Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction ...Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.展开更多
Anammox bacteria in constructed wetlands(CWs)play pivotal role in sustainable nitrogen transformation,yet existing studies lack comprehensive analysis of environmental gradients and microbial interactions,both key fac...Anammox bacteria in constructed wetlands(CWs)play pivotal role in sustainable nitrogen transformation,yet existing studies lack comprehensive analysis of environmental gradients and microbial interactions,both key factors in anammox bacteria enrichment.This study investigated the mechanisms driving anammox bacteria enrichment in lab-scale simulated CWs treating high-nitrogen wastewater,focusing on bacterial community re-sponses across wetland layers with various strategies,including continuous up-flow influent,nitrogen loading increase,effluent recirculation,intermittent influent,and anammox bacteria inoculation.Results showed that total relative and absolute abundances of anammox bacteria ranged from 0.77%to 12.50%and from 0.13 to 6.46×10^(7) copies/g,respectively.Dissolved oxygen and pH had significant positive correlations with the absolute abundance of anammox bacteria,while organic matter and nitrate negatively impacted their relative abundance.Permutational multivariate analysis of variance indicated that spatial heterogeneity explained more variation in anammox bacteria abundance(43.44%)compared to operational strategies(8.58%).In terms of microbial interactions,60 dominant species exhibited potential correlations with anammox bacteria,comprising 170 interactions(105 positive and 65 negative),which suggested that anammox bacteria generally foster cooperative relationships with dominant bacteria.Notably,significant interspecies interactions were observed between Candidatus Kuenenia(dominant anammox bacteria in CWs)and species within the genera Chitinivibrio-nia and Anaerolineaceae,suggesting that microbial interactions primarily manifest as indirect facilitative effects rather than direct mutualistic relationships.Given that the Normalized Stochasticity Ratio in CWs were<50%,this study inferred that environmental gradients have greater influence on anammox bacteria than microbial interactions.展开更多
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
Global environmental changes including climate warming,extreme weather events,ambient air pollution,freshwater contamination,and landscape transformation are reshaping the epidemiology of infectious diseases with unpr...Global environmental changes including climate warming,extreme weather events,ambient air pollution,freshwater contamination,and landscape transformation are reshaping the epidemiology of infectious diseases with unprecedented complexity,particularly in the post-COVID-19 era.This review synthesizes evidence from the past decade(2015-2024)to systematically elucidate how key environmental drivers modulate pathogen emergence,transmission dynamics,and clinical outcomes,with a focus on underlying mechanistic pathways.Specifically,we highlight:(1)the temperature-and precipitation-dependent transmission of vector-borne diseases(e.g.,malaria,dengue)via expanded vector habitats and accelerated pathogen incubation;(2)the exacerbation of respiratory infections(including COVID-19)by particulate matter(PM2.5)and nitrogen dioxide(NO2)through impaired mucosal immunity and enhanced inflammatory responses;(3)the persistence of diarrheal diseases in low-and middle-income countries(LMICs)linked to water insecurity and climate-induced infrastructure failure;and(4)zoonotic spillover risks amplified by urbanization and deforestation-driven human-wildlife interface disruption.Integrating the One Health socioecological framework,we further summarize methodological advances from high-resolution genomic surveillance to climate-informed machine learning models that have improved causal inference and predictive accuracy.Our synthesis confirms that environmental factors are not merely contextual but central,modifiable determinants of infectious disease risk,with disproportionate impacts on vulnerable populations.To mitigate future threats,we emphasize the urgency of interdisciplinary collaboration,integrated environmental-health monitoring platforms,and climate-resilient public health policies tailored to post-pandemic challenges.This review provides a timely roadmap for translating environmental epidemiology insights into actionable strategies to strengthen global health resilience.展开更多
Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure f...Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.展开更多
In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracte...In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracted much attention,and formulating scientific and reasonable environmental test plans has become an important step to ensure product quality and reliability.展开更多
