-established in the health centres, but it remains important to ensure that suspected cases are investigated and that the time between sampling and the availability of laboratory results is respected.展开更多
Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely availabl...Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely available. In Congo there is little published data on this entity. Objectives: To describe the epidemiological, diagnostic, and progression characteristics of peritoneal tuberculosis at the university hospital center in Brazzaville. Patients and Methods: This study is a descriptive and retrospective analysis conducted from January 1, 2015, to December 31, 2021, in the Gastroenterology and Internal Medicine department of the CHU of Brazzaville. It included all patients hospitalized during this period with a confirmed diagnosis of peritoneal tuberculosis, encompassing 54 records that met the inclusion criteria. Results: Out of the study period, 54 records that fulfilled the inclusion criteria were analyzed. The annual incidence of peritoneal tuberculosis was 7.7 patients, with a prevalence of 1.4%, showing a male predominance of 61% and an average age of 39.93 ± 14.62 years. The primary symptoms were abdominal bloating and abdominal pain, present in 100% and 74% of cases, respectively. The clinical presentation was primarily characterized by febrile ascites observed in all patients. HIV co-infection was noted in 29.6% of cases. Anemia was present in 79.6% of patients, and an elevated sedimentation rate was observed in 74% of cases. The tuberculin skin test returned positive in 50% of cases. The ascitic fluid was exudative, rich in proteins and white blood cells (exceeding 1000/mm3, predominantly lymphocytes) in the majority of cases (100%, 83.3%, 83.3%, respectively). The diagnosis was deemed highly probable based on the clinical and paraclinical signs and the favorable response to treatment in 79.6% of cases. There were instances of pleural involvement (33.3%) and lymph node involvement (pulmonary 22.2% and lymph node 16.6%). Treatment outcomes were favorable in 37% of cases, with a mortality rate of 9%. Conclusion: Peritoneal tuberculosis is prevalent in Brazzaville, predominantly affecting young males. The diagnosis relies chiefly on a combination of clinical, paraclinical, and progression indicators.展开更多
Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
Objective:To analyze the epidemiological characteristics of a varicella outbreak in X Primary School in 2024,evaluate the protective efficacy of varicella vaccine,summarize the characteristics of varicella outbreaks,a...Objective:To analyze the epidemiological characteristics of a varicella outbreak in X Primary School in 2024,evaluate the protective efficacy of varicella vaccine,summarize the characteristics of varicella outbreaks,and provide references for the prevention and control of infectious diseases in schools and emergency response.Methods:Symptoms of all ill students were analyzed to clarify the epidemiological characteristics,and the Cox regression model was used to analyze the protective efficacy of varicella vaccine.Results:The varicella epidemic lasted for one month,involving 3 classes in 2 grades.A total of 16 varicella cases were identified in the school,with an attack rate of 1.78%.The vaccination status of 142 students was analyzed for vaccine protective efficacy.Comparison with unvaccinated students showed that the protective efficacy of 1 dose of varicella vaccine was not significant,while the protective efficacy of 2 doses of varicella vaccine was 82.10%.Conclusion:Vaccination with 2 doses of varicella vaccine provides the best protective effect.Timely isolation of ill students after the outbreak can effectively control large-scale varicella outbreaks.展开更多
Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological m...Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and epidemiological trends of hepatitis B data in Harbin from 2010 to 2023.Results:A total of 38,604 cases of hepatitis B were reported in Harbin from 2010 to 2023,with an average annual incidence rate of 26.38 per 100,000.The majority of hepatitis B cases were chronic.There was no obvious seasonal distribution pattern of hepatitis B.The average incidence rate was lowest in the<10-year-old group(1.72 per 100,000)and highest in the 40-year-old group(34.71 per 100,000).Cases were mainly concentrated in the 30-69-year-old population,accounting for 75.35%.The male-to-female ratio was 1.35:1.The majority of cases were farmers,accounting for 57.31%.Conclusion:Except for a significant decrease from 2020 to 2022,the overall incidence of hepatitis B showed a trend of decreasing first and then increasing from 2010 to 2023.The prevention and control measures for the 0-19-year-old population were effective.It is necessary to strengthen the prevention and control of hepatitis B among adults over 20 years old,especially to develop differentiated hepatitis B prevention and control strategies targeting key areas and high-risk populations.展开更多
Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the...Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.展开更多
The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to D...The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to December 31, 2023, on 225 patients seen in consultation for anxiety disorders in the department. The prevalence of anxiety disorders was 2.5% in consultation. The 20 - 29 age group was the most represented at 33.3%. Females were slightly represented at 55.1%, with a sex ratio of 1.2. The secondary level was the most affected, accounting for 36.4% of cases. Insomnia was the most frequent reason for consultation, accounting for 71.1% of cases. A larger general population study would be necessary to better assess the extent of anxiety disorders in Guinea.展开更多