This study examines the empirical feasibility of quantitatively integrating environmental value information into Strategic Environmental Assessment(SEA).An analytical framework was established to incorporate environme...This study examines the empirical feasibility of quantitatively integrating environmental value information into Strategic Environmental Assessment(SEA).An analytical framework was established to incorporate environmental cost estimates into the SEA process by utilizing ecosystem service unit values provided by the Environmental Valuation Information System(EVIS),a national platform developed to support the evaluation of policies and projects.The framework was applied to a case study involving a multipurpose rural water development project in South Korea.Ecosystem service losses resulting from the project were quantified using biophysical indicators,such as vegetation biomass,forest area,and hydrological functions,and subsequently monetized through the application of the market price method,replacement cost method,and contingent valuation method.The total annual environmental cost was estimated to be approximately KRW 56.18 billion,with the majority attributable to losses in forest conservation and climate regulation services.These findings demonstrate that quantified environmental data can serve as a robust basis for alternative comparison and site evaluation within SEA.The study provides empirical evidence supporting the advancement of SEA from a predominantly procedural tool focused on environmental protection to a more comprehensive sustainability assessment framework that integrates environmental,economic,and social considerations.Furthermore,the results suggest that EVIS-based quantitative information holds potential for broader application in other national evaluation systems,such as preliminary feasibility studies and regulatory impact assessments.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OEC...This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.展开更多
Plantshave evolvedvariousmechanismsto interact withmicroorganisms,which help them acquire nutrients from the soil and enhance their tolerance to environmental stresses.One of the most widespread mutualistic interactio...Plantshave evolvedvariousmechanismsto interact withmicroorganisms,which help them acquire nutrients from the soil and enhance their tolerance to environmental stresses.One of the most widespread mutualistic interactions is arbuscular mycorrhizal(AM)symbiosis,which is formed by 80%-90%of terrestrial plants in association with AM fungi.In AM symbiosis,plants acquire mineral nutrients from the fungi in exchange for fatty acids and sugars that are produced during photosynthesis(Jiang et al.,2017).展开更多
As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major c...As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major challenge,but it is an unavoidable issue.In the past decade,the artificial nanozymes have been widely used for environmental pollutant monitoring and control,because of their low cost,high stability,easy mass production,etc.However,the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface,complex composition,low catalytic activity,etc.In contrast,the emerging single-atom nanozymes(SANs)have attracted much attention in the field of environmental monitoring and control,due to their multiple advantages of atomically dispersed active sites,high atom utilization efficiency,tunable coordination environment,etc.To date,the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants.Building on the recent advances in the field,this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants.Finally,we critically evaluate the limitations and challenges of SANs,and provide the insights into their future prospects for the monitoring and control of environmental pollutants.展开更多
Modules enable students to engage with content at their own pace,fostering autonomy and deeper understanding.The modular approach ensures clarity in presenting objectives,instructions,and concepts,while having illustr...Modules enable students to engage with content at their own pace,fostering autonomy and deeper understanding.The modular approach ensures clarity in presenting objectives,instructions,and concepts,while having illustrations,activities,and assessments could enhance comprehension and retention.This paper was a developmental study on STS module for college students using the ADDIE Model(Analysis,Design,Development,Implementation,and Evaluation).Sampled 673 first-year students from Northwest Samar State University participated in the study,with 299 participating in a test try-out and 374 in the students’performance evaluation.Three expert evaluators with backgrounds in science,English,and psychology,each with over four years of experience,assessed the modules to ensure alignment with the study’s constructivist learning goals and instructional integrity.The findings revealed that both students and experts had rated the instructional module positively,indicating its effectiveness in facilitating learning and completing lessons.Key aspects such as the style of illustrations and written expressions,the usefulness of learning activities,and the guidance provided by illustrations and captions were especially well-received.The module was praised for its clear objectives,understandable instructions,and engaging tasks like trivia and puzzles.Expert evaluations highlighted relevance,simplicity,and balanced emphasis on topics in the module content.Furthermore,students in test group demonstrated significant improvement in performance,with post-test scores notably higher than pre-test scores,confirming the module’s effectiveness in enhancing learning outcomes.Consequently,this paper provides an opportunity to integrate science learning with initiatives aimed at promoting environmental preservation and driving social change.展开更多
INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chem...INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chemical factors(e.g.,heavy metals,nanomaterials,per-and polyfluoroalkyl substances),physical factors(e.g.,noise,radiation,and extreme weather)biological factors(e.g.,pathogenic microorganisms and parasites),natural disasters(e.g.,earthquakes and floods),and anthropogenic incidents(e.g.,chemical spills,fires,and explosions).展开更多
This paper develops an economic growth model incorporating China’s Environmental Target Responsibility System(ETRS)to analyze its impact on both economic growth and social welfare.We find that the ETRS’s effect on e...This paper develops an economic growth model incorporating China’s Environmental Target Responsibility System(ETRS)to analyze its impact on both economic growth and social welfare.We find that the ETRS’s effect on economic growth is complex,resulting from the interplay of three key factors:its potential to improve environmental quality,its potential dampening effect on total factor productivity(TFP),and its influence on local government spending on environmental governance.A balanced ETRS can improve environmental quality,promote technological innovation,and enhance social welfare.However,excessively stringent targets and overly emphasized responsibility may lead to declines in both economic growth and social welfare.From the perspective of balancing economic growth and social welfare,we find that the ETRS that maximizes economic growth is less stringent than the ETRS that maximizes social welfare.Crucially,the economic growth cost of shifting from a growth-maximizing to a welfare-maximizing ETRS is minimal.In other words,significant improvements in environmental quality and public well-being can be achieved without substantially sacrificing economic dynamism.This paper attempts to model China’s unique environmental target assessment system within the framework of endogenous growth theory,offering a new perspective for understanding the dynamic relationship between economic growth and environmental quality in China.展开更多
ⅡEnvironmental education is gaining increasing recognition in Morocco as a fundamental pillar for achieving the Sustainable Development Goals(SDGs).Within this context,school-based environmental clubs play a crucial ...ⅡEnvironmental education is gaining increasing recognition in Morocco as a fundamental pillar for achieving the Sustainable Development Goals(SDGs).Within this context,school-based environmental clubs play a crucial role in promoting awareness and building climate resilience among students at various educational levels.These clubs serve not only as platforms for ecological engagement but also as practical tools for embedding sustainability into everyday learning.This study explores the main factors that influence the creation,activation,and effectiveness of environmental clubs in Moroccan schools.Relying on a quantitative survey conducted with 42 respondents,including both teachers and school administrators,the research highlights several key enablers.Among the most significant are access to adequate training in environmental education,the presence of strong institutional support,and the availability of sufficient resources.The analysis uses descriptive statistics,chi-square testing,and a Weighted Average Index to better understand the relationships between these variables.Findings reveal a strong correlation between environmental training and the initiation of clubs,although this does not always translate into high levels of student engagement.The main obstacles identified include insufficient time,lack of funding,and a shortage of appropriate educational materials.In conclusion,the study emphasizes the importance of expanding training initiatives,dedicating specific time within school schedules,and improving access to materials.These steps are essential to fully integrate environmental clubs into the Moroccan educational system and to enhance their overall impact.展开更多
Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current ...Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current UAV path planning methodologies often inadequately account for environmental risk factors and exhibit limitations in balancing global and local optimization efficiency.To address these gaps,this study proposes a hybrid path planning framework integrating an improved Ant Colony Optimization(ACO)algorithm with an Orthogonal Jump Point Search(OJPS)algorithm.Firstly,a two-dimensional grid model is constructed to simulate urban environments,with key monitoring nodes selected based on grid-specific environmental risk values.Subsequently,the improved ACO algorithm is used for global path planning,and the OJPS algorithm is integrated to optimize the local path.The improved ACO algorithm introduces the risk value of environmental events,which is used to direct the UAV to the area with higher risk.In the OJPS algorithm,the path search direction is restricted to the orthogonal direction,which improves the computational efficiency of local path optimization.In order to evaluate the performance of the model,this paper utilizes the metrics of the average risk value of the path,the flight time,and the number of turns.The experimental results demonstrate that the proposed improved ACO algorithm performs well in the average risk value of the paths traveled within the first 5 min,within the first 8 min,and within the first 10 min,with improvements of 48.33%,26.10%,and 6.746%,respectively,over the Particle Swarm Optimization(PSO)algorithm and 70.33%,19.08%,and 10.246%,respectively,over theArtificial Rabbits Optimization(ARO)algorithm.TheOJPS algorithmdemonstrates superior performance in terms of flight time and number of turns,exhibiting a reduction of 40%,40%and 57.1%in flight time compared to the other three algorithms,and a reduction of 11.1%,11.1%and 33.8%in the number of turns compared to the other three algorithms.These results highlight the effectiveness of the proposed method in improving the UAV’s ability to respond efficiently to urban environmental events,offering significant implications for the future of UAV path planning in complex urban settings.展开更多
Corporate environmental sustainability has become a critical concern,particularly in resource-intensive industries such as pharmaceuticals,where regulatory pressures and stakeholder expectations continue to rise.Despi...Corporate environmental sustainability has become a critical concern,particularly in resource-intensive industries such as pharmaceuticals,where regulatory pressures and stakeholder expectations continue to rise.Despite increasing attention to green leadership,limited research has explored how environmentally responsible leadership(ERL)influences corporate environmental performance(CEP)through employee-driven sustainability behaviors.This study addresses this gap by examining the mediating roles of green knowledge-sharing behavior(GKSB),green innovative behavior(GIB),and voluntary green behavior(VGB),as well as the moderating role of green shared vision(GSV)in the ERL-CEP relationship.The study is grounded in Resource-Based View(RBV),Knowledge-Based View(KBV),Environmental-Based View(EBV),and Triple Bottom Line(TBL)theories,which collectively explain how leadership-driven sustainability efforts create long-term competitive advantages,drive environmental responsibility,and balance economic,social,and environmental sustainability.A quantitative research design was employed,using survey data from 384 employees in Bangladesh’s pharmaceutical sector.Data were analyzed using Partial Least Squares Structural Equation Modeling(PLS-SEM)in Smart-PLS 4.0 to assess direct,indirect,and moderating effects.The results confirm that ERL has a significant positive impact on CEP,with GKSB,GIB,and VGB acting as mediators,while GSV strengthens the ERL-CEP relationship.This study provides novel empirical evidence on the mechanisms linking green leadership to corporate sustainability,extending the application of RBV,KBV,EBV,and TBL to leadership-driven environmental management.The findings emphasize the importance of leadership training programs,sustainability-focused organizational cultures,and shared environmental visions.Policymakers should consider incentives for companies adopting ERL practices,ensuring that sustainability becomes a strategic,rather than compliance-driven,priority.This study contributes to leadership and sustainability literature by offering a comprehensive framework for integrating ERL into corporate governance and environmental strategies.展开更多
The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications.This review provides a comprehensive overview of the recent advan...The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications.This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology,highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms.The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways.By incorporating cutting-edge technologies such as artificial intelligence(Al),high-throughput screening,and omics approaches,the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations,promote environmental conservation efforts,contribute to safeguarding human health,and advance sustainable development objectives.展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
基金supported by the Innovation Promotion Program of NHC and Shanghai Key Labs,SIBPT(grant number PT2025-01)。
文摘Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.
基金supported by Natural Science Foundation of Xiamen,China(No.3502Z20227232)the STS Project of Fujian-CAS(No.2023T3018)Bureau of International Cooperation,Chinese Academy of Sciences(No.322GJHZ2022035MI).