Abortion is one of the leading causes of maternal death in Cameroon, despite numerous policies and strategies put in place to reduce it by 2030.This study aims to describe the epidemiologic aspects of abortions within...Abortion is one of the leading causes of maternal death in Cameroon, despite numerous policies and strategies put in place to reduce it by 2030.This study aims to describe the epidemiologic aspects of abortions within hospitals in the city of Yaoundé in 2023. Methods: This was a descriptive cross-sectional study with prospective data collection in the maternity wards of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital, and the Yaoundé Central Hospital for 7 months, from the 1st of November 2022 to the 31st of May 2023. The variables studied were demographic and clinical characteristics, means of recourse and post-abortion contraception. The frequency of abortions was calculated as the ratio of the number of abortions to the number of deliveries. The calculation of numbers and frequencies was used to describe the study population, and to highlight the sociodemographic and clinical characteristics of the patients recruited. Quantitative variables were expressed as mean ± standard deviation. Data were collected numerically and classified according to type, then analyzed using Epi-info version 7.2 software. Microsoft Office Excel 2013 was used to produce figures and tables. Results: During the study period, 169 patients were selected out of 1882 patients who had consulted for gynaecological emergencies;but only 164 of them accepted to participate. The frequency of abortions was 9.6% (169/1882). The age group of 25 to 29 years was the most represented, with 29.3% (48/164). They were mainly single 76.2% (125/164), and housewives 33.5% (55/164). The notion of previous abortion was found in 30.5% (50/164) of them. Approximately 19.5% of patients (32/164) reported to have conceived while using contraception, 56.2% of whom (18/32) used male condoms. At the time of admission to the emergency unit, the predominant symptom was bleeding in 70.7% of cases. The abortions were mainly spontaneous, in 75% of cases (123/164). In cases of induced abortions, 24.4% (10/41) of them took place after 14 weeks. Unexpected pregnancy was the main reason for termination in 46.3% of cases (19/41). Regarding induced abortion, 58.54% (24/41) of them resorted to voluntary medical termination. The mortality rate was 1.2%. The acceptability rate of a modern contraceptive method before discharge was 31.7%. Conclusion: Although frequent in our environment, data relating to abortion remain under-evaluated. Abortions occur mainly among young, single women, with a still very high proportion of induced abortions. The acceptability of post-abortion contraception remains poor. Prevention of unwanted pregnancies and risk factors is necessary to reduce the burden of abortions in low-income countries.展开更多
Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on f...Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on farms.Disease is a serious constraint to the healthy development of small ruminant farming.Studies published on PubMed,CNKI,VIP,Wanfang and the resulting references of selected studies were included.Risk factors affecting prevalence were analyzed and stratified by geographic location and climatic variables,age,sex,feeding model,season,sample year,breeds and environment.The total prevalence of coccidia in sheep and goats reached more than 60%in most regions,in which the dominant species in sheep were mainly E.parva,E.ovinoidalis,and E.parva and E.ahsata.East China had the lowest prevalence of coccidia infection in sheep(43.24%),and the dominant species were different from those in the other regions,mainly E.bakuensis and E.gonzalezi.Southwestern China and Central China had slightly less than 40.0%goat coccidia infection,and the dominant species in goats were mainly E.arloingi,E.aligevi,E.hirci and E.ninakohlyakimovae.Sheep/goats of different ages can be infected with coccidiosis,but lambs between 1 and 3 months of age are more susceptible to the disease.When lambs become infected,the pathogen spreads rapidly throughout the herd.Spring,summer and autumn are the seasons with a high incidence of this disease.Environmental pollution may be a significant factor in the development of coccidiosis in sheep raised in large-scale housing.This study provides a comprehensive overview of the species,morphology and geographic distribution of Eimeria species in sheep and goats,summary prevalence in different regions of China,risk factors affecting prevalence,and prevention and control strategies.展开更多
Introduction:Night shift work is a complex and frequent occupational exposure,and breast cancer stands as the most prevalent cancer in women.The International Agency for Research on Cancer(IARC)has twice classified ni...Introduction:Night shift work is a complex and frequent occupational exposure,and breast cancer stands as the most prevalent cancer in women.The International Agency for Research on Cancer(IARC)has twice classified night shift work as a probable breast carcinogen,with the latest classification in June 2019.Since that time,new epidemiologic data has emerged.Methods:We searched PubMed for original articles based on cohort and case-control studies of“breast cancer and night shift work”published after the IARC evaluation in June 2019.Results:In total six cohorts and four case-control studies were included in our review.Overall,we observed some support for associations between persistent(long duration or high frequency)night shift work and an increase in breast cancer risk,though most studies were relatively small and statistically under-powered.Moreover,the recent studies do not contribute further evidence regarding the interaction with menopausal status,diurnal preference,hormonal subtypes of breast cancer or gene-environment aspects,which were issues that were left from the IARC evaluation.Conclusions:The available new results somewhat consolidate the epidemiological evidence from IARC’s 2019 evaluation,and do not provide further evidence regarding interaction of interest,e.g.menopausal status,etc.Therefore,long term follow-up of prospective cohorts or nested case-control studies,including precise exposure assessment and examinations of relevant interactions such as menopausal status,diurnal preference,hormonal subtypes of breast cancer and gene-environment aspects,are warranted.Meanwhile,protective measures for the night workers should be considered.展开更多
BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple c...BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple chemotherapy regimens at different stages.METHODS This was a retrospective study conducted from 2005 to 2014,involving six cancer hospitals and eight general hospitals across seven geographical regions of China(East,South,North,Central,Southwest,Northwest,and Northeast).Stratified sampling was used based on the population distribution of each region.Efficacy assessments were conducted by Cox proportional hazards regression models.When assessing the effectiveness of various chemotherapy regimens,traditional drugs such as gemcitabine used as monotherapy served as the reference.RESULTS A total of 3256 patients were included.The median follow-up time was 407 days,and the median overall survival was 183 days.At diagnosis,56%of patients were already in stage IV.Chemotherapy was administered to 39.73%of patients.In the adjuvant therapy phase,gemcitabine+fluorouracil was superior to gemcitabine monotherapy[hazard ratio(HR)=0.35,95%confidence interval(CI):0.14-0.89].In fluorouracil-based regimens,other combination regimens did not show effectiveness relative to monotherapy.For first-line treatment in patients with advanced disease,tegafur alone(HR=0.20,95%CI:0.06-0.66),gemcitabine plus cisplatin(HR=0.16,95%CI:0.04-0.70),and tegafur,gemcitabine plus platinum-based agents(HR=0.32,95%CI:0.11-0.91)were associated with a lower risk of death compared to gemcitabine alone.In second-line treatment,there were no significant differences in efficacy among various drugs,but FOLFIRINOX(irinotecan+oxaliplatin+leucovorin+5-fluorouracil)had an outstanding point estimate(HR=0.10,95%CI:0.01-1.27).CONCLUSION In China,pancreatic cancer is often diagnosed at advanced stages,emphasizing the need for early diagnosis and treatment.Combined therapies in adjuvant and first-line settings may reduce the risk of death compared with monotherapy,and FOLFIRINOX might offer more significant benefits in second-line treatment.展开更多
Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective...Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.展开更多
[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and ex...[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.展开更多
The incidence and mortality of prostate cancer(PCa)in China have risen sharply in recent years,posing an escalating public health concern.In contrast to Western populations,Chinese patients are more frequently diagnos...The incidence and mortality of prostate cancer(PCa)in China have risen sharply in recent years,posing an escalating public health concern.In contrast to Western populations,Chinese patients are more frequently diagnosed at advanced stages,often with metastatic disease and suboptimal survival outcomes.These disparities reflect in-trinsic differences in epidemiological patterns,molecular landscapes,and healthcare delivery systems unique to the Chinese context.Nevertheless,prevailing PCa management paradigms,largely derived from Western-centric evidence,remain inadequately calibrated to the biological and clinical realities of Chinese patients.This review provides a comprehensive synthesis of the epidemiology,genomic alterations,clinical presentations,and treatment disparities of PCa in China,highlighting the urgent need for population-specific strategies.Priority areas include the development of ethnically optimized screening protocols,the integration of precision medicine approaches,and the implementation of regionally adapted prevention and early detection programs.Furthermore,expanding participation in clinical trials and accelerating translational research efforts,particularly in multi-omics and biomarker discovery,will be critical to bridging current gaps.By aligning emerging scientific innovations with localized healthcare needs,China holds the potential to reshape its prostate cancer care paradigm,improving outcomes,reducing disparities,and contributing to the global advancement of precision oncology.展开更多
Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are...Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are influenced by multiple factors,especially during the COVID-19 pandemic.Based on data from the National Influenza Surveillance Program in China,we analyzed the epidemiological and genomic data in Tianjin collected from 2017 to 2025.A total of 77,473 throat swabs were collected,of which 9144 were IAV-positive.The A/pdm09 H1N1 and A/H3N2 lineages exhibited distinct epidemics across different influenza seasons,with a decline in cases observed during the COVID-19 pandemic.We sequenced the genomes of 128 A/pdm09 H1N1 and 113 A/H3N2 clinical isolates and characterized their temporal evolution and genetic diversity using time-scaled phylogenetic analysis.Additionally,we conducted a genetic risk evaluation of the hemagglutinin and neuraminidase segments,identifying key amino acid residues associated with viral adaptation,transmissibility,virulence,and drug resistance.Moreover,no antigenic variants were found in clinical isolates during the recent influenza seasons,though reduced sensitivity to oseltamivir and zanamivir was observed in individual strains.Our surveillance highlights the epidemiology and evolution of IAV before and after the COVID-19 pandemic in Tianjin.展开更多
Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,...Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,064 patients were collected from 555 hospitals in 28 provinces of China.Results:Among 9,064 NHL patients,there were 5,241 males(57.8%)and 3,823 females(42.2%),with a male-to-female ratio of 1.37:1.Patients aged≥45 years accounted for 89.6%,with a mean age of 61.87±13.30 years.The predominant NHL subtypes were diffuse large B-cell lymphoma(DLBCL,45.2%),chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL,19.8%),marginal zone lymphoma(MZL,13.9%),mantle cell lymphoma(MCL,9.7%),and central nervous system lymphoma(CNSL,4.3%).Combination therapy served as the primary treatment modality across all NHL subtypes.Conclusions:NHL in China demonstrates male predominance and primarily affects middle-aged and elderly populations,with combination chemotherapy remaining the mainstay therapeutic approach.展开更多
Tigecycline is one of the most critical drugs for treating Gram-negative bacterial infections;however,the emergence of the tigecycline resistance efflux pump TMexCD1-TOprJ1 poses a global health threat.The evolutionar...Tigecycline is one of the most critical drugs for treating Gram-negative bacterial infections;however,the emergence of the tigecycline resistance efflux pump TMexCD1-TOprJ1 poses a global health threat.The evolutionary relationships and epidemiological trends of tmexCD1-toprJ1-positive strains across various ecological niches remain largely unexplored.In this study,we employed whole-genome sequencing(WGS)of tmexCD1-toprJ1-positive bacteria from humans,food,animals,and the environment in China to assess the epidemiological and genomic features of these strains,analyzing both newly collected strains and data from the GenBank database.From 3434 samples collected during 2019-2022,145tmexCD1-toprJ1-carrying strains(4.5%)were isolated.The majority of the tmexCD1-toprJ1-positive Enterobacterales exhibited resistance to nearly all antimicrobials,including colistin(42.13%).tmexCD1-toprJ1 was predominantly identified in Klebsiella pneumoniae(K.pneumoniae)from chicken feces in China but was also detected in multiple ecological niches and other countries.Phylogenetic analysis revealed the clonal transmission of tmexCD1-toprJ1-positive ST37 K.pneumoniae across diverse ecological niches as well as the international spread of the ST15 K.pneumoniae clone-producing TMexCD1-TOprJ1.tmexCD1-toprJ1 is mainly carried by Klebsiella spp.specific narrow host range plasmids,which may limit the spread of tmexCD1-toprJ1 across different bacterial species.Notably,due to the fitness cost posed by tmexCD1-toprJ1,the occurrence of tmexCD1-toprJ1-positive Enterobacterales in both food animals and humans in China has declined significantly following the withdrawal of antibiotics as growth promoters in food animals in China since 2020.However,tmexCD1-toprJ1 has been captured by broad-host-range plasmids and hypervirulent carbapenem-resistant K.pneumoniae ST11-KL64 strains in healthcare settings.The frequent use of tetracyclines in chicken farming likely contributes to the high detection rate of tmexCD1-toprJ1;therefore,to reduce the threat of tmexCD1-toprJ1-positive K.pneumoniae,continuous monitoring of tmexCD1-toprJ1 across different ecological niches and strict enforcement of antimicrobial policies in animal husbandry,particularly in the poultry industry,are urgently required.展开更多
The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential th...The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential threat to the poultry industry and public health.During the period from 2011 to 2022,we conducted an active surveillance programm.A total of 154,762 swab samples were collected across various provinces,and 427 H4 viruses were detected,resulting in a positivity rate of 0.28%.All H4 viruses were isolated from poultry,primarily from ducks in live poultry markets.We further investigated the genetic evolutionary characteristics and pathogenicity of 20 H4Nx viruses isolated in our program.Phylogenetic analysis revealed that the 20 H4Nx viruses belonged to the Eurasian lineage and exhibited significant genetic diversity,with 19 distinct genotypes identified.Molecular characterization indicated that these viruses were low-pathogenicity AIVs with limited binding affinity to human receptors,yet they contained mutations associated with enhanced viral replication and pathogenicity in mammals.Pathogenicity tests conducted in ducks demonstrated that H4 viruses were weakly pathogenic,exhibiting limited replication and transmission capabilities.However,some viruses were able to replicate effectively in mice and induce weight loss.For instance,DK/AH/AG61/11(H4N6)can replicate efficiently in MDCK cells,indicating a potential threat to mammals.These findings underscore the importance of ongoing surveillance of H4 AIVs to better understand their evolution and transmission dynamics and to prevent potential public health risks.展开更多
文摘Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.
基金supported by Public Health Talent Training and Surport Plan(National Administration of Disease Prevention and Control)Research and application of new technology for rapid monitoring and tracing of emergent infectious diseases among entry-exit population(2024YFFK0056)Monitoring,Early warning and Response of Major Infectious Diseases(2022ZDZX0017).
文摘Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.
文摘Introduction: The WHO’s measles control strategy is based on epidemiological surveillance and vaccination. Little is currently known about the performance of the surveillance system, particularly in outlying areas. It is in this context that the present study was carried out to evaluate the measles epidemiological surveillance system in the Kangaba health district. Method: This was a descriptive cross-sectional study with retrospective data collection for the period from 1 January to 31 December 2022 in the Kangaba health district with 18 epidemiological surveillance officers. Data were collected using an observation grid and documentary analysis. Results: We found a simplicity of 97%, a representativeness of 95% and a reactivity of 53%. Not all notified cases were sampled (64%). Of the 17 CSCom, 8 were positive. A total of 34 confirmed cases of measles were recorded, with one death. Conclusion: Overall, the system is functional and well-established in the health centres, but it remains important to ensure that suspected cases are investigated and that the time between sampling and the availability of laboratory results is respected.
文摘Peritoneal tuberculosis is the most common digestive location of tuberculosis. Its diagnosis is often based on a combination of clinical and biological arguments, and confirmed by bacteriology which is rarely available. In Congo there is little published data on this entity. Objectives: To describe the epidemiological, diagnostic, and progression characteristics of peritoneal tuberculosis at the university hospital center in Brazzaville. Patients and Methods: This study is a descriptive and retrospective analysis conducted from January 1, 2015, to December 31, 2021, in the Gastroenterology and Internal Medicine department of the CHU of Brazzaville. It included all patients hospitalized during this period with a confirmed diagnosis of peritoneal tuberculosis, encompassing 54 records that met the inclusion criteria. Results: Out of the study period, 54 records that fulfilled the inclusion criteria were analyzed. The annual incidence of peritoneal tuberculosis was 7.7 patients, with a prevalence of 1.4%, showing a male predominance of 61% and an average age of 39.93 ± 14.62 years. The primary symptoms were abdominal bloating and abdominal pain, present in 100% and 74% of cases, respectively. The clinical presentation was primarily characterized by febrile ascites observed in all patients. HIV co-infection was noted in 29.6% of cases. Anemia was present in 79.6% of patients, and an elevated sedimentation rate was observed in 74% of cases. The tuberculin skin test returned positive in 50% of cases. The ascitic fluid was exudative, rich in proteins and white blood cells (exceeding 1000/mm3, predominantly lymphocytes) in the majority of cases (100%, 83.3%, 83.3%, respectively). The diagnosis was deemed highly probable based on the clinical and paraclinical signs and the favorable response to treatment in 79.6% of cases. There were instances of pleural involvement (33.3%) and lymph node involvement (pulmonary 22.2% and lymph node 16.6%). Treatment outcomes were favorable in 37% of cases, with a mortality rate of 9%. Conclusion: Peritoneal tuberculosis is prevalent in Brazzaville, predominantly affecting young males. The diagnosis relies chiefly on a combination of clinical, paraclinical, and progression indicators.