文摘Anammox bacteria in constructed wetlands(CWs)play pivotal role in sustainable nitrogen transformation,yet existing studies lack comprehensive analysis of environmental gradients and microbial interactions,both key factors in anammox bacteria enrichment.This study investigated the mechanisms driving anammox bacteria enrichment in lab-scale simulated CWs treating high-nitrogen wastewater,focusing on bacterial community re-sponses across wetland layers with various strategies,including continuous up-flow influent,nitrogen loading increase,effluent recirculation,intermittent influent,and anammox bacteria inoculation.Results showed that total relative and absolute abundances of anammox bacteria ranged from 0.77%to 12.50%and from 0.13 to 6.46×10^(7) copies/g,respectively.Dissolved oxygen and pH had significant positive correlations with the absolute abundance of anammox bacteria,while organic matter and nitrate negatively impacted their relative abundance.Permutational multivariate analysis of variance indicated that spatial heterogeneity explained more variation in anammox bacteria abundance(43.44%)compared to operational strategies(8.58%).In terms of microbial interactions,60 dominant species exhibited potential correlations with anammox bacteria,comprising 170 interactions(105 positive and 65 negative),which suggested that anammox bacteria generally foster cooperative relationships with dominant bacteria.Notably,significant interspecies interactions were observed between Candidatus Kuenenia(dominant anammox bacteria in CWs)and species within the genera Chitinivibrio-nia and Anaerolineaceae,suggesting that microbial interactions primarily manifest as indirect facilitative effects rather than direct mutualistic relationships.Given that the Normalized Stochasticity Ratio in CWs were<50%,this study inferred that environmental gradients have greater influence on anammox bacteria than microbial interactions.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
基金the Natural Science Basic Research Program of Shaanxi Province,China[2023-JC-QN-0858]the Free Exploration Program of the Second Affiliated Hospital,School of Medicine,Xi’an Jiaotong University[2020YJ(ZYTS)605]the National Natural Science Foundation of China[81900620].
文摘Global environmental changes including climate warming,extreme weather events,ambient air pollution,freshwater contamination,and landscape transformation are reshaping the epidemiology of infectious diseases with unprecedented complexity,particularly in the post-COVID-19 era.This review synthesizes evidence from the past decade(2015-2024)to systematically elucidate how key environmental drivers modulate pathogen emergence,transmission dynamics,and clinical outcomes,with a focus on underlying mechanistic pathways.Specifically,we highlight:(1)the temperature-and precipitation-dependent transmission of vector-borne diseases(e.g.,malaria,dengue)via expanded vector habitats and accelerated pathogen incubation;(2)the exacerbation of respiratory infections(including COVID-19)by particulate matter(PM2.5)and nitrogen dioxide(NO2)through impaired mucosal immunity and enhanced inflammatory responses;(3)the persistence of diarrheal diseases in low-and middle-income countries(LMICs)linked to water insecurity and climate-induced infrastructure failure;and(4)zoonotic spillover risks amplified by urbanization and deforestation-driven human-wildlife interface disruption.Integrating the One Health socioecological framework,we further summarize methodological advances from high-resolution genomic surveillance to climate-informed machine learning models that have improved causal inference and predictive accuracy.Our synthesis confirms that environmental factors are not merely contextual but central,modifiable determinants of infectious disease risk,with disproportionate impacts on vulnerable populations.To mitigate future threats,we emphasize the urgency of interdisciplinary collaboration,integrated environmental-health monitoring platforms,and climate-resilient public health policies tailored to post-pandemic challenges.This review provides a timely roadmap for translating environmental epidemiology insights into actionable strategies to strengthen global health resilience.
基金supported by the National Key R&D Program of China(Nos.2018YFC1004300 and 2018YFC1004302)the Science&Technology Program of Guizhou Province(Nos.QKHHBZ[2020]3002,QKHPTRC-GCC[2022]039-1 and QKHPTRCCXTD[2022]014)the Scientific Research Program of Guizhou Provincial Department of Education(No.QJJ[2023]019).
文摘Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.
文摘In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracted much attention,and formulating scientific and reasonable environmental test plans has become an important step to ensure product quality and reliability.
基金funded by Korea Environmental Industry&Technology Institute(KEITI)through“Development of Aquatic Ecosystem Service Evaluation Indicators and Valuation Technology”of the Korea Ministry of Environment(MOE)(RS-2025-02214985).