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
文摘Objective:To analyze the epidemiological characteristics of a varicella outbreak in X Primary School in 2024,evaluate the protective efficacy of varicella vaccine,summarize the characteristics of varicella outbreaks,and provide references for the prevention and control of infectious diseases in schools and emergency response.Methods:Symptoms of all ill students were analyzed to clarify the epidemiological characteristics,and the Cox regression model was used to analyze the protective efficacy of varicella vaccine.Results:The varicella epidemic lasted for one month,involving 3 classes in 2 grades.A total of 16 varicella cases were identified in the school,with an attack rate of 1.78%.The vaccination status of 142 students was analyzed for vaccine protective efficacy.Comparison with unvaccinated students showed that the protective efficacy of 1 dose of varicella vaccine was not significant,while the protective efficacy of 2 doses of varicella vaccine was 82.10%.Conclusion:Vaccination with 2 doses of varicella vaccine provides the best protective effect.Timely isolation of ill students after the outbreak can effectively control large-scale varicella outbreaks.
基金Heilongjiang Provincial Health Commission(Project No.:20231212050085)。
文摘Objective:To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies.Methods:Descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and epidemiological trends of hepatitis B data in Harbin from 2010 to 2023.Results:A total of 38,604 cases of hepatitis B were reported in Harbin from 2010 to 2023,with an average annual incidence rate of 26.38 per 100,000.The majority of hepatitis B cases were chronic.There was no obvious seasonal distribution pattern of hepatitis B.The average incidence rate was lowest in the<10-year-old group(1.72 per 100,000)and highest in the 40-year-old group(34.71 per 100,000).Cases were mainly concentrated in the 30-69-year-old population,accounting for 75.35%.The male-to-female ratio was 1.35:1.The majority of cases were farmers,accounting for 57.31%.Conclusion:Except for a significant decrease from 2020 to 2022,the overall incidence of hepatitis B showed a trend of decreasing first and then increasing from 2010 to 2023.The prevention and control measures for the 0-19-year-old population were effective.It is necessary to strengthen the prevention and control of hepatitis B among adults over 20 years old,especially to develop differentiated hepatitis B prevention and control strategies targeting key areas and high-risk populations.
文摘Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.
文摘The general objective of our study was to describe the clinical and epidemiological aspects of anxiety disorders. This was a retrospective descriptive cross-sectional study, lasting 5 years, from January 01, 2019 to December 31, 2023, on 225 patients seen in consultation for anxiety disorders in the department. The prevalence of anxiety disorders was 2.5% in consultation. The 20 - 29 age group was the most represented at 33.3%. Females were slightly represented at 55.1%, with a sex ratio of 1.2. The secondary level was the most affected, accounting for 36.4% of cases. Insomnia was the most frequent reason for consultation, accounting for 71.1% of cases. A larger general population study would be necessary to better assess the extent of anxiety disorders in Guinea.
文摘Abortion is one of the leading causes of maternal death in Cameroon, despite numerous policies and strategies put in place to reduce it by 2030.This study aims to describe the epidemiologic aspects of abortions within hospitals in the city of Yaoundé in 2023. Methods: This was a descriptive cross-sectional study with prospective data collection in the maternity wards of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital, and the Yaoundé Central Hospital for 7 months, from the 1st of November 2022 to the 31st of May 2023. The variables studied were demographic and clinical characteristics, means of recourse and post-abortion contraception. The frequency of abortions was calculated as the ratio of the number of abortions to the number of deliveries. The calculation of numbers and frequencies was used to describe the study population, and to highlight the sociodemographic and clinical characteristics of the patients recruited. Quantitative variables were expressed as mean ± standard deviation. Data were collected numerically and classified according to type, then analyzed using Epi-info version 7.2 software. Microsoft Office Excel 2013 was used to produce figures and tables. Results: During the study period, 169 patients were selected out of 1882 patients who had consulted for gynaecological emergencies;but only 164 of them accepted to participate. The frequency of abortions was 9.6% (169/1882). The age group of 25 to 29 years was the most represented, with 29.3% (48/164). They were mainly single 76.2% (125/164), and housewives 33.5% (55/164). The notion of previous abortion was found in 30.5% (50/164) of them. Approximately 19.5% of patients (32/164) reported to have conceived while using contraception, 56.2% of whom (18/32) used male condoms. At the time of admission to the emergency unit, the predominant symptom was bleeding in 70.7% of cases. The abortions were mainly spontaneous, in 75% of cases (123/164). In cases of induced abortions, 24.4% (10/41) of them took place after 14 weeks. Unexpected pregnancy was the main reason for termination in 46.3% of cases (19/41). Regarding induced abortion, 58.54% (24/41) of them resorted to voluntary medical termination. The mortality rate was 1.2%. The acceptability rate of a modern contraceptive method before discharge was 31.7%. Conclusion: Although frequent in our environment, data relating to abortion remain under-evaluated. Abortions occur mainly among young, single women, with a still very high proportion of induced abortions. The acceptability of post-abortion contraception remains poor. Prevention of unwanted pregnancies and risk factors is necessary to reduce the burden of abortions in low-income countries.