文摘This study examines the empirical feasibility of quantitatively integrating environmental value information into Strategic Environmental Assessment(SEA).An analytical framework was established to incorporate environmental cost estimates into the SEA process by utilizing ecosystem service unit values provided by the Environmental Valuation Information System(EVIS),a national platform developed to support the evaluation of policies and projects.The framework was applied to a case study involving a multipurpose rural water development project in South Korea.Ecosystem service losses resulting from the project were quantified using biophysical indicators,such as vegetation biomass,forest area,and hydrological functions,and subsequently monetized through the application of the market price method,replacement cost method,and contingent valuation method.The total annual environmental cost was estimated to be approximately KRW 56.18 billion,with the majority attributable to losses in forest conservation and climate regulation services.These findings demonstrate that quantified environmental data can serve as a robust basis for alternative comparison and site evaluation within SEA.The study provides empirical evidence supporting the advancement of SEA from a predominantly procedural tool focused on environmental protection to a more comprehensive sustainability assessment framework that integrates environmental,economic,and social considerations.Furthermore,the results suggest that EVIS-based quantitative information holds potential for broader application in other national evaluation systems,such as preliminary feasibility studies and regulatory impact assessments.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘This research extends the literature on the environmental Phillips curve(EPC)and environmental Kuznets curve(EKC)by focusing on the 38 member economies of the Organization for Economic Co-operation and Development(OECD).Using panel data from 2000 to 2021,the study employs several econometric techniques,including fixed effects,feasible generalized least squares,two-stage least squares,and the generalized method of moments.Our primary findings reveal that unemployment has a significant negative impact on CO_(2)emissions,thereby supporting the validity of the EPC hypothesis within OECD countries.This suggests a trade-off between unemployment and reductions in CO_(2)emissions.Similarly,the results validate the EKC hypothesis,with further analysis indicating that the EKC exhibits an N-shaped curve-an important contribution to the literature on environmental dynamics in advanced economies.Additionally,the results show that both trade openness and renewable energy usage have significantly improved environmental quality in OECD economies.Finally,extensive causality testing identifies both one-way and two-way causal relationships among the key variables examined.These findings have important policy implications for the management of environmental quality and macroeconomic variables in the OECD context.
基金supported by the National Key R&D Program of China(2022YFF1001800)the National Natural Science Foundation of China(32088102)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0630103).
文摘Plantshave evolvedvariousmechanismsto interact withmicroorganisms,which help them acquire nutrients from the soil and enhance their tolerance to environmental stresses.One of the most widespread mutualistic interactions is arbuscular mycorrhizal(AM)symbiosis,which is formed by 80%-90%of terrestrial plants in association with AM fungi.In AM symbiosis,plants acquire mineral nutrients from the fungi in exchange for fatty acids and sugars that are produced during photosynthesis(Jiang et al.,2017).
基金supported by the National Natural Science Foundation of China(22422604,32472435)the National Key Research and Development Program of China(2021YFD1700300)+1 种基金the Agricultural Science and Technology Innovation Program of CAAS(CAAS-ASTIP-IQSTAP-04)the State Key Laboratory of Analytical Chemistry for Life Science。
文摘As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major challenge,but it is an unavoidable issue.In the past decade,the artificial nanozymes have been widely used for environmental pollutant monitoring and control,because of their low cost,high stability,easy mass production,etc.However,the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface,complex composition,low catalytic activity,etc.In contrast,the emerging single-atom nanozymes(SANs)have attracted much attention in the field of environmental monitoring and control,due to their multiple advantages of atomically dispersed active sites,high atom utilization efficiency,tunable coordination environment,etc.To date,the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants.Building on the recent advances in the field,this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants.Finally,we critically evaluate the limitations and challenges of SANs,and provide the insights into their future prospects for the monitoring and control of environmental pollutants.
文摘Modules enable students to engage with content at their own pace,fostering autonomy and deeper understanding.The modular approach ensures clarity in presenting objectives,instructions,and concepts,while having illustrations,activities,and assessments could enhance comprehension and retention.This paper was a developmental study on STS module for college students using the ADDIE Model(Analysis,Design,Development,Implementation,and Evaluation).Sampled 673 first-year students from Northwest Samar State University participated in the study,with 299 participating in a test try-out and 374 in the students’performance evaluation.Three expert evaluators with backgrounds in science,English,and psychology,each with over four years of experience,assessed the modules to ensure alignment with the study’s constructivist learning goals and instructional integrity.The findings revealed that both students and experts had rated the instructional module positively,indicating its effectiveness in facilitating learning and completing lessons.Key aspects such as the style of illustrations and written expressions,the usefulness of learning activities,and the guidance provided by illustrations and captions were especially well-received.The module was praised for its clear objectives,understandable instructions,and engaging tasks like trivia and puzzles.Expert evaluations highlighted relevance,simplicity,and balanced emphasis on topics in the module content.Furthermore,students in test group demonstrated significant improvement in performance,with post-test scores notably higher than pre-test scores,confirming the module’s effectiveness in enhancing learning outcomes.Consequently,this paper provides an opportunity to integrate science learning with initiatives aimed at promoting environmental preservation and driving social change.
基金supported by the commissioned project of the Department of Health and Immunization Planning under the National Disease Control and Prevention Administration(No.BX2024100800015)The preliminary study project on standardization of the Chinese Center for Disease Control and Prevention(No.BZ2025-Q155)The National Natural Science Foundation of China(No.82404299).
文摘INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chemical factors(e.g.,heavy metals,nanomaterials,per-and polyfluoroalkyl substances),physical factors(e.g.,noise,radiation,and extreme weather)biological factors(e.g.,pathogenic microorganisms and parasites),natural disasters(e.g.,earthquakes and floods),and anthropogenic incidents(e.g.,chemical spills,fires,and explosions).
基金supported by the National Social Science Fund of China(NSSFC)Project“Research on Economic Growth Theory”(Grant No.22VRC176)the National Natural Science Foundation of China(NSFC)Project“Economic Dynamic Equilibrium and Optimal Regulation Policy Framework Design in the Process of Population Aging”(Grant No.72342033)+1 种基金NSFC Project“Research on the Macroeconomic Impact Mechanism of Local Government Land Allocation Behavior”(Grant No.72003211)the Central University of Finance and Economics Youth Research Innovation Team Support Program Project“Research on Data-Based Platform Anti-Monopoly Regulation”(Grant No.20230047).
文摘This paper develops an economic growth model incorporating China’s Environmental Target Responsibility System(ETRS)to analyze its impact on both economic growth and social welfare.We find that the ETRS’s effect on economic growth is complex,resulting from the interplay of three key factors:its potential to improve environmental quality,its potential dampening effect on total factor productivity(TFP),and its influence on local government spending on environmental governance.A balanced ETRS can improve environmental quality,promote technological innovation,and enhance social welfare.However,excessively stringent targets and overly emphasized responsibility may lead to declines in both economic growth and social welfare.From the perspective of balancing economic growth and social welfare,we find that the ETRS that maximizes economic growth is less stringent than the ETRS that maximizes social welfare.Crucially,the economic growth cost of shifting from a growth-maximizing to a welfare-maximizing ETRS is minimal.In other words,significant improvements in environmental quality and public well-being can be achieved without substantially sacrificing economic dynamism.This paper attempts to model China’s unique environmental target assessment system within the framework of endogenous growth theory,offering a new perspective for understanding the dynamic relationship between economic growth and environmental quality in China.
文摘ⅡEnvironmental education is gaining increasing recognition in Morocco as a fundamental pillar for achieving the Sustainable Development Goals(SDGs).Within this context,school-based environmental clubs play a crucial role in promoting awareness and building climate resilience among students at various educational levels.These clubs serve not only as platforms for ecological engagement but also as practical tools for embedding sustainability into everyday learning.This study explores the main factors that influence the creation,activation,and effectiveness of environmental clubs in Moroccan schools.Relying on a quantitative survey conducted with 42 respondents,including both teachers and school administrators,the research highlights several key enablers.Among the most significant are access to adequate training in environmental education,the presence of strong institutional support,and the availability of sufficient resources.The analysis uses descriptive statistics,chi-square testing,and a Weighted Average Index to better understand the relationships between these variables.Findings reveal a strong correlation between environmental training and the initiation of clubs,although this does not always translate into high levels of student engagement.The main obstacles identified include insufficient time,lack of funding,and a shortage of appropriate educational materials.In conclusion,the study emphasizes the importance of expanding training initiatives,dedicating specific time within school schedules,and improving access to materials.These steps are essential to fully integrate environmental clubs into the Moroccan educational system and to enhance their overall impact.