基金supported,in part,by Key Research and Development Projects of Henan,China(231111111600)the National Key R&D Program(2023YFD1801200)the China Agriculture(sheep and goats)Research System(CARS-38).
文摘Sheep and goat coccidiosis has a worldwide distribution and is an important disease on lambing farms.Infection with multiple Eimeria species can lead to severe intestinal damage in sheep/goats and economic losses on farms.Disease is a serious constraint to the healthy development of small ruminant farming.Studies published on PubMed,CNKI,VIP,Wanfang and the resulting references of selected studies were included.Risk factors affecting prevalence were analyzed and stratified by geographic location and climatic variables,age,sex,feeding model,season,sample year,breeds and environment.The total prevalence of coccidia in sheep and goats reached more than 60%in most regions,in which the dominant species in sheep were mainly E.parva,E.ovinoidalis,and E.parva and E.ahsata.East China had the lowest prevalence of coccidia infection in sheep(43.24%),and the dominant species were different from those in the other regions,mainly E.bakuensis and E.gonzalezi.Southwestern China and Central China had slightly less than 40.0%goat coccidia infection,and the dominant species in goats were mainly E.arloingi,E.aligevi,E.hirci and E.ninakohlyakimovae.Sheep/goats of different ages can be infected with coccidiosis,but lambs between 1 and 3 months of age are more susceptible to the disease.When lambs become infected,the pathogen spreads rapidly throughout the herd.Spring,summer and autumn are the seasons with a high incidence of this disease.Environmental pollution may be a significant factor in the development of coccidiosis in sheep raised in large-scale housing.This study provides a comprehensive overview of the species,morphology and geographic distribution of Eimeria species in sheep and goats,summary prevalence in different regions of China,risk factors affecting prevalence,and prevention and control strategies.
文摘Introduction:Night shift work is a complex and frequent occupational exposure,and breast cancer stands as the most prevalent cancer in women.The International Agency for Research on Cancer(IARC)has twice classified night shift work as a probable breast carcinogen,with the latest classification in June 2019.Since that time,new epidemiologic data has emerged.Methods:We searched PubMed for original articles based on cohort and case-control studies of“breast cancer and night shift work”published after the IARC evaluation in June 2019.Results:In total six cohorts and four case-control studies were included in our review.Overall,we observed some support for associations between persistent(long duration or high frequency)night shift work and an increase in breast cancer risk,though most studies were relatively small and statistically under-powered.Moreover,the recent studies do not contribute further evidence regarding the interaction with menopausal status,diurnal preference,hormonal subtypes of breast cancer or gene-environment aspects,which were issues that were left from the IARC evaluation.Conclusions:The available new results somewhat consolidate the epidemiological evidence from IARC’s 2019 evaluation,and do not provide further evidence regarding interaction of interest,e.g.menopausal status,etc.Therefore,long term follow-up of prospective cohorts or nested case-control studies,including precise exposure assessment and examinations of relevant interactions such as menopausal status,diurnal preference,hormonal subtypes of breast cancer and gene-environment aspects,are warranted.Meanwhile,protective measures for the night workers should be considered.
文摘BACKGROUND The survival rate of pancreatic cancer is low,and there is a lack of effective treatment.AIM To explore the epidemiological characteristics of patients with pancreatic cancer in China and compare multiple chemotherapy regimens at different stages.METHODS This was a retrospective study conducted from 2005 to 2014,involving six cancer hospitals and eight general hospitals across seven geographical regions of China(East,South,North,Central,Southwest,Northwest,and Northeast).Stratified sampling was used based on the population distribution of each region.Efficacy assessments were conducted by Cox proportional hazards regression models.When assessing the effectiveness of various chemotherapy regimens,traditional drugs such as gemcitabine used as monotherapy served as the reference.RESULTS A total of 3256 patients were included.The median follow-up time was 407 days,and the median overall survival was 183 days.At diagnosis,56%of patients were already in stage IV.Chemotherapy was administered to 39.73%of patients.In the adjuvant therapy phase,gemcitabine+fluorouracil was superior to gemcitabine monotherapy[hazard ratio(HR)=0.35,95%confidence interval(CI):0.14-0.89].In fluorouracil-based regimens,other combination regimens did not show effectiveness relative to monotherapy.For first-line treatment in patients with advanced disease,tegafur alone(HR=0.20,95%CI:0.06-0.66),gemcitabine plus cisplatin(HR=0.16,95%CI:0.04-0.70),and tegafur,gemcitabine plus platinum-based agents(HR=0.32,95%CI:0.11-0.91)were associated with a lower risk of death compared to gemcitabine alone.In second-line treatment,there were no significant differences in efficacy among various drugs,but FOLFIRINOX(irinotecan+oxaliplatin+leucovorin+5-fluorouracil)had an outstanding point estimate(HR=0.10,95%CI:0.01-1.27).CONCLUSION In China,pancreatic cancer is often diagnosed at advanced stages,emphasizing the need for early diagnosis and treatment.Combined therapies in adjuvant and first-line settings may reduce the risk of death compared with monotherapy,and FOLFIRINOX might offer more significant benefits in second-line treatment.
文摘Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.
基金Supported by TCM Scientific Research Guidance Program of Hubei Provincial Administration of Traditional Chinese Medicine(ZY2023F074).
文摘[Objectives]To systematically analyze the epidemiological characteristics and influencing factors associated with a cohort of 3273 rural patients diagnosed with mental disorders in Zhushan County,Hubei Province and explore an integrated management path that is applicable to rural areas.[Methods]A cross-sectional survey,in conjunction with a retrospective cohort analysis,was conducted.The samples were obtained from the National Management Information System for Severe Mental Disorders(2020-2024),and all registered rural patients in Zhushan County were included through cluster sampling.All participants provided informed consent,and the study received approval from the Ethics Committee of the Zhushan County Mental Health Center.Diagnoses were made in accordance with the International Classification of Diseases,10 th Revision(ICD-10).The research utilized a self-developed socio-ecological scale,which was validated through two rounds of the Delphi method conducted by an expert group,yielding a Cronbach sαof 0.82.The data were collected by trained investigators who conducted household visits.The data entry process involved double entry by two individuals to ensure accuracy for system review.Statistical analysis was performed using SPSS 26.0,employing the chi-square(χ2)test and logistic regression models for analysis.[Results]Schizophrenia was identified as the predominant disorder,affecting 68.4%of the patient population,followed by bipolar disorder,which accounted for 18.8%.Notably,individuals aged over 60 years constituted 40.36%of the sample.Furthermore,the poverty rate within this population was alarmingly high at 87.87%,while the illiteracy rate stood at 41.37%.The treatment experienced a significant delay,with a median duration of 14.2 months.Additionally,there was a substantial gap in standardized treatment,measured at 23.59%.The family care function was found to be inadequate,particularly for families lacking guardianship capacity,which was reported at 11.31%.An analysis of the underlying causes indicates that social structural imbalances(such as left-behind children and marital breakdown),along with economic poverty and insufficient educational opportunities,were critical risk factors contributing to these issues.The development of a model that integrates dynamic screening,full-chain intervention,and collaborative management is beneficial for fostering the efficient and systematic advancement of the rural mental health system.[Conclusions]Patients with mental disorders residing in rural areas face dual vulnerabilities.Therefore,it is essential to implement integrated management that encompasses early screening,standardized treatment,family support,and policy assistance.It is recommended that these elements should be integrated into the framework for local health policy development to enhance equitable access to mental health services and to provide psychological support for rural revitalization efforts.
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(grant number:2023ZD0510300)National Natural Science Foundation of China(grant numbers:82403377,82473192)+1 种基金China Postdoctoral Science Foundation(grant number:2024M750538)Shanghai Municipal Health Bureau(grant number:2020CXJQ03).
文摘The incidence and mortality of prostate cancer(PCa)in China have risen sharply in recent years,posing an escalating public health concern.In contrast to Western populations,Chinese patients are more frequently diagnosed at advanced stages,often with metastatic disease and suboptimal survival outcomes.These disparities reflect in-trinsic differences in epidemiological patterns,molecular landscapes,and healthcare delivery systems unique to the Chinese context.Nevertheless,prevailing PCa management paradigms,largely derived from Western-centric evidence,remain inadequately calibrated to the biological and clinical realities of Chinese patients.This review provides a comprehensive synthesis of the epidemiology,genomic alterations,clinical presentations,and treatment disparities of PCa in China,highlighting the urgent need for population-specific strategies.Priority areas include the development of ethnically optimized screening protocols,the integration of precision medicine approaches,and the implementation of regionally adapted prevention and early detection programs.Furthermore,expanding participation in clinical trials and accelerating translational research efforts,particularly in multi-omics and biomarker discovery,will be critical to bridging current gaps.By aligning emerging scientific innovations with localized healthcare needs,China holds the potential to reshape its prostate cancer care paradigm,improving outcomes,reducing disparities,and contributing to the global advancement of precision oncology.
基金supported by Tianjin Municipal Health Commission(TJWJ2022ZD010)Tianjin Key Medical Discipline(Specialty)Construction Project.
文摘Influenza A virus(IAV)remains a global public health concern,causing influenza-like illness and severe respiratory tract infections.Two major subtypes,A/pdm09 H1N1 and A/H3N2,circulate globally,and their epidemics are influenced by multiple factors,especially during the COVID-19 pandemic.Based on data from the National Influenza Surveillance Program in China,we analyzed the epidemiological and genomic data in Tianjin collected from 2017 to 2025.A total of 77,473 throat swabs were collected,of which 9144 were IAV-positive.The A/pdm09 H1N1 and A/H3N2 lineages exhibited distinct epidemics across different influenza seasons,with a decline in cases observed during the COVID-19 pandemic.We sequenced the genomes of 128 A/pdm09 H1N1 and 113 A/H3N2 clinical isolates and characterized their temporal evolution and genetic diversity using time-scaled phylogenetic analysis.Additionally,we conducted a genetic risk evaluation of the hemagglutinin and neuraminidase segments,identifying key amino acid residues associated with viral adaptation,transmissibility,virulence,and drug resistance.Moreover,no antigenic variants were found in clinical isolates during the recent influenza seasons,though reduced sensitivity to oseltamivir and zanamivir was observed in individual strains.Our surveillance highlights the epidemiology and evolution of IAV before and after the COVID-19 pandemic in Tianjin.