基金supported by the Special Project forKey Fields of Ordinary Universities in Guangdong Province(Number:2023ZDZX1076).
文摘Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current UAV path planning methodologies often inadequately account for environmental risk factors and exhibit limitations in balancing global and local optimization efficiency.To address these gaps,this study proposes a hybrid path planning framework integrating an improved Ant Colony Optimization(ACO)algorithm with an Orthogonal Jump Point Search(OJPS)algorithm.Firstly,a two-dimensional grid model is constructed to simulate urban environments,with key monitoring nodes selected based on grid-specific environmental risk values.Subsequently,the improved ACO algorithm is used for global path planning,and the OJPS algorithm is integrated to optimize the local path.The improved ACO algorithm introduces the risk value of environmental events,which is used to direct the UAV to the area with higher risk.In the OJPS algorithm,the path search direction is restricted to the orthogonal direction,which improves the computational efficiency of local path optimization.In order to evaluate the performance of the model,this paper utilizes the metrics of the average risk value of the path,the flight time,and the number of turns.The experimental results demonstrate that the proposed improved ACO algorithm performs well in the average risk value of the paths traveled within the first 5 min,within the first 8 min,and within the first 10 min,with improvements of 48.33%,26.10%,and 6.746%,respectively,over the Particle Swarm Optimization(PSO)algorithm and 70.33%,19.08%,and 10.246%,respectively,over theArtificial Rabbits Optimization(ARO)algorithm.TheOJPS algorithmdemonstrates superior performance in terms of flight time and number of turns,exhibiting a reduction of 40%,40%and 57.1%in flight time compared to the other three algorithms,and a reduction of 11.1%,11.1%and 33.8%in the number of turns compared to the other three algorithms.These results highlight the effectiveness of the proposed method in improving the UAV’s ability to respond efficiently to urban environmental events,offering significant implications for the future of UAV path planning in complex urban settings.
文摘Corporate environmental sustainability has become a critical concern,particularly in resource-intensive industries such as pharmaceuticals,where regulatory pressures and stakeholder expectations continue to rise.Despite increasing attention to green leadership,limited research has explored how environmentally responsible leadership(ERL)influences corporate environmental performance(CEP)through employee-driven sustainability behaviors.This study addresses this gap by examining the mediating roles of green knowledge-sharing behavior(GKSB),green innovative behavior(GIB),and voluntary green behavior(VGB),as well as the moderating role of green shared vision(GSV)in the ERL-CEP relationship.The study is grounded in Resource-Based View(RBV),Knowledge-Based View(KBV),Environmental-Based View(EBV),and Triple Bottom Line(TBL)theories,which collectively explain how leadership-driven sustainability efforts create long-term competitive advantages,drive environmental responsibility,and balance economic,social,and environmental sustainability.A quantitative research design was employed,using survey data from 384 employees in Bangladesh’s pharmaceutical sector.Data were analyzed using Partial Least Squares Structural Equation Modeling(PLS-SEM)in Smart-PLS 4.0 to assess direct,indirect,and moderating effects.The results confirm that ERL has a significant positive impact on CEP,with GKSB,GIB,and VGB acting as mediators,while GSV strengthens the ERL-CEP relationship.This study provides novel empirical evidence on the mechanisms linking green leadership to corporate sustainability,extending the application of RBV,KBV,EBV,and TBL to leadership-driven environmental management.The findings emphasize the importance of leadership training programs,sustainability-focused organizational cultures,and shared environmental visions.Policymakers should consider incentives for companies adopting ERL practices,ensuring that sustainability becomes a strategic,rather than compliance-driven,priority.This study contributes to leadership and sustainability literature by offering a comprehensive framework for integrating ERL into corporate governance and environmental strategies.
基金supported by the Leading Goose R&D Program of Zhejiang(No.2024C03230)the Fundamental Research Funds for the Central Universities。
文摘The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications.This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology,highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms.The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways.By incorporating cutting-edge technologies such as artificial intelligence(Al),high-throughput screening,and omics approaches,the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations,promote environmental conservation efforts,contribute to safeguarding human health,and advance sustainable development objectives.
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