文摘Objective:This study aimed to investigate the epidemiological characteristics and treatment regimens of non-Hodgkin lymphoma(NHL)in China through a retrospective analysis of 9,064 NHL cases.Methods:Clinical data of 9,064 patients were collected from 555 hospitals in 28 provinces of China.Results:Among 9,064 NHL patients,there were 5,241 males(57.8%)and 3,823 females(42.2%),with a male-to-female ratio of 1.37:1.Patients aged≥45 years accounted for 89.6%,with a mean age of 61.87±13.30 years.The predominant NHL subtypes were diffuse large B-cell lymphoma(DLBCL,45.2%),chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL,19.8%),marginal zone lymphoma(MZL,13.9%),mantle cell lymphoma(MCL,9.7%),and central nervous system lymphoma(CNSL,4.3%).Combination therapy served as the primary treatment modality across all NHL subtypes.Conclusions:NHL in China demonstrates male predominance and primarily affects middle-aged and elderly populations,with combination chemotherapy remaining the mainstay therapeutic approach.
基金funded by the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)the National Natural Science Foundation of China(32141002)+1 种基金the National Key Research and Development Program of China(2022YFC2303900)the Science and Technology Program of Guangzhou,China(2023A04J0755 and 202201010300)。
文摘Tigecycline is one of the most critical drugs for treating Gram-negative bacterial infections;however,the emergence of the tigecycline resistance efflux pump TMexCD1-TOprJ1 poses a global health threat.The evolutionary relationships and epidemiological trends of tmexCD1-toprJ1-positive strains across various ecological niches remain largely unexplored.In this study,we employed whole-genome sequencing(WGS)of tmexCD1-toprJ1-positive bacteria from humans,food,animals,and the environment in China to assess the epidemiological and genomic features of these strains,analyzing both newly collected strains and data from the GenBank database.From 3434 samples collected during 2019-2022,145tmexCD1-toprJ1-carrying strains(4.5%)were isolated.The majority of the tmexCD1-toprJ1-positive Enterobacterales exhibited resistance to nearly all antimicrobials,including colistin(42.13%).tmexCD1-toprJ1 was predominantly identified in Klebsiella pneumoniae(K.pneumoniae)from chicken feces in China but was also detected in multiple ecological niches and other countries.Phylogenetic analysis revealed the clonal transmission of tmexCD1-toprJ1-positive ST37 K.pneumoniae across diverse ecological niches as well as the international spread of the ST15 K.pneumoniae clone-producing TMexCD1-TOprJ1.tmexCD1-toprJ1 is mainly carried by Klebsiella spp.specific narrow host range plasmids,which may limit the spread of tmexCD1-toprJ1 across different bacterial species.Notably,due to the fitness cost posed by tmexCD1-toprJ1,the occurrence of tmexCD1-toprJ1-positive Enterobacterales in both food animals and humans in China has declined significantly following the withdrawal of antibiotics as growth promoters in food animals in China since 2020.However,tmexCD1-toprJ1 has been captured by broad-host-range plasmids and hypervirulent carbapenem-resistant K.pneumoniae ST11-KL64 strains in healthcare settings.The frequent use of tetracyclines in chicken farming likely contributes to the high detection rate of tmexCD1-toprJ1;therefore,to reduce the threat of tmexCD1-toprJ1-positive K.pneumoniae,continuous monitoring of tmexCD1-toprJ1 across different ecological niches and strict enforcement of antimicrobial policies in animal husbandry,particularly in the poultry industry,are urgently required.
基金funded by the National Key Research and Development Program of China(Grant No.2021YFD1800201).
文摘The H4 subtype of avian influenza virus(AIV)is prevalent worldwide,but only receives little attention due to its low pathogenicity in poultry.Consequently,it remains largely unclear whether H4 AIVs pose a potential threat to the poultry industry and public health.During the period from 2011 to 2022,we conducted an active surveillance programm.A total of 154,762 swab samples were collected across various provinces,and 427 H4 viruses were detected,resulting in a positivity rate of 0.28%.All H4 viruses were isolated from poultry,primarily from ducks in live poultry markets.We further investigated the genetic evolutionary characteristics and pathogenicity of 20 H4Nx viruses isolated in our program.Phylogenetic analysis revealed that the 20 H4Nx viruses belonged to the Eurasian lineage and exhibited significant genetic diversity,with 19 distinct genotypes identified.Molecular characterization indicated that these viruses were low-pathogenicity AIVs with limited binding affinity to human receptors,yet they contained mutations associated with enhanced viral replication and pathogenicity in mammals.Pathogenicity tests conducted in ducks demonstrated that H4 viruses were weakly pathogenic,exhibiting limited replication and transmission capabilities.However,some viruses were able to replicate effectively in mice and induce weight loss.For instance,DK/AH/AG61/11(H4N6)can replicate efficiently in MDCK cells,indicating a potential threat to mammals.These findings underscore the importance of ongoing surveillance of H4 AIVs to better understand their evolution and transmission dynamics and to prevent potential public health risks.
